메뉴 건너뛰기




Volumn 4, Issue 12, 2013, Pages 2186-2207

Drug resistance in multiple myeloma: Latest findings and new concepts on molecular mechanisms

Author keywords

Oncotargets

Indexed keywords

BENDAMUSTINE; BORTEZOMIB; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH RECEPTOR; POMALIDOMIDE; PROTEASOME INHIBITOR; PROTEIN P53; WNT PROTEIN;

EID: 84891909864     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1497     Document Type: Article
Times cited : (130)

References (253)
  • 2
    • 33747480248 scopus 로고    scopus 로고
    • Monoclonal gammopathy of undetermined significance
    • Kyle RA and Rajkumar SV. Monoclonal gammopathy of undetermined significance. Br J Haematol. 2006; 134(6):573-589.
    • (2006) Br J Haematol. , vol.134 , Issue.6 , pp. 573-589
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 5
    • 77950826827 scopus 로고    scopus 로고
    • Multiple myeloma: a paradigm for translation of the cancer stem cell hypothesis
    • Agarwal JR and Matsui W. Multiple myeloma: a paradigm for translation of the cancer stem cell hypothesis. Anticancer Agents Med Chem. 2010; 10(2):116-120.
    • (2010) Anticancer Agents Med Chem. , vol.10 , Issue.2 , pp. 116-120
    • Agarwal, J.R.1    Matsui, W.2
  • 6
    • 58349102840 scopus 로고    scopus 로고
    • Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy
    • Ullah MF. Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy. Asian Pac J Cancer Prev. 2008; 9(1):1-6.
    • (2008) Asian Pac J Cancer Prev. , vol.9 , Issue.1 , pp. 1-6
    • Ullah, M.F.1
  • 7
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med. 2002; 53:615-627.
    • (2002) Annu Rev Med. , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 8
    • 2542632720 scopus 로고    scopus 로고
    • Multidrug resistance in haematological malignancies
    • Sonneveld P. Multidrug resistance in haematological malignancies. J Intern Med. 2000; 247(5):521-534.
    • (2000) J Intern Med. , vol.247 , Issue.5 , pp. 521-534
    • Sonneveld, P.1
  • 9
    • 84863652136 scopus 로고    scopus 로고
    • Circumventing cancer drug resistance in the era of personalized medicine
    • Garraway LA and Janne PA. Circumventing cancer drug resistance in the era of personalized medicine. Cancer Discov. 2012; 2(3):214-226.
    • (2012) Cancer Discov. , vol.2 , Issue.3 , pp. 214-226
    • Garraway, L.A.1    Janne, P.A.2
  • 10
    • 77955709954 scopus 로고    scopus 로고
    • Anti-cancer drug resistance: understanding the mechanisms through the use of integrative genomics and functional RNA interference
    • Tan DS, Gerlinger M, Teh BT and Swanton C. Anti-cancer drug resistance: understanding the mechanisms through the use of integrative genomics and functional RNA interference. Eur J Cancer. 2010; 46(12):2166-2177.
    • (2010) Eur J Cancer. , vol.46 , Issue.12 , pp. 2166-2177
    • Tan, D.S.1    Gerlinger, M.2    Teh, B.T.3    Swanton, C.4
  • 11
    • 34548772963 scopus 로고    scopus 로고
    • ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia
    • Raaijmakers MH. ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia. Leukemia. 2007; 21(10):2094-2102.
    • (2007) Leukemia. , vol.21 , Issue.10 , pp. 2094-2102
    • Raaijmakers, M.H.1
  • 12
    • 0034765167 scopus 로고    scopus 로고
    • Drug resistance in hematologic malignancies
    • Marie JP. Drug resistance in hematologic malignancies. Curr Opin Oncol. 2001; 13(6):463-469.
    • (2001) Curr Opin Oncol. , vol.13 , Issue.6 , pp. 463-469
    • Marie, J.P.1
  • 13
    • 0035079539 scopus 로고    scopus 로고
    • Ceramide glycosylation potentiates cellular multidrug resistance
    • Liu YY, Han TY, Giuliano AE and Cabot MC. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J. 2001; 15(3):719-730.
    • (2001) FASEB J. , vol.15 , Issue.3 , pp. 719-730
    • Liu, Y.Y.1    Han, T.Y.2    Giuliano, A.E.3    Cabot, M.C.4
  • 14
    • 84877802533 scopus 로고    scopus 로고
    • Oncogenic properties of sphingosine kinases in haematological malignancies
    • Wallington-Beddoe CT, Bradstock KF and Bendall LJ. Oncogenic properties of sphingosine kinases in haematological malignancies. Br J Haematol. 2013; 161(5):623-638.
    • (2013) Br J Haematol. , vol.161 , Issue.5 , pp. 623-638
    • Wallington-Beddoe, C.T.1    Bradstock, K.F.2    Bendall, L.J.3
  • 15
    • 33845284855 scopus 로고    scopus 로고
    • Sphingolipid players in the leukemia arena
    • Ricci C, Onida F and Ghidoni R. Sphingolipid players in the leukemia arena. Biochim Biophys Acta. 2006; 1758(12):2121-2132.
    • (2006) Biochim Biophys Acta. , vol.1758 , Issue.12 , pp. 2121-2132
    • Ricci, C.1    Onida, F.2    Ghidoni, R.3
  • 16
    • 84861371742 scopus 로고    scopus 로고
    • Expression of ABCB5 gene in hematological malignances and its significance
    • Yang M, Li W, Fan D, Yan Y, Zhang X, Zhang Y and Xiong D. Expression of ABCB5 gene in hematological malignances and its significance. Leuk Lymphoma. 2012; 53(6):1211-1215.
    • (2012) Leuk Lymphoma. , vol.53 , Issue.6 , pp. 1211-1215
    • Yang, M.1    Li, W.2    Fan, D.3    Yan, Y.4    Zhang, X.5    Zhang, Y.6    Xiong, D.7
  • 17
    • 77952580739 scopus 로고    scopus 로고
    • NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science
    • Cairo MS, Jordan CT, Maley CC, Chao C, Melnick A, Armstrong SA, Shlomchik W, Molldrem J, Ferrone S, Mackall C, Zitvogel L, Bishop MR, Giralt SA and June CH. NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science. Biol Blood Marrow Transplant. 2010; 16(6):709-728.
    • (2010) Biol Blood Marrow Transplant. , vol.16 , Issue.6 , pp. 709-728
    • Cairo, M.S.1    Jordan, C.T.2    Maley, C.C.3    Chao, C.4    Melnick, A.5    Armstrong, S.A.6    Shlomchik, W.7    Molldrem, J.8    Ferrone, S.9    Mackall, C.10    Zitvogel, L.11    Bishop, M.R.12    Giralt, S.A.13    June, C.H.14
  • 18
    • 84897437312 scopus 로고    scopus 로고
    • The resistance mechanisms of proteasome inhibitor bortezomib
    • Wang SLaJ. The resistance mechanisms of proteasome inhibitor bortezomib. Biomarker Research. 2013; 1(13):1-9.
    • (2013) Biomarker Research. , vol.1 , Issue.13 , pp. 1-9
    • Wang, S.L.A.J.1
  • 20
    • 63849240546 scopus 로고    scopus 로고
    • Dysfunctional homologous recombination mediates genomic instability and progression in myeloma
    • Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C and Munshi NC. Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Blood. 2009; 113(10):2290-2297.
    • (2009) Blood. , vol.113 , Issue.10 , pp. 2290-2297
    • Shammas, M.A.1    Shmookler Reis, R.J.2    Koley, H.3    Batchu, R.B.4    Li, C.5    Munshi, N.C.6
  • 22
    • 84870893647 scopus 로고    scopus 로고
    • Understanding the molecular biology of myeloma and its therapeutic implications
    • Boyd KD, Pawlyn C, Morgan GJ and Davies FE. Understanding the molecular biology of myeloma and its therapeutic implications. Expert Rev Hematol. 2012; 5(6):603-617.
