The fundamental role of epigenetics in hematopoietic malignancies

Blood Reviews

Volumn 20, Issue 1, 2006, Pages 1-13

  Galm, Oliver ^a   Herman, James G ^b   Baylin, Stephen B ^b  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

CpG island; DNA methylation; Epigenetics; Histone modifications; Transcriptional silencing

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 METHYLCYTOSINE; ABELSON KINASE; ALKYLATING AGENT; AZACITIDINE; BIOLOGICAL MARKER; CARMUSTINE; CELLULAR RETINOL BINDING PROTEIN 1; CYCLOPHOSPHAMIDE; CYTOSINE; DEATH ASSOCIATED PROTEIN KINASE; GLUTATHIONE TRANSFERASE; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; IMATINIB; METHYLTRANSFERASE; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN P16; PROTEIN P57; PROTEIN P73; RETINOIC ACID RECEPTOR BETA; S ADENOSYLMETHIONINE; SODIUM PHENYLBUTYRATE; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG; UVOMORULIN;

CANCER CELL; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CHROMATIN STRUCTURE; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CPG ISLAND; DEACETYLATION; DEAMINATION; DNA METHYLATION; DNA SEQUENCE; DRUG EFFECT; EPIGENETICS; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE SILENCING; GLIOMA; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HISTONE CODE; HUMAN; HUMAN GENOME; LARGE CELL LYMPHOMA; LOW DRUG DOSE; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN PROCESSING; REVIEW; TRANSCRIPTION INITIATION; TREATMENT OUTCOME; TUMOR SUPPRESSOR GENE;

EID: 30844462355     PISSN: 0268960X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.blre.2005.01.006     Document Type: Article

References (127)

1. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
2. P.A. Jones, and P.W. Laird Cancer epigenetics comes of age Nat Genet 21 1999 163 167
3. M. Esteller CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future Oncogene 21 2002 5427 5440
4. J.G. Herman, and S.B. Baylin Gene silencing in cancer in association with promoter hypermethylation N Engl J Med 349 2003 2042 2054
5. R. Holliday, and G.W. Grigg DNA methylation and mutation Mutat Res 285 1993 61 67
6. A. Bird DNA methylation patterns and epigenetic memory Genes Dev 16 2002 6 21
7. M. Gardiner-Garden, and M. Frommer CpG islands in vertebrate genomes J Mol Biol 196 1987 261 282
8. M. Esteller, and J.G. Herman Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours J Pathol 196 2002 1 7
9. P.A. Jones, and S.B. Baylin The fundamental role of epigenetic events in cancer Nat Rev Genet 3 2002 415 428
10. M. Constancia, B. Pickard, G. Kelsey, and W. Reik Imprinting mechanisms Genome Res 8 1998 881 900
11. K.D. Robertson, and P.A. Jones DNA methylation: past, present and future directions Carcinogenesis 21 2000 461 467
12. R. Jaenisch, and A. Bird Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nat Genet 33 Suppl 2003 245 254
13. W. Fischle, Y. Wang, and C.D. Allis Histone and chromatin cross-talk Curr Opin Cell Biol 15 2003 172 183
14. B.M. Turner Cellular memory and the histone code Cell 111 2002 285 291
15. B.D. Strahl, and C.D. Allis The language of covalent histone modifications Nature 403 2000 41 45
16. G. Felsenfeld, and M. Groudine Controlling the double helix Nature 421 2003 448 453
17. E.J. Richards, and S.C. Elgin Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects Cell 108 2002 489 500
18. M. Lachner, and T. Jenuwein The many faces of histone lysine methylation Curr Opin Cell Biol 14 2002 286 298
19. A.P. Feinberg, and B. Vogelstein Hypomethylation distinguishes genes of some human cancers from their normal counterparts Nature 301 1983 89 92
20. A.P. Feinberg, C.W. Gehrke, K.C. Kuo, and M. Ehrlich Reduced genomic 5-methylcytosine content in human colonic neoplasia Cancer Res 48 1988 1159 1161
21. M. Ehrlich DNA methylation in cancer: too much, but also too little Oncogene 21 2002 5400 5413
22. F. Gaudet, J.G. Hodgson, A. Eden, L. Jackson-Grusby, J. Dausman, and J.W. Gray Induction of tumors in mice by genomic hypomethylation Science 300 2003 489 492
23. S.B. Baylin, and J.G. Herman DNA hypermethylation in tumorigenesis: epigenetics joins genetics Trends Genet 16 2000 168 174
24. G. Egger, G. Liang, A. Aparicio, and P.A. Jones Epigenetics in human disease and prospects for epigenetic therapy Nature 429 2004 457 463
25. A.G. Knudson Two genetic hits (more or less) to cancer Nat Rev Cancer 1 2001 157 162
26. M. Okano, S. Xie, and E. Li Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases Nat Genet 19 1998 219 220
27. M. Okano, D.W. Bell, D.A. Haber, and E. Li DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell 99 1999 247 257
28. F. Fuks, W.A. Burgers, A. Brehm, L. Hughes-Davies, and T. Kouzarides DNA methyltransferase Dnmt1 associates with histone deacetylase activity Nat Genet 24 2000 88 91
29. M.R. Rountree, K.E. Bachman, and S.B. Baylin DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci Nat Genet 25 2000 269 277
30. K. Struhl Histone acetylation and transcriptional regulatory mechanisms Genes Dev 12 1998 599 606
31. P.L. Jones, G.J. Veenstra, P.A. Wade, D. Vermaak, S.U. Kass, and N. Landsberger Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription Nat Genet 19 1998 187 191
32. S.B. Baylin, M. Esteller, M.R. Rountree, K.E. Bachman, K. Schuebel, and J.G. Herman Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer Hum Mol Genet 10 2001 687 692
33. T. Jenuwein, and C.D. Allis Translating the histone code Science 293 2001 1074 1080
34. S.B. Hake, A. Xiao, and C.D. Allis Linking the epigenetic 'language' of covalent histone modifications to cancer Br J Cancer 90 2004 761 769
35. J.P. Jackson, A.M. Lindroth, X. Cao, and S.E. Jacobsen Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase Nature 416 2002 556 560
36. H. Tamaru, X. Zhang, D. McMillen, P.B. Singh, J. Nakayama, and S.I. Grewal Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa Nat Genet 34 2003 75 79
37. K.E. Bachman, B.H. Park, I. Rhee, H. Rajagopalan, J.G. Herman, and S.B. Baylin Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene Cancer Cell 3 2003 89 95
38. E.E. Cameron, K.E. Bachman, S. Myohanen, J.G. Herman, and S.B. Baylin Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer Nat Genet 21 1999 103 107
39. M. Esteller, P.G. Corn, S.B. Baylin, and J.G. Herman A gene hypermethylation profile of human cancer Cancer Res 61 2001 3225 3229
