메뉴 건너뛰기




Volumn 115, Issue 1, 2010, Pages 61-70

Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CASPASE; EARLY GROWTH RESPONSE FACTOR 1; SURVIVIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR JUN; UNCLASSIFIED DRUG; BIRC5 PROTEIN, HUMAN; BORONIC ACID DERIVATIVE; EGR1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN C JUN; PYRAZINE DERIVATIVE;

EID: 74949107707     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-03-210526     Document Type: Article
Times cited : (78)

References (49)
  • 2
    • 0141994805 scopus 로고    scopus 로고
    • Consequences of interactions between the bone marrow stroma and myeloma
    • Epstein J, Yaccoby S. Consequences of interactions between the bone marrow stroma and myeloma. Hematol J. 2003;4(5):310-314.
    • (2003) Hematol J , vol.4 , Issue.5 , pp. 310-314
    • Epstein, J.1    Yaccoby, S.2
  • 3
    • 33746326785 scopus 로고    scopus 로고
    • The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: Interplay of growth factors, their receptors and stromal interactions
    • Mitsiades CS, Mitsiades NS, Munshi NC, Richardson PG, Anderson KC. The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions. Eur J Cancer. 2006;42(11):1564-1573.
    • (2006) Eur J Cancer , vol.42 , Issue.11 , pp. 1564-1573
    • Mitsiades, C.S.1    Mitsiades, N.S.2    Munshi, N.C.3    Richardson, P.G.4    Anderson, K.C.5
  • 4
    • 0035971493 scopus 로고    scopus 로고
    • AP-1 in cell proliferation and survival
    • Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene. 2001;20:2390-2400.
    • (2001) Oncogene , vol.20 , pp. 2390-2400
    • Shaulian, E.1    Karin, M.2
  • 5
    • 34248582787 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia
    • Zhang JY, Adams AE, Ridky TW, Tao S, Khavari PA. Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia. Cancer Res. 2007;67:3827-3834.
    • (2007) Cancer Res , vol.67 , pp. 3827-3834
    • Zhang, J.Y.1    Adams, A.E.2    Ridky, T.W.3    Tao, S.4    Khavari, P.A.5
  • 6
    • 0037200098 scopus 로고    scopus 로고
    • Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells
    • Lu A, Zhang F, Gupta A, Liu J. Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells. J Biol Chem. 2002;277:31364-31372.
    • (2002) J Biol Chem , vol.277 , pp. 31364-31372
    • Lu, A.1    Zhang, F.2    Gupta, A.3    Liu, J.4
  • 7
    • 0035086099 scopus 로고    scopus 로고
    • The role of AP-1 in glucocorticoid resistance in leukaemia
    • Bailey S, Hall AG, Pearson AD, Redfern CP. The role of AP-1 in glucocorticoid resistance in leukaemia. Leukemia. 2001;15:391-397.
    • (2001) Leukemia , vol.15 , pp. 391-397
    • Bailey, S.1    Hall, A.G.2    Pearson, A.D.3    Redfern, C.P.4
  • 8
    • 35648935982 scopus 로고    scopus 로고
    • Suppression of p53-dependent senescence by the JNK signal transduction pathway
    • Das M, Jiang F, Sluss HK, et al. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A. 2007;104:15759-15764.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15759-15764
    • Das, M.1    Jiang, F.2    Sluss, H.K.3
  • 9
    • 0023625090 scopus 로고
    • Phorbol esterinducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
    • Angel P, Imagawa M, Chiu R, et al. Phorbol esterinducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell. 1987;49:729-739.
    • (1987) Cell , vol.49 , pp. 729-739
    • Angel, P.1    Imagawa, M.2    Chiu, R.3
  • 10
    • 0024276523 scopus 로고
    • The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
    • Angel P, Hattori K, Smeal T, Karin M. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell. 1988;55:875-885.
    • (1988) Cell , vol.55 , pp. 875-885
    • Angel, P.1    Hattori, K.2    Smeal, T.3    Karin, M.4
  • 11
    • 0029032249 scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 1995;270:16483-16486.
