메뉴 건너뛰기




Volumn 21, Issue 22, 2003, Pages 4239-4247

Overcoming drug resistance in multiple myeloma: The emergence of therapeutic approaches to induce apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BORTEZOMIB; DAUNORUBICIN; EPIPODOPHYLLOTOXIN; GLYCOPROTEIN P; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; TOPOTECAN; VINBLASTINE; VINCA ALKALOID; PROTEINASE INHIBITOR;

EID: 0642378063     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2003.06.001     Document Type: Article
Times cited : (83)

References (92)
  • 1
    • 0031435837 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in hematologic malignancies
    • Dalton WS: Mechanisms of drug resistance in hematologic malignancies. Semin Hematol 34:3-8, 1997
    • (1997) Semin Hematol , vol.34 , pp. 3-8
    • Dalton, W.S.1
  • 2
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman MM, Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427, 1993
    • (1993) Annu Rev Biochem , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 3
    • 0027095653 scopus 로고
    • Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
    • Cole SP, Bhradwaj G, Gerlach JH, et al: Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654, 1992
    • (1992) Science , vol.258 , pp. 1650-1654
    • Cole, S.P.1    Bhradwaj, G.2    Gerlach, J.H.3
  • 4
    • 0034081847 scopus 로고    scopus 로고
    • The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)
    • Litman T, Brangi M, Hudson E, et al: The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci 113:2011-2021, 2000
    • (2000) J Cell Sci , vol.113 , pp. 2011-2021
    • Litman, T.1    Brangi, M.2    Hudson, E.3
  • 5
    • 0034501399 scopus 로고    scopus 로고
    • Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer
    • Scheffer GL, Schroeijers AB, Izquierdo MA, et al: Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer. Curr Opin Oncol 12:550-556, 2000
    • (2000) Curr Opin Oncol , vol.12 , pp. 550-556
    • Scheffer, G.L.1    Schroeijers, A.B.2    Izquierdo, M.A.3
  • 6
    • 0033400809 scopus 로고    scopus 로고
    • Apoptosis in cancer drug targeting
    • Sellers WR, Fisher DE: Apoptosis in cancer drug targeting. J Clin Invest 104:1655-1661, 1999
    • (1999) J Clin Invest , vol.104 , pp. 1655-1661
    • Sellers, W.R.1    Fisher, D.E.2
  • 7
    • 0032905030 scopus 로고    scopus 로고
    • Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
    • Wang CY, Cusack JC, Liu R, et al: Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nat Med 5:412-417, 1999
    • (1999) Nat Med , vol.5 , pp. 412-417
    • Wang, C.Y.1    Cusack, J.C.2    Liu, R.3
  • 8
    • 0028578004 scopus 로고
    • Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
    • Muller M, Meijer C, Zaman GJ, et al: Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci U S A 91:13033-13041, 1994
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 13033-13041
    • Muller, M.1    Meijer, C.2    Zaman, G.J.3
  • 9
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • Borst P, Evers R, Kool M, et al: A family of drug transporters: The multidrug resistance-associated proteins. J Natl Cancer Inst 92:1295-1302, 2000
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3
  • 11
    • 0033530286 scopus 로고    scopus 로고
    • Multidrug resistance and the lung resistance related protein in human colon carcinoma SW-620 cells
    • Kitazono M, Sumizawa T, Takebayashi T, et al: Multidrug resistance and the lung resistance related protein in human colon carcinoma SW-620 cells. J Natl Cancer Inst 91:1647-1653, 1999
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1647-1653
    • Kitazono, M.1    Sumizawa, T.2    Takebayashi, T.3
  • 12
    • 0032843181 scopus 로고    scopus 로고
    • Drug resistance in multiple myeloma: Approaches to circumvention
    • Dalton WS, Jove R: Drug resistance in multiple myeloma: Approaches to circumvention. Semin Oncol 26:23-27, 1999
    • (1999) Semin Oncol , vol.26 , pp. 23-27
    • Dalton, W.S.1    Jove, R.2
  • 13
    • 0027507266 scopus 로고
    • P-glycoprotein expression in human plasma cell myeloma: Correlation with prior chemotherapy
