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Volumn 122, Issue 8, 2013, Pages 1437-1447

RARα2 expression confers myeloma stem cell features

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENT; CAY 10404; CYCLOPAMINE; ITRACONAZOLE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; PROTEIN; PROTEIN BCL 2; RARALPHA2 PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; 3 (4 METHYLSULFONYLPHENYL) 4 PHENYL 5 TRIFLUOROMETHYLISOXAZOLE; 3-(4-METHYLSULFONYLPHENYL)-4-PHENYL-5-TRIFLUOROMETHYLISOXAZOLE; ISOXAZOLE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; SULFONE; SYNDECAN 1; VERATRUM ALKALOID;

EID: 84886819205     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-02-482919     Document Type: Article
Times cited : (63)

References (44)
  • 1
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105-111.
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 3
    • 1542283717 scopus 로고    scopus 로고
    • Characterization of clonogenic multiple myeloma cells
    • Matsui W, Huff CA, Wang Q, et al. Characterization of clonogenic multiple myeloma cells. Blood. 2004;103(6):2332-2336.
    • (2004) Blood , vol.103 , Issue.6 , pp. 2332-2336
    • Matsui, W.1    Huff, C.A.2    Wang, Q.3
  • 4
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444(7120):756-760.
    • (2006) Nature , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 5
    • 38549132452 scopus 로고    scopus 로고
    • Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance
    • Matsui W, Wang Q, Barber JP, et al. Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res. 2008;68(1):190-197.
    • (2008) Cancer Res. , vol.68 , Issue.1 , pp. 190-197
    • Matsui, W.1    Wang, Q.2    Barber, J.P.3
  • 6
    • 84869209212 scopus 로고    scopus 로고
    • Stemness of B-cell progenitors in multiple myeloma bone marrow
    • Boucher K, Parquet N, Widen R, et al. Stemness of B-cell progenitors in multiple myeloma bone marrow. Clin Cancer Res. 2012;18(22): 6155-6168.
    • (2012) Clin Cancer Res. , vol.18 , Issue.22 , pp. 6155-6168
    • Boucher, K.1    Parquet, N.2    Widen, R.3
  • 7
    • 84871238560 scopus 로고    scopus 로고
    • CD19-CD45 low/-CD38 high/CD1381 plasma cells enrich for human tumorigenic myeloma cells
    • Kim D, Park CY, Medeiros BC, Weissman IL. CD19-CD45 low/-CD38 high/CD1381 plasma cells enrich for human tumorigenic myeloma cells. Leukemia. 2012;26(12):2530-2537.
    • (2012) Leukemia , vol.26 , Issue.12 , pp. 2530-2537
    • Kim, D.1    Park, C.Y.2    Medeiros, B.C.3    Weissman, I.L.4
  • 8
    • 79955974540 scopus 로고    scopus 로고
    • Lenalidomide targets clonogenic side population in multiple myeloma: Pathophysiologic and clinical implications
    • Jakubikova J, Adamia S, Kost-Alimova M, et al. Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications. Blood. 2011;117(17):4409-4419.
    • (2011) Blood , vol.117 , Issue.17 , pp. 4409-4419
    • Jakubikova, J.1    Adamia, S.2    Kost-Alimova, M.3
  • 9
    • 70149089770 scopus 로고    scopus 로고
    • RARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma
    • Wang S, Tricot G, Shi L, et al. RARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma. Blood. 2009;114(3): 600-607.
    • (2009) Blood , vol.114 , Issue.3 , pp. 600-607
    • Wang, S.1    Tricot, G.2    Shi, L.3
  • 10
    • 0026069580 scopus 로고
    • Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid
    • Leroy P, Krust A, Zelent A, et al. Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO J. 1991;10(1): 59-69.
    • (1991) EMBO J. , vol.10 , Issue.1 , pp. 59-69
    • Leroy, P.1    Krust, A.2    Zelent, A.3
  • 11
    • 0035969113 scopus 로고    scopus 로고
    • Function of RARalpha during the maturation of neutrophils
    • Kastner P, Chan S. Function of RARalpha during the maturation of neutrophils. Oncogene. 2001; 20(49):7178-7185.