    • (1995) J Biol Chem , vol.270 , pp. 16483-16486
    • Karin, M.1
  • 12
    • 0033961711 scopus 로고    scopus 로고
    • C-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents
    • Kolbus A, Herr I, Schreiber M, Debatin KM, Wagner EF, Angel P. c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol. 2000;20:575-582.
    • (2000) Mol Cell Biol , vol.20 , pp. 575-582
    • Kolbus, A.1    Herr, I.2    Schreiber, M.3    Debatin, K.M.4    Wagner, E.F.5    Angel, P.6
  • 13
    • 33847710605 scopus 로고    scopus 로고
    • Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma
    • Podar K, Raab MS, Tonon G, et al. Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. Cancer Res. 2007;67: 1680-1688.
    • (2007) Cancer Res , vol.67 , pp. 1680-1688
    • Podar, K.1    Raab, M.S.2    Tonon, G.3
  • 14
    • 40349083966 scopus 로고    scopus 로고
    • Critical roles for JNK, c-Jun, and Fas/FasLsignaling in vitamin e analog-induced apoptosis in human prostate cancer cells
    • Jia L, Yu W, Wang P, Li J, Sanders BG, Kline K. Critical roles for JNK, c-Jun, and Fas/FasLsignaling in vitamin E analog-induced apoptosis in human prostate cancer cells. Prostate. 2008; 68:427-441.
    • (2008) Prostate , vol.68 , pp. 427-441
    • Jia, L.1    Yu, W.2    Wang, P.3    Li, J.4    Sanders, B.G.5    Kline, K.6
  • 15
    • 34248394360 scopus 로고    scopus 로고
    • The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells
    • Colla S, Zhan F, Xiong W, et al. The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. Blood. 2007;109:4470-4477.
    • (2007) Blood , vol.109 , pp. 4470-4477
    • Colla, S.1    Zhan, F.2    Xiong, W.3
  • 16
    • 0037441760 scopus 로고    scopus 로고
    • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
    • Hideshima T, Mitsiades C, Akiyama M, et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood. 2003;101:1530-1534.
    • (2003) Blood , vol.101 , pp. 1530-1534
    • Hideshima, T.1    Mitsiades, C.2    Akiyama, M.3
  • 17
    • 33744532339 scopus 로고    scopus 로고
    • Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines
    • Kajiguchi T, Yamamoto K, Iida S, Ueda R, Emi N, Naoe T. Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines. Cancer Sci. 2006;97:540-545.
    • (2006) Cancer Sci , vol.97 , pp. 540-545
    • Kajiguchi, T.1    Yamamoto, K.2    Iida, S.3    Ueda, R.4    Emi, N.5    Naoe, T.6
  • 18
    • 0036888651 scopus 로고    scopus 로고
    • Regulation of life and death by the zinc finger transcription factor Egr-1
    • Thiel G, Cibelli G. Regulation of life and death by the zinc finger transcription factor Egr-1. J Cell Physiol. 2002;193:287-292.
    • (2002) J Cell Physiol , vol.193 , pp. 287-292
    • Thiel, G.1    Cibelli, G.2
  • 19
    • 0035021950 scopus 로고    scopus 로고
    • ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
    • Harada T, Morooka T, Ogawa S, Nishida E. ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat Cell Biol. 2001;3: 453-459.
    • (2001) Nat Cell Biol , vol.3 , pp. 453-459
    • Harada, T.1    Morooka, T.2    Ogawa, S.3    Nishida, E.4
  • 20
    • 0024281381 scopus 로고
    • A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
    • Sukhatme VP, Cao XM, Chang LC, et al. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988;53:37-43.
    • (1988) Cell , vol.53 , pp. 37-43
    • Sukhatme, V.P.1    Cao, X.M.2    Chang, L.C.3
  • 21
    • 0035881797 scopus 로고    scopus 로고
    • Epidermal growth factor and platelet-derived growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells
    • Kaufmann K, Thiel G. Epidermal growth factor and platelet-derived growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells. J Neurol Sci. 2001;189:83-91.
