Antimicrobial peptides in animals and their role in host defences

International Journal of Antimicrobial Agents

Volumn 22, Issue 5, 2003, Pages 465-478

  Brogden, Kim A ^a   Ackermann, Mark ^b   McCray Jr , Paul B ^c   Tack, Brian F ^c  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Anionic peptides; Antimicrobial peptides; Cathelicidins; Cationic peptides; Defensins; Domesticated animals; Innate defence; Livestock

Indexed keywords

ALPHA DEFENSIN; ANION; ANTIINFECTIVE AGENT; BETA DEFENSIN; CATHELICIDIN; CATHELIN; CATION; CECROPIN; CECROPIN P1; CYSTEINE DERIVATIVE; DEFENSIN; INDOLICIDIN; PEPTIDE; PROLINE DERIVATIVE; PROPHENIN; PROTEGRIN; PROTEIN BAC5; PROTEIN BAC7; PROTEIN BNBD 1; PROTEIN BNBD 2; PROTEIN BNBD 3; PROTEIN BNBD 4; PROTEIN BNBD 5; PROTEIN BNBD 6; PROTEIN BNBD 7; PROTEIN BNBD 8; PROTEIN PR 39; PROTEIN SMAP29; SEMEN PLASMIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACHROMOBACTER; ALPHA HELIX; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACTERIAL PNEUMONIA; BETA SHEET; BOVIDS; BURKHOLDERIA CEPACIA; CATTLE; CELLULAR DISTRIBUTION; DOMESTIC ANIMAL; DRUG EFFICACY; DRUG ISOLATION; DRUG POTENCY; DRUG SPECIFICITY; EPITHELIUM CELL; ESCHERICHIA COLI; FUNGUS; GOAT; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HORSE; HOST RESISTANCE; IMMUNE RESPONSE; INFECTION; INFLAMMATION; LISTERIA MONOCYTOGENES; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MUCOSA CELL; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NEUTROPHIL; NONHUMAN; POULTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PSEUDOMONAS AERUGINOSA; SHEEP; STENOTROPHOMONAS MALTOPHILIA; SWINE;

EID: 0242353107     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(03)00180-8     Document Type: Review

References (141)

1. Wegener H.C., Aarestrup F.M., Jensen L.B., Hammerum A.M., Bager F. Use of antimicrobial growth promoters in food animals and Enterococcus faecium resistance to therapeutic antimicrobial drugs in Europe. Emerg. Infect. Dis. 5:1999;329-335.
2. Witte W. Medical consequences of antibiotic use in agriculture. Science. 279:1998;996-997.
3. Witte W., Tschape H., Klare I., Werner G. Antibiotics in animal feed. Acta Vet. Scand. 93:(Suppl):2000;37-45.
4. Diekema D.J., Brueggemann A.B., Doern G.V. Antimicrobial-drug use and changes in resistance in Streptococcus pneumoniae. Emerg. Infect. Dis. 6:2000;552-556.
5. Gaynes R., Monnet D. The contribution of antibiotic use on the frequency of antibiotic resistance in hospitals. Ciba Found Symp. 207:1997;47-56.
6. Gaynes R. The impact of antimicrobial use on the emergence of antimicrobial-resistant bacteria in hospitals. Infect. Dis. Clin. North Am. 11:1997;757-765.
7. Marwick C. Animal feed antibiotic use raises drug resistance fear. J. Am. Med. Assoc. 282:1999;120-122.
8. Gorbach S.L. Antimicrobial use in animal feed - time to stop. N. Engl. J. Med. 345:2001;1202-1203.
9. Arthur M., Reynolds P., Courvalin P. Glycopeptide resistance in enterococci. Trends Microbiol. 4:1996;401-407.
10. Jacoby G.A. Antimicrobial-resistant pathogens in the 1990s. Annu. Rev. Med. 47:1996;169-179.
11. Travis S.M., Anderson N.N., Forsyth W.R., et al. Bactericidal activity of mammalian cathelicidin-derived peptides. Infect. Immun. 68:2000;2748-2755.