    • (2012) Expert Rev Hematol. , vol.5 , Issue.6 , pp. 603-617
    • Boyd, K.D.1    Pawlyn, C.2    Morgan, G.J.3    Davies, F.E.4
  • 24
    • 84871074734 scopus 로고    scopus 로고
    • The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies
    • Kalff A and Spencer A. The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies. Blood Cancer J. 2012; 2:e89.
    • (2012) Blood Cancer J. , vol.2
    • Kalff, A.1    Spencer, A.2
  • 26
    • 27244451500 scopus 로고    scopus 로고
    • Clinical outcomes in t(4;14) multiple myeloma: a chemotherapy-sensitive disease characterized by rapid relapse and alkylating agent resistance
    • Jaksic W, Trudel S, Chang H, Trieu Y, Qi X, Mikhael J, Reece D, Chen C and Stewart AK. Clinical outcomes in t(4;14) multiple myeloma: a chemotherapy-sensitive disease characterized by rapid relapse and alkylating agent resistance. J Clin Oncol. 2005; 23(28):7069-7073.
    • (2005) J Clin Oncol. , vol.23 , Issue.28 , pp. 7069-7073
    • Jaksic, W.1    Trudel, S.2    Chang, H.3    Trieu, Y.4    Qi, X.5    Mikhael, J.6    Reece, D.7    Chen, C.8    Stewart, A.K.9
  • 29
    • 1842557964 scopus 로고    scopus 로고
    • The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant
    • Chang H, Sloan S, Li D, Zhuang L, Yi QL, Chen CI, Reece D, Chun K and Keith Stewart A. The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant. Br J Haematol. 2004; 125(1):64-68.
    • (2004) Br J Haematol. , vol.125 , Issue.1 , pp. 64-68
    • Chang, H.1    Sloan, S.2    Li, D.3    Zhuang, L.4    Yi, Q.L.5    Chen, C.I.6    Reece, D.7    Chun, K.8    Keith Stewart, A.9
  • 32
    • 34249790264 scopus 로고    scopus 로고
    • Bortezomib therapy response is independent of cytogenetic abnormalities in relapsed/refractory multiple myeloma
    • Chang H, Trieu Y, Qi X, Xu W, Stewart KA and Reece D. Bortezomib therapy response is independent of cytogenetic abnormalities in relapsed/refractory multiple myeloma. Leuk Res. 2007; 31(6):779-782.
    • (2007) Leuk Res. , vol.31 , Issue.6 , pp. 779-782
    • Chang, H.1    Trieu, Y.2    Qi, X.3    Xu, W.4    Stewart, K.A.5    Reece, D.6
  • 33
    • 78650169662 scopus 로고    scopus 로고
    • Impact of cytogenetics in patients with relapsed or refractory multiple myeloma treated with bortezomib: Adverse effect of 1q21 gains
    • Chang H, Trieu Y, Qi X, Jiang NN, Xu W and Reece D. Impact of cytogenetics in patients with relapsed or refractory multiple myeloma treated with bortezomib: Adverse effect of 1q21 gains. Leuk Res. 2011; 35(1):95-98.
    • (2011) Leuk Res. , vol.35 , Issue.1 , pp. 95-98
    • Chang, H.1    Trieu, Y.2    Qi, X.3    Jiang, N.N.4    Xu, W.5    Reece, D.6
  • 35
    • 0035892119 scopus 로고    scopus 로고
    • Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors
    • Avet-Loiseau H, Gerson F, Magrangeas F, Minvielle S, Harousseau JL and Bataille R. Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors. Blood. 2001; 98(10):3082-3086.
    • (2001) Blood. , vol.98 , Issue.10 , pp. 3082-3086
    • Avet-Loiseau, H.1    Gerson, F.2    Magrangeas, F.3    Minvielle, S.4    Harousseau, J.L.5    Bataille, R.6
  • 38
    • 0025743048 scopus 로고
    • Expression of the c-myc proto-oncogene in multiple myeloma and chronic lymphocytic leukemia: an in situ analysis
    • Greil R, Fasching B, Loidl P and Huber H. Expression of the c-myc proto-oncogene in multiple myeloma and chronic lymphocytic leukemia: an in situ analysis. Blood. 1991; 78(1):180-191.
    • (1991) Blood. , vol.78 , Issue.1 , pp. 180-191
    • Greil, R.1    Fasching, B.2    Loidl, P.3    Huber, H.4
  • 40
    • 79952720734 scopus 로고    scopus 로고
    • Treatment options for relapsed and refractory multiple myeloma
    • Lonial S, Mitsiades CS and Richardson PG. Treatment options for relapsed and refractory multiple myeloma. Clin Cancer Res. 2011; 17(6):1264-1277.
    • (2011) Clin Cancer Res. , vol.17 , Issue.6 , pp. 1264-1277
    • Lonial, S.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 42
    • 84878311335 scopus 로고    scopus 로고
    • MEK inhibitors as a chemotherapeutic intervention in multiple myeloma
    • Chang-Yew Leow C, Gerondakis S and Spencer A. MEK inhibitors as a chemotherapeutic intervention in multiple myeloma. Blood Cancer J. 2013; 3:e105.
    • (2013) Blood Cancer J. , vol.3
    • Chang-Yew Leow, C.1    Gerondakis, S.2    Spencer, A.3
  • 43
    • 79952142407 scopus 로고    scopus 로고
    • MEK and MAF in myeloma therapy
    • Popovic R and Licht JD. MEK and MAF in myeloma therapy. Blood. 2011; 117(8):2300-2302.
    • (2011) Blood. , vol.117 , Issue.8 , pp. 2300-2302
    • Popovic, R.1    Licht, J.D.2
  • 45
    • 33748196399 scopus 로고    scopus 로고
    • Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation
    • Hanamura I, Stewart JP, Huang Y, Zhan F, Santra M, Sawyer JR, Hollmig K, Zangarri M, Pineda-Roman M, van Rhee F, Cavallo F, Burington B, Crowley J, Tricot G, Barlogie B and Shaughnessy JD, Jr. Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation. Blood. 2006; 108(5):1724-1732.
    • (2006) Blood. , vol.108 , Issue.5 , pp. 1724-1732
    • Hanamura, I.1    Stewart, J.P.2    Huang, Y.3    Zhan, F.4    Santra, M.5    Sawyer, J.R.6    Hollmig, K.7    Zangarri, M.8    Pineda-Roman, M.9    van Rhee, F.10    Cavallo, F.11    Burington, B.12    Crowley, J.13    Tricot, G.14    Barlogie, B.15    Shaughnessy, J.D.16
  • 46
    • 3042683879 scopus 로고    scopus 로고
    • Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma
    • Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M and Inazawa J. Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma. Am J Pathol. 2004; 165(1):71-81.
    • (2004) Am J Pathol. , vol.165 , Issue.1 , pp. 71-81
    • Inoue, J.1    Otsuki, T.2    Hirasawa, A.3    Imoto, I.4    Matsuo, Y.5    Shimizu, S.6    Taniwaki, M.7    Inazawa, J.8
  • 47
    • 29244455863 scopus 로고    scopus 로고
    • Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma
    • Shaughnessy J. Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma. Hematology. 2005; 10 Suppl 1:117-126.
    • (2005) Hematology , vol.10 , Issue.SUPPL. 1 , pp. 117-126
    • Shaughnessy, J.1
  • 48
    • 0031883886 scopus 로고    scopus 로고
    • Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains
    • Kocher O, Comella N, Tognazzi K and Brown LF. Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains. Lab Invest. 1998; 78(1):117-125.
    • (1998) Lab Invest. , vol.78 , Issue.1 , pp. 117-125
    • Kocher, O.1    Comella, N.2    Tognazzi, K.3    Brown, L.F.4
  • 49
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
    • Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F and Borst P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 1997; 57(16):3537-3547.