    • (2001) J Neurol Sci , vol.189 , pp. 83-91
    • Kaufmann, K.1    Thiel, G.2
  • 22
    • 0036212895 scopus 로고    scopus 로고
    • Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator
    • Kaufmann K, Thiel G. Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator. J Cell Biochem. 2002;85:381-391.
    • (2002) J Cell Biochem , vol.85 , pp. 381-391
    • Kaufmann, K.1    Thiel, G.2
  • 23
    • 0031602586 scopus 로고    scopus 로고
    • Suppression of growth and transformation and induction of apoptosis by EGR-1
    • Liu C, Rangnekar VM, Adamson E, Mercola D. Suppression of growth and transformation and induction of apoptosis by EGR-1. Cancer Gene Ther. 1998;5:3-28.
    • (1998) Cancer Gene Ther , vol.5 , pp. 3-28
    • Liu, C.1    Rangnekar, V.M.2    Adamson, E.3    Mercola, D.4
  • 25
    • 0035199914 scopus 로고    scopus 로고
    • The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
    • Virolle T, Adamson ED, Baron V, et al. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol. 2001; 3:1124-1128.
    • (2001) Nat Cell Biol , vol.3 , pp. 1124-1128
    • Virolle, T.1    Adamson, E.D.2    Baron, V.3
  • 26
    • 0035882383 scopus 로고    scopus 로고
    • A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation
    • Levkovitz Y, Baraban JM. A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation. J Neurosci. 2001;21:5893-5901.
    • (2001) J Neurosci , vol.21 , pp. 5893-5901
    • Levkovitz, Y.1    Baraban, J.M.2
  • 27
    • 0035141521 scopus 로고    scopus 로고
    • Blockade of NGF-induced neurite outgrowth by a dominant-negative inhibitor of the egr family of transcription regulatory factors
    • Levkovitz Y, O'Donovan KJ, Baraban JM. Blockade of NGF-induced neurite outgrowth by a dominant-negative inhibitor of the egr family of transcription regulatory factors. J Neurosci. 2001; 21:45-52.
    • (2001) J Neurosci , vol.21 , pp. 45-52
    • Levkovitz, Y.1    O'Donovan, K.J.2    Baraban, J.M.3
  • 28
    • 45549094532 scopus 로고    scopus 로고
    • Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway
    • Hoffmann E, Ashouri J, Wolter S, et al. Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. J Biol Chem. 2008; 283:12120-12128.
    • (2008) J Biol Chem , vol.283 , pp. 12120-12128
    • Hoffmann, E.1    Ashouri, J.2    Wolter, S.3
  • 29
    • 54049092386 scopus 로고    scopus 로고
    • Leukemia suppressor function of Egr-1 is dependent on transforming oncogene
    • Gibbs JD, Liebermann DA, Hoffman B. Leukemia suppressor function of Egr-1 is dependent on transforming oncogene. Leukemia. 2008;22: 1909-1916.
    • (2008) Leukemia , vol.22 , pp. 1909-1916
    • Gibbs, J.D.1    Liebermann, D.A.2    Hoffman, B.3
  • 30
    • 37849038561 scopus 로고    scopus 로고
    • Egr-1 abrogates the E2F-1 block in terminal myeloid differentiation and suppresses leukemia
    • Gibbs JD, Liebermann DA, Hoffman B. Egr-1 abrogates the E2F-1 block in terminal myeloid differentiation and suppresses leukemia. Oncogene. 2008;27:98-106.
    • (2008) Oncogene , vol.27 , pp. 98-106
    • Gibbs, J.D.1    Liebermann, D.A.2    Hoffman, B.3
  • 31
    • 33746119582 scopus 로고    scopus 로고
    • Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth
    • Lucerna M, Pomyje J, Mechtcheriakova D, et al. Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth. Cancer Res. 2006;66:6708-6713.