    • Grogan TM, Spier CM, Salmon SE, et al: P-glycoprotein expression in human plasma cell myeloma: Correlation with prior chemotherapy. Blood 81:490-495, 1993
    • (1993) Blood , vol.81 , pp. 490-495
    • Grogan, T.M.1    Spier, C.M.2    Salmon, S.E.3
  • 14
    • 0027954249 scopus 로고
    • MDR1 expression and response to vincristine, doxorubicin and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents
    • Cornelissan J, Sonneveld P, Schoester M, et al: MDR1 expression and response to vincristine, doxorubicin and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents. J Clin Oneol 12:115-119, 1994
    • (1994) J Clin Oneol , vol.12 , pp. 115-119
    • Cornelissan, J.1    Sonneveld, P.2    Schoester, M.3
  • 15
    • 0026594202 scopus 로고
    • Levels of expression of the mdr 1 gene and glutathione-S-transferase genes 1 and 2 and response to chemotherapy in multiple myeloma
    • Lynsenmeyer ME, Jefferson S, Wolf M, et al: Levels of expression of the mdr 1 gene and glutathione-S-transferase genes 1 and 2 and response to chemotherapy in multiple myeloma. Br J Cancer 65:471-475, 1992
    • (1992) Br J Cancer , vol.65 , pp. 471-475
    • Lynsenmeyer, M.E.1    Jefferson, S.2    Wolf, M.3
  • 16
    • 0034765167 scopus 로고    scopus 로고
    • Drug resistance in hematologic malignancies
    • Marie JP: Drug resistance in hematologic malignancies. Curr Opin Oncol 13:463-469, 2001
    • (2001) Curr Opin Oncol , vol.13 , pp. 463-469
    • Marie, J.P.1
  • 17
    • 0034009217 scopus 로고    scopus 로고
    • Novel mechanisms of drug resistance in leukemia
    • Ross DD: Novel mechanisms of drug resistance in leukemia. Leukemia 14:467-473, 2000
    • (2000) Leukemia , vol.14 , pp. 467-473
    • Ross, D.D.1
  • 18
    • 0033518874 scopus 로고    scopus 로고
    • Atypical multidrug resistance: Breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines
    • Ross DD, Yang W, Abruzzo LV, et al: Atypical multidrug resistance: Breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. J Natl Cancer Inst 91:429-433, 1999
    • (1999) J Natl Cancer Inst , vol.91 , pp. 429-433
    • Ross, D.D.1    Yang, W.2    Abruzzo, L.V.3
  • 19
    • 13144304081 scopus 로고    scopus 로고
    • Lung-resistance protein expression is a negative predictive factor for response to alkylating chemotherapy and survival in multiple myeloma
    • suppl
    • Lokhorts HM, Izquierdo MAI, Raaijmakers MGP, et al: Lung-resistance protein expression is a negative predictive factor for response to alkylating chemotherapy and survival in multiple myeloma. Blood 88:640a, 1996 (suppl)
    • (1996) Blood , vol.88
    • Lokhorts, H.M.1    Izquierdo, M.A.I.2    Raaijmakers, M.G.P.3
  • 20
    • 0032840591 scopus 로고    scopus 로고
    • The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma
    • Rimsza LM, Campbell K, Dalton WS, et al: The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma. Leuk Lymphoma 34:315-324, 1999
    • (1999) Leuk Lymphoma , vol.34 , pp. 315-324
    • Rimsza, L.M.1    Campbell, K.2    Dalton, W.S.3
  • 21
    • 0029974821 scopus 로고    scopus 로고
    • Pharmacological considerations in the modulation of multidrug resistance
    • abstr
    • Fisher GA, Lum BL, Hausdorff J, et al: Pharmacological considerations in the modulation of multidrug resistance. Eur J Cancer 32a:1082-1088, 1996 (abstr)
    • (1996) Eur J Cancer , vol.32 a , pp. 1082-1088
    • Fisher, G.A.1    Lum, B.L.2    Hausdorff, J.3
  • 22
    • 0028816350 scopus 로고
    • A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma: A Southwest Oncology Group study
    • Dalton WS, Crowley JJ, Salmon SS, et al: A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma: A Southwest Oncology Group study. Cancer 75:815-820, 1995
    • (1995) Cancer , vol.75 , pp. 815-820
    • Dalton, W.S.1    Crowley, J.J.2    Salmon, S.S.3
  • 23
    • 0036566201 scopus 로고    scopus 로고
    • Maintenance therapy with alternative-day prednisone improves survival in multiple myeloma patients
    • Berenson JR, Crowley JJ, Grogan TM, et al: Maintenance therapy with alternative-day prednisone improves survival in multiple myeloma patients. Blood 99:3163-3168, 2002