    • (1997) Cancer Res. , vol.57 , Issue.16 , pp. 3537-3547
    • Kool, M.1    de Haas, M.2    Scheffer, G.L.3    Scheper, R.J.4    van Eijk, M.J.5    Juijn, J.A.6    Baas, F.7    Borst, P.8
  • 50
    • 34249652414 scopus 로고    scopus 로고
    • CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms
    • Zhan F, Colla S, Wu X, Chen B, Stewart JP, Kuehl WM, Barlogie B and Shaughnessy JD, Jr. CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms. Blood. 2007; 109(11):4995-5001.
    • (2007) Blood. , vol.109 , Issue.11 , pp. 4995-5001
    • Zhan, F.1    Colla, S.2    Wu, X.3    Chen, B.4    Stewart, J.P.5    Kuehl, W.M.6    Barlogie, B.7    Shaughnessy, J.D.8
  • 52
    • 34548569309 scopus 로고    scopus 로고
    • Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myeloma
    • Chang H, Ning Y, Qi X, Yeung J and Xu W. Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myeloma. Br J Haematol. 2007; 139(1):51-54.
    • (2007) Br J Haematol. , vol.139 , Issue.1 , pp. 51-54
    • Chang, H.1    Ning, Y.2    Qi, X.3    Yeung, J.4    Xu, W.5
  • 54
    • 0037111779 scopus 로고    scopus 로고
    • Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance
    • Pollett JB, Trudel S, Stern D, Li ZH and Stewart AK. Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance. Blood. 2002; 100(10):3819-3821.
    • (2002) Blood. , vol.100 , Issue.10 , pp. 3819-3821
    • Pollett, J.B.1    Trudel, S.2    Stern, D.3    Li, Z.H.4    Stewart, A.K.5
  • 55
    • 2342566403 scopus 로고    scopus 로고
    • Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074
    • Grand EK, Chase AJ, Heath C, Rahemtulla A and Cross NC. Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074. Leukemia. 2004; 18(5):962-966.
    • (2004) Leukemia. , vol.18 , Issue.5 , pp. 962-966
    • Grand, E.K.1    Chase, A.J.2    Heath, C.3    Rahemtulla, A.4    Cross, N.C.5
  • 58
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: clinical applications
    • Hideshima T, Bergsagel PL, Kuehl WM and Anderson KC. Advances in biology of multiple myeloma: clinical applications. Blood. 2004; 104(3):607-618.
    • (2004) Blood. , vol.104 , Issue.3 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 59
    • 84867158927 scopus 로고    scopus 로고
    • Molecular pathogenesis of multiple myeloma and its premalignant precursor
    • Kuehl WM and Bergsagel PL. Molecular pathogenesis of multiple myeloma and its premalignant precursor. J Clin Invest. 2012; 122(10):3456-3463.
    • (2012) J Clin Invest. , vol.122 , Issue.10 , pp. 3456-3463
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 61
    • 54249092519 scopus 로고    scopus 로고
    • Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myelome
    • Decaux O, Lode L, Magrangeas F, Charbonnel C, Gouraud W, Jezequel P, Attal M, Harousseau JL, Moreau P, Bataille R, Campion L, Avet-Loiseau H and Minvielle S. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myelome. J Clin Oncol. 2008; 26(29):4798-4805.
    • (2008) J Clin Oncol. , vol.26 , Issue.29 , pp. 4798-4805
    • Decaux, O.1    Lode, L.2    Magrangeas, F.3    Charbonnel, C.4    Gouraud, W.5    Jezequel, P.6    Attal, M.7    Harousseau, J.L.8    Moreau, P.9    Bataille, R.10    Campion, L.11    Avet-Loiseau, H.12    Minvielle, S.13
  • 62
    • 84856092448 scopus 로고    scopus 로고
    • Genomic stratification of multiple myeloma treated with novel agents
    • Jiang A, Reece D and Chang H. Genomic stratification of multiple myeloma treated with novel agents. Leuk Lymphoma. 2012; 53(2):202-207.
    • (2012) Leuk Lymphoma. , vol.53 , Issue.2 , pp. 202-207
    • Jiang, A.1    Reece, D.2    Chang, H.3
  • 65
    • 11144219996 scopus 로고    scopus 로고
    • p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation
    • Chang H, Qi C, Yi QL, Reece D and Stewart AK. p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation. Blood. 2005; 105(1):358-360.
    • (2005) Blood , vol.105 , Issue.1 , pp. 358-360
    • Chang, H.1    Qi, C.2    Yi, Q.L.3    Reece, D.4    Stewart, A.K.5
  • 66
    • 58149165366 scopus 로고    scopus 로고
    • An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma
    • Xiong W, Wu X, Starnes S, Johnson SK, Haessler J, Wang S, Chen L, Barlogie B, Shaughnessy JD, Jr. and Zhan F. An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma. Blood. 2008; 112(10):4235-4246.
    • (2008) Blood. , vol.112 , Issue.10 , pp. 4235-4246
    • Xiong, W.1    Wu, X.2    Starnes, S.3    Johnson, S.K.4    Haessler, J.5    Wang, S.6    Chen, L.7    Barlogie, B.8    Shaughnessy, J.D.9    Zhan, F.10
  • 67
    • 30844462355 scopus 로고    scopus 로고
    • The fundamental role of epigenetics in hematopoietic malignancies
    • Galm O, Herman JG and Baylin SB. The fundamental role of epigenetics in hematopoietic malignancies. Blood Rev. 2006; 20(1):1-13.
    • (2006) Blood Rev. , vol.20 , Issue.1 , pp. 1-13
    • Galm, O.1    Herman, J.G.2    Baylin, S.B.3
  • 68
    • 0037044560 scopus 로고    scopus 로고
    • Alterations of DNA methylation in hematologic malignancies
    • Rush LJ and Plass C. Alterations of DNA methylation in hematologic malignancies. Cancer Lett. 2002; 185(1):1-12.
    • (2002) Cancer Lett. , vol.185 , Issue.1 , pp. 1-12
    • Rush, L.J.1    Plass, C.2
  • 69
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP and Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 1983; 301(5895):89-92.
    • (1983) Nature. , vol.301 , Issue.5895 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 70
    • 0036216505 scopus 로고    scopus 로고
    • Epigenomics and epigenetic therapy of cancer
    • Brown R and Strathdee G. Epigenomics and epigenetic therapy of cancer. Trends Mol Med. 2002; 8(4 Suppl):S43-48.
    • (2002) Trends Mol Med , vol.8 , Issue.4 SUPPL.
    • Brown, R.1    Strathdee, G.2
  • 73
    • 2642532716 scopus 로고    scopus 로고
    • DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies
    • Seidl S, Ackermann J, Kaufmann H, Keck A, Nosslinger T, Zielinski CC, Drach J and Zochbauer-Muller S. DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies. Cancer. 2004; 100(12):2598-2606.
    • (2004) Cancer. , vol.100 , Issue.12 , pp. 2598-2606
    • Seidl, S.1    Ackermann, J.2    Kaufmann, H.3    Keck, A.4    Nosslinger, T.5    Zielinski, C.C.6    Drach, J.7    Zochbauer-Muller, S.8
  • 75
    • 0038784365 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
    • Galm O, Yoshikawa H, Esteller M, Osieka R and Herman JG. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood. 2003; 101(7):2784-2788.
    • (2003) Blood. , vol.101 , Issue.7 , pp. 2784-2788
    • Galm, O.1    Yoshikawa, H.2    Esteller, M.3    Osieka, R.4    Herman, J.G.5
  • 78
    • 28044455426 scopus 로고    scopus 로고
    • Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with multiple myeloma
    • Takada S, Morita K, Hayashi K, Matsushima T, Sawamura M, Murakami H and Nojima Y. Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with multiple myeloma. Eur J Haematol. 2005; 75(6):505-510.
    • (2005) Eur J Haematol. , vol.75 , Issue.6 , pp. 505-510
    • Takada, S.1    Morita, K.2    Hayashi, K.3    Matsushima, T.4    Sawamura, M.5    Murakami, H.6    Nojima, Y.7
  • 79
    • 1042289347 scopus 로고    scopus 로고
    • Methylation profiling in multiple myeloma
    • Chim CS, Kwong YL, Fung TK and Liang R. Methylation profiling in multiple myeloma. Leuk Res. 2004; 28(4):379-385.
