메뉴 건너뛰기




Volumn 588, Issue 2, 2014, Pages 253-260

Recent advances in mammalian protein production

Author keywords

Clonal selection; Mammalian expression; Protein production; Therapeutics

Indexed keywords

LENTIVIRUS VECTOR; RECOMBINANT PROTEIN;

EID: 84892367415     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.11.035     Document Type: Review
Times cited : (183)

References (100)
  • 1
    • 84862541940 scopus 로고    scopus 로고
    • Mammalian cell protein expression for biopharmaceutical production
    • J. Zhu Mammalian cell protein expression for biopharmaceutical production Biotechnol. Adv. 30 2012 1158 1170
    • (2012) Biotechnol. Adv. , vol.30 , pp. 1158-1170
    • Zhu, J.1
  • 4
    • 84879160899 scopus 로고    scopus 로고
    • The structural basis of R-spondin recognition by LGR5 and RNF43
    • P.-H. Chen, X. Chen, Z. Lin, D. Fang, and X. He The structural basis of R-spondin recognition by LGR5 and RNF43 Genes Dev. 2013 1345 1350
    • (2013) Genes Dev. , pp. 1345-1350
    • Chen, P.-H.1    Chen, X.2    Lin, Z.3    Fang, D.4    He, X.5
  • 5
    • 84870990715 scopus 로고    scopus 로고
    • Recent advances in technology supporting biopharmaceutical production from mammalian cells
    • M. Butler, and A. Meneses-Acosta Recent advances in technology supporting biopharmaceutical production from mammalian cells Appl. Microbiol. Biotechnol. 96 2012 885 894
    • (2012) Appl. Microbiol. Biotechnol. , vol.96 , pp. 885-894
    • Butler, M.1    Meneses-Acosta, A.2
  • 6
    • 84870949388 scopus 로고    scopus 로고
    • What's fueling the biotech engine-2011 to 2012
    • S.R. Aggarwal What's fueling the biotech engine-2011 to 2012 Nat. Biotechnol. 30 2012 1191 1197
    • (2012) Nat. Biotechnol. , vol.30 , pp. 1191-1197
    • Aggarwal, S.R.1
  • 7
    • 24344483533 scopus 로고    scopus 로고
    • Biopharmaceutical proteins: Opportunities and challenges
    • J.R. Birch, and Y. Onakunle Biopharmaceutical proteins: opportunities and challenges Methods Mol. Biol. 308 2005 1 16
    • (2005) Methods Mol. Biol. , vol.308 , pp. 1-16
    • Birch, J.R.1    Onakunle, Y.2
  • 8
    • 0035313635 scopus 로고    scopus 로고
    • Industrial choices for protein production by large-scale cell culture
    • L. Chu, and D.K. Robinson Industrial choices for protein production by large-scale cell culture Curr. Opin. Biotechnol. 2001 180 187
    • (2001) Curr. Opin. Biotechnol. , pp. 180-187
    • Chu, L.1    Robinson, D.K.2
  • 9
    • 84873782420 scopus 로고
    • Genetics of somatic mammalian cells III. Long-term cultivation of euploid cells from human and animal subjects
    • T. Puck, S. Cieciura, and A. Robinson Genetics of somatic mammalian cells III. Long-term cultivation of euploid cells from human and animal subjects J. Exp. Med. 108 1958 945 956
    • (1958) J. Exp. Med. , vol.108 , pp. 945-956
    • Puck, T.1    Cieciura, S.2    Robinson, A.3
  • 10
    • 2642675221 scopus 로고    scopus 로고
    • Effective use of BCH-2763, a new potent injectable direct thrombin inhibitor, in combination with tissue plasminogen activator (tPA) in a rat arterial thrombolysis model
    • I. Deschênes, C.D. Finkle, and P.D. Winocour Effective use of BCH-2763, a new potent injectable direct thrombin inhibitor, in combination with tissue plasminogen activator (tPA) in a rat arterial thrombolysis model Thromb. Haemost. 80 1998 186 191
    • (1998) Thromb. Haemost. , vol.80 , pp. 186-191
    • Deschênes, I.1    Finkle, C.D.2    Winocour, P.D.3
  • 12
    • 41849140828 scopus 로고    scopus 로고
    • Recombinant protein therapeutics from CHO cells-20 years and counting
    • K. Jayapal, and K. Wlaschin Recombinant protein therapeutics from CHO cells-20 years and counting Chem. Eng. Prog. 103 2007 40 47
    • (2007) Chem. Eng. Prog. , vol.103 , pp. 40-47
    • Jayapal, K.1    Wlaschin, K.2
  • 13
    • 8344271026 scopus 로고    scopus 로고
    • Production of recombinant protein therapeutics in cultivated mammalian cells
    • F.M. Wurm Production of recombinant protein therapeutics in cultivated mammalian cells Nat. Biotechnol. 22 2004 1393 1398
    • (2004) Nat. Biotechnol. , vol.22 , pp. 1393-1398
    • Wurm, F.M.1
  • 14
    • 61649087668 scopus 로고    scopus 로고
    • Glycosylation as a strategy to improve antibody-based therapeutics
    • R. Jefferis Glycosylation as a strategy to improve antibody-based therapeutics Nat. Rev. Drug Discovery 8 2009 226 234
