-
1
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105-111.
-
(2001)
Nature
, vol.414
, Issue.6859
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
3
-
-
1542283717
-
Characterization of clonogenic multiple myeloma cells
-
Matsui W, Huff CA, Wang Q, et al. Characterization of clonogenic multiple myeloma cells. Blood. 2004;103(6):2332-2336.
-
(2004)
Blood
, vol.103
, Issue.6
, pp. 2332-2336
-
-
Matsui, W.1
Huff, C.A.2
Wang, Q.3
-
4
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444(7120):756-760.
-
(2006)
Nature
, vol.444
, Issue.7120
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
-
5
-
-
38549132452
-
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance
-
Matsui W, Wang Q, Barber JP, et al. Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res. 2008;68(1):190-197.
-
(2008)
Cancer Res.
, vol.68
, Issue.1
, pp. 190-197
-
-
Matsui, W.1
Wang, Q.2
Barber, J.P.3
-
6
-
-
84869209212
-
Stemness of B-cell progenitors in multiple myeloma bone marrow
-
Boucher K, Parquet N, Widen R, et al. Stemness of B-cell progenitors in multiple myeloma bone marrow. Clin Cancer Res. 2012;18(22): 6155-6168.
-
(2012)
Clin Cancer Res.
, vol.18
, Issue.22
, pp. 6155-6168
-
-
Boucher, K.1
Parquet, N.2
Widen, R.3
-
7
-
-
84871238560
-
CD19-CD45 low/-CD38 high/CD1381 plasma cells enrich for human tumorigenic myeloma cells
-
Kim D, Park CY, Medeiros BC, Weissman IL. CD19-CD45 low/-CD38 high/CD1381 plasma cells enrich for human tumorigenic myeloma cells. Leukemia. 2012;26(12):2530-2537.
-
(2012)
Leukemia
, vol.26
, Issue.12
, pp. 2530-2537
-
-
Kim, D.1
Park, C.Y.2
Medeiros, B.C.3
Weissman, I.L.4
-
8
-
-
79955974540
-
Lenalidomide targets clonogenic side population in multiple myeloma: Pathophysiologic and clinical implications
-
Jakubikova J, Adamia S, Kost-Alimova M, et al. Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications. Blood. 2011;117(17):4409-4419.
-
(2011)
Blood
, vol.117
, Issue.17
, pp. 4409-4419
-
-
Jakubikova, J.1
Adamia, S.2
Kost-Alimova, M.3
-
9
-
-
70149089770
-
RARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma
-
Wang S, Tricot G, Shi L, et al. RARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma. Blood. 2009;114(3): 600-607.
-
(2009)
Blood
, vol.114
, Issue.3
, pp. 600-607
-
-
Wang, S.1
Tricot, G.2
Shi, L.3
-
10
-
-
0026069580
-
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid
-
Leroy P, Krust A, Zelent A, et al. Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO J. 1991;10(1): 59-69.
-
(1991)
EMBO J.
, vol.10
, Issue.1
, pp. 59-69
-
-
Leroy, P.1
Krust, A.2
Zelent, A.3
-
11
-
-
0035969113
-
Function of RARalpha during the maturation of neutrophils
-
Kastner P, Chan S. Function of RARalpha during the maturation of neutrophils. Oncogene. 2001; 20(49):7178-7185.
-
(2001)
Oncogene
, vol.20
, Issue.49
, pp. 7178-7185
-
-
Kastner, P.1
Chan, S.2
-
12
-
-
0027407954
-
Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene
-
Li E, Sucov HM, Lee KF, Evans RM, Jaenisch R. Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. Proc Natl Acad Sci USA. 1993; 90(4):1590-1594.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.4
, pp. 1590-1594
-
-
Li, E.1
Sucov, H.M.2
Lee, K.F.3
Evans, R.M.4
Jaenisch, R.5
-
13
-
-
0032528489
-
Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors alpha1 and gamma
-
Labrecque J, Allan D, Chambon P, Iscove NN, Lohnes D, Hoang T. Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors alpha1 and gamma. Blood. 1998;92(2):607-615.
-
(1998)
Blood
, vol.92
, Issue.2
, pp. 607-615
-
-
Labrecque, J.1
Allan, D.2
Chambon, P.3
Iscove, N.N.4
Lohnes, D.5
Hoang, T.6
-
14
-
-
0035902140
-
The Hedgehog and Wnt signalling pathways in cancer
-
Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature. 2001; 411(6835):349-354.
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
15
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998;281(5382):1509-1512.
-
(1998)
Science
, vol.281
, Issue.5382
, pp. 1509-1512
-
-
He, T.C.1
Sparks, A.B.2
Rago, C.3
-
16
-
-
0033545845
-
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
-
Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA. 1999; 96(10):5522-5527.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, Issue.10
, pp. 5522-5527
-
-
Shtutman, M.1
Zhurinsky, J.2
Simcha, I.3
-
17
-
-
0033119801
-
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
-
Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999;398(6726):422-426.