    • (2004) Leuk Res. , vol.28 , Issue.4 , pp. 379-385
    • Chim, C.S.1    Kwong, Y.L.2    Fung, T.K.3    Liang, R.4
  • 83
    • 84891930710 scopus 로고    scopus 로고
    • Singhal. Epigenomic Profiling of Multiple Myeloma Shows Widespread Stage Specific Alterations In DNA Methylation That Occur Early During Myelomagenesis
    • Abstract No. 784
    • Christoph Heuck JM, Joseph Tariman, Natalie Pulliam, Yiting Yu,Tushar D. Bhagat, Sangeeta Nischal, Richard Meagher, Caroline Y. Hu, Amit Verma and Seema B. Singhal. Epigenomic Profiling of Multiple Myeloma Shows Widespread Stage Specific Alterations In DNA Methylation That Occur Early During Myelomagenesis. ASH congress. 2010; Abstract No. 784
    • (2010) ASH congress
    • Christoph Heuck, J.M.1    Tariman, J.2    Pulliam, N.3    Yu, Y.4    Bhagat, T.D.5    Nischal, S.6    Meagher, R.7    Caroline Hu, Y.8    Verma, A.9    Seema, B.10
  • 85
    • 76449105686 scopus 로고    scopus 로고
    • The potential role of epigenetic therapy in multiple myeloma
    • Smith EM, Boyd K and Davies FE. The potential role of epigenetic therapy in multiple myeloma. Br J Haematol. 2010; 148(5):702-713.
    • (2010) Br J Haematol. , vol.148 , Issue.5 , pp. 702-713
    • Smith, E.M.1    Boyd, K.2    Davies, F.E.3
  • 90
    • 0346025548 scopus 로고    scopus 로고
    • Disruption of INK4/CDK/Rb cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS
    • CS Chim TK Fung, R Liang. Disruption of INK4/CDK/Rb cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS. Leukemia. 2003; 17:2533-2535.
    • (2003) Leukemia. , vol.17 , pp. 2533-2535
    • Chim, T.K.1    Fung, C.S.2    Liang, R.3
  • 91
    • 0024411714 scopus 로고
    • P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD
    • Epstein J, Xiao HQ and Oba BK. P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD. Blood. 1989; 74(3):913-917.
    • (1989) Blood. , vol.74 , Issue.3 , pp. 913-917
    • Epstein, J.1    Xiao, H.Q.2    Oba, B.K.3
  • 92
    • 0028094485 scopus 로고
    • Clinical modulation of multidrug resistance in multiple myeloma: effect of cyclosporine on resistant tumor cells
    • Sonneveld P, Schoester M and de Leeuw K. Clinical modulation of multidrug resistance in multiple myeloma: effect of cyclosporine on resistant tumor cells. J Clin Oncol. 1994; 12(8):1584-1591.
    • (1994) J Clin Oncol. , vol.12 , Issue.8 , pp. 1584-1591
    • Sonneveld, P.1    Schoester, M.2    de Leeuw, K.3
  • 93
    • 0027954249 scopus 로고
    • MDR-1 expression and response to vincristine, doxorubicin, and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents
    • Cornelissen JJ, Sonneveld P, Schoester M, Raaijmakers HG, Nieuwenhuis HK, Dekker AW and Lokhorst HM. MDR-1 expression and response to vincristine, doxorubicin, and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents. J Clin Oncol. 1994; 12(1):115-119.
    • (1994) J Clin Oncol. , vol.12 , Issue.1 , pp. 115-119
    • Cornelissen, J.J.1    Sonneveld, P.2    Schoester, M.3    Raaijmakers, H.G.4    Nieuwenhuis, H.K.5    Dekker, A.W.6    Lokhorst, H.M.7
  • 95
    • 0028816350 scopus 로고
    • A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A Southwest Oncology Group study
    • Dalton WS, Crowley JJ, Salmon SS, Grogan TM, Laufman LR, Weiss GR and Bonnet JD. A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A Southwest Oncology Group study. Cancer. 1995; 75(3):815-820.
    • (1995) Cancer. , vol.75 , Issue.3 , pp. 815-820
    • Dalton, W.S.1    Crowley, J.J.2    Salmon, S.S.3    Grogan, T.M.4    Laufman, L.R.5    Weiss, G.R.6    Bonnet, J.D.7
  • 96
    • 32544437036 scopus 로고    scopus 로고
    • Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): a trial of the Eastern Cooperative Oncology Group
    • Friedenberg WR, Rue M, Blood EA, Dalton WS, Shustik C, Larson RA, Sonneveld P and Greipp PR. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): a trial of the Eastern Cooperative Oncology Group. Cancer. 2006; 106(4):830-838.
    • (2006) Cancer. , vol.106 , Issue.4 , pp. 830-838
    • Friedenberg, W.R.1    Rue, M.2    Blood, E.A.3    Dalton, W.S.4    Shustik, C.5    Larson, R.A.6    Sonneveld, P.7    Greipp, P.R.8
  • 97
    • 0642378063 scopus 로고    scopus 로고
    • Overcoming drug resistance in multiple myeloma: the emergence of therapeutic approaches to induce apoptosis
    • Yang HH, Ma MH, Vescio RA and Berenson JR. Overcoming drug resistance in multiple myeloma: the emergence of therapeutic approaches to induce apoptosis. J Clin Oncol. 2003; 21(22):4239-4247.
    • (2003) J Clin Oncol. , vol.21 , Issue.22 , pp. 4239-4247
    • Yang, H.H.1    Ma, M.H.2    Vescio, R.A.3    Berenson, J.R.4
  • 100
    • 77956962955 scopus 로고    scopus 로고
    • Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin
    • Buda G, Ricci D, Huang CC, Favis R, Cohen N, Zhuang SH, Harousseau JL, Sonneveld P, Blade J and Orlowski RZ. Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin. Ann Hematol. 2010; 89(11):1133-1140.
    • (2010) Ann Hematol. , vol.89 , Issue.11 , pp. 1133-1140
    • Buda, G.1    Ricci, D.2    Huang, C.C.3    Favis, R.4    Cohen, N.5    Zhuang, S.H.6    Harousseau, J.L.7    Sonneveld, P.8    Blade, J.9    Orlowski, R.Z.10
  • 102
    • 84875583581 scopus 로고    scopus 로고
    • Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1
    • Hawley TS, Riz I, Yang W, Wakabayashi Y, Depalma L, Chang YT, Peng W, Zhu J and Hawley RG. Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Am J Hematol. 2013; 88(4):265-272.
    • (2013) Am J Hematol. , vol.88 , Issue.4 , pp. 265-272
    • Hawley, T.S.1    Riz, I.2    Yang, W.3    Wakabayashi, Y.4    Depalma, L.5    Chang, Y.T.6    Peng, W.7    Zhu, J.8    Hawley, R.G.9
  • 106
    • 84875359668 scopus 로고    scopus 로고
    • Targeting p53 by small molecules in hematological malignancies
    • Saha MN, Qiu L and Chang H. Targeting p53 by small molecules in hematological malignancies. J Hematol Oncol. 2013; 6:23.
    • (2013) J Hematol Oncol. , vol.6 , pp. 23
    • Saha, M.N.1    Qiu, L.2    Chang, H.3
  • 107
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B and Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004; 10(8):789-799.
    • (2004) Nat Med. , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 108
    • 77952305665 scopus 로고    scopus 로고
    • The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer
    • Farnebo M, Bykov VJ and Wiman KG. The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer. Biochem Biophys Res Commun. 2010; 396(1):85-89.
    • (2010) Biochem Biophys Res Commun. , vol.396 , Issue.1 , pp. 85-89
    • Farnebo, M.1    Bykov, V.J.2    Wiman, K.G.3
  • 109
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the Light: The Growing Complexity of p53
    • Vousden KH and Prives C. Blinded by the Light: The Growing Complexity of p53. Cell. 2009; 137(3):413-431.