40. J.P. Issa, Y.L. Ottaviano, P. Celano, S.R. Hamilton, N.E. Davidson, and S.B. Baylin Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon Nat Genet 7 1994 536 540
41. J.G. Herman, F. Latif, Y. Weng, M.I. Lerman, B. Zbar, and S. Liu Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma Proc Natl Acad Sci USA 91 1994 9700 9704
42. J.R. Graff, J.G. Herman, R.G. Lapidus, H. Chopra, R. Xu, and D.F. Jarrard E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas Cancer Res 55 1995 5195 5199
43. A. Merlo, J.G. Herman, L. Mao, D.J. Lee, E. Gabrielson, and P.C. Burger 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers Nat Med 1 1995 686 692
44. C. Stirzaker, D.S. Millar, C.L. Paul, P.M. Warnecke, J. Harrison, and P.C. Vincent Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors Cancer Res 57 1997 2229 2237
45. A. Dobrovic, and D. Simpfendorfer Methylation of the BRCA1 gene in sporadic breast cancer Cancer Res 57 1997 3347 3350
46. M. Esteller, P.G. Corn, J.M. Urena, E. Gabrielson, S.B. Baylin, and J.G. Herman Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia Cancer Res 58 1998 4515 4518
47. J.G. Herman, A. Umar, K. Polyak, J.R. Graff, N. Ahuja, and J.P. Issa Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma Proc Natl Acad Sci USA 95 1998 6870 6875
48. M. Esteller, S.R. Hamilton, P.C. Burger, S.B. Baylin, and J.G. Herman Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia Cancer Res 59 1999 793 797
49. K.E. Bachman, J.G. Herman, P.G. Corn, A. Merlo, J.F. Costello, and W.K. Cavenee Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers Cancer Res 59 1999 798 802
50. P.G. Corn, S.J. Kuerbitz, M.M. van Noesel, M. Esteller, N. Compitello, and S.B. Baylin Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation Cancer Res 59 1999 3352 3356
51. R.A. Katzenellenbogen, S.B. Baylin, and J.G. Herman Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies Blood 93 1999 4347 4353
52. E.E. Cameron, S.B. Baylin, and J.G. Herman p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing Blood 94 1999 2445 2451
53. A.K. Virmani, A. Rathi, S. Zochbauer-Muller, N. Sacchi, Y. Fukuyama, and D. Bryant Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas J Natl Cancer Inst 92 2000 1303 1307
54. M. Esteller, S. Tortola, M. Toyota, G. Capella, M.A. Peinado, and S.B. Baylin Hypermethylation-associated inactivation of p14 (ARF) is independent of p16 (INK4a) methylation and p53 mutational status Cancer Res 60 2000 129 133
55. K.E. Conway, B.B. McConnell, C.E. Bowring, C.D. Donald, S.T. Warren, and P.M. Vertino TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers Cancer Res 60 2000 6236 6242
56. H. Yoshikawa, K. Matsubara, G.S. Qian, P. Jackson, J.D. Groopman, and J.E. Manning SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity Nat Genet 28 2001 29 35
57. B. Banelli, I. Casciano, M. Croce, A. Di Vinci, I. Gelvi, and G. Pagnan Expression and methylation of CASP8 in neuroblastoma: identification of a promoter region Nat Med 8 2002 1333 1335 author reply 1335
58. M. Esteller, M. Guo, V. Moreno, M.A. Peinado, G. Capella, and O. Galm Hypermethylation-associated inactivation of the cellular retinol-binding-protein 1 Gene in human cancer Cancer Res 62 2002 5902 5905
59. B. He, L. You, K. Uematsu, K. Zang, Z. Xu, and A.Y. Lee SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer Proc Natl Acad Sci USA 100 2003 14133 14138
60. M.F. Kane, M. Loda, G.M. Gaida, J. Lipman, R. Mishra, and H. Goldman Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines Cancer Res 57 1997 808 811
61. A.S. Fleisher, M. Esteller, S. Wang, G. Tamura, H. Suzuki, and J. Yin Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability Cancer Res 59 1999 1090 1095
62. M. Esteller, M. Toyota, M. Sanchez-Cespedes, G. Capella, M.A. Peinado, and D.N. Watkins Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis Cancer Res 60 2000 2368 2371
63. W.Y. Chen, X. Zeng, M.G. Carter, C.N. Morrell, R.W. Chiu Yen, and M. Esteller Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors Nat Genet 33 2003 197 202
64. H. Suzuki, D.N. Watkins, K.W. Jair, K.E. Schuebel, S.D. Markowitz, and W. Dong Chen Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer Nat Genet 36 2004 417 422
65. M. Esteller Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg Clin Immunol 109 2003 80 88
66. B. Quesnel, G. Guillerm, R. Vereecque, E. Wattel, C. Preudhomme, and F. Bauters Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression Blood 91 1998 2985 2990
67. G. Guillerm, E. Gyan, D. Wolowiec, T. Facon, H. Avet-Loiseau, and K. Kuliczkowski p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance Blood 98 2001 244 246
68. Y. Li, H. Nagai, T. Ohno, M. Yuge, S. Hatano, and E. Ito Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype Blood 100 2002 2572 2577