-
(1999)
Nature
, vol.398
, Issue.6726
, pp. 422-426
-
-
Tetsu, O.1
McCormick, F.2
-
18
-
-
0032912720
-
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
-
Wielenga VJ, Smits R, Korinek V, et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol. 1999;154(2):515-523.
-
(1999)
Am J Pathol.
, vol.154
, Issue.2
, pp. 515-523
-
-
Wielenga, V.J.1
Smits, R.2
Korinek, V.3
-
19
-
-
0037905677
-
Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas
-
Schwartz DR, Wu R, Kardia SL, et al. Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res. 2003;63(11):2913-2922.
-
(2003)
Cancer Res.
, vol.63
, Issue.11
, pp. 2913-2922
-
-
Schwartz, D.R.1
Wu, R.2
Kardia, S.L.3
-
20
-
-
34247192972
-
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
-
Peacock CD, Wang Q, Gesell GS, et al. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci USA. 2007;104(10):4048-4053.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.10
, pp. 4048-4053
-
-
Peacock, C.D.1
Wang, Q.2
Gesell, G.S.3
-
21
-
-
11144355390
-
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
-
Derksen PW, Tjin E, Meijer HP, et al. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci USA. 2004; 101(16):6122-6127.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.16
, pp. 6122-6127
-
-
Derksen, P.W.1
Tjin, E.2
Meijer, H.P.3
-
22
-
-
47249099749
-
Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib
-
Zhou L, Hou J, Fu W, Wang D, Yuan Z, Jiang H. Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008;32(11): 1674-1683.
-
(2008)
Leuk Res.
, vol.32
, Issue.11
, pp. 1674-1683
-
-
Zhou, L.1
Hou, J.2
Fu, W.3
Wang, D.4
Yuan, Z.5
Jiang, H.6
-
23
-
-
36349013133
-
Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
-
Chim CS, Pang R, Fung TK, Choi CL, Liang R. Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. Leukemia. 2007; 21(12):2527-2536.
-
(2007)
Leukemia
, vol.21
, Issue.12
, pp. 2527-2536
-
-
Chim, C.S.1
Pang, R.2
Fung, T.K.3
Choi, C.L.4
Liang, R.5
-
24
-
-
84872373803
-
NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers
-
Zhou W, Yang Y, Xia J, et al. NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell. 2013; 23(1):48-62.
-
(2013)
Cancer Cell
, vol.23
, Issue.1
, pp. 48-62
-
-
Zhou, W.1
Yang, Y.2
Xia, J.3
-
25
-
-
34249652414
-
CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms
-
Zhan F, Colla S, Wu X, et al. CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms. Blood. 2007;109(11):4995-5001.
-
(2007)
Blood
, vol.109
, Issue.11
, pp. 4995-5001
-
-
Zhan, F.1
Colla, S.2
Wu, X.3
-
26
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata CM, Davis RE, Demchenko Y, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007;12(2):115-130.
-
(2007)
Cancer Cell
, vol.12
, Issue.2
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
-
27
-
-
33745779502
-
The molecular classification of multiple myeloma
-
Zhan F, Huang Y, Colla S, et al. The molecular classification of multiple myeloma. Blood. 2006; 108(6):2020-2028.
-
(2006)
Blood
, vol.108
, Issue.6
, pp. 2020-2028
-
-
Zhan, F.1
Huang, Y.2
Colla, S.3
-
28
-
-
33846894934
-
Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis
-
Zhan F, Barlogie B, Arzoumanian V, et al. Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis. Blood. 2007;109(4): 1692-1700.
-
(2007)
Blood
, vol.109
, Issue.4
, pp. 1692-1700
-
-
Zhan, F.1
Barlogie, B.2
Arzoumanian, V.3
-
29
-
-
0030819379
-
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
-
Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol. 1997;15(9):871-875.
-
(1997)
Nat Biotechnol.
, vol.15
, Issue.9
, pp. 871-875
-
-
Zufferey, R.1
Nagy, D.2
Mandel, R.J.3
Naldini, L.4
Trono, D.5
-
30
-
-
82755162926
-
Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells
-
Das S, Jena S, Levasseur DN. Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells. J Biol Chem. 2011;286(49): 42690-42703.
-
(2011)
J Biol Chem.
, vol.286
, Issue.49
, pp. 42690-42703
-
-
Das, S.1
Jena, S.2
Levasseur, D.N.3
-
31
-
-
23944524848
-
Wnts induce migration and invasion of myeloma plasma cells
-
Qiang YW, Walsh K, Yao L, et al. Wnts induce migration and invasion of myeloma plasma cells. Blood. 2005;106(5):1786-1793.
-
(2005)
Blood
, vol.106
, Issue.5
, pp. 1786-1793
-
-
Qiang, Y.W.1
Walsh, K.2
Yao, L.3
-
32
-
-
70350247558
-
Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer
-
Carpentino JE, Hynes MJ, Appelman HD, Zheng T, Steindler DA, Scott EW, Huang EH. Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res. 2009;69(20): 8208-8215.
-
(2009)
Cancer Res.