    • (2009) Cell. , vol.137 , Issue.3 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 112
    • 0030800922 scopus 로고    scopus 로고
    • Mdm2: keeping p53 under control
    • Piette J, Neel H and Marechal V. Mdm2: keeping p53 under control. Oncogene. 1997; 15(9):1001-1010.
    • (1997) Oncogene. , vol.15 , Issue.9 , pp. 1001-1010
    • Piette, J.1    Neel, H.2    Marechal, V.3
  • 113
    • 14644403700 scopus 로고    scopus 로고
    • MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy
    • Rayburn E, Zhang R, He J and Wang H. MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Curr Cancer Drug Targets. 2005; 5(1):27-41.
    • (2005) Curr Cancer Drug Targets. , vol.5 , Issue.1 , pp. 27-41
    • Rayburn, E.1    Zhang, R.2    He, J.3    Wang, H.4
  • 115
    • 0035977168 scopus 로고    scopus 로고
    • High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance
    • Cocker HA, Hobbs SM, Tiffin N, Pritchard-Jones K, Pinkerton CR and Kelland LR. High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance. Br J Cancer. 2001; 85(11):1746-1752.
    • (2001) Br J Cancer. , vol.85 , Issue.11 , pp. 1746-1752
    • Cocker, H.A.1    Hobbs, S.M.2    Tiffin, N.3    Pritchard-Jones, K.4    Pinkerton, C.R.5    Kelland, L.R.6
  • 116
    • 1542713502 scopus 로고    scopus 로고
    • Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children
    • Wilda M, Bruch J, Harder L, Rawer D, Reiter A, Borkhardt A and Woessmann W. Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children. Leukemia. 2004; 18(3):584-588.
    • (2004) Leukemia. , vol.18 , Issue.3 , pp. 584-588
    • Wilda, M.1    Bruch, J.2    Harder, L.3    Rawer, D.4    Reiter, A.5    Borkhardt, A.6    Woessmann, W.7
  • 117
    • 84856041539 scopus 로고    scopus 로고
    • Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma
    • Saha MN, Jiang H, Yang Y, Zhu X, Wang X, Schimmer AD, Qiu L and Chang H. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma. PLoS One. 2012; 7(1):e30215.
    • (2012) PLoS One. , vol.7 , Issue.1
    • Saha, M.N.1    Jiang, H.2    Yang, Y.3    Zhu, X.4    Wang, X.5    Schimmer, A.D.6    Qiu, L.7    Chang, H.8
  • 118
    • 78649645749 scopus 로고    scopus 로고
    • RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses
    • Saha MN, Jiang H, Mukai A and Chang H. RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses. Mol Cancer Ther. 2010; 9(11):3041-3051.
    • (2010) Mol Cancer Ther. , vol.9 , Issue.11 , pp. 3041-3051
    • Saha, M.N.1    Jiang, H.2    Mukai, A.3    Chang, H.4
  • 119
    • 77957174185 scopus 로고    scopus 로고
    • Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways
    • Saha MN, Jiang H and Chang H. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer Biol Ther. 2010; 10(6):567-578.
    • (2010) Cancer Biol Ther. , vol.10 , Issue.6 , pp. 567-578
    • Saha, M.N.1    Jiang, H.2    Chang, H.3
  • 120
    • 79952277220 scopus 로고    scopus 로고
    • MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity
    • Saha MN, Jiang H, Jayakar J, Reece D, Branch DR and Chang H. MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity. Cancer Biol Ther. 2010; 9(11):936-944.
    • (2010) Cancer Biol Ther. , vol.9 , Issue.11 , pp. 936-944
    • Saha, M.N.1    Jiang, H.2    Jayakar, J.3    Reece, D.4    Branch, D.R.5    Chang, H.6
  • 123
    • 84880755309 scopus 로고    scopus 로고
    • Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: Relevance of p53 and its clinical implications
    • Valdez BC, Wang G, Murray D, Nieto Y, Li Y, Shah J, Turturro F, Wang M, Weber DM, Champlin RE, Qazilbash MH and Andersson BS. Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: Relevance of p53 and its clinical implications. Exp Hematol. 2013; 41(8):719-730.
    • (2013) Exp Hematol. , vol.41 , Issue.8 , pp. 719-730
    • Valdez, B.C.1    Wang, G.2    Murray, D.3    Nieto, Y.4    Li, Y.5    Shah, J.6    Turturro, F.7    Wang, M.8    Weber, D.M.9    Champlin, R.E.10    Qazilbash, M.H.11    Andersson, B.S.12
  • 124
    • 0034725694 scopus 로고    scopus 로고
    • Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase
    • Ohki R, Nemoto J, Murasawa H, Oda E, Inazawa J, Tanaka N and Taniguchi T. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. J Biol Chem. 2000; 275(30):22627-22630.
    • (2000) J Biol Chem. , vol.275 , Issue.30 , pp. 22627-22630
    • Ohki, R.1    Nemoto, J.2    Murasawa, H.3    Oda, E.4    Inazawa, J.5    Tanaka, N.6    Taniguchi, T.7
  • 126
    • 84863228976 scopus 로고    scopus 로고
    • Fludarabine nucleoside induces accumulations of p53, p63 and p73 in the nuclei of human B-lymphoid cell lines, with cytosolic and mitochondrial increases in p53
    • Almazi JG, Mactier S, Best OG, Crossett B, Mulligan SP and Christopherson RI. Fludarabine nucleoside induces accumulations of p53, p63 and p73 in the nuclei of human B-lymphoid cell lines, with cytosolic and mitochondrial increases in p53. Proteomics Clin Appl. 2012; 6(5-6):279-290.
    • (2012) Proteomics Clin Appl. , vol.6 , Issue.5-6 , pp. 279-290
    • Almazi, J.G.1    Mactier, S.2    Best, O.G.3    Crossett, B.4    Mulligan, S.P.5    Christopherson, R.I.6
  • 128
    • 33847077135 scopus 로고    scopus 로고
    • A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells
    • Yu J, Baron V, Mercola D, Mustelin T and Adamson ED. A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death Differ. 2007; 14(3):436-446.
    • (2007) Cell Death Differ. , vol.14 , Issue.3 , pp. 436-446
    • Yu, J.1    Baron, V.2    Mercola, D.3    Mustelin, T.4    Adamson, E.D.5
  • 130
  • 131
    • 80052887167 scopus 로고    scopus 로고
    • A critical role for the NFkB pathway in multiple myeloma
    • Demchenko YN and Kuehl WM. A critical role for the NFkB pathway in multiple myeloma. Oncotarget. 2010; 1(1):59-68.
    • (2010) Oncotarget. , vol.1 , Issue.1 , pp. 59-68
    • Demchenko, Y.N.1    Kuehl, W.M.2
  • 135
    • 77951719881 scopus 로고    scopus 로고
    • Positioning NK-kappaB in multiple myeloma
    • Klein B. Positioning NK-kappaB in multiple myeloma. Blood. 2010; 115(17):3422-3424.
    • (2010) Blood. , vol.115 , Issue.17 , pp. 3422-3424
    • Klein, B.1
  • 139
    • 84863784534 scopus 로고    scopus 로고
    • Heat shock proteins in hematopoietic malignancies
    • Mjahed H, Girodon F, Fontenay M and Garrido C. Heat shock proteins in hematopoietic malignancies. Exp Cell Res. 2012; 318(15):1946-1958.
    • (2012) Exp Cell Res. , vol.318 , Issue.15 , pp. 1946-1958
    • Mjahed, H.1    Girodon, F.2    Fontenay, M.3    Garrido, C.4
  • 144
    • 47649111320 scopus 로고    scopus 로고
    • HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma
    • Nimmanapalli R, Gerbino E, Dalton WS, Gandhi V and Alsina M. HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma. Br J Haematol. 2008; 142(4):551-561.
    • (2008) Br J Haematol. , vol.142 , Issue.4 , pp. 551-561
    • Nimmanapalli, R.1    Gerbino, E.2    Dalton, W.S.3    Gandhi, V.4    Alsina, M.5
  • 145
  • 146
    • 80053948169 scopus 로고    scopus 로고
    • Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma
    • Khong T and Spencer A. Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma. Mol Cancer Ther. 2011; 10(10):1909-1917.