12. Hirata M., Shimomura Y., Yoshida M., et al. Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity. Infect. Immun. 62:1994;1421-1426.
13. Zanetti M., Gennaro R., Romeo D. Cathelicidins: a novel protein family with a common proregion and a variabe C-terminal antimicrobial domain. FEBS Lett. 374:1995;1-5.
14. Gallo R.L., Kim K.J., Bernfield M., et al. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J. Biol. Chem. 272:1997;13088-13093.
15. Sawa T., Kurahashi K., Ohara M., et al. Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model. Antimicrob. Agents Chemother. 42:1998;3269-3275.
16. Boman H.G. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol. 13:1995;61-92.
17. Nissen-Meyer J., Nes I.F. Ribosomally synthesized antimicrobial peptides: their function, structure, biogenesis, and mechanism of action. Arch. Microbiol. 167:1997;67-77.
18. Lehrer R.I., Ganz T. Antimicrobial peptides in mammalian and insect host defence. Curr. Opin. Immunol. 11:1999;23-27.
19. Hancock R.E.W. Peptide antibiotics. Lancet. 349:1997;418-422.
20. Nicolas P., Mor A. Peptides as weapons against microorganisms in the chemical defense system of vertebrates. Annu. Rev. Microbiol. 49:1995;277-304.
21. Brogden K.A. Ovine pulmonary surfactant induces killing of Pasteurella haemolytica, Escherichia coli, and Klebsiella pneumoniae by normal serum. Infect. Immun. 60:1992;5182-5189.
22. Brogden K.A., De Lucca A.J., Bland J., Elliott S. Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica. Proc. Natl. Acad. Sci. USA. 93:1996;412-416.
23. de Haen C., Neurath H., Teller D.C. The phylogeny of trypsin-related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationships. J. Mol. Biol. 92:1975;225-259.
24. Brogden K.A., Ackermann M., Huttner K.M. Small, anionic, and charge-neutralizing propeptide fragments of zymogens are antimicrobial. Antimicrob. Agents Chem. 41:1997;1615-1617.
25. Caverly J.M., Radi Z.A., Andreasen C.B., Dixon R.A., Brogden K.A., Ackermann M.R. Comparison of bronchoalveolar lavage fluid obtained from Mannheimia haemolytica-inoculated calves with and without prior treatment with the selectin inhibitor TBC1269. Am. J. Vet. Res. 62:2001;665-672.
26. Brogden K.A., Ackermann M., Huttner K.M. Detection of anionic antimicrobial peptides in ovine bronchoalveolar lavage fluid and respiratory epithelium. Infect. Immun. 66:1998;5948-5954.
27. Schlievert P., Johnson W., Galask R.P. Bacterial growth inhibition by amniotic fluid. VI. Evidence for a zinc-peptide antibacterial system. Am. J. Obstet. Gynecol. 125:1976;906-910.
28. Ellison R.T. III, Boose D., LaForce F.M. Isolation of an antibacterial peptide from human lung lavage fluid. J. Infect. Dis. 151:1985;1123-1129.
29. LaForce F.M., Boose D.S. Effect of zinc and phosphate on an antibacterial peptide isolated from lung lavage. Infect. Immun. 45:1984;692-696.
30. Bottari E. Zinc(II) complexes with aspartate and glutamate. J. Coord. Chem. 21:1990;215-224.
31. Littauer U.Z., Sela M. An ultracentrifugal study of the efficiency of some macromolecular inhibitors of ribonuclease. Biochim. Biophys. Acta. 61:1962;609-611.
32. Sela M. Inhibition of ribonuclease by copolymers of glutamic acid and aromatic amino acids. J. Biol. Chem. 237:1962;418-421.
33. Vandendriessche L. Inhibitors of ribonuclease activity. Arch. Biochem. Biophys. 65:1956;347-353.
34. Scocchi M., Wang S.L., Zanetti M. Structural organization of the bovine cathelicidin gene family and identification of a novel member. FEBS Lett. 417:1997;311-315.
35. Scocchi M., Bontempo D., Boscolo S., Tomasinsig L., Giulotto E., Zanetti M. Novel cathelicidins in horse leukocytes. FEBS Lett. 457:1999;459-464.