    • (2009) Nat. Rev. Drug Discovery , vol.8 , pp. 226-234
    • Jefferis, R.1
  • 15
    • 60849113728 scopus 로고    scopus 로고
    • Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins
    • A. Beck, and E. Wagner-Rousset Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins Curr. Pharm. Biotechnol. 9 2008 482 501
    • (2008) Curr. Pharm. Biotechnol. , vol.9 , pp. 482-501
    • Beck, A.1    Wagner-Rousset, E.2
  • 18
    • 45549091317 scopus 로고    scopus 로고
    • Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3- galactose
    • author reply 2735-6
    • D.F. Arnold, and S.A. Misbah Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose N. Engl. J. Med. 358 2008 2735 author reply 2735-6
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2735
    • Arnold, D.F.1    Misbah, S.A.2
  • 19
    • 0016745641 scopus 로고
    • Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells
    • L.A. Chasin, and G. Urlaub Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells Science 187 1975 1091 1093
    • (1975) Science , vol.187 , pp. 1091-1093
    • Chasin, L.A.1    Urlaub, G.2
  • 20
    • 0020426483 scopus 로고
    • Model involving gene inactivation in the generation of autosomal recessive mutants in mammalian cells in culture
    • A.E. Simon, M.W. Taylor, W.E. Bradley, and L.H. Thompson Model involving gene inactivation in the generation of autosomal recessive mutants in mammalian cells in culture Mol. Cell. Biol. 2 1982 1126 1133
    • (1982) Mol. Cell. Biol. , vol.2 , pp. 1126-1133
    • Simon, A.E.1    Taylor, M.W.2    Bradley, W.E.3    Thompson, L.H.4
  • 21
    • 0001127374 scopus 로고
    • Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity
    • G. Urlaub, and L.A. Chasin Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity Proc. Natl. Acad. Sci. U.S.A. 77 1980 4216 4220
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 4216-4220
    • Urlaub, G.1    Chasin, L.A.2
  • 23
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • F.L. Graham, J. Smiley, W.C. Russell, and R. Nairn Characteristics of a human cell line transformed by DNA from human adenovirus type 5 J. Gen. Virol. 36 1977 59 74
    • (1977) J. Gen. Virol. , vol.36 , pp. 59-74
    • Graham, F.L.1    Smiley, J.2    Russell, W.C.3    Nairn, R.4
  • 24
    • 0015857646 scopus 로고
    • Transformation of rat cells by DNA of human adenovirus 5
    • F.L. Graham, and A.J. van der Eb Transformation of rat cells by DNA of human adenovirus 5 Virology 54 1973 536 539
    • (1973) Virology , vol.54 , pp. 536-539
    • Graham, F.L.1    Van Der Eb, A.J.2
  • 25
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • F.L. Graham, and A.J. van der Eb A new technique for the assay of infectivity of human adenovirus 5 DNA Virology 52 1973 456 467
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Van Der Eb, A.J.2
  • 26
    • 0023122268 scopus 로고
    • Growth of 293 cells in suspension culture
    • F.L. Graham Growth of 293 cells in suspension culture J. Gen. Virol. 68 Pt 3 1987 937 940
    • (1987) J. Gen. Virol. , vol.68 , Issue.PART 3 , pp. 937-940
    • Graham, F.L.1
  • 27
    • 0028696562 scopus 로고
    • Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells
    • A. Garnier, J. Côté, I. Nadeau, A. Kamen, and B. Massie Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells Cytotechnology 15 1994 145 155
    • (1994) Cytotechnology , vol.15 , pp. 145-155
    • Garnier, A.1    Côté, J.2    Nadeau, I.3    Kamen, A.4    Massie, B.5
  • 29
    • 0037082158 scopus 로고    scopus 로고
    • High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells
    • Y. Durocher, S. Perret, and A. Kamen High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells Nucleic Acids Res. 30 2002 e9
    • (2002) Nucleic Acids Res. , vol.30 , pp. 9
    • Durocher, Y.1    Perret, S.2    Kamen, A.3
  • 30
    • 77956458110 scopus 로고    scopus 로고
    • Post-translational modifications of protein biopharmaceuticals
    • G. Walsh Post-translational modifications of protein biopharmaceuticals Drug Discovery Today 15 2010 773 780
    • (2010) Drug Discovery Today , vol.15 , pp. 773-780
    • Walsh, G.1
  • 31
    • 50849109798 scopus 로고    scopus 로고
    • Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions
    • G. Backliwal, M. Hildinger, S. Chenuet, S. Wulhfard, M. De Jesus, and F.M. Wurm Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions Nucleic Acids Res. 36 2008 e96
    • (2008) Nucleic Acids Res. , vol.36 , pp. 96
    • Backliwal, G.1    Hildinger, M.2    Chenuet, S.3    Wulhfard, S.4    De Jesus, M.5    Wurm, F.M.6
  • 32
    • 0013261473 scopus 로고    scopus 로고
    • Establishment of a human somatic hybrid cell line for recombinant protein production
    • M.S. Cho, H. Yee, and S. Chan Establishment of a human somatic hybrid cell line for recombinant protein production J. Biomed. Sci. 9 2002 631 638
    • (2002) J. Biomed. Sci. , vol.9 , pp. 631-638
    • Cho, M.S.1    Yee, H.2    Chan, S.3
  • 33
    • 33845923722 scopus 로고    scopus 로고
    • Expression of human coagulation factor VIII in a human hybrid cell line, HKB11
    • B. Mei, Y. Chen, J. Chen, C.Q. Pan, and J.E. Murphy Expression of human coagulation factor VIII in a human hybrid cell line, HKB11 Mol. Biotechnol. 34 2006 165 178
    • (2006) Mol. Biotechnol. , vol.34 , pp. 165-178
    • Mei, B.1    Chen, Y.2    Chen, J.3    Pan, C.Q.4    Murphy, J.E.5
  • 34
    • 17344373287 scopus 로고    scopus 로고
    • New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses
    • F. Fallaux, and A. Bout New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses Hum. Gene Ther. 9 1998 1909 1917
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1909-1917
    • Fallaux, F.1    Bout, A.2
  • 36
    • 0034633740 scopus 로고    scopus 로고
    • Efficient transformation of primary human amniocytes by E1 functions of Ad5: Generation of new cell lines for adenoviral vector production
    • G. Schiedner, S. Hertel, and S. Kochanek Efficient transformation of primary human amniocytes by E1 functions of Ad5: generation of new cell lines for adenoviral vector production Hum. Gene Ther. 11 2000 2105 2116
    • (2000) Hum. Gene Ther. , vol.11 , pp. 2105-2116
    • Schiedner, G.1    Hertel, S.2    Kochanek, S.3
  • 38
    • 58749101153 scopus 로고    scopus 로고
    • Reflections on more than 10 years of TGE approaches
    • S. Geisse Reflections on more than 10 years of TGE approaches Protein Expr. Purif. 64 2009 99 107
    • (2009) Protein Expr. Purif. , vol.64 , pp. 99-107
    • Geisse, S.1
  • 39
    • 34147125994 scopus 로고    scopus 로고
    • Recombinant protein production by large-scale transient gene expression in mammalian cells: State of the art and future perspectives
    • L. Baldi, D.L. Hacker, M. Adam, and F.M. Wurm Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives Biotechnol. Lett. 29 2007 677 684
    • (2007) Biotechnol. Lett. , vol.29 , pp. 677-684
    • Baldi, L.1    Hacker, D.L.2    Adam, M.3    Wurm, F.M.4
  • 40
    • 14244252530 scopus 로고    scopus 로고
    • Orbital shaker technology for the cultivation of mammalian cells in suspension
    • N. Muller, P. Girard, D.L. Hacker, M. Jordan, and F.M. Wurm Orbital shaker technology for the cultivation of mammalian cells in suspension Biotechnol. Bioeng. 89 2005 400 406
    • (2005) Biotechnol. Bioeng. , vol.89 , pp. 400-406
    • Muller, N.1    Girard, P.2    Hacker, D.L.3    Jordan, M.4    Wurm, F.M.5
  • 41
    • 44049095731 scopus 로고    scopus 로고
    • Shaken helical track bioreactors: Providing oxygen to high-density cultures of mammalian cells at volumes up to 1000 L by surface aeration with air
    • X. Zhang, M. Stettler, O. Reif, A. Kocourek, M. Dejesus, D.L. Hacker, and F.M. Wurm Shaken helical track bioreactors: providing oxygen to high-density cultures of mammalian cells at volumes up to 1000 L by surface aeration with air New Biotechnol. 25 2008 68 75
    • (2008) New Biotechnol. , vol.25 , pp. 68-75
    • Zhang, X.1    Stettler, M.2    Reif, O.3    Kocourek, A.4    Dejesus, M.5    Hacker, D.L.6    Wurm, F.M.7
  • 42
    • 26444612689 scopus 로고    scopus 로고
    • Large-scale transient transfection of mammalian cells: A newly emerging attractive option for recombinant protein production
    • S. Geisse, and M. Henke Large-scale transient transfection of mammalian cells: a newly emerging attractive option for recombinant protein production J. Struct. Funct. Genomics 6 2005 165 170
    • (2005) J. Struct. Funct. Genomics , vol.6 , pp. 165-170
    • Geisse, S.1    Henke, M.2
  • 43
    • 0035682949 scopus 로고    scopus 로고
    • Non-GMP plasmid production for transient transfection in bioreactors