    • (2001) Oncogene , vol.20 , Issue.49 , pp. 7178-7185
    • Kastner, P.1    Chan, S.2
  • 12
    • 0027407954 scopus 로고
    • Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene
    • Li E, Sucov HM, Lee KF, Evans RM, Jaenisch R. Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. Proc Natl Acad Sci USA. 1993; 90(4):1590-1594.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.4 , pp. 1590-1594
    • Li, E.1    Sucov, H.M.2    Lee, K.F.3    Evans, R.M.4    Jaenisch, R.5
  • 13
    • 0032528489 scopus 로고    scopus 로고
    • Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors alpha1 and gamma
    • Labrecque J, Allan D, Chambon P, Iscove NN, Lohnes D, Hoang T. Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors alpha1 and gamma. Blood. 1998;92(2):607-615.
    • (1998) Blood , vol.92 , Issue.2 , pp. 607-615
    • Labrecque, J.1    Allan, D.2    Chambon, P.3    Iscove, N.N.4    Lohnes, D.5    Hoang, T.6
  • 14
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature. 2001; 411(6835):349-354.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 15
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998;281(5382):1509-1512.
    • (1998) Science , vol.281 , Issue.5382 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3
  • 16
    • 0033545845 scopus 로고    scopus 로고
    • The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    • Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA. 1999; 96(10):5522-5527.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.10 , pp. 5522-5527
    • Shtutman, M.1    Zhurinsky, J.2    Simcha, I.3
  • 17
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999;398(6726):422-426.
    • (1999) Nature , vol.398 , Issue.6726 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 18
    • 0032912720 scopus 로고    scopus 로고
    • Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
    • Wielenga VJ, Smits R, Korinek V, et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol. 1999;154(2):515-523.
    • (1999) Am J Pathol. , vol.154 , Issue.2 , pp. 515-523
    • Wielenga, V.J.1    Smits, R.2    Korinek, V.3
  • 19
    • 0037905677 scopus 로고    scopus 로고
    • Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas
    • Schwartz DR, Wu R, Kardia SL, et al. Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res. 2003;63(11):2913-2922.
    • (2003) Cancer Res. , vol.63 , Issue.11 , pp. 2913-2922
    • Schwartz, D.R.1    Wu, R.2    Kardia, S.L.3
  • 20
    • 34247192972 scopus 로고    scopus 로고
    • Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
    • Peacock CD, Wang Q, Gesell GS, et al. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci USA. 2007;104(10):4048-4053.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.10 , pp. 4048-4053
    • Peacock, C.D.1    Wang, Q.2    Gesell, G.S.3
  • 21
    • 11144355390 scopus 로고    scopus 로고
    • Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
    • Derksen PW, Tjin E, Meijer HP, et al. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci USA. 2004; 101(16):6122-6127.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.16 , pp. 6122-6127
    • Derksen, P.W.1    Tjin, E.2    Meijer, H.P.3
  • 22
    • 47249099749 scopus 로고    scopus 로고
    • Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib
    • Zhou L, Hou J, Fu W, Wang D, Yuan Z, Jiang H. Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008;32(11): 1674-1683.
    • (2008) Leuk Res. , vol.32 , Issue.11 , pp. 1674-1683
    • Zhou, L.1    Hou, J.2    Fu, W.3    Wang, D.4    Yuan, Z.5    Jiang, H.6
  • 23
    • 36349013133 scopus 로고    scopus 로고
    • Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
    • Chim CS, Pang R, Fung TK, Choi CL, Liang R. Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. Leukemia. 2007; 21(12):2527-2536.
    • (2007) Leukemia , vol.21 , Issue.12 , pp. 2527-2536
    • Chim, C.S.1    Pang, R.2    Fung, T.K.3    Choi, C.L.4    Liang, R.5
  • 24
    • 84872373803 scopus 로고    scopus 로고
    • NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers
    • Zhou W, Yang Y, Xia J, et al. NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell. 2013; 23(1):48-62.