    • (2002) Blood , vol.99 , pp. 3163-3168
    • Berenson, J.R.1    Crowley, J.J.2    Grogan, T.M.3
  • 24
    • 0026634681 scopus 로고
    • Modulation of multidrug resistant multiple myeloma by cyclosporin
    • Sonneveld P, Marier JP, Huisman C, et al: Modulation of multidrug resistant multiple myeloma by cyclosporin. Lancet 340:255-259, 1992
    • (1992) Lancet , vol.340 , pp. 255-259
    • Sonneveld, P.1    Marier, J.P.2    Huisman, C.3
  • 25
    • 0029549566 scopus 로고
    • Analysis of the interactions of SDZ PSC 833 ([3′keto-BMTI)-Val2]cyclosporine), a multidrug resistance modulator, with P-glycoprotein
    • Archinal Mattheis A, Rzepka RW, Watanabe T, et al: Analysis of the interactions of SDZ PSC 833 ([3′keto-BMTI)-Val2]cyclosporine), a multidrug resistance modulator, with P-glycoprotein. Oncol Res 7:603-610, 1995
    • (1995) Oncol Res , vol.7 , pp. 603-610
    • Archinal Mattheis, A.1    Rzepka, R.W.2    Watanabe, T.3
  • 26
    • 0030069632 scopus 로고    scopus 로고
    • Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer
    • Boote DJ, Dennis IF, Twentyman PR, et ai: Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer. J Clin Oncol 14:610-618, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 610-618
    • Boote, D.J.1    Dennis, I.F.2    Twentyman, P.R.3    et ai4
  • 27
    • 0027518135 scopus 로고
    • Clinical trials of modulation of resistance: Pharmacokinetics and pharmacodynamics considerations
    • Lum BL, Fisher GA, Brophy NA, et al: Clinical trials of modulation of resistance: Pharmacokinetics and pharmacodynamics considerations. Cancer 72:3502-3514, 1993
    • (1993) Cancer , vol.72 , pp. 3502-3514
    • Lum, B.L.1    Fisher, G.A.2    Brophy, N.A.3
  • 28
    • 0000419475 scopus 로고    scopus 로고
    • Treatment of refractory/ relapsed AML with PSC 833 plus mitoxantrone, etoposide, cytarabine (PSC-MEC vs MEC): Randomized phase III trial
    • abstr
    • Greenberg P, Advani R, Tallman L, et al: Treatment of refractory/ relapsed AML with PSC 833 plus mitoxantrone, etoposide, cytarabine (PSC-MEC vs MEC): Randomized phase III trial. Blood 94:383a, 1999 (abstr)
    • (1999) Blood , vol.94
    • Greenberg, P.1    Advani, R.2    Tallman, L.3
  • 29
    • 4243287600 scopus 로고    scopus 로고
    • Phase III study of the multidrug resistance (MDR) modulator PSC-833 in previously untreated acute myeloid leukemia (AML) patients 60 years old: Correlation of outcome with functional MDR
    • abstr
    • Baer MR, George SL, Dodge RK, et al: Phase III study of the multidrug resistance (MDR) modulator PSC-833 in previously untreated acute myeloid leukemia (AML) patients 60 years old: Correlation of outcome with functional MDR. Blood 98:461a, 2002 (abstr)
    • (2002) Blood , vol.98
    • Baer, M.R.1    George, S.L.2    Dodge, R.K.3
  • 30
    • 0025562606 scopus 로고
    • Mechanism of multidrug resistance in human tumor cells: The role of P-glycoprotein, DNA topoisomerase II and other factors
    • Beck WT: Mechanism of multidrug resistance in human tumor cells: The role of P-glycoprotein, DNA topoisomerase II and other factors. Cancer Treat Rev 17:11-20, 1990
    • (1990) Cancer Treat Rev , vol.17 , pp. 11-20
    • Beck, W.T.1
  • 31
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 100:57-70, 2000
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 32
    • 0032189535 scopus 로고    scopus 로고
    • Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
    • Fulda S, Susin S, Kroemer G, et al: Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res 58:4453-4460, 1998
    • (1998) Cancer Res , vol.58 , pp. 4453-4460
    • Fulda, S.1    Susin, S.2    Kroemer, G.3
  • 33
    • 0033820092 scopus 로고    scopus 로고
    • Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies
    • Solay E, Droin N, Bettaieb A, et al: Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies. Leukemia 14:1833-1849, 2000
    • (2000) Leukemia , vol.14 , pp. 1833-1849
    • Solay, E.1    Droin, N.2    Bettaieb, A.3
  • 34
    • 0029858387 scopus 로고    scopus 로고
    • TNF-alpha and cancer therapy-induced cell death
    • Wang CY, Mayo MW, Baldwin AS: TNF-alpha and cancer therapy-induced cell death. Science 274:784-787, 1996