69. M. Esteller, G. Gaidano, S.N. Goodman, V. Zagonel, D. Capello, and B. Botto Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma J Natl Cancer Inst 94 2002 26 32
70. D. Rossi, D. Capello, A. Gloghini, S. Franceschetti, M. Paulli, and K. Bhatia Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia Haematologica 89 2004 154 164
71. M.H. Ng, Y.F. Chung, K.W. Lo, N.W. Wickham, J.C. Lee, and D.P. Huang Frequent hypermethylation of p16 and p15 genes in multiple myeloma Blood 89 1997 2500 2506
72. M. Gonzalez, M.V. Mateos, R. Garcia-Sanz, A. Balanzategui, R. Lopez-Perez, and M.C. Chillon De novo methylation of tumor suppressor gene p16/INK4a is a frequent finding in multiple myeloma patients at diagnosis Leukemia 14 2000 183 187
73. M.H. Ng, K.W. To, K.W. Lo, S. Chan, K.S. Tsang, and S.H. Cheng Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma Clin Cancer Res 7 2001 1724 1729
74. O. Galm, H. Yoshikawa, M. Esteller, R. Osieka, and J.G. Herman SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma Blood 101 2003 2784 2788
75. S. Seidl, J. Ackermann, H. Kaufmann, A. Keck, T. Nosslinger, and C.C. Zielinski DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies Cancer 100 2004 2598 2606
76. T.T. Nguyen, A.F. Mohrbacher, Y.C. Tsai, J. Groffen, N. Heisterkamp, and P.W. Nichols Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications Blood 95 2000 2990 2992
77. B. Sun, G. Jiang, M.A. Zaydan, V.F. La Russa, H. Safah, and M. Ehrlich ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors Cancer Res 61 2001 6931 6937
78. G. Garcia-Manero, J. Daniel, T.L. Smith, S.M. Kornblau, M.S. Lee, and H.M. Kantarjian DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia Clin Cancer Res 8 2002 2217 2224
79. M.I. Gutierrez, A.K. Siraj, M. Bhargava, U. Ozbek, S. Banavali, and M.A. Chaudhary Concurrent methylation of multiple genes in childhood ALL: correlation with phenotype and molecular subgroup Leukemia 17 2003 1845 1850
80. J. Roman-Gomez, A. Jimenez-Velasco, J.A. Castillejo, X. Agirre, M. Barrios, and G. Navarro Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia Blood 104 2004 2492 2498
81. J.R. Melki, P.C. Vincent, and S.J. Clark Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia Cancer Res 59 1999 3730 3740
82. M. Toyota, K.J. Kopecky, M.O. Toyota, K.W. Jair, C.L. Willman, and J.P. Issa Methylation profiling in acute myeloid leukemia Blood 97 2001 2823 2829
83. M. Esteller, M.F. Fraga, M.F. Paz, E. Campo, D. Colomer, and F.J. Novo Cancer epigenetics and methylation Science 297 2002 1807 1808
84. C.Y. Chen, W. Tsay, J.L. Tang, H.L. Shen, S.W. Lin, and S.Y. Huang SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia Genes Chromosomes Cancer 37 2003 300 305
85. O. Galm, S. Wilop, J. Reichelt, E. Jost, G. Gehbauer, and J.G. Herman DNA methylation changes in multiple myeloma Leukemia 18 2004 1687 1692
86. L. Di Croce, V.A. Raker, M. Corsaro, F. Fazi, M. Fanelli, and M. Faretta Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor Science 295 2002 1079 1082
87. D.G. Gilliland, and J.D. Griffin The roles of FLT3 in hematopoiesis and leukemia Blood 100 2002 1532 1542
88. D. Sidransky Emerging molecular markers of cancer Nat Rev Cancer 2 2002 210 219
89. P.W. Laird Early detection: The power and the promise of DNA methylation markers Nat Rev Cancer 3 2003 253 266
90. M.F. Fraga, and M. Esteller DNA methylation: a profile of methods and applications Biotechniques 33 2002 632 634, 636-49
91. M. Frommer, L.E. McDonald, D.S. Millar, C.M. Collis, F. Watt, and G.W. Grigg A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands Proc Natl Acad Sci USA 89 1992 1827 1831
92. S.J. Clark, J. Harrison, C.L. Paul, and M. Frommer High sensitivity mapping of methylated cytosines Nucleic Acids Res 22 1994 2990 2997
93. M.L. Gonzalgo, and P.A. Jones Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE) Nucleic Acids Res 25 1997 2529 2531
94. R. Sadri, and P.J. Hornsby Rapid analysis of DNA methylation using new restriction enzyme sites created by bisulfite modification Nucleic Acids Res 24 1996 5058 5059
95. Z. Xiong, and P.W. Laird COBRA: a sensitive and quantitative DNA methylation assay Nucleic Acids Res 25 1997 2532 2534
96. O. Galm, M.R. Rountree, K.E. Bachman, K.W. Jair, S.B. Baylin, and J.G. Herman Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density Genome Res 12 2002 153 157
97. J.G. Herman, J.R. Graff, S. Myohanen, B.D. Nelkin, and S.B. Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci USA 93 1996 9821 9826
98. P.G. Corn, B.D. Smith, E.S. Ruckdeschel, D. Douglas, S.B. Baylin, and J.G. Herman E-cadherin expression is silenced by 5′ CpG island methylation in acute leukemia Clin Cancer Res 6 2000 4243 4248
99. M. Esteller, J. Garcia-Foncillas, E. Andion, S.N. Goodman, O.F. Hidalgo, and V. Vanaclocha Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents N Engl J Med 343 2000 1350 1354