36. Gennaro R., Zanetti M. Structural features and biological activities of the cathelicidin- derived antimicrobial peptides. Biopolymers. 55:2000;31-49.
37. Gazit E., Boman A., Boman H.G., Shai Y. Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles. Biochemistry. 34:1995;11479-11488.
38. Vunnam S., Juvvadi P., Merrifield R.B. Synthesis and antibacterial action of cecropin and proline-arginine-rich peptides from pig intestine. J. Pept. Res. 49:1997;59-66.
39. Lee J.-Y., Boman A., Chuanxin S., et al. Antibacterial peptides from pig intestine: Isolation of a mammalian cecropin. Proc. Natl. Acad. Sci. USA. 86:1989;9159-9162.
40. Zanetti M., Storici P., Tossi A., Scocchi M., Gennaro R. Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells. J. Biol. Chem. 269:1994;7855-7858.
41. Zhang G., Ross C.R., Blecha F. Porcine antimicrobial peptides: new prospects for ancient molecules of host defense. Vet. Res. 31:2000;277-296.
42. Lee D.G., Kim D.H., Park Y., et al. Fungicidal effect of antimicrobial peptide, PMAP-23, isolated from porcine myeloid against Candida albicans. Biochem. Biophys. Res. Commun. 282:2001;570-574.
43. Brogden K.A., Kalfa V.C., Ackermann M.R., Palmquist D.E., McCray P.B. Jr., Tack B.F. The ovine cathelicidin SMAP29 kills ovine respiratory pathogens In vitro and in an ovine model of pulmonary infection. Antimicrob. Agents Chemother. 45:2001;331-334.
44. Bagella L., Scocchi M., Zanetti M. cDNA sequences of three sheep myeloid cathelicidins. FEBS Lett. 376:1995;225-228.
45. Mahoney M.M., Lee A.Y., Brezinski-Caliguri D.J., Huttner K.M. Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide. FEBS Lett. 377:1995;519-522.
46. Skerlavaj B., Benincasa M., Risso A., Zanetti M., Gennaro R. SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. FEBS Lett. 463:1999;58-62.
47. Saiman L., Tabibi S., Starner T.D., et al. Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis. Antimicrob. Agents Chemother. 45:2001;2838-2844.
48. Kalfa V.C., Jia H.P., Kunkle R.A., McCray P.B. Jr., Tack B.F., Brogden K.A. Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells. Antimicrob. Agents Chemother. 45:2001;3256-3261.
49. Gennaro R., Scocchi M., Merluzzi L., Zanetti M. Biological characterization of a novel mammalian antimicrobial peptide. Biochim. Biophys. Acta. 1425:1998;361-368.
50. Skerlavaj B., Scocchi M., Gennaro R., Risso A., Zanetti M. Structural and functional analysis of horse cathelicidin peptides. Antimicrob. Agents Chemother. 45:2001;715-722.
51. Skerlavaj B, Romeo D, Gennaro R. Rapid membrane permeabilization and inhibition of vital functions of Gram-negative bacteria by bactenecins, Infect Immun 1990;58:3724-30.
52. Frank R.W., Gennaro R., Schneider K., Przybylski M., Romeo D. Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils. J. Biol. Chem. 265:1990;18871-18874.
53. Gennaro R., Skerlavaj B., Romeo D. Purification, composition, and activity of two bactenecins, antibacterial peptides of bovine neutrophils. Infect. Immun. 57:1989;3142-3146.
54. Shamova O., Brogden K.A., Zhao C., Nguyen T., Kokryakov V.N., Lehrer R.I. Purification and properties of proline-rich antimicrobial peptides from sheep and goat leukocytes. Infect. Immun. 67:1999;4106-4111.
55. Scocchi M., Wang S.L., Gennaro R., Zanetti M. Cloning and analysis of a transcript derived from two contiguous genes of the cathelicidin family. Biochim. Biophys. Acta Gene Struct. Expr. 1398:1998;393-396.
56. Zanetti M., Del Sal G., Storici P., Schneider C., Romeo D. The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics. J. Biol. Chem. 268:1993;522-526.