    • (2013) Cancer Cell , vol.23 , Issue.1 , pp. 48-62
    • Zhou, W.1    Yang, Y.2    Xia, J.3
  • 25
    • 34249652414 scopus 로고    scopus 로고
    • CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms
    • Zhan F, Colla S, Wu X, et al. CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms. Blood. 2007;109(11):4995-5001.
    • (2007) Blood , vol.109 , Issue.11 , pp. 4995-5001
    • Zhan, F.1    Colla, S.2    Wu, X.3
  • 26
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
    • Annunziata CM, Davis RE, Demchenko Y, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007;12(2):115-130.
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 115-130
    • Annunziata, C.M.1    Davis, R.E.2    Demchenko, Y.3
  • 27
    • 33745779502 scopus 로고    scopus 로고
    • The molecular classification of multiple myeloma
    • Zhan F, Huang Y, Colla S, et al. The molecular classification of multiple myeloma. Blood. 2006; 108(6):2020-2028.
    • (2006) Blood , vol.108 , Issue.6 , pp. 2020-2028
    • Zhan, F.1    Huang, Y.2    Colla, S.3
  • 28
    • 33846894934 scopus 로고    scopus 로고
    • Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis
    • Zhan F, Barlogie B, Arzoumanian V, et al. Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis. Blood. 2007;109(4): 1692-1700.
    • (2007) Blood , vol.109 , Issue.4 , pp. 1692-1700
    • Zhan, F.1    Barlogie, B.2    Arzoumanian, V.3
  • 29
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol. 1997;15(9):871-875.
    • (1997) Nat Biotechnol. , vol.15 , Issue.9 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3    Naldini, L.4    Trono, D.5
  • 30
    • 82755162926 scopus 로고    scopus 로고
    • Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells
    • Das S, Jena S, Levasseur DN. Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells. J Biol Chem. 2011;286(49): 42690-42703.
    • (2011) J Biol Chem. , vol.286 , Issue.49 , pp. 42690-42703
    • Das, S.1    Jena, S.2    Levasseur, D.N.3
  • 31
    • 23944524848 scopus 로고    scopus 로고
    • Wnts induce migration and invasion of myeloma plasma cells
    • Qiang YW, Walsh K, Yao L, et al. Wnts induce migration and invasion of myeloma plasma cells. Blood. 2005;106(5):1786-1793.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1786-1793
    • Qiang, Y.W.1    Walsh, K.2    Yao, L.3
  • 32
    • 70350247558 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer
    • Carpentino JE, Hynes MJ, Appelman HD, Zheng T, Steindler DA, Scott EW, Huang EH. Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res. 2009;69(20): 8208-8215.
    • (2009) Cancer Res. , vol.69 , Issue.20 , pp. 8208-8215
    • Carpentino, J.E.1    Hynes, M.J.2    Appelman, H.D.3    Zheng, T.4    Steindler, D.A.5    Scott, E.W.6    Huang, E.H.7
  • 33
    • 65949112714 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    • Huang EH, Hynes MJ, Zhang T, et al. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res. 2009;69(8): 3382-3389.
    • (2009) Cancer Res. , vol.69 , Issue.8 , pp. 3382-3389
    • Huang, E.H.1    Hynes, M.J.2    Zhang, T.3
  • 34
    • 42549167500 scopus 로고    scopus 로고
    • Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway
    • Cusimano A, Foderà D, D'Alessandro N, et al. Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. Cancer Biol Ther. 2007;6(9):1461-1468.
    • (2007) Cancer Biol Ther. , vol.6 , Issue.9 , pp. 1461-1468
    • Cusimano, A.1    Foderà, D.2    D'Alessandro, N.3
  • 35
    • 69049098171 scopus 로고    scopus 로고
    • Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells
    • Cho Y, Park MJ, Park M, et al. Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. Respirology. 2009;14(6): 850-858.