    • G. Schmid, E.J. Schlaeger, and B. Wipf Non-GMP plasmid production for transient transfection in bioreactors Cytotechnology 35 2001 157 164
    • (2001) Cytotechnology , vol.35 , pp. 157-164
    • Schmid, G.1    Schlaeger, E.J.2    Wipf, B.3
  • 44
    • 38449108659 scopus 로고    scopus 로고
    • Large-scale production of endotoxin-free plasmids for transient expression in mammalian cell culture
    • A. Rozkov, B. Larsson, S. Gillström, R. Björnestedt, and S.R. Schmidt Large-scale production of endotoxin-free plasmids for transient expression in mammalian cell culture Biotechnol. Bioeng. 99 2008 557 566
    • (2008) Biotechnol. Bioeng. , vol.99 , pp. 557-566
    • Rozkov, A.1    Larsson, B.2    Gillström, S.3    Björnestedt, R.4    Schmidt, S.R.5
  • 45
    • 33845936631 scopus 로고    scopus 로고
    • Serum-free suspension large-scale transient transfection of CHO cells in WAVE bioreactors
    • R. Haldankar, D. Li, Z. Saremi, C. Baikalov, and R. Deshpande Serum-free suspension large-scale transient transfection of CHO cells in WAVE bioreactors Mol. Biotechnol. 34 2006 191 199
    • (2006) Mol. Biotechnol. , vol.34 , pp. 191-199
    • Haldankar, R.1    Li, D.2    Saremi, Z.3    Baikalov, C.4    Deshpande, R.5
  • 46
    • 24344436812 scopus 로고    scopus 로고
    • Large-scale transient expression of therapeutic proteins in mammalian cells
    • S. Geisse, M. Jordan, and F.M. Wurm Large-scale transient expression of therapeutic proteins in mammalian cells Methods Mol. Biol. 308 2005 87 98
    • (2005) Methods Mol. Biol. , vol.308 , pp. 87-98
    • Geisse, S.1    Jordan, M.2    Wurm, F.M.3
  • 47
    • 46349100443 scopus 로고    scopus 로고
    • Transient transfection factors for high-level recombinant protein production in suspension cultured mammalian cells
    • C. Liu, B. Dalby, W. Chen, J.M. Kilzer, and H.C. Chiou Transient transfection factors for high-level recombinant protein production in suspension cultured mammalian cells Mol. Biotechnol. 39 2008 141 153
    • (2008) Mol. Biotechnol. , vol.39 , pp. 141-153
    • Liu, C.1    Dalby, B.2    Chen, W.3    Kilzer, J.M.4    Chiou, H.C.5
  • 48
    • 79955536348 scopus 로고    scopus 로고
    • A simple high-yielding process for transient gene expression in CHO cells
    • Y. Rajendra, D. Kiseljak, L. Baldi, D.L. Hacker, and F.M. Wurm A simple high-yielding process for transient gene expression in CHO cells J. Biotechnol. 153 2011 22 26
    • (2011) J. Biotechnol. , vol.153 , pp. 22-26
    • Rajendra, Y.1    Kiseljak, D.2    Baldi, L.3    Hacker, D.L.4    Wurm, F.M.5
  • 49
    • 38449121649 scopus 로고    scopus 로고
    • High-density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI
    • G. Backliwal, M. Hildinger, and V. Hasija High-density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI Biotechnology 99 2008 721 727
    • (2008) Biotechnology , vol.99 , pp. 721-727
    • Backliwal, G.1    Hildinger, M.2    Hasija, V.3
  • 51
    • 0034607272 scopus 로고    scopus 로고
    • Influence of bcl-2 on cell death during the cultivation of a Chinese hamster ovary cell line expressing a chimeric antibody
    • B.T. Tey, R.P. Singh, L. Piredda, M. Piacentini, and M. Al-Rubeai Influence of bcl-2 on cell death during the cultivation of a Chinese hamster ovary cell line expressing a chimeric antibody Biotechnol. Bioeng. 68 2000 31 43
    • (2000) Biotechnol. Bioeng. , vol.68 , pp. 31-43
    • Tey, B.T.1    Singh, R.P.2    Piredda, L.3    Piacentini, M.4    Al-Rubeai, M.5
  • 52
    • 0037161629 scopus 로고    scopus 로고
    • Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: Effect of Bcl-2 overexpression
    • N.S. Kim, and G.M. Lee Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression J. Biotechnol. 95 2002 237 248
    • (2002) J. Biotechnol. , vol.95 , pp. 237-248
    • Kim, N.S.1    Lee, G.M.2
  • 53
    • 53549124125 scopus 로고    scopus 로고
    • Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-x(L)
    • B.S. Majors, M.J. Betenbaugh, N.E. Pederson, and G.G. Chiang Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-x(L) Biotechnol. Bioeng. 101 2008 567 578
    • (2008) Biotechnol. Bioeng. , vol.101 , pp. 567-578
    • Majors, B.S.1    Betenbaugh, M.J.2    Pederson, N.E.3    Chiang, G.G.4
  • 54
    • 0038247891 scopus 로고    scopus 로고