57. Zanetti M., Litteri L., Gennaro R., Horstmann H., Romeo D. Bactenecins, defense polypeptides of bovine neutrophils, are generated from precursor molecules stored in the large granules. J. Cell. Biol. 111:1990;1363-1371.
58. Boman H.G., Agerberth B., Boman A. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect. Immun. 61:1993;2978-2984.
59. Shi J., Ross C.R., Chengappa M.M., Sylte M.J., McVey D.S., Blecha F. Antibacterial activity of a synthetic peptide (PR-26) derived from PR-39, a proline-arginine-rich neutrophil antimicrobial peptide. Antimicrob. Agents Chem. 40:1996;115-121.
60. Zhao C., Ganz T., Lehrer R.I. Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39. FEBS Lett. 376:1995;130-134.
61. Zhang G., Ross C.R., Dritz S.S., Nietfeld J.C., Blecha F. Salmonella infection increases porcine antibacterial peptide concentrations in serum. Clin. Diagn. Lab. Immunol. 4:1997;774-777.
62. Shi J., Ross C.R., Chengappa M.M., Blecha F. Identification of a proline-argining-rich antibacterial peptide from neutrophils that is analogous to PR-39, and antibacterial peptide from the small intestine. J. Leukoc. Biol. 56:1994;807-811.
63. Linde C.M., Hoffner S.E., Refai E., Andersson M. In vitro activity of PR-39, a proline-arginine-rich peptide, against susceptible and multi-drug-resistant Mycobacterium tuberculosis. J. Antimicrob. Chemother. 47:2001;575-580.
64. Chan Y.R., Zanetti M., Gennaro R., Gallo R.L. Anti-microbial activity and cell binding are controlled by sequence determinants in the anti-microbial peptide PR-39. J. Invest. Dermatol. 116:2001;230-235.
65. Ikeda Y., Young L.H., Scalia R., Ross C.R., Lefer A.M. PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia-reperfusion. Cardiovasc. Res. 49:2001;69-77.
66. Huang H.J., Ross C.R., Blecha F. Chemoattractant properties of PR-39, a neutrophil antibacterial peptide. J. Leukoc. Biol. 61:1997;624-629.
67. Harwig S.S., Kokryakov V.N., Swiderek K.M., Aleshina G.M., Zhao C., Lehrer R.I. Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes. FEBS Lett. 362:1995;65-69.
68. Strukelj B., Pungercar J., Kopitar G., et al. Molecular cloning and identification of a novel porcine cathelin-like antibacterial peptide precursor. Biol. Chem. Hoppe-Seyler. 376:1995;507-510.
69. Selsted M.E., Novotny M.J., Morris W.L., Tang Y.Q., Smith W., Cullor J.S. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J. Biol. Chem. 267:1992;4292-4295.
70. Del Sal G., Storici P., Schneider C., Romeo D., Zanetti M. cDNA cloning of the neutrophil bactericidal peptide indolicidin. Biochem. Biophys. Res. Commun. 187:1992;467-472.
71. Ladokhin A.S., Selsted M.E., White S.H. Bilayer interactions of indolicidin, a small antimicrobial peptide rich in tryptophan, proline, and basic amino acids. Biophys. J. 72:1997;794-805.
72. Ganz T., Lehrer R.I. Defensins. Pharmac. Ther. 66:1995;191-205.
73. Lehrer R.I., Selsted M.E., Szklarek D., Fleischmann J. Antibacterial activity of microbicidal cationic proteins 1 and 2, matural peptide antibiotics of rabbit lung macrophages. Infect. Immun. 42:1983;10-14.
74. Lehrer R.I., Ganz T., Szklarek D., Selsted M.E. Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J. Clin. Invest. 81:1988;1829-1835.
75. Lehrer R.I., Daher K., Ganz T., Selsted M.E. Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes. J. Virol. 54:1985;467-472.
76. Ganz T., Selsted M.E., Lehrer R.I. Defensins. Eur. J. Haematol. 44:1990;1-8.
77. Selsted M.E., Tang Y.-Q., Morris W.L., et al. Purification, primary structures, and antibacterial activities of β-defensins, a new family of antimicrobial peptides from bovine neutrophils. Biol. Chem. 268:1993;6641-6648.