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 35
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa-B and iota-kappa-B proteins: New discoveries and insights
    • Baldwin AS: The NF-kappa-B and iota-kappa-B proteins: New discoveries and insights. Annu Rev Immunol 14:649-681, 1996
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-681
    • Baldwin, A.S.1
  • 36
    • 0033596127 scopus 로고    scopus 로고
    • Control of apoptosis by Rel/NF-kappa-B transcription factors
    • Barkett M, Gilmore T: Control of apoptosis by Rel/NF-kappa-B transcription factors. Oncogene 18:6910-6924, 1999
    • (1999) Oncogene , vol.18 , pp. 6910-6924
    • Barkett, M.1    Gilmore, T.2
  • 37
    • 0036009115 scopus 로고    scopus 로고
    • NF-B at the crossroad of life and death
    • Karin M, Lin A: NF-B at the crossroad of life and death. Nat Immunol 3:221-227, 2000
    • (2000) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 38
    • 0032588170 scopus 로고    scopus 로고
    • NF-kappa-B function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition
    • Hinz M, Krappman D, Eichten A, et al: NF-kappa-B function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19:2690-2698, 1999
    • (1999) Mol Cell Biol , vol.19 , pp. 2690-2698
    • Hinz, M.1    Krappman, D.2    Eichten, A.3
  • 39
    • 0033767858 scopus 로고    scopus 로고
    • The role of human and viral cytokines in the pathogenesis of multiple myeloma
    • Berenson JR, Sjak-Shie N, Vescio RA: The role of human and viral cytokines in the pathogenesis of multiple myeloma. Semin Cancer Biol 10:383-391, 2000
    • (2000) Semin Cancer Biol , vol.10 , pp. 383-391
    • Berenson, J.R.1    Sjak-Shie, N.2    Vescio, R.A.3
  • 40
    • 0031897632 scopus 로고    scopus 로고
    • NF-B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May M, Kopp E: NF-B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260, 1998
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.2    Kopp, E.3
  • 41
    • 0033031799 scopus 로고    scopus 로고
    • Matrix metalloproteinase 9 expression in induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2
    • Takeshita H, Yashizaki T, Miller WE, et al: Matrix metalloproteinase 9 expression in induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2. J Virol 73:5548-5555, 1999
    • (1999) J Virol , vol.73 , pp. 5548-5555
    • Takeshita, H.1    Yashizaki, T.2    Miller, W.E.3
  • 42
    • 0027097806 scopus 로고
    • Interleukin-8 as a macrophage-derived mediator of angiogenesis
    • Koch AE, Polverini PJ, Kunkel SL, et al: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258:1798-1801, 1992
    • (1992) Science , vol.258 , pp. 1798-1801
    • Koch, A.E.1    Polverini, P.J.2    Kunkel, S.L.3
  • 43
    • 0034306969 scopus 로고    scopus 로고
    • Blockade of NF-kappa-B signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin-8
    • Huang S, Robinson JB, Deguzman A, et al: Blockade of NF-kappa-B signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin-8. Cancer Res 60:5334-5339, 2000
    • (2000) Cancer Res , vol.60 , pp. 5334-5339
    • Huang, S.1    Robinson, J.B.2    Deguzman, A.3
  • 44
    • 0026642195 scopus 로고
    • Induction of apoptosis in fibroblasts by c-myc protein
    • Evan GL, Wyllie AH, Gilber CS, et al: Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119-128, 1992
    • (1992) Cell , vol.69 , pp. 119-128
    • Evan, G.L.1    Wyllie, A.H.2    Gilber, C.S.3
  • 45
    • 0036190344 scopus 로고    scopus 로고
    • Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappa-B and AP-1 activation and enhances myocardial damage
    • Zingarelli B, Hake PW, Yang Z, et al: Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappa-B and AP-1 activation and enhances myocardial damage. FASEB J 16:327-342, 2002
    • (2002) FASEB J , vol.16 , pp. 327-342
    • Zingarelli, B.1    Hake, P.W.2    Yang, Z.3
  • 46
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the iota-kappa-B kinase 2 gene
    • Li Q, Van Antwerp D, Mercurio F, et al: Severe liver degeneration in mice lacking the iota-kappa-B kinase 2 gene. Science 284:321-325, 1999