    • (2011) Mol Cancer Ther. , vol.10 , Issue.10 , pp. 1909-1917
    • Khong, T.1    Spencer, A.2
  • 148
    • 85039604181 scopus 로고    scopus 로고
    • The Importance of Notch Signaling in Myeloma Cell-Osteoclast Interactions
    • Abe TMaM. The Importance of Notch Signaling in Myeloma Cell-Osteoclast Interactions. BoneKEy-Osteovision. 2005; 2(2):7-10.
    • (2005) BoneKEy-Osteovision. , vol.2 , Issue.2 , pp. 7-10
    • Abe, T.1    Ma, M.2
  • 149
    • 1942425110 scopus 로고    scopus 로고
    • Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines
    • Nefedova Y, Cheng P, Alsina M, Dalton WS and Gabrilovich DI. Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood. 2004; 103(9):3503-3510.
    • (2004) Blood. , vol.103 , Issue.9 , pp. 3503-3510
    • Nefedova, Y.1    Cheng, P.2    Alsina, M.3    Dalton, W.S.4    Gabrilovich, D.I.5
  • 150
    • 19544377569 scopus 로고    scopus 로고
    • Notch signaling: a key to the pathogenesis of multiple myeloma?
    • Milner LA. Notch signaling: a key to the pathogenesis of multiple myeloma? Blood. 2004; 103:3253-3254.
    • (2004) Blood. , vol.103 , pp. 3253-3254
    • Milner, L.A.1
  • 154
    • 84862022388 scopus 로고    scopus 로고
    • Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation
    • Xu D, Hu J, Xu S, De Bruyne E, Menu E, Van Camp B, Vanderkerken K and Van Valckenborgh E. Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation. Leukemia. 2012; 26(6):1402-1405.
    • (2012) Leukemia. , vol.26 , Issue.6 , pp. 1402-1405
    • Xu, D.1    Hu, J.2    Xu, S.3    De Bruyne, E.4    Menu, E.5    Van Camp, B.6    Vanderkerken, K.7    Van Valckenborgh, E.8
  • 155
    • 84868640245 scopus 로고    scopus 로고
    • The tumor microenvironment controls drug sensitivity
    • Ostman A. The tumor microenvironment controls drug sensitivity. Nat Med. 2012; 18(9):1332-1334.
    • (2012) Nat Med. , vol.18 , Issue.9 , pp. 1332-1334
    • Ostman, A.1
  • 156
    • 84857155905 scopus 로고    scopus 로고
    • Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma
    • Kocemba KA, Groen RW, van Andel H, Kersten MJ, Mahtouk K, Spaargaren M and Pals ST. Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma. PLoS One. 2012; 7(2):e30359.
    • (2012) PLoS One. , vol.7 , Issue.2
    • Kocemba, K.A.1    Groen, R.W.2    van Andel, H.3    Kersten, M.J.4    Mahtouk, K.5    Spaargaren, M.6    Pals, S.T.7
  • 157
    • 36349013133 scopus 로고    scopus 로고
    • Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
    • Chim CS, Pang R, Fung TK, Choi CL and Liang R. Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. Leukemia. 2007; 21(12):2527-2536.
    • (2007) Leukemia. , vol.21 , Issue.12 , pp. 2527-2536
    • Chim, C.S.1    Pang, R.2    Fung, T.K.3    Choi, C.L.4    Liang, R.5
  • 169
    • 0346336773 scopus 로고    scopus 로고
    • Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma
    • Wang ES, Wu K, Chin AC, Chen-Kiang S, Pongracz K, Gryaznov S and Moore MA. Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma. Blood. 2004; 103(1):258-266.
    • (2004) Blood. , vol.103 , Issue.1 , pp. 258-266
    • Wang, E.S.1    Wu, K.2    Chin, A.C.3    Chen-Kiang, S.4    Pongracz, K.5    Gryaznov, S.6    Moore, M.A.7
  • 172
    • 84865537671 scopus 로고    scopus 로고
    • MicroRNAs: new players in multiple myeloma
    • Flavia Pichiorri LDLaRIA, (Article 22)
    • Flavia Pichiorri LDLaRIA. MicroRNAs: new players in multiple myeloma. Frontiers in Genetics. 2011; 2(Article 22).
    • (2011) Frontiers in Genetics , pp. 2
  • 175
    • 84865566726 scopus 로고    scopus 로고
    • DNA methylation of microRNA genes in multiple myeloma
    • XHaCSC
    • Kwan Yeung Wong XHaCSC. DNA methylation of microRNA genes in multiple myeloma. Carcinogenesis. 2012; 33(9):1629-1638.
    • (2012) Carcinogenesis. , vol.33 , Issue.9 , pp. 1629-1638
    • Wong, K.Y.1
  • 179
    • 79955654560 scopus 로고    scopus 로고
    • Gunaratne. Role for MicroRNAs in Regulating Glucocorticoid Response and Resistance in Multiple Myeloma
    • Michael A. Tessel ALB, Nancy L. Krett, Steven T. Rosen, Preethi H. Gunaratne. Role for MicroRNAs in Regulating Glucocorticoid Response and Resistance in Multiple Myeloma. HORM CANC. 2011; 2:182-189.
    • (2011) HORM CANC. , vol.2 , pp. 182-189
    • Michael, A.1    Tessel, A.L.B.2    Krett, N.L.3    Rosen, S.T.4    Preethi, H.5
  • 180
    • 80052062422 scopus 로고    scopus 로고
    • Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression
    • Hao M, Zhang L, An G, Meng H, Han Y, Xie Z, Xu Y, Li C, Yu Z, Chang H and Qiu L. Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression. Leuk Lymphoma. 2011; 52(9):1787-1794.
    • (2011) Leuk Lymphoma. , vol.52 , Issue.9 , pp. 1787-1794
    • Hao, M.1    Zhang, L.2    An, G.3    Meng, H.4    Han, Y.5    Xie, Z.6    Xu, Y.7    Li, C.8    Yu, Z.9    Chang, H.10    Qiu, L.11
  • 184
    • 84883643294 scopus 로고    scopus 로고
    • Kruppel-like factor 4 blocks tumor cell proliferation and promotes drug resistance in multiple myeloma
    • Schoenhals M, Kassambara A, Veyrune JL, Moreaux J, Goldschmidt H, Hose D and Klein B. Kruppel-like factor 4 blocks tumor cell proliferation and promotes drug resistance in multiple myeloma. Haematologica. 2013; 98(9):1442-1449.
    • (2013) Haematologica. , vol.98 , Issue.9 , pp. 1442-1449
    • Schoenhals, M.1    Kassambara, A.2    Veyrune, J.L.3    Moreaux, J.4    Goldschmidt, H.5    Hose, D.6    Klein, B.7
  • 185
    • 42749092078 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis
    • Li QF, Wu CT, Guo Q, Wang H and Wang LS. Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. Biochem Biophys Res Commun. 2008; 371(1):159-162.
    • (2008) Biochem Biophys Res Commun. , vol.371 , Issue.1 , pp. 159-162
    • Li, Q.F.1    Wu, C.T.2    Guo, Q.3    Wang, H.4    Wang, L.S.5
  • 186
    • 34547647448 scopus 로고    scopus 로고
    • Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis
    • Li QF, Wu CT, Duan HF, Sun HY, Wang H, Lu ZZ, Zhang QW, Liu HJ and Wang LS. Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis. Br J Haematol. 2007; 138(5):632-639.
    • (2007) Br J Haematol. , vol.138 , Issue.5 , pp. 632-639
    • Li, Q.F.1    Wu, C.T.2    Duan, H.F.3    Sun, H.Y.4    Wang, H.5    Lu, Z.Z.6    Zhang, Q.W.7    Liu, H.J.8    Wang, L.S.9
  • 187
    • 84881499644 scopus 로고    scopus 로고
    • Targeting BRAF in Multiple Myeloma
    • O'Donnell E and Raje NS. Targeting BRAF in Multiple Myeloma. Cancer Discov. 2013; 3(8):840-842.