78. Yount N.Y., Yuan J., Tarver A., et al. Cloning and expression of bovine neutrophil beta-defensins. Biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules. J. Biol. Chem. 274:1999;26249-26258.
79. Tang Y.Q., Selsted M.E. Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils. J. Biol. Chem. 268:1993;6649-6653.
80. Ryan L.K., Rhodes J., Bhat M., Diamond G. Expression of beta-defensin genes in bovine alveolar macrophages. Infect. Immun. 66:1998;878-881.
81. Diamond G., Zasloff M., Eck H., Brasseur M., Maloy W.L., Bevins C.L. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc. Natl. Acad. Sci. USA. 88:1991;3952-3956.
82. Diamond G., Zasloff M., Eck H., Brasseur M., Maloy W., Bevins C. A novel antimicrobial peptide from mammalian tracheal mucosa. Chest. 101:1992;47S.
83. Schonwetter B.S., Stolzenberg E.D., Zasloff M.A. Epithelial antibiotics induced at sites of inflammation. Science. 267:1995;1645-1648.
84. Diamond G., Jones D.E., Bevins C.L. Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc. Natl. Acad. Sci. USA. 90:1993;4596-4600.
85. Diamond G., Bevins C. Endotoxin upregulates expression of an antimicrobial peptide gene in mammalian airway epithelial cells. Chest. 105:1994;51S-52S.
86. Huttner K.M. Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract. Am. Soc. Nutr. Sci. 1998;297S-299S.
87. Iannuzzi L., Gallagher D.S., Di Meo G.P., Diamond G., Bevins C.L., Womack J.E. High-resolution FISH mapping of β-defensin genes to river buffalo and sheep chromosomes suggests a chromosome discrepancy in cattle standard karyotypes. Cytogenet. Cell. Genet. 75:1996;10-13.
88. Zhao C., Nguyen T., Liu L., Shamova O., Brogden K., Lehrer R.I. Differential expression of caprine β-defensins in digestive and respiratory tissues. Infect. Immun. 67:1999;6221-6224.
89. Shi J., Zhang G., Wu H., Ross C., Blecha F., Ganz T. Porcine epithelial β-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect. Immun. 67:1999;3121-3127.
90. Brockus C.W., Jackwood M.W., Harmon B.G. Characterization of beta-defensin prepropeptide mRNA from chicken and turkey bone marrow. Anim. Genet. 29:1998;283-289.
91. Harwig S.S., Swiderek K.M., Kokryakov V.N., et al. Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes. FEBS Lett. 342:1994;281-285.
92. Evans E.W., Beach F.G., Moore K.M., Jackwood M.W., Glisson J.R., Harmon B.G. Antimicrobial activity of chicken and turkey heterophil peptides CHP1, CHP2, THP1, and THP3. Vet. Microbiol. 47:1995;295-303.
93. Zhao C., Nguyen T., Liu L., Sacco R.E., Brogden K.A., Lehrer R.I. Gallinacin-3, an inducible epithelial beta-defensin in the chicken. Infect. Immun. 69:2001;2684-2691.
94. Tang Y.Q., Yuan J., Osapay G., et al. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science. 286:1999;498-502.
95. Trabi M., Schirra H.J., Craik D.J. Three-dimensional structure of RTD-1, a cyclic antimicrobial defensin from rhesus macaque leukocytes. Biochemistry. 40:2001;4211-4221.
96. Roumestand C., Louis V., Aumelas A., Grassy G., Calas B., Chavanieu A. Oligomerization of protegrin-1 in the presence of DPC micelles. A proton high-resolution NMR study. FEBS Lett. 421:1998;263-267.
97. Kokryakov V.N., Harwig S.S., Panyutich E.A., et al. Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins. FEBS Lett. 327:1993;231-236.
98. Shi J.S., Ganz T. The role of protegrins and other elastase-activated polypeptides in the bactericidal properties of porcine inflammatory fluids. Infect. Immun. 66:1998;3611-3617.