    • (2006) Cancer Res , vol.66 , pp. 6708-6713
    • Lucerna, M.1    Pomyje, J.2    Mechtcheriakova, D.3
  • 32
    • 23844518684 scopus 로고    scopus 로고
    • Early growth response gene 1 (EGR1) is deleted in estrogen receptor-negative human breast carcinoma
    • Ronski K, Sanders M, Burleson JA, Moyo V, Benn P, Fang M. Early growth response gene 1 (EGR1) is deleted in estrogen receptor-negative human breast carcinoma. Cancer. 2005; 104:925-930.
    • (2005) Cancer , vol.104 , pp. 925-930
    • Ronski, K.1    Sanders, M.2    Burleson, J.A.3    Moyo, V.4    Benn, P.5    Fang, M.6
  • 33
    • 34250878387 scopus 로고    scopus 로고
    • Incorporating bortezomib into upfront treatment for multiple myeloma: Early results of total therapy 3
    • Barlogie B, Anaissie E, van Rhee F, et al. Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3. Br J Haematol. 2007;138:176-185.
    • (2007) Br J Haematol , vol.138 , pp. 176-185
    • Barlogie, B.1    Anaissie, E.2    Van Rhee, F.3
  • 34
    • 34249275302 scopus 로고    scopus 로고
    • Testing standard and genetic parameters in 220 patients with multiple myeloma with complete data sets: Superiority of molecular genetics
    • Shaughnessy JD Jr, Haessler J, van Rhee F, et al. Testing standard and genetic parameters in 220 patients with multiple myeloma with complete data sets: superiority of molecular genetics. Br J Haematol. 2007;137:530-536.
    • (2007) Br J Haematol , vol.137 , pp. 530-536
    • Shaughnessy Jr., S.J.D.1    Haessler, J.2    Van Rhee, F.3
  • 35
    • 36749031118 scopus 로고    scopus 로고
    • The Arkansas approach to therapy of patients with multiple myeloma
    • Barlogie B, Anaissie E, van Rhee F, et al. The Arkansas approach to therapy of patients with multiple myeloma. Best Pract Res Clin Haematol. 2007;20:761-781.
    • (2007) Best Pract Res Clin Haematol , vol.20 , pp. 761-781
    • Barlogie, B.1    Anaissie, E.2    Van Rhee, F.3
  • 36
    • 46049106797 scopus 로고    scopus 로고
    • Completion of pre-maintenance phases in total therapies 2 and 3 improves clinical outcomes in multiple myeloma - An important variable to be considered in clinical trial designs
    • Barlogie B, Haessler J, Pineda-Roman M, et al. Completion of pre-maintenance phases in total therapies 2 and 3 improves clinical outcomes in multiple myeloma - an important variable to be considered in clinical trial designs. Cancer. 2008; 112:2720-2725.
    • (2008) Cancer , vol.112 , pp. 2720-2725
    • Barlogie, B.1    Haessler, J.2    Pineda-Roman, M.3
  • 37
    • 1542720384 scopus 로고    scopus 로고
    • Cancer and the microenvironment: Myeloma-osteoclast interactions as a model
    • Yaccoby S, Wezeman MJ, Henderson A, et al. Cancer and the microenvironment: myeloma-osteoclast interactions as a model. Cancer Res. 2004;64:2016-2023.
    • (2004) Cancer Res , vol.64 , pp. 2016-2023
    • Yaccoby, S.1    Wezeman, M.J.2    Henderson, A.3
  • 38
    • 33745779502 scopus 로고    scopus 로고
    • The molecular classification of multiple myeloma
    • Zhan F, Huang Y, Colla S, et al. The molecular classification of multiple myeloma. Blood. 2006; 108:2020-2028.
    • (2006) Blood , vol.108 , pp. 2020-2028
    • Zhan, F.1    Huang, Y.2    Colla, S.3
  • 39
    • 33947217497 scopus 로고    scopus 로고
    • A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
    • Shaughnessy JD Jr, Zhan F, Burington BE, et al. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood. 2007;109:2276-2284.