    • Development of apoptosis-resistant dihydrofolate reductase-deficient Chinese hamster ovary cell line
    • S.K. Lee, and G.M. Lee Development of apoptosis-resistant dihydrofolate reductase-deficient Chinese hamster ovary cell line Biotechnol. Bioeng. 82 2003 872 876
    • (2003) Biotechnol. Bioeng. , vol.82 , pp. 872-876
    • Lee, S.K.1    Lee, G.M.2
  • 55
    • 13544265276 scopus 로고    scopus 로고
    • Transient production of recombinant proteins by Chinese hamster ovary cells using polyethyleneimine/DNA complexes in combination with microtubule disrupting anti-mitotic agents
    • A.S. Tait, C.J. Brown, D.J. Galbraith, M.J. Hines, M. Hoare, J.R. Birch, and D.C. James Transient production of recombinant proteins by Chinese hamster ovary cells using polyethyleneimine/DNA complexes in combination with microtubule disrupting anti-mitotic agents Biotechnol. Bioeng. 88 2004 707 721
    • (2004) Biotechnol. Bioeng. , vol.88 , pp. 707-721
    • Tait, A.S.1    Brown, C.J.2    Galbraith, D.J.3    Hines, M.J.4    Hoare, M.5    Birch, J.R.6    James, D.C.7
  • 56
    • 84864123068 scopus 로고    scopus 로고
    • Transient expression technologies: Past, present, and future
    • S. Geisse Transient expression technologies: past, present, and future Methods Mol. Biol. (Clifton, NJ) 899 2012
    • (2012) Methods Mol. Biol. (Clifton, NJ) , vol.899
    • Geisse, S.1
  • 57
    • 0024236101 scopus 로고
    • Isolation of overproducing recombinant mammalian cell lines by a fast and simple selection procedure
    • M. Wirth, J. Bode, G. Zettlmeissl, and H. Hauser Isolation of overproducing recombinant mammalian cell lines by a fast and simple selection procedure Gene 73 1988 419 426
    • (1988) Gene , vol.73 , pp. 419-426
    • Wirth, M.1    Bode, J.2    Zettlmeissl, G.3    Hauser, H.4
  • 59
    • 77956123402 scopus 로고    scopus 로고
    • Multiplexing RMCE: Versatile extensions of the Flp-recombinase-mediated cassette-exchange technology
    • S. Turan, J. Kuehle, A. Schambach, C. Baum, and J. Bode Multiplexing RMCE: versatile extensions of the Flp-recombinase-mediated cassette-exchange technology J. Mol. Biol. 402 2010 52 69
    • (2010) J. Mol. Biol. , vol.402 , pp. 52-69
    • Turan, S.1    Kuehle, J.2    Schambach, A.3    Baum, C.4    Bode, J.5
  • 60
    • 77954373875 scopus 로고    scopus 로고
    • Recombinase mediated cassette exchange into genomic targets using an adenovirus vector
    • D.A. Sorrell, C.J. Robinson, J.-A. Smith, and A.F. Kolb Recombinase mediated cassette exchange into genomic targets using an adenovirus vector Nucleic Acids Res. 38 2010 e123
    • (2010) Nucleic Acids Res. , vol.38 , pp. 123
    • Sorrell, D.A.1    Robinson, C.J.2    Smith, J.-A.3    Kolb, A.F.4
  • 61
    • 79956355672 scopus 로고    scopus 로고
    • Non-integrative lentivirus drives high-frequency cre-mediated cassette exchange in human cells
    • R. Torres, A. García, M. Payá, and J.C. Ramirez Non-integrative lentivirus drives high-frequency cre-mediated cassette exchange in human cells PLoS ONE 6 2011 e19794
    • (2011) PLoS ONE , vol.6 , pp. 19794
    • Torres, R.1    García, A.2    Payá, M.3    Ramirez, J.C.4
  • 62
    • 84861683733 scopus 로고    scopus 로고
    • Strategies for rapid production of therapeutic proteins in mammalian cells
    • V. Agrawal Strategies for rapid production of therapeutic proteins in mammalian cells Bioprocess Int. 10 2012
    • (2012) Bioprocess Int. , vol.10
    • Agrawal, V.1
  • 63
    • 11344252479 scopus 로고    scopus 로고
    • Harnessing HIV for therapy, basic research and biotechnology
    • M. Wiznerowicz, and D. Trono Harnessing HIV for therapy, basic research and biotechnology Trends Biotechnol. 23 2005 42 47
    • (2005) Trends Biotechnol. , vol.23 , pp. 42-47
    • Wiznerowicz, M.1    Trono, D.2
  • 64
    • 82255185569 scopus 로고    scopus 로고
    • Daedalus: A robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors
    • A.D. Bandaranayake, C. Correnti, B.Y. Ryu, M. Brault, R.K. Strong, and D.J. Rawlings Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors Nucleic Acids Res. 39 2011 e143
    • (2011) Nucleic Acids Res. , vol.39 , pp. 143
    • Bandaranayake, A.D.1    Correnti, C.2    Ryu, B.Y.3    Brault, M.4    Strong, R.K.5    Rawlings, D.J.6
  • 65
    • 82255175933 scopus 로고    scopus 로고
    • Generation of stable, high-producing CHO cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture
    • A. Oberbek, M. Matasci, D.L. Hacker, and F.M. Wurm Generation of stable, high-producing CHO cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture Biotechnol. Bioeng. 41 2010
    • (2010) Biotechnol. Bioeng. , vol.41
    • Oberbek, A.1    Matasci, M.2    Hacker, D.L.3    Wurm, F.M.4
  • 66
    • 84876959581 scopus 로고    scopus 로고
    • Advances in mammalian cell line development technologies for recombinant protein production
    • T. Lai, Y. Yang, and S. Ng Advances in mammalian cell line development technologies for recombinant protein production Pharmaceuticals 6 2013 579 603
    • (2013) Pharmaceuticals , vol.6 , pp. 579-603
    • Lai, T.1    Yang, Y.2    Ng, S.3
  • 67
    • 0035942193 scopus 로고    scopus 로고
    • Overexpression of 5-methylcytosine DNA glycosylase in human embryonic kidney cells EcR293 demethylates the promoter of a hormone-regulated reporter gene
    • B. Zhu, D. Benjamin, Y. Zheng, H. Angliker, S. Thiry, M. Siegmann, and J.P. Jost Overexpression of 5-methylcytosine DNA glycosylase in human embryonic kidney cells EcR293 demethylates the promoter of a hormone-regulated reporter gene Proc. Natl. Acad. Sci. U.S.A. 98 2001 5031 5036
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 5031-5036
    • Zhu, B.1    Benjamin, D.2    Zheng, Y.3    Angliker, H.4    Thiry, S.5    Siegmann, M.6    Jost, J.P.7
  • 68
    • 0035504496 scopus 로고    scopus 로고
    • 5-Methylcytosine DNA glycosylase participates in the genome-wide loss of DNA methylation occurring during mouse myoblast differentiation
    • J.P. Jost, E.J. Oakeley, B. Zhu, D. Benjamin, S. Thiry, M. Siegmann, and Y.C. Jost 5-Methylcytosine DNA glycosylase participates in the genome-wide loss of DNA methylation occurring during mouse myoblast differentiation Nucleic Acids Res. 29 2001 4452 4461
    • (2001) Nucleic Acids Res. , vol.29 , pp. 4452-4461
    • Jost, J.P.1    Oakeley, E.J.2    Zhu, B.3    Benjamin, D.4    Thiry, S.5    Siegmann, M.6    Jost, Y.C.7
  • 70
    • 0033529654 scopus 로고    scopus 로고
    • The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
    • A.C. Bell, A.G. West, and G. Felsenfeld The protein CTCF is required for the enhancer blocking activity of vertebrate insulators Cell 98 1999 387 396
    • (1999) Cell , vol.98 , pp. 387-396
    • Bell, A.C.1    West, A.G.2    Felsenfeld, G.3
  • 72
    • 21344449323 scopus 로고    scopus 로고
    • Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines
    • P.-A. Girod, M. Zahn-Zabal, and N. Mermod Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines Biotechnol. Bioeng. 91 2005 1 11
    • (2005) Biotechnol. Bioeng. , vol.91 , pp. 1-11
    • Girod, P.-A.1    Zahn-Zabal, M.2    Mermod, N.3
  • 73
    • 20144374138 scopus 로고    scopus 로고
    • Efficient selection of stable chinese hamster ovary (CHO) cell lines for expression of recombinant proteins by using human interferon beta SAR element
    • J. Do Kim, Y. Yoon, H.-Y. Hwang, J.S. Park, S. Yu, J. Lee, K. Baek, and J. Yoon Efficient selection of stable chinese hamster ovary (CHO) cell lines for expression of recombinant proteins by using human interferon beta SAR element Biotechnol. Prog. 21 2005 933 937
    • (2005) Biotechnol. Prog. , vol.21 , pp. 933-937
    • Kim, J.D.1    Yoon, Y.2    Hwang, H.-Y.3    Park, J.S.4    Yu, S.5    Lee, J.6    Baek, K.7    Yoon, J.8
  • 74
    • 0346094306 scopus 로고    scopus 로고
    • Improved recombinant gene expression in CHO cells using matrix attachment regions
    • J.-M. Kim, J.-S. Kim, D.-H. Park, H.S. Kang, J. Yoon, K. Baek, and Y. Yoon Improved recombinant gene expression in CHO cells using matrix attachment regions J. Biotechnol. 107 2004 95 105
    • (2004) J. Biotechnol. , vol.107 , pp. 95-105
    • Kim, J.-M.1    Kim, J.-S.2    Park, D.-H.3    Kang, H.S.4    Yoon, J.5    Baek, K.6    Yoon, Y.7
  • 77
    • 26944481086 scopus 로고    scopus 로고
    • CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells
    • S. Williams, T. Mustoe, T. Mulcahy, M. Griffiths, D. Simpson, M. Antoniou, A. Irvine, A. Mountain, and R. Crombie CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells BMC Biotechnol. 5 2005 17
    • (2005) BMC Biotechnol. , vol.5 , pp. 17
    • Williams, S.1    Mustoe, T.2    Mulcahy, T.3    Griffiths, M.4    Simpson, D.5    Antoniou, M.6    Irvine, A.7    Mountain, A.8    Crombie, R.9