    • (2013) Cancer Discov. , vol.3 , Issue.8 , pp. 840-842
    • O'Donnell, E.1    Raje, N.S.2
  • 188
    • 33744488766 scopus 로고    scopus 로고
    • Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance
    • Hoang B, Zhu L, Shi Y, Frost P, Yan H, Sharma S, Goodglick L, Dubinett S and Lichtenstein A. Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance. Blood. 2006; 107(11):4484-4490.
    • (2006) Blood. , vol.107 , Issue.11 , pp. 4484-4490
    • Hoang, B.1    Zhu, L.2    Shi, Y.3    Frost, P.4    Yan, H.5    Sharma, S.6    Goodglick, L.7    Dubinett, S.8    Lichtenstein, A.9
  • 190
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • Hideshima T, Mitsiades C, Tonon G, Richardson PG and Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer. 2007; 7(8):585-598.
    • (2007) Nat Rev Cancer. , vol.7 , Issue.8 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 192
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: a major contributor to minimal residual disease
    • Meads MB, Gatenby RA and Dalton WS. Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer. 2009; 9(9):665-674.
    • (2009) Nat Rev Cancer. , vol.9 , Issue.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 193
  • 195
    • 0035502588 scopus 로고    scopus 로고
    • Cell adhesion is a key determinant in de novo multidrug resistance (MDR): new targets for the prevention of acquired MDR
    • Shain KH and Dalton WS. Cell adhesion is a key determinant in de novo multidrug resistance (MDR): new targets for the prevention of acquired MDR. Mol Cancer Ther. 2001; 1(1):69-78.
    • (2001) Mol Cancer Ther. , vol.1 , Issue.1 , pp. 69-78
    • Shain, K.H.1    Dalton, W.S.2
  • 196
    • 0034501628 scopus 로고    scopus 로고
    • The tumor microenvironment as a determinant of cancer cell survival: a possible mechanism for de novo drug resistance
    • Shain KH, Landowski TH and Dalton WS. The tumor microenvironment as a determinant of cancer cell survival: a possible mechanism for de novo drug resistance. Curr Opin Oncol. 2000; 12(6):557-563.
    • (2000) Curr Opin Oncol. , vol.12 , Issue.6 , pp. 557-563
    • Shain, K.H.1    Landowski, T.H.2    Dalton, W.S.3
  • 197
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
    • Chauhan D, Uchiyama H, Akbarali Y, Urashima M, Yamamoto K, Libermann TA and Anderson KC. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood. 1996; 87(3):1104-1112.
    • (1996) Blood. , vol.87 , Issue.3 , pp. 1104-1112
    • Chauhan, D.1    Uchiyama, H.2    Akbarali, Y.3    Urashima, M.4    Yamamoto, K.5    Libermann, T.A.6    Anderson, K.C.7
  • 199
    • 59149083547 scopus 로고    scopus 로고
    • Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation
    • Shain KH, Yarde DN, Meads MB, Huang M, Jove R, Hazlehurst LA and Dalton WS. Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. Cancer Res. 2009; 69(3):1009-1015.
    • (2009) Cancer Res. , vol.69 , Issue.3 , pp. 1009-1015
    • Shain, K.H.1    Yarde, D.N.2    Meads, M.B.3    Huang, M.4    Jove, R.5    Hazlehurst, L.A.6    Dalton, W.S.7
  • 200
    • 0031029911 scopus 로고    scopus 로고
    • Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells
    • Chauhan D, Kharbanda S, Ogata A, Urashima M, Teoh G, Robertson M, Kufe DW and Anderson KC. Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood. 1997; 89(1):227-234.
    • (1997) Blood. , vol.89 , Issue.1 , pp. 227-234
    • Chauhan, D.1    Kharbanda, S.2    Ogata, A.3    Urashima, M.4    Teoh, G.5    Robertson, M.6    Kufe, D.W.7    Anderson, K.C.8
  • 202
    • 0029019664 scopus 로고
    • Interleukin-6 inhibits apoptosis of malignant plasma cells
    • Lichtenstein A, Tu Y, Fady C, Vescio R and Berenson J. Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol. 1995; 162(2):248-255.
    • (1995) Cell Immunol. , vol.162 , Issue.2 , pp. 248-255
    • Lichtenstein, A.1    Tu, Y.2    Fady, C.3    Vescio, R.4    Berenson, J.5
  • 204
    • 0035863942 scopus 로고    scopus 로고
    • Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis
    • Frassanito MA, Cusmai A, Iodice G and Dammacco F. Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis. Blood. 2001; 97(2):483-489.
    • (2001) Blood. , vol.97 , Issue.2 , pp. 483-489
    • Frassanito, M.A.1    Cusmai, A.2    Iodice, G.3    Dammacco, F.4
  • 207
    • 0033105537 scopus 로고    scopus 로고
    • Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines
    • Damiano JS, Cress AE, Hazlehurst LA, Shtil AA and Dalton WS. Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood. 1999; 93(5):1658-1667.
    • (1999) Blood. , vol.93 , Issue.5 , pp. 1658-1667
    • Damiano, J.S.1    Cress, A.E.2    Hazlehurst, L.A.3    Shtil, A.A.4    Dalton, W.S.5
  • 208
    • 0034618384 scopus 로고    scopus 로고
    • Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)
    • Hazlehurst LA, Damiano JS, Buyuksal I, Pledger WJ and Dalton WS. Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR). Oncogene. 2000; 19(38):4319-4327.
    • (2000) Oncogene. , vol.19 , Issue.38 , pp. 4319-4327
    • Hazlehurst, L.A.1    Damiano, J.S.2    Buyuksal, I.3    Pledger, W.J.4    Dalton, W.S.5
  • 210
    • 4444282702 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase
    • Schmidmaier R, Baumann P, Simsek M, Dayyani F, Emmerich B and Meinhardt G. The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase. Blood. 2004; 104(6):1825-1832.
    • (2004) Blood. , vol.104 , Issue.6 , pp. 1825-1832
    • Schmidmaier, R.1    Baumann, P.2    Simsek, M.3    Dayyani, F.4    Emmerich, B.5    Meinhardt, G.6
  • 212
    • 33846542647 scopus 로고    scopus 로고
    • Evidence for cell adhesion-mediated drug resistance of multiple myeloma cells in vivo
    • Schmidmaier R, Morsdorf K, Baumann P, Emmerich B and Meinhardt G. Evidence for cell adhesion-mediated drug resistance of multiple myeloma cells in vivo. Int J Biol Markers. 2006; 21(4):218-222.
    • (2006) Int J Biol Markers. , vol.21 , Issue.4 , pp. 218-222
    • Schmidmaier, R.1    Morsdorf, K.2    Baumann, P.3    Emmerich, B.4    Meinhardt, G.5
  • 214
    • 0036499140 scopus 로고    scopus 로고
    • Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines
    • Shain KH, Landowski TH and Dalton WS. Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines. J Immunol. 2002; 168(5):2544-2553.
    • (2002) J Immunol. , vol.168 , Issue.5 , pp. 2544-2553
    • Shain, K.H.1    Landowski, T.H.2    Dalton, W.S.3
  • 215
    • 0038717067 scopus 로고    scopus 로고
    • Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms
    • Nefedova Y, Landowski TH and Dalton WS. Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms. Leukemia. 2003; 17(6):1175-1182.
    • (2003) Leukemia. , vol.17 , Issue.6 , pp. 1175-1182
    • Nefedova, Y.1    Landowski, T.H.2    Dalton, W.S.3
  • 217
    • 77955980391 scopus 로고    scopus 로고
    • Survivin is upregulated in myeloma cell lines cocultured with mesenchymal stem cells
    • Wang X, Zhang Z and Yao C. Survivin is upregulated in myeloma cell lines cocultured with mesenchymal stem cells. Leuk Res. 2010; 34(10):1325-1329.