    • (2007) Blood , vol.109 , pp. 2276-2284
    • Shaughnessy Jr., J.D.1    Zhan, F.2    Burington, B.E.3
  • 40
    • 1542514781 scopus 로고    scopus 로고
    • Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors
    • Ahmed MM. Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors. Curr Cancer Drug Targets. 2004; 4:43-52.
    • (2004) Curr Cancer Drug Targets , vol.4 , pp. 43-52
    • Ahmed, M.M.1
  • 41
    • 58149165366 scopus 로고    scopus 로고
    • An analysis of the clinical and biological significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma
    • Xiong W, Wu X, Starnes S, et al. An analysis of the clinical and biological significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma. Blood. 2008;112:4235-4246.
    • (2008) Blood , vol.112 , pp. 4235-4246
    • Xiong, W.1    Wu, X.2    Starnes, S.3
  • 42
    • 0034669945 scopus 로고    scopus 로고
    • Loss of PTEN expression leading to high Akt activation in human multiple myelomas
    • Hyun T, Yam A, Pece S, et al. Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood. 2000;96:3560-3568.
    • (2000) Blood , vol.96 , pp. 3560-3568
    • Hyun, T.1    Yam, A.2    Pece, S.3
  • 43
    • 33751099815 scopus 로고    scopus 로고
    • Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator
    • Hurt EM, Thomas SB, Peng B, Farrar WL. Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator. Cancer Biol Ther. 2006;5:1154-1160.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1154-1160
    • Hurt, E.M.1    Thomas, S.B.2    Peng, B.3    Farrar, W.L.4
  • 44
    • 39649102735 scopus 로고    scopus 로고
    • Transcriptional regulation of human survivin by early growth response (Egr)-1 transcription factor
    • Wagner M, Schmelz K, Dorken B, Tamm I. Transcriptional regulation of human survivin by early growth response (Egr)-1 transcription factor. Int J Cancer. 2008;122:1278-1287.
    • (2008) Int J Cancer , vol.122 , pp. 1278-1287
    • Wagner, M.1    Schmelz, K.2    Dorken, B.3    Tamm, I.4
  • 45
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    • Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997;3:917-921.
    • (1997) Nat Med , vol.3 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 46
    • 0036648414 scopus 로고    scopus 로고
    • Increased expression of survivin in gastric cancer patients and in first degree relatives
    • Yu J, Leung WK, Ebert MP, et al. Increased expression of survivin in gastric cancer patients and in first degree relatives. Br J Cancer. 2002;87:91-97.
    • (2002) Br J Cancer , vol.87 , pp. 91-97
    • Yu, J.1    Leung, W.K.2    Ebert, M.P.3
  • 47
    • 0035878930 scopus 로고    scopus 로고
    • Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors
    • Satoh K, Kaneko K, Hirota M, Masamune A, Satoh A, Shimosegawa T. Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors. Cancer. 2001;92: 271-278.
    • (2001) Cancer , vol.92 , pp. 271-278
    • Satoh, K.1    Kaneko, K.2    Hirota, M.3    Masamune, A.4    Satoh, A.5    Shimosegawa, T.6
  • 48
    • 50149115578 scopus 로고    scopus 로고
    • Cancer cells survive with survivin
    • Yamamoto H, Ngan CY, Monden M. Cancer cells survive with survivin. Cancer Sci. 2008;99:1709-1714.
    • (2008) Cancer Sci , vol.99 , pp. 1709-1714
    • Yamamoto, H.1    Ngan, C.Y.2    Monden, M.3
  • 49
    • 0035969963 scopus 로고    scopus 로고
    • An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7
    • Shin S, Sung BJ, Cho YS, et al. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry. 2001;40:1117-1123.
    • (2001) Biochemistry , vol.40 , pp. 1117-1123
    • Shin, S.1    Sung, B.J.2    Cho, Y.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.