    • (1999) Science , vol.284 , pp. 321-325
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3
  • 47
    • 0030882666 scopus 로고    scopus 로고
    • Oncogenic Ha-Kas-induced signaling activates NF-kappa-B transcriptional activity which is required for cellular transformation
    • Finco T, Westwick JK, Norris JL, et al: Oncogenic Ha-Kas-induced signaling activates NF-kappa-B transcriptional activity which is required for cellular transformation. J Biol Chem 272:24113-24116, 1997
    • (1997) J Biol Chem , vol.272 , pp. 24113-24116
    • Finco, T.1    Westwick, J.K.2    Norris, J.L.3
  • 48
    • 0037342894 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma cells to chemotherapeutic agents
    • Ma HM, Parker KM, Manyak S, et al: Proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma cells to chemotherapeutic agents. Clin Cancer Res 9:1136-1144, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 1136-1144
    • Ma, H.M.1    Parker, K.M.2    Manyak, S.3
  • 49
    • 0032885416 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 in cancer therapy
    • Teicher BA, Ara G, Herbst R, et al: The proteasome inhibitor PS-341 in cancer therapy. Clin Cancer Res 5:2638-2645, 1999
    • (1999) Clin Cancer Res , vol.5 , pp. 2638-2645
    • Teicher, B.A.1    Ara, G.2    Herbst, R.3
  • 50
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • Adams J, Palombella VJ, Sausville EA, et al: Proteasome inhibitors: A novel class of potent and effective antitumor agents. Cancer Res 59:2615-2622, 1999
    • (1999) Cancer Res , vol.59 , pp. 2615-2622
    • Adams, J.1    Palombella, V.J.2    Sausville, E.A.3
  • 51
    • 0032189685 scopus 로고    scopus 로고
    • Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor
    • Orlowski RZ, Eswara JR, Lafond-Walker A, et al: Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor. Cancer Res 58:4342-4348, 1998
    • (1998) Cancer Res , vol.58 , pp. 4342-4348
    • Orlowski, R.Z.1    Eswara, J.R.2    Lafond-Walker, A.3
  • 52
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, et al: The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 61:3071-3076, 2001
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 53
    • 79960971463 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 inhibits human multiple myeloma cell growth in a murine model
    • abstr
    • LeBlanc R, Catley L, Hideshima T, et al: Proteasome inhibitor PS-341 inhibits human multiple myeloma cell growth in a murine model. Blood 98:774a, 2001 (abstr)
    • (2001) Blood , vol.98
    • LeBlanc, R.1    Catley, L.2    Hideshima, T.3
  • 54
    • 0034062989 scopus 로고    scopus 로고
    • Proteasome inhibition: A new strategy in cancer treatment
    • Adams J, Palombella VJ, Elliott PJ: Proteasome inhibition: A new strategy in cancer treatment. Invest New Drugs 18:109-121, 2000
    • (2000) Invest New Drugs , vol.18 , pp. 109-121
    • Adams, J.1    Palombella, V.J.2    Elliott, P.J.3
  • 55
    • 0037973279 scopus 로고    scopus 로고
    • Phase II study of bortezomib in relapsed, refractory myeloma
    • Richardson, PG, Berenson J, Irwin D, et al: Phase II study of bortezomib in relapsed, refractory myeloma. N Engl J Med 348:2609-2617, 2003
    • (2003) N Engl J Med , vol.348 , pp. 2609-2617
    • Richardson, P.G.1    Berenson, J.2    Irwin, D.3
  • 56
    • 18844465632 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappa-B-RelA is required for proliferation and survival of Hodgkin's disease tumor cells
    • Bargou R, Emmerich F, Krappmann D, et al: Constitutive activation of NF-kappa-B-RelA is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 100:2961-2969, 1997
    • (1997) J Clin Invest , vol.100 , pp. 2961-2969
    • Bargou, R.1    Emmerich, F.2    Krappmann, D.3
  • 57
    • 0031440245 scopus 로고    scopus 로고
    • Aberrant nuclear factor-B/Rel expression and the pathogenesis of breast cancer
    • Sovak MA, Bellas RE, Kim DW, et al: Aberrant nuclear factor-B/Rel expression and the pathogenesis of breast cancer. J Clin Invest 100:2952-2960, 1997
    • (1997) J Clin Invest , vol.100 , pp. 2952-2960
    • Sovak, M.A.1    Bellas, R.E.2    Kim, D.W.3