  • 78
    • 34548843603 scopus 로고    scopus 로고
    • Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
    • F. Zhang, S.I. Thornhill, S.J. Howe, M. Ulaganathan, A. Schambach, J. Sinclair, C. Kinnon, H.B. Gaspar, M. Antoniou, and A.J. Thrasher Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells Blood 110 2007 1448 1457
    • (2007) Blood , vol.110 , pp. 1448-1457
    • Zhang, F.1    Thornhill, S.I.2    Howe, S.J.3    Ulaganathan, M.4    Schambach, A.5    Sinclair, J.6    Kinnon, C.7    Gaspar, H.B.8    Antoniou, M.9    Thrasher, A.J.10
  • 79
    • 77956265818 scopus 로고    scopus 로고
    • A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors
    • F. Zhang, A.R. Frost, M.P. Blundell, O. Bales, M.N. Antoniou, and A.J. Thrasher A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors Mol. Ther. 18 2010 1640 1649
    • (2010) Mol. Ther. , vol.18 , pp. 1640-1649
    • Zhang, F.1    Frost, A.R.2    Blundell, M.P.3    Bales, O.4    Antoniou, M.N.5    Thrasher, A.J.6
  • 81
    • 15944391987 scopus 로고    scopus 로고
    • Selection of high-producing CHO cells using NPT selection marker with reduced enzyme activity
    • K. Sautter, and B. Enenkel Selection of high-producing CHO cells using NPT selection marker with reduced enzyme activity Biotechnol. Bioeng. 89 2005 530 538
    • (2005) Biotechnol. Bioeng. , vol.89 , pp. 530-538
    • Sautter, K.1    Enenkel, B.2
  • 82
    • 84855237715 scopus 로고    scopus 로고
    • IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines
    • S.C.L. Ho, M. Bardor, H. Feng, Mariati, Y.W. Tong, Z. Song, M.G.S. Yap, and Y. Yang IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines J. Biotechnol. 157 2012 130 139
    • (2012) J. Biotechnol. , vol.157 , pp. 130-139
    • Ho, S.C.L.1    Bardor, M.2    Feng, H.3    Mariati4    Tong, Y.W.5    Song, Z.6    Yap, M.G.S.7    Yang, Y.8
  • 83
    • 0025884056 scopus 로고
    • Efficient selection for high-expression transfectants with a novel eukaryotic vector
    • H. Niwa, K. Yamamura, and J. Miyazaki Efficient selection for high-expression transfectants with a novel eukaryotic vector Gene 108 1991 193 199
    • (1991) Gene , vol.108 , pp. 193-199
    • Niwa, H.1    Yamamura, K.2    Miyazaki, J.3
  • 84
    • 78650197691 scopus 로고    scopus 로고
    • Improved recombinant protein yield using a codon deoptimized DHFR selectable marker in a CHEF1 expression plasmid
    • A.D. Westwood, D.A. Rowe, and H.R.G. Clarke Improved recombinant protein yield using a codon deoptimized DHFR selectable marker in a CHEF1 expression plasmid Biotechnol. Prog. 26 2010 1558 1566
    • (2010) Biotechnol. Prog. , vol.26 , pp. 1558-1566
    • Westwood, A.D.1    Rowe, D.A.2    Clarke, H.R.G.3
  • 85
    • 84867783904 scopus 로고    scopus 로고
    • Monoclonal antibody expression in Mammalian cells
    • R. Zhang, and W. Shen Monoclonal antibody expression in Mammalian cells Antib. Eng. 907 2012 341 358
    • (2012) Antib. Eng. , vol.907 , pp. 341-358
    • Zhang, R.1    Shen, W.2
  • 86
    • 0020574233 scopus 로고
    • Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells
    • G. Urlaub, E. Käs, A.M. Carothers, and L.A. Chasin Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells Cell 33 1983 405 412
    • (1983) Cell , vol.33 , pp. 405-412
    • Urlaub, G.1    Käs, E.2    Carothers, A.M.3    Chasin, L.A.4
  • 87
    • 0020400592 scopus 로고
    • Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene
    • R.J. Kaufman, and P.A. Sharp Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene J. Mol. Biol. 159 1982 601 621
    • (1982) J. Mol. Biol. , vol.159 , pp. 601-621
    • Kaufman, R.J.1    Sharp, P.A.2
  • 88
    • 34249741495 scopus 로고    scopus 로고
    • Application of destabilizing sequences on selection marker for improved recombinant protein productivity in CHO-DG44
    • S.K. Ng, D.I.C. Wang, and M.G.S. Yap Application of destabilizing sequences on selection marker for improved recombinant protein productivity in CHO-DG44 Metab. Eng. 9 2007 304 316
    • (2007) Metab. Eng. , vol.9 , pp. 304-316
    • Ng, S.K.1    Wang, D.I.C.2    Yap, M.G.S.3
  • 89
    • 84871556009 scopus 로고    scopus 로고
    • Production of functional soluble Dectin-1 glycoprotein using an IRES-linked destabilized-dihydrofolate reductase expression vector
