Rapid establishment of high-producing cell lines using dicistronic vectors with glutamine synthetase as the selection marker

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 10, Issue 1, 1998, Pages 17-25

  Pu, Haifeng ^a   Cashion, Linda M ^a   Kretschmer, Peter J ^a   Liu, Zhong ^b  

^a BAYER AG   (Germany)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Chinese hamster ovary cells; Gene amplification; Glutamine synthetase; Plasmid vectors; Protein expression

Indexed keywords

GLUTAMATE AMMONIA LIGASE;

ANIMAL CELL; ARTICLE; CHO CELL; DRUG DESIGN; DRUG SCREENING; ENCEPHALOMYOCARDITIS VIRUS; EXPRESSION VECTOR; GENE AMPLIFICATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

EID: 0031694586     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02745860     Document Type: Article

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