    • (2009) Respirology , vol.14 , Issue.6 , pp. 850-858
    • Cho, Y.1    Park, M.J.2    Park, M.3
  • 36
    • 35748937334 scopus 로고    scopus 로고
    • Retinoic acid inhibits beta-catenin through suppression of Cox-2: A role for truncated adenomatous polyposis coli
    • Eisinger AL, Nadauld LD, Shelton DN, Prescott SM, Stafforini DM, Jones DA. Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. J Biol Chem. 2007;282(40): 29394-29400.
    • (2007) J Biol Chem. , vol.282 , Issue.40 , pp. 29394-29400
    • Eisinger, A.L.1    Nadauld, L.D.2    Shelton, D.N.3    Prescott, S.M.4    Stafforini, D.M.5    Jones, D.A.6
  • 37
    • 84873566331 scopus 로고    scopus 로고
    • Improvement in long-term outcomes with successive total therapy trials for multiple myeloma: Are patients now being cured?
    • Usmani SZ, Crowley J, Hoering A, et al. Improvement in long-term outcomes with successive Total Therapy trials for multiple myeloma: are patients now being cured? Leukemia. 2013;27(1): 226-232.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 226-232
    • Usmani, S.Z.1    Crowley, J.2    Hoering, A.3
  • 38
    • 72249119222 scopus 로고    scopus 로고
    • Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA
    • Noubissi FK, Goswami S, Sanek NA, et al. Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res. 2009;69(22): 8572-8578.
    • (2009) Cancer Res. , vol.69 , Issue.22 , pp. 8572-8578
    • Noubissi, F.K.1    Goswami, S.2    Sanek, N.A.3
  • 39
    • 34548285028 scopus 로고    scopus 로고
    • Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells
    • Avvisato CL, Yang X, Shah S, et al. Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. J Cell Sci. 2007;120(Pt 15):2672-2682.
    • (2007) J Cell Sci. , vol.120 , pp. 2672-2682
    • Avvisato, C.L.1    Yang, X.2    Shah, S.3
  • 40
    • 84866702740 scopus 로고    scopus 로고
    • Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms
    • Ibrahim EE, Babaei-Jadidi R, Saadeddin A, et al. Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. Stem Cells. 2012;30(10):2076-2087.
    • (2012) Stem Cells , vol.30 , Issue.10 , pp. 2076-2087
    • Ibrahim, E.E.1    Babaei-Jadidi, R.2    Saadeddin, A.3
  • 41
    • 79959963618 scopus 로고    scopus 로고
    • Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal
    • Yi F, Pereira L, Hoffman JA, Shy BR, Yuen CM, Liu DR, Merrill BJ. Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol. 2011;13(7): 762-770.
    • (2011) Nat Cell Biol. , vol.13 , Issue.7 , pp. 762-770
    • Yi, F.1    Pereira, L.2    Hoffman, J.A.3    Shy, B.R.4    Yuen, C.M.5    Liu, D.R.6    Merrill, B.J.7
  • 42
    • 79551594937 scopus 로고    scopus 로고
    • β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism
    • Kelly KF, Ng DY, Jayakumaran G, Wood GA, Koide H, Doble BW. β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell. 2011;8(2):214-227.
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 214-227
    • Kelly, K.F.1    Ng, D.Y.2    Jayakumaran, G.3    Wood, G.A.4    Koide, H.5    Doble, B.W.6
  • 43
    • 44649117905 scopus 로고    scopus 로고
    • Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
    • Chen X, Xu H, Yuan P, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 2008;133(6):1106-1117.
    • (2008) Cell , vol.133 , Issue.6 , pp. 1106-1117
    • Chen, X.1    Xu, H.2    Yuan, P.3
  • 44
    • 34548029751 scopus 로고    scopus 로고
    • The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells
    • Levitt RJ, Zhao Y, Blouin MJ, Pollak M. The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells. Cancer Lett. 2007;255(2): 300-306.
    • (2007) Cancer Lett. , vol.255 , Issue.2 , pp. 300-306
    • Levitt, R.J.1    Zhao, Y.2    Blouin, M.J.3    Pollak, M.4


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