100. P. Cairns, M. Esteller, J.G. Herman, M. Schoenberg, C. Jeronimo, and M. Sanchez-Cespedes Molecular detection of prostate cancer in urine by GSTP1 hypermethylation Clin Cancer Res 7 2001 2727 2730
101. S.A. Ahrendt, J.T. Chow, L.H. Xu, S.C. Yang, C.F. Eisenberger, and M. Esteller Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer J Natl Cancer Inst 91 1999 332 339
102. W.A. Palmisano, K.K. Divine, G. Saccomanno, F.D. Gilliland, S.B. Baylin, and J.G. Herman Predicting lung cancer by detecting aberrant promoter methylation in sputum Cancer Res 60 2000 5954 5958
103. M. van Engeland, G.M. Roemen, M. Brink, M.M. Pachen, M.P. Weijenberg, and A.P. de Bruine K-ras mutations and RASSF1A promoter methylation in colorectal cancer Oncogene 21 2002 3792 3795
104. M.G. House, M. Guo, C. Iacobuzio-Donahue, and J.G. Herman Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas Carcinogenesis 24 2003 193 198
105. M.V. Brock, M. Gou, Y. Akiyama, A. Muller, T.T. Wu, and E. Montgomery Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma Clin Cancer Res 9 2003 2912 2919
106. D. Grimwade, H. Walker, F. Oliver, K. Wheatley, C. Harrison, and G. Harrison The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties Blood 92 1998 2322 2333
107. T. Hideshima, P.L. Bergsagel, W.M. Kuehl, and K.C. Anderson Advances in biology of multiple myeloma: clinical applications Blood 104 2004 607 618
108. I.H. Wong, M.H. Ng, D.P. Huang, and J.C. Lee Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications Blood 95 2000 1942 1949
109. C.S. Chim, R. Liang, C.Y. Tam, and Y.L. Kwong Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance J Clin Oncol 19 2001 2033 2040
110. A. Kramer, B. Schultheis, J. Bergmann, A. Willer, U. Hegenbart, and A.D. Ho Alterations of the cyclin D1/pRb/p16 (INK4A) pathway in multiple myeloma Leukemia 16 2002 1844 1851
111. M.V. Mateos, R. Garcia-Sanz, R. Lopez-Perez, M.J. Moro, E. Ocio, and J. Hernandez Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival Br J Haematol 118 2002 1034 1040
112. M.E. Hegi, A.C. Diserens, S. Godard, P.Y. Dietrich, L. Regli, and S. Ostermann Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide Clin Cancer Res 10 2004 1871 1874
113. M.F. Paz, R. Yaya-Tur, I. Rojas-Marcos, G. Reynes, M. Pollan, and L. Aguirre-Cruz CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas Clin Cancer Res 10 2004 4933 4938
114. R. Claus, and M. Lubbert Epigenetic targets in hematopoietic malignancies Oncogene 22 2003 6489 6496
115. P.A. Jones, and S.M. Taylor Cellular differentiation, cytidine analogs and DNA methylation Cell 20 1980 85 93
116. M.F. Paz, M.F. Fraga, S. Avila, M. Guo, M. Pollan, and J.G. Herman A systematic profile of DNA methylation in human cancer cell lines Cancer Res 63 2003 1114 1121
117. J.P. Issa Decitabine Curr Opin Oncol 15 2003 446 451
118. M. Lubbert DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action Curr Top Microbiol Immunol 249 2000 135 164
119. L.R. Silverman, E.P. Demakos, B.L. Peterson, A.B. Kornblith, J.C. Holland, and R. Odchimar-Reissig Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B J Clin Oncol 20 2002 2429 2440
120. P. Wijermans, M. Lubbert, G. Verhoef, A. Bosly, C. Ravoet, and M. Andre Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients J Clin Oncol 18 2000 956 962
121. P. Greenberg, C. Cox, M.M. LeBeau, P. Fenaux, P. Morel, and G. Sanz International scoring system for evaluating prognosis in myelodysplastic syndromes Blood 89 1997 2079 2088
122. M. Daskalakis, T.T. Nguyen, C. Nguyen, P. Guldberg, G. Kohler, and P. Wijermans Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment Blood 100 2002 2957 2964
123. H.M. Kantarjian, S. O'Brien, J. Cortes, F.J. Giles, S. Faderl, and J.P. Issa Results of decitabine (5-aza-2′-deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia Cancer 98 2003 522 528
124. J.P. Issa, G. Garcia-Manero, F.J. Giles, R. Mannari, D. Thomas, and S. Faderl Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies Blood 103 2004 1635 1640
125. H. Suzuki, E. Gabrielson, W. Chen, R. Anbazhagan, M. van Engeland, and M.P. Weijenberg A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer Nat Genet 31 2002 141 149
126. C.B. Miller, J.G. Herman, S.B. Baylin, O. Galm, J.A. Yerian, and S.D. Gore A phase I dose deescalation trial of combined DNA methyltransferase (MeT)/histone deacetylase (HDAC) inhibition in myeloid malignancies [abstract] Blood 98 2001 622a
127. S. Liu, T. Shen, L.J. Rush, B. Becknel, M.I. Klisovic, and S.P. Whitman AML1/ETO associates with DNA methyltransferase I (DNMT1) in inducing transcriptional repression of the AML1-target gene interleukin-3 (IL-3) [abstract] Blood 102 2003 218a