, vol.69
, Issue.20
, pp. 8208-8215
-
-
Carpentino, J.E.1
Hynes, M.J.2
Appelman, H.D.3
Zheng, T.4
Steindler, D.A.5
Scott, E.W.6
Huang, E.H.7
-
33
-
-
65949112714
-
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
-
Huang EH, Hynes MJ, Zhang T, et al. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res. 2009;69(8): 3382-3389.
-
(2009)
Cancer Res.
, vol.69
, Issue.8
, pp. 3382-3389
-
-
Huang, E.H.1
Hynes, M.J.2
Zhang, T.3
-
34
-
-
42549167500
-
Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway
-
Cusimano A, Foderà D, D'Alessandro N, et al. Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. Cancer Biol Ther. 2007;6(9):1461-1468.
-
(2007)
Cancer Biol Ther.
, vol.6
, Issue.9
, pp. 1461-1468
-
-
Cusimano, A.1
Foderà, D.2
D'Alessandro, N.3
-
35
-
-
69049098171
-
Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells
-
Cho Y, Park MJ, Park M, et al. Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. Respirology. 2009;14(6): 850-858.
-
(2009)
Respirology
, vol.14
, Issue.6
, pp. 850-858
-
-
Cho, Y.1
Park, M.J.2
Park, M.3
-
36
-
-
35748937334
-
Retinoic acid inhibits beta-catenin through suppression of Cox-2: A role for truncated adenomatous polyposis coli
-
Eisinger AL, Nadauld LD, Shelton DN, Prescott SM, Stafforini DM, Jones DA. Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. J Biol Chem. 2007;282(40): 29394-29400.
-
(2007)
J Biol Chem.
, vol.282
, Issue.40
, pp. 29394-29400
-
-
Eisinger, A.L.1
Nadauld, L.D.2
Shelton, D.N.3
Prescott, S.M.4
Stafforini, D.M.5
Jones, D.A.6
-
37
-
-
84873566331
-
Improvement in long-term outcomes with successive total therapy trials for multiple myeloma: Are patients now being cured?
-
Usmani SZ, Crowley J, Hoering A, et al. Improvement in long-term outcomes with successive Total Therapy trials for multiple myeloma: are patients now being cured? Leukemia. 2013;27(1): 226-232.
-
(2013)
Leukemia
, vol.27
, Issue.1
, pp. 226-232
-
-
Usmani, S.Z.1
Crowley, J.2
Hoering, A.3
-
38
-
-
72249119222
-
Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA
-
Noubissi FK, Goswami S, Sanek NA, et al. Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res. 2009;69(22): 8572-8578.
-
(2009)
Cancer Res.
, vol.69
, Issue.22
, pp. 8572-8578
-
-
Noubissi, F.K.1
Goswami, S.2
Sanek, N.A.3
-
39
-
-
34548285028
-
Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells
-
Avvisato CL, Yang X, Shah S, et al. Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. J Cell Sci. 2007;120(Pt 15):2672-2682.
-
(2007)
J Cell Sci.
, vol.120
, pp. 2672-2682
-
-
Avvisato, C.L.1
Yang, X.2
Shah, S.3
-
40
-
-
84866702740
-
Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms
-
Ibrahim EE, Babaei-Jadidi R, Saadeddin A, et al. Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. Stem Cells. 2012;30(10):2076-2087.
-
(2012)
Stem Cells
, vol.30
, Issue.10
, pp. 2076-2087
-
-
Ibrahim, E.E.1
Babaei-Jadidi, R.2
Saadeddin, A.3
-
41
-
-
79959963618
-
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal
-
Yi F, Pereira L, Hoffman JA, Shy BR, Yuen CM, Liu DR, Merrill BJ. Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol. 2011;13(7): 762-770.
-
(2011)
Nat Cell Biol.
, vol.13
, Issue.7
, pp. 762-770
-
-
Yi, F.1
Pereira, L.2
Hoffman, J.A.3
Shy, B.R.4
Yuen, C.M.5
Liu, D.R.6
Merrill, B.J.7
-
42
-
-
79551594937
-
β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism
-
Kelly KF, Ng DY, Jayakumaran G, Wood GA, Koide H, Doble BW. β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell. 2011;8(2):214-227.
-
(2011)
Cell Stem Cell
, vol.8
, Issue.2
, pp. 214-227
-
-
Kelly, K.F.1
Ng, D.Y.2
Jayakumaran, G.3
Wood, G.A.4
Koide, H.5
Doble, B.W.6
-
43
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen X, Xu H, Yuan P, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 2008;133(6):1106-1117.
-
(2008)
Cell
, vol.133
, Issue.6
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
-
44
-
-
34548029751
-
The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells
-
Levitt RJ, Zhao Y, Blouin MJ, Pollak M. The hedgehog pathway inhibitor cyclopamine increases levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells. Cancer Lett. 2007;255(2): 300-306.
-
(2007)
Cancer Lett.
, vol.255
, Issue.2
, pp. 300-306
-
-
Levitt, R.J.1
Zhao, Y.2
Blouin, M.J.3
Pollak, M.4
|