99. Pellegrini A., Thomas U., Bramaz N., Klauser S., Hunziker P., von Fellenberg R. Identification and isolation of a bactericidal domain in chicken egg white lysozyme. J. Appl. Microbiol. 82:1997;372-378.
100. Dionysius D.A., Milne J.M. Antibacterial peptides of bovine lactoferrin: purification and characterization. J. Dairy Sci. 80:1997;667-674.
101. Haug B.E., Skar M.L., Svendsen J.S. Bulky aromatic amino acids increase the antibacterial activity of 15-residue bovine lactoferricin derivatives. J. Pept. Sci. 7:2001;425-432.
102. Kuwata H., Yip T.T., Yip C.L., Tomita M., Hutchens T.W. Bactericidal domain of lactoferrin: detection, quantitation, and characterization of lactoferricin in serum by SELDI affinity mass spectrometry. Biochem. Biophys. Res. Commun. 245:1998;764-773.
103. Kuwata H., Yip T.T., Tomita M., Hutchens T.W. Direct evidence of the generation in human stomach of an antimicrobial peptide domain (lactoferricin) from ingested lactoferrin. Biochim. Biophys. Acta. 1429:1998;129-141.
104. Ueta E., Tanida T., Osaki T. A novel bovine lactoferrin peptide, FKCRRWQWRM, suppresses Candida cell growth and activates neutrophils. J. Pept. Res. 57:2001;240-249.
105. Ibrahim H.R., Sugimoto Y., Aoki T. Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism. Biochim. Biophys. Acta. 1523:2000;196-205.
106. Kalfa V.C., Palmquist D., Ackermann M.R., Brogden K.A. Suppression of Mannheimia (Pasteurella) haemolytica serovar 1 infection in lambs by intrapulmonary administration of ovine antimicrobial anionic peptide. Int. J. Antimicrob. Agents. 17:2001;505-510.
107. Bensch L.W., Raida M., Magert H.-J., Schulz-Knappe P., Forssmann W.-G. hBD-1: a novel β-Defensin from human plasma. FEBS Lett. 368:1995;331-335.
108. Valore E.V., Park C.H., Quayle A.J., Wiles K.R., McCray P.B. Jr., Ganz T. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101:1998;1633-1642.
109. Schroder J.M., Harder J. Human beta-defensin-2. Int. J. Biochem. Cell. Biol. 31:1999;645-651.
110. Harder J., Bartels J., Christophers E., Schroder J.M. Isolation and characterization of human β-Defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276:2001;5707-5713.
111. Jia HP, Schutte BC, Schudy A et al. Discovery of new human b-defensins using a genomics-based approach, Gene 2001; In press.
112. Garcia J.R., Krause A., Schulz S., et al. Human b-defensin 4: a novel inducible peptide with a specific salt- sensitive spectrum of antimicrobial activity. FASEB J. 15:2001;1819-1821.
113. Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr. Discovery of five conserved b-defensin gene clusters using a computational search strategy. Proc. Natl. Acad. Sci. USA. 99:2002;2129-2133.
114. Iwasa M., Kaito M., Ikoma J., et al. Lactoferrin inhibits hepatitis C virus viremia in chronic hepatitis C patients with high viral loads and HCV genotype 1b. Am. J. Gastroenterol. 97:2002;766-767.
115. Tomita M., Wakabayashi H., Yamauchi K., Teraguchi S., Hayasawa H. Bovine lactoferrin and lactoferricin derived from milk: production and applications. Biochem. Cell. Biol. 80:2002;109-112.
116. van Berkel P.H., Welling M.M., Geerts M., et al. Large scale production of recombinant human lactoferrin in the milk of transgenic cows. Nat. Biotechnol. 20:2002;484-487.
117. Yamauchi K., Toida T., Nishimura S., et al. 13-Week oral repeated administration toxicity study of bovine lactoferrin in rats. Food Chem. Toxicol. 38:2000;503-512.
118. Zagulski T., Lipinski P., Zagulska A., Broniek S., Jarzabek Z. Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo. Br. J. Exp. Pathol. 70:1989;697-704.