  • 58
    • 0029814063 scopus 로고    scopus 로고
    • Inhibition of NF-B/Rel induces apoptosis of murine B cells
    • Wu M, Lee H, Bellas RE, et al: Inhibition of NF-B/Rel induces apoptosis of murine B cells. EMBO 15:4682-4690, 1996
    • (1996) EMBO , vol.15 , pp. 4682-4690
    • Wu, M.1    Lee, H.2    Bellas, R.E.3
  • 59
    • 0033177897 scopus 로고    scopus 로고
    • NF-kappa-B and chemoresistance potentiation of cancer chemotherapy via inhibition of NF-kappa-B
    • Cusack J, Liu R, Baldwin A: NF-kappa-B and chemoresistance potentiation of cancer chemotherapy via inhibition of NF-kappa-B. Drug Resist Updat 2:271-273, 1999
    • (1999) Drug Resist Updat , vol.2 , pp. 271-273
    • Cusack, J.1    Liu, R.2    Baldwin, A.3
  • 60
    • 0032905030 scopus 로고    scopus 로고
    • Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappa-B
    • Wang CY, Cusack J, Liu R, et al.: Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappa-B. Nat Med 4:412-417, 1999
    • (1999) Nat Med , vol.4 , pp. 412-417
    • Wang, C.Y.1    Cusack, J.2    Liu, R.3
  • 61
    • 0006213882 scopus 로고    scopus 로고
    • Inducible chemoresistance to CPT-11 in colorectal cancer cells and a xenograft model is overcome by inhibition of NF-kappa-B
    • Cusack J, Liu R, Baldwin A: Inducible chemoresistance to CPT-11 in colorectal cancer cells and a xenograft model is overcome by inhibition of NF-kappa-B. Cancer Res 60:1323-1330, 2000
    • (2000) Cancer Res , vol.60 , pp. 1323-1330
    • Cusack, J.1    Liu, R.2    Baldwin, A.3
  • 62
    • 0034662496 scopus 로고    scopus 로고
    • NF-kappa-B/IB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells
    • Huang Y, Johnson K, Norris J, et al: NF-kappa-B/IB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res 60:4426-4432, 2000
    • (2000) Cancer Res , vol.60 , pp. 4426-4432
    • Huang, Y.1    Johnson, K.2    Norris, J.3
  • 63
    • 0031132604 scopus 로고    scopus 로고
    • Glucocorticosteroids and ambroxol inhibit secretion of inflammatory cytokines in tracheobronchial epithelial cells: Possible role of the NF-kappa B transcription factor
    • Betz R: Glucocorticosteroids and ambroxol inhibit secretion of inflammatory cytokines in tracheobronchial epithelial cells: Possible role of the NF-kappa B transcription factor. Pneumologie 51:491-492, 1997
    • (1997) Pneumologie , vol.51 , pp. 491-492
    • Betz, R.1
  • 64
    • 0034680928 scopus 로고    scopus 로고
    • Inhibition of NF-kappa-B activation by arsenite through reaction with critical cysteine in the activation loop of iota-kappa-B kinase
    • Kapahi P, Takahashi T, Natoli G, et al: Inhibition of NF-kappa-B activation by arsenite through reaction with critical cysteine in the activation loop of iota-kappa-B kinase. J Biol Chem 275:36062-36066, 2000
    • (2000) J Biol Chem , vol.275 , pp. 36062-36066
    • Kapahi, P.1    Takahashi, T.2    Natoli, G.3
  • 65
    • 0035877967 scopus 로고    scopus 로고
    • Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis
    • Sordet O, Rebe C, Leroy I, et al: Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis. Blood 97:3931-3940, 2001
    • (2001) Blood , vol.97 , pp. 3931-3940
    • Sordet, O.1    Rebe, C.2    Leroy, I.3
  • 66
    • 0003298249 scopus 로고    scopus 로고
    • Arsenic compounds induce apoptosis in multiple myeloma (MM), activate pro-caspase-3 but not affect BCL2 family members
    • suppl 1
    • Tang B, Bajenova O, Feinman-Siegal R, et al: Arsenic compounds induce apoptosis in multiple myeloma (MM), activate pro-caspase-3 but not affect BCL2 family members. Blood 92:638a, 1998 (suppl 1)
    • (1998) Blood , vol.92
    • Tang, B.1    Bajenova, O.2    Feinman-Siegal, R.3
  • 67
    • 0035895082 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2- infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage
    • Mahieux R, Pise-Maison C, Gessain A, et al: Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2- infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage. Blood 98:3762-3769, 2001
    • (2001) Blood , vol.98 , pp. 3762-3769
    • Mahieux, R.1    Pise-Maison, C.2    Gessain, A.3
  • 68