    • (2010) Leuk Res. , vol.34 , Issue.10 , pp. 1325-1329
    • Wang, X.1    Zhang, Z.2    Yao, C.3
  • 221
    • 34347400169 scopus 로고    scopus 로고
    • Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway
    • Liu J, Hamrouni A, Wolowiec D, Coiteux V, Kuliczkowski K, Hetuin D, Saudemont A and Quesnel B. Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood. 2007; 110(1):296-304.
    • (2007) Blood. , vol.110 , Issue.1 , pp. 296-304
    • Liu, J.1    Hamrouni, A.2    Wolowiec, D.3    Coiteux, V.4    Kuliczkowski, K.5    Hetuin, D.6    Saudemont, A.7    Quesnel, B.8
  • 224
    • 1442285889 scopus 로고    scopus 로고
    • Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma
    • Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM and Staudt LM. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell. 2004; 5(2):191-199.
    • (2004) Cancer Cell. , vol.5 , Issue.2 , pp. 191-199
    • Hurt, E.M.1    Wiestner, A.2    Rosenwald, A.3    Shaffer, A.L.4    Campo, E.5    Grogan, T.6    Bergsagel, P.L.7    Kuehl, W.M.8    Staudt, L.M.9
  • 227
    • 70449477633 scopus 로고    scopus 로고
    • Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis
    • Zheng Y, Cai Z, Wang S, Zhang X, Qian J, Hong S, Li H, Wang M, Yang J and Yi Q. Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood. 2009; 114(17):3625-3628.
    • (2009) Blood. , vol.114 , Issue.17 , pp. 3625-3628
    • Zheng, Y.1    Cai, Z.2    Wang, S.3    Zhang, X.4    Qian, J.5    Hong, S.6    Li, H.7    Wang, M.8    Yang, J.9    Yi, Q.10
  • 229
    • 80054022144 scopus 로고    scopus 로고
    • The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma
    • Martin SK, Diamond P, Gronthos S, Peet DJ and Zannettino AC. The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma. Leukemia. 2011; 25(10):1533-1542.
    • (2011) Leukemia. , vol.25 , Issue.10 , pp. 1533-1542
    • Martin, S.K.1    Diamond, P.2    Gronthos, S.3    Peet, D.J.4    Zannettino, A.C.5
  • 230
    • 84876000935 scopus 로고    scopus 로고
    • Characterization of the Toll-like receptor expression profile in human multiple myeloma cells
    • Abdi J, Mutis T, Garssen J and Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS One. 2013; 8(4):e60671.
    • (2013) PLoS One. , vol.8 , Issue.4
    • Abdi, J.1    Mutis, T.2    Garssen, J.3    Redegeld, F.4
  • 231
    • 33744465220 scopus 로고    scopus 로고
    • Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors
    • Jego G, Bataille R, Geffroy-Luseau A, Descamps G and Pellat-Deceunynck C. Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors. Leukemia. 2006; 20(6):1130-1137.
    • (2006) Leukemia. , vol.20 , Issue.6 , pp. 1130-1137
    • Jego, G.1    Bataille, R.2    Geffroy-Luseau, A.3    Descamps, G.4    Pellat-Deceunynck, C.5
  • 233
    • 84878316176 scopus 로고    scopus 로고
    • Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells
    • Abdi J, Mutis T, Garssen J and Redegeld F. Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells. Blood Cancer J. 2013; 3:e119.
    • (2013) Blood Cancer J. , vol.3
    • Abdi, J.1    Mutis, T.2    Garssen, J.3    Redegeld, F.4
  • 234
    • 70449522900 scopus 로고    scopus 로고
    • Cancer stem cells: controversies in multiple myeloma
    • Brennan SK and Matsui W. Cancer stem cells: controversies in multiple myeloma. J Mol Med (Berl). 2009; 87(11):1079-1085.
    • (2009) J Mol Med (Berl). , vol.87 , Issue.11 , pp. 1079-1085
    • Brennan, S.K.1    Matsui, W.2
  • 235
    • 61849148751 scopus 로고    scopus 로고
    • Cancer stem cells in multiple myeloma
    • Ghosh N and Matsui W. Cancer stem cells in multiple myeloma. Cancer Lett. 2009; 277(1):1-7.
    • (2009) Cancer Lett. , vol.277 , Issue.1 , pp. 1-7
    • Ghosh, N.1    Matsui, W.2
  • 239
    • 84884327949 scopus 로고    scopus 로고
    • Clonogenic Multiple Myeloma Cells have Shared stemness Signature Assocuated with Patient Survival
    • Reghunathan R, Bi C, Liu SC, Loong KT, Chung TH, Huang G and Chng WJ. Clonogenic Multiple Myeloma Cells have Shared stemness Signature Assocuated with Patient Survival. Oncotarget. 2013; 4(8):1230-1240.
    • (2013) Oncotarget. , vol.4 , Issue.8 , pp. 1230-1240
    • Reghunathan, R.1    Bi, C.2    Liu, S.C.3    Loong, K.T.4    Chung, T.H.5    Huang, G.6    Chng, W.J.7
  • 241
    • 0036794974 scopus 로고    scopus 로고
    • Clonotypic myeloma cells able to xenograft myeloma to nonobese diabetic severe combined immunodeficient mice copurify with CD34 (+) hematopoietic progenitors
    • Pilarski LM and Belch AR. Clonotypic myeloma cells able to xenograft myeloma to nonobese diabetic severe combined immunodeficient mice copurify with CD34 (+) hematopoietic progenitors. Clin Cancer Res. 2002; 8(10):3198-3204.
    • (2002) Clin Cancer Res. , vol.8 , Issue.10 , pp. 3198-3204
    • Pilarski, L.M.1    Belch, A.R.2
  • 242
    • 0028908877 scopus 로고
    • In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain
    • Bergsagel PL, Smith AM, Szczepek A, Mant MJ, Belch AR and Pilarski LM. In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain. Blood. 1995; 85(2):436-447.
    • (1995) Blood. , vol.85 , Issue.2 , pp. 436-447
    • Bergsagel, P.L.1    Smith, A.M.2    Szczepek, A.3    Mant, M.J.4    Belch, A.R.5    Pilarski, L.M.6
  • 244
    • 84891934923 scopus 로고    scopus 로고
    • ALDH1 Activity Identifies Chemotherapy-Resistant Multiple Myeloma Stem Cells
    • Abstract 990
    • Fenghuang Zhan WZ, Maurizio Zangari, Hongwei Xu, MD, MS and Guido J. Tricot. ALDH1 Activity Identifies Chemotherapy-Resistant Multiple Myeloma Stem Cells. ASH congress. 2011; Abstract 990.
    • (2011) ASH congress
    • Fenghuang Zhan, W.Z.1    Zangari, M.2    Xu, H.3    Guido Tricot, J.4
  • 248
    • 77953693899 scopus 로고    scopus 로고
    • Targeting Hedgehog--a cancer stem cell pathway
    • Merchant AA and Matsui W. Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res. 2010; 16(12):3130-3140.
    • (2010) Clin Cancer Res. , vol.16 , Issue.12 , pp. 3130-3140
    • Merchant, A.A.1    Matsui, W.2
  • 249
    • 77958584577 scopus 로고    scopus 로고
    • Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms
    • Brennan SK, Wang Q, Tressler R, Harley C, Go N, Bassett E, Huff CA, Jones RJ and Matsui W. Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms. PLoS One. 2010; 5(9).
    • (2010) PLoS One , vol.5 , Issue.9
    • Brennan, S.K.1    Wang, Q.2    Tressler, R.3    Harley, C.4    Go, N.5    Bassett, E.6    Huff, C.A.7    Jones, R.J.8    Matsui, W.9
  • 252
    • 84860557226 scopus 로고    scopus 로고
    • HSP90 inhibitors as therapy for multiple myeloma
    • Usmani SZ and Chiosis G. HSP90 inhibitors as therapy for multiple myeloma. Clin Lymphoma Myeloma Leuk. 2011; 11 Suppl 1:S77-81.
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , Issue.SUPPL. 1
    • Usmani, S.Z.1    Chiosis, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.