    • S.K. Ng, T.R.M. Tan, Y. Wang, D. Ng, L.-T. Goh, M. Bardor, V.V.T. Wong, and K.P. Lam Production of functional soluble Dectin-1 glycoprotein using an IRES-linked destabilized-dihydrofolate reductase expression vector PLoS ONE 7 2012 e52785
    • (2012) PLoS ONE , vol.7 , pp. 52785
    • Ng, S.K.1    Tan, T.R.M.2    Wang, Y.3    Ng, D.4    Goh, L.-T.5    Bardor, M.6    Wong, V.V.T.7    Lam, K.P.8
  • 90
    • 0034122420 scopus 로고    scopus 로고
    • Advances in animal cell recombinant protein production: GS-NS0 expression system
    • L.M. Barnes, C.M. Bentley, and A.J. Dickson Advances in animal cell recombinant protein production: GS-NS0 expression system Cytotechnology 32 2000 109 123
    • (2000) Cytotechnology , vol.32 , pp. 109-123
    • Barnes, L.M.1    Bentley, C.M.2    Dickson, A.J.3
  • 91
    • 0031694586 scopus 로고    scopus 로고
    • Rapid establishment of high-producing cell lines using dicistronic vectors with glutamine synthetase as the selection marker
    • H. Pu, L.M. Cashion, P.J. Kretschmer, and Z. Liu Rapid establishment of high-producing cell lines using dicistronic vectors with glutamine synthetase as the selection marker Mol. Biotechnol. 10 1998 17 25
    • (1998) Mol. Biotechnol. , vol.10 , pp. 17-25
    • Pu, H.1    Cashion, L.M.2    Kretschmer, P.J.3    Liu, Z.4
  • 93
    • 84857444298 scopus 로고    scopus 로고
    • Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells
    • L. Fan, I. Kadura, L.E. Krebs, C.C. Hatfield, M.M. Shaw, and C.C. Frye Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells Biotechnol. Bioeng. 109 2012 1007 1015
    • (2012) Biotechnol. Bioeng. , vol.109 , pp. 1007-1015
    • Fan, L.1    Kadura, I.2    Krebs, L.E.3    Hatfield, C.C.4    Shaw, M.M.5    Frye, C.C.6
  • 94
    • 0030071624 scopus 로고    scopus 로고
    • General concepts about cell sorting techniques
    • A. Orfao, and A. Ruiz-Arguelles General concepts about cell sorting techniques Clin. Biochem. 29 1996 5 9
    • (1996) Clin. Biochem. , vol.29 , pp. 5-9
    • Orfao, A.1    Ruiz-Arguelles, A.2
  • 95
    • 20444374044 scopus 로고    scopus 로고
    • High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands
    • S.M. Young, C. Bologa, E.R. Prossnitz, T.I. Oprea, L.A. Sklar, and B.S. Edwards High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands J. Biomol. Screen. 10 2005 374 382
    • (2005) J. Biomol. Screen. , vol.10 , pp. 374-382
    • Young, S.M.1    Bologa, C.2    Prossnitz, E.R.3    Oprea, T.I.4    Sklar, L.A.5    Edwards, B.S.6
  • 96
    • 0037309153 scopus 로고    scopus 로고
    • High-speed cell sorting: Fundamentals and recent advances
    • S.F. Ibrahim, and G. van den Engh High-speed cell sorting: fundamentals and recent advances Curr. Opin. Biotechnol. 14 2003 5 12
    • (2003) Curr. Opin. Biotechnol. , vol.14 , pp. 5-12
    • Ibrahim, S.F.1    Van Den Engh, G.2
  • 98
    • 64249163225 scopus 로고    scopus 로고
    • A study on the temperature dependency and time course of the cold capture antibody secretion assay
    • J. Pichler, F. Hesse, M. Wieser, R. Kunert, S.S. Galosy, J.E. Mott, and N. Borth A study on the temperature dependency and time course of the cold capture antibody secretion assay J. Biotechnol. 141 2009 80 83
    • (2009) J. Biotechnol. , vol.141 , pp. 80-83
    • Pichler, J.1    Hesse, F.2    Wieser, M.3    Kunert, R.4    Galosy, S.S.5    Mott, J.E.6    Borth, N.7
  • 99
    • 0035812441 scopus 로고    scopus 로고
    • Flow cytometry: An improved method for the selection of highly productive gene-amplified CHO cells using flow cytometry
    • T. Yoshikawa, F. Nakanishi, Y. Ogura, D. Oi, T. Omasa, Y. Katakura, M. Kishimoto, and K.I. Suga Flow cytometry: an improved method for the selection of highly productive gene-amplified CHO cells using flow cytometry Biotechnol. Bioeng. 74 2001 435 442
    • (2001) Biotechnol. Bioeng. , vol.74 , pp. 435-442
    • Yoshikawa, T.1    Nakanishi, F.2    Ogura, Y.3    Oi, D.4    Omasa, T.5    Katakura, Y.6    Kishimoto, M.7    Suga, K.I.8
  • 100
    • 70449710875 scopus 로고    scopus 로고
    • Expression systems for therapeutic glycoprotein production
    • Y. Durocher, and M. Butler Expression systems for therapeutic glycoprotein production Curr. Opin. Biotechnol. 20 2009 700 707
    • (2009) Curr. Opin. Biotechnol. , vol.20 , pp. 700-707
    • Durocher, Y.1    Butler, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.