119. Lillard J.W. Jr., Boyaka P.N., Chertov O., Oppenheim J.J., McGhee J.R. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc. Natl. Acad. Sci. USA. 96:1999;651-656.
120. Brogden K.A., Heidari M., Sacco R.E., et al. Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiol. Immunol. 18:2003;95-99.
121. Sitaram N., Subbalakshmi C., Krishnakumari V., Nagaraj R. Identification of the region that plays an important role in determining antibacterial activity of bovine seminalplasmin. FEBS Lett. 400:1997;289-292.
122. Lehrer R.I., Lichtenstein A.K., Ganz T. Defensins: Antimicrobial and cytotoxic peptides of mammalian cells. Annu. Rev. Immunol. 11:1993;105-128.
123. Tarver A.P., Clark D.P., Diamond G., et al. Enteric beta defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect. Immun. 66:1998;1045-1056.
124. Skerlavaj B., Gennaro R., Bagella L., Merluzzi L., Risso A., Zanetti M. Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. J. Biol. Chem. 271:1996;28375-28381.
125. Scocchi M., Romeo D., Zanetti M. Molecular cloning of Bac7, a proline- and arginine-rich antimicrobial peptide from bovine neutrophils. FEBS Lett. 352:1994;197-200.
126. Storici P., Del Sal G., Schneider C., Zanetti M. cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils. FEBS Lett. 314:1992;187-190.
127. Romeo D., Skerlavaj B., Bolognesi M., Gennaro R. Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils. J. Biol. Chem. 263:1988;9573-9575.
128. Huttner K.M., Lambeth M.R., Burkin H.R., Burkin D.J., Broad T.E. Localization and genomic organization of sheep antimicrobial peptide genes. Gene. 206:1998;85-91.
129. Zhang G., Wu H., Shi J., Ganz T., Ross C.R., Blecha F. Molecular cloning and tissue expression of porcine b-defensin-1. FEBS Lett. 424:1998;37-40.
130. Storici P., Scocchi M., Tossi A., Gennaro R., Zanetti M. Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA. FEBS Lett. 337:1994;303-307.
131. Tossi A., Scocchi M., Zanetti M., Storici P., Gennaro R. PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity. Eur. J. Biochem. 228:1995;941-946.
132. Agerberth B., Lee J.Y., Bergman T., et al. Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides. Eur. J. Biochem. 202:1991;849-854.
133. Tkachenko S.B., Kokriakov V.N., Ashmarin I.P., Kubatiev A.A. Prophenin and PR39X - novel antimicrobial leukocyte peptides regulating functional activity of thrombocytes. Dokl. Akad. Nauk. 350:1996;704-706.
134. Zhao C., Ganz T., Lehrer R.I. The structure of porcine protegrin genes. FEBS Lett. 368:1995;197-202.
135. Couto M.A., Harwig S.S., Cullor J.S., Hughes J.P., Lehrer R.I. Identification of eNAP-1, an antimicrobial peptide from equine neutrophils. Infect. Immun. 60:1992;3065-3071.
136. Brockus C.W., Jackwood M.W., Harmon B.G. Characterization of beta-defensin prepropeptide mRNA from chicken and turkey bone marrow. Anim. Genet. 29:1998;283-289.
137. Evans E.W., Beach G.G., Wunderlich J., Harmon B.G. Isolation of antimicrobial peptides from avian heterophils. J. Leukoc. Biol. 56:1994;661-665.
138. Zhao C., Liu L., Lehrer R.I. Identification of a new member of the protegrin family by cDNA cloning. FEBS Lett. 346:1994;285-288.
139. Zhao C., Nguyen T., Liu L., Shamova O., Brogden K., Lehrer R.I. Differential expression of caprine b-defensins in digestive and respiratory tissues. Infect. Immun. 67:1999;6221-6224.
140. Christensen B., Fink J., Merrifield R.B., Mauzerall D. Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc. Natl. Acad. Sci. USA. 85:1988;5072-5076.
141. Kagan B.L., Selsted M.E., Ganz T., Lehrer R.I. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc. Natl. Acad. Sci. USA. 87:1990;210-214.