    • 0030610687 scopus 로고    scopus 로고
    • 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients
    • 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89:3354-3360, 1997
    • (1997) Blood , vol.89 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3
  • 69
    • 84871469041 scopus 로고    scopus 로고
    • Arsenic trioxide cause apoptosis, growth inhibition and increased sensitivity of chemotherapeutic agents in multiple myeloma cells through inhibition of nuclear factor (NF)-kappa-B activity
    • Friedman JM, Ma MH, Manyak S, et al: Arsenic trioxide cause apoptosis, growth inhibition and increased sensitivity of chemotherapeutic agents in multiple myeloma cells through inhibition of nuclear factor (NF)-kappa-B activity. Proc Am Assoc Cancer Res 43:4585, 2002
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 4585
    • Friedman, J.M.1    Ma, M.H.2    Manyak, S.3
  • 71
    • 0035229427 scopus 로고    scopus 로고
    • The mitochondrion in apoptosis: How Pandora's box opens
    • Zamzami N, Kroemer G: The mitochondrion in apoptosis: How Pandora's box opens. Nat Rev Mol Cell Biol 2:67-71, 2001
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 67-71
    • Zamzami, N.1    Kroemer, G.2
  • 73
    • 0032575688 scopus 로고    scopus 로고
    • The bcl-2 protein family: Arbiters of cell survival
    • Adams JM, Cory S: The bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326, 1998
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 74
    • 0026527344 scopus 로고
    • Expression of bcl-2 gene in human multiple myeloma cell lines and normal plasma cells
    • Pettersson M, Jernberg-Wiklund H, Larssin L-G, et al: Expression of bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood 79:495-502, 1992
    • (1992) Blood , vol.79 , pp. 495-502
    • Pettersson, M.1    Jernberg-Wiklund, H.2    Larssin, L.-G.3
  • 75
    • 79960971606 scopus 로고    scopus 로고
    • Bcl-2 antisense oligonucleotide (ASO) enhances apoptosis and cytotoxicity in drug-resistant myeloma cells
    • abstr
    • Gazitti Y, Liu Q, Vesole D, et al: Bcl-2 antisense oligonucleotide (ASO) enhances apoptosis and cytotoxicity in drug-resistant myeloma cells. Blood 98:641a, 2001 (abstr)
    • (2001) Blood , vol.98
    • Gazitti, Y.1    Liu, Q.2    Vesole, D.3
  • 76
    • 0032734301 scopus 로고    scopus 로고
    • Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, mutation stage, and cytogenetics
    • Wuchter C, Karawajew L, Ruppert V, et al: Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, mutation stage, and cytogenetics. Leukemia 13:1943-1953, 1999
    • (1999) Leukemia , vol.13 , pp. 1943-1953
    • Wuchter, C.1    Karawajew, L.2    Ruppert, V.3
  • 77
    • 0032481131 scopus 로고    scopus 로고
    • Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53
    • Herrmann JL, Briones F Jr, Brisbay S, et al: Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53. Oncogens 3:2889-2899, 1998
    • (1998) Oncogens , vol.3 , pp. 2889-2899
    • Herrmann, J.L.1    Briones Jr, F.2    Brisbay, S.3
  • 78
    • 0032429122 scopus 로고    scopus 로고
    • Novel dipeptidyl proteasome inhibitors overcomes Bcl-2 protective function and selective accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed but not normal human fibroblasts
    • An B, Goldfarb RH, Siman R, et al: Novel dipeptidyl proteasome inhibitors overcomes Bcl-2 protective function and selective accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed but not normal human fibroblasts. Cell Death Differ 12:1062-1075, 1998
    • (1998) Cell Death Differ , vol.12 , pp. 1062-1075
    • An, B.1    Goldfarb, R.H.2    Siman, R.3
  • 79
    • 79960970830 scopus 로고    scopus 로고
    • Proteasome inhibitor PS341 inhibits constitutive NF-B activity and bypasses the anti-apoptotic bcl-2 signal in human multiple myeloma cells
    • abstr
    • Feinman R, Gangurde P, Miller S, et al: Proteasome inhibitor PS341 inhibits constitutive NF-B activity and bypasses the anti-apoptotic bcl-2 signal in human multiple myeloma cells. Blood 98:640a, 2001 (abstr)
    • (2001) Blood , vol.98
    • Feinman, R.1    Gangurde, P.2    Miller, S.3
  • 80
    • 0031029911 scopus 로고    scopus 로고
    • Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells
    • Chauhan D, Kharbands S, Ogata A, et al: Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood 89:227-234, 1997
    • (1997) Blood , vol.89 , pp. 227-234
    • Chauhan, D.1    Kharbands, S.2    Ogata, A.3
  • 81
    • 0031225483 scopus 로고    scopus 로고
    • IL-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade
    • Ogata A, Chauhan D, Teoh G, et al: IL-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade. J Immunol 159: 2212-2221, 1997
    • (1997) J Immunol , vol.159 , pp. 2212-2221
    • Ogata, A.1    Chauhan, D.2    Teoh, G.3
  • 82
    • 0029019664 scopus 로고
    • Interleukin-6 inhibits apoptosis of malignant plasma cells
    • Lichtenstein A, Tu Y, Fady C, et al: Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol 162:248-255, 1995
    • (1995) Cell Immunol , vol.162 , pp. 248-255
    • Lichtenstein, A.1    Tu, Y.2    Fady, C.3
  • 83
    • 0036242247 scopus 로고    scopus 로고
    • Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
    • Wang W, Chen JX, Liao R: Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 22:3389-3403, 2002
    • (2002) Mol Cell Biol , vol.22 , pp. 3389-3403
    • Wang, W.1    Chen, J.X.2    Liao, R.3
  • 84
    • 0032530301 scopus 로고    scopus 로고
    • Apoptotic regulation in primitive hematopoietic precursors
    • Peters R, Leyvraz S, Perey L: Apoptotic regulation in primitive hematopoietic precursors. Blood 92:2041-2052, 1998
    • (1998) Blood , vol.92 , pp. 2041-2052
    • Peters, R.1    Leyvraz, S.2    Perey, L.3
  • 85
    • 85014210290 scopus 로고    scopus 로고
    • Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes
    • Wierenga AT, Schuringa JJ, Eggen BJ: Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Leukemia 16:675-682, 2002
    • (2002) Leukemia , vol.16 , pp. 675-682
    • Wierenga, A.T.1    Schuringa, J.J.2    Eggen, B.J.3
  • 86
    • 0035136846 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
    • Epling-Burnette PK, Liu JH, Catlett-Falcone R: Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 107:351-362, 2001
    • (2001) J Clin Invest , vol.107 , pp. 351-362
    • Epling-Burnette, P.K.1    Liu, J.H.2    Catlett-Falcone, R.3
  • 87
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, Landowski TH, Oshiro MM, et al: Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10:105-115, 1999
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3
  • 88
    • 0033105537 scopus 로고    scopus 로고
    • Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
    • Damiano JS, Cress AE, Hazlehurst LA, et al: Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 93:1658-1667, 1999
    • (1999) Blood , vol.93 , pp. 1658-1667
    • Damiano, J.S.1    Cress, A.E.2    Hazlehurst, L.A.3
  • 89
    • 0034009920 scopus 로고    scopus 로고
    • Integrin-mediated drug resistance in multiple myeloma
    • Damiano JS, Dalton WS: Integrin-mediated drug resistance in multiple myeloma. Leuk Lymphoma 38:71-81, 2000
    • (2000) Leuk Lymphoma , vol.38 , pp. 71-81
    • Damiano, J.S.1    Dalton, W.S.2
  • 90
    • 0026787347 scopus 로고
    • Characterization of adhesion molecules on human myeloma cell lines
    • Uchiyama H, Barut BA, Chauhan D, et al: Characterization of adhesion molecules on human myeloma cell lines. Blood 80:2306-2314, 1992
    • (1992) Blood , vol.80 , pp. 2306-2314
    • Uchiyama, H.1    Barut, B.A.2    Chauhan, D.3
  • 91
    • 0029946652 scopus 로고    scopus 로고
    • Regulation of leukocyte integrin function: Affinity vs. avidity
    • Stewart MP, Hogg N: Regulation of leukocyte integrin function: Affinity vs. avidity. J Cell Biochem 61:554-561, 1996
    • (1996) J Cell Biochem , vol.61 , pp. 554-561
    • Stewart, M.P.1    Hogg, N.2
  • 92
    • 0032498543 scopus 로고    scopus 로고
    • LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain
    • Stewart MP, McDowell A, Hogg N: LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain. J Cell Biol 140:699-707, 1998
    • (1998) J Cell Biol , vol.140 , pp. 699-707
    • Stewart, M.P.1    McDowell, A.2    Hogg, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.