Recent advances in technology supporting biopharmaceutical production from mammalian cells

Applied Microbiology and Biotechnology

Volumn 96, Issue 4, 2012, Pages 885-894

  Butler, M ^a   Meneses Acosta, A ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

Author keywords

Antibodies; Apoptosis; Biopharmaceuticals; CHO cells; Glycosylation; Vaccines

Indexed keywords

BIOPHARMACEUTICALS; CANCER THERAPY; CHINESE HAMSTER OVARY CELLS; CHO CELL; CLINICAL EFFICACY; CONSISTENT QUALITY; CULTURE MEDIA; CULTURE SYSTEMS; DOWNSTREAM-PROCESSING; FED BATCHES; HIGH PURITY; HUMANIZED MONOCLONAL ANTIBODY; MAMMALIAN CELL CULTURE; MAMMALIAN CELLS; MEDICAL NEEDS; PROCESS EFFICIENCY; PROGRAMMED CELL DEATHS; RECOMBINANT GLYCOPROTEINS; SPECIFIC PRODUCTIVITY; VIABLE CELLS;

ANIMAL CELL CULTURE; ANTIBODIES; BIOREACTORS; CELL DEATH; EFFICIENCY; GLYCOPROTEINS; GLYCOSYLATION; MAINTENANCE; MONOCLONAL ANTIBODIES; VACCINES;

MOLECULAR BIOLOGY;

AMMONIA; FC RECEPTOR; GAMMA INTERFERON; GLUCOSE; GLUTAMINE; GLYCOPROTEIN; IMMUNOGLOBULIN G ANTIBODY; LACTIC ACID; MONOCLONAL ANTIBODY; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT GLYCOPROTEIN GP 120;

ADVANCED TECHNOLOGY; ANTIBODY; APOPTOSIS; BIOREACTOR; BIOTECHNOLOGY; DISEASE TREATMENT; DRUG; PROTEIN; RODENT; VACCINE;

APOPTOSIS; AUTOPHAGOSOME; BIOREACTOR; CELL VIABILITY; CHO CELL; CRYSTALLIZATION; DRUG MANUFACTURE; GENE EXPRESSION; GLYCOSYLATION; MAMMAL CELL; NONHUMAN; OSMOLARITY; PURIFICATION; REVIEW; SIALYLATION; STABLE TRANSFECTION;

ANIMALS; BIOLOGICAL FACTORS; BIOLOGICAL PRODUCTS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; HUMANS; RECOMBINANT PROTEINS;

ANIMALIA; CRICETULUS GRISEUS; MAMMALIA;

EID: 84870990715     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4451-z     Document Type: Review

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