-
1
-
-
0031435837
-
Mechanisms of drug resistance in hematologic malignancies
-
Dalton WS: Mechanisms of drug resistance in hematologic malignancies. Semin Hematol 34:3-8, 1997
-
(1997)
Semin Hematol
, vol.34
, pp. 3-8
-
-
Dalton, W.S.1
-
2
-
-
0027218689
-
Biochemistry of multidrug resistance mediated by the multidrug transporter
-
Gottesman MM, Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427, 1993
-
(1993)
Annu Rev Biochem
, vol.62
, pp. 385-427
-
-
Gottesman, M.M.1
Pastan, I.2
-
3
-
-
0027095653
-
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
-
Cole SP, Bhradwaj G, Gerlach JH, et al: Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654, 1992
-
(1992)
Science
, vol.258
, pp. 1650-1654
-
-
Cole, S.P.1
Bhradwaj, G.2
Gerlach, J.H.3
-
4
-
-
0034081847
-
The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)
-
Litman T, Brangi M, Hudson E, et al: The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci 113:2011-2021, 2000
-
(2000)
J Cell Sci
, vol.113
, pp. 2011-2021
-
-
Litman, T.1
Brangi, M.2
Hudson, E.3
-
5
-
-
0034501399
-
Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer
-
Scheffer GL, Schroeijers AB, Izquierdo MA, et al: Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer. Curr Opin Oncol 12:550-556, 2000
-
(2000)
Curr Opin Oncol
, vol.12
, pp. 550-556
-
-
Scheffer, G.L.1
Schroeijers, A.B.2
Izquierdo, M.A.3
-
6
-
-
0033400809
-
Apoptosis in cancer drug targeting
-
Sellers WR, Fisher DE: Apoptosis in cancer drug targeting. J Clin Invest 104:1655-1661, 1999
-
(1999)
J Clin Invest
, vol.104
, pp. 1655-1661
-
-
Sellers, W.R.1
Fisher, D.E.2
-
7
-
-
0032905030
-
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
-
Wang CY, Cusack JC, Liu R, et al: Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nat Med 5:412-417, 1999
-
(1999)
Nat Med
, vol.5
, pp. 412-417
-
-
Wang, C.Y.1
Cusack, J.C.2
Liu, R.3
-
8
-
-
0028578004
-
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
-
Muller M, Meijer C, Zaman GJ, et al: Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci U S A 91:13033-13041, 1994
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 13033-13041
-
-
Muller, M.1
Meijer, C.2
Zaman, G.J.3
-
9
-
-
0034674901
-
A family of drug transporters: The multidrug resistance-associated proteins
-
Borst P, Evers R, Kool M, et al: A family of drug transporters: The multidrug resistance-associated proteins. J Natl Cancer Inst 92:1295-1302, 2000
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1295-1302
-
-
Borst, P.1
Evers, R.2
Kool, M.3
-
11
-
-
0033530286
-
Multidrug resistance and the lung resistance related protein in human colon carcinoma SW-620 cells
-
Kitazono M, Sumizawa T, Takebayashi T, et al: Multidrug resistance and the lung resistance related protein in human colon carcinoma SW-620 cells. J Natl Cancer Inst 91:1647-1653, 1999
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1647-1653
-
-
Kitazono, M.1
Sumizawa, T.2
Takebayashi, T.3
-
12
-
-
0032843181
-
Drug resistance in multiple myeloma: Approaches to circumvention
-
Dalton WS, Jove R: Drug resistance in multiple myeloma: Approaches to circumvention. Semin Oncol 26:23-27, 1999
-
(1999)
Semin Oncol
, vol.26
, pp. 23-27
-
-
Dalton, W.S.1
Jove, R.2
-
13
-
-
0027507266
-
P-glycoprotein expression in human plasma cell myeloma: Correlation with prior chemotherapy
-
Grogan TM, Spier CM, Salmon SE, et al: P-glycoprotein expression in human plasma cell myeloma: Correlation with prior chemotherapy. Blood 81:490-495, 1993
-
(1993)
Blood
, vol.81
, pp. 490-495
-
-
Grogan, T.M.1
Spier, C.M.2
Salmon, S.E.3
-
14
-
-
0027954249
-
MDR1 expression and response to vincristine, doxorubicin and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents
-
Cornelissan J, Sonneveld P, Schoester M, et al: MDR1 expression and response to vincristine, doxorubicin and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents. J Clin Oneol 12:115-119, 1994
-
(1994)
J Clin Oneol
, vol.12
, pp. 115-119
-
-
Cornelissan, J.1
Sonneveld, P.2
Schoester, M.3
-
15
-
-
0026594202
-
Levels of expression of the mdr 1 gene and glutathione-S-transferase genes 1 and 2 and response to chemotherapy in multiple myeloma
-
Lynsenmeyer ME, Jefferson S, Wolf M, et al: Levels of expression of the mdr 1 gene and glutathione-S-transferase genes 1 and 2 and response to chemotherapy in multiple myeloma. Br J Cancer 65:471-475, 1992
-
(1992)
Br J Cancer
, vol.65
, pp. 471-475
-
-
Lynsenmeyer, M.E.1
Jefferson, S.2
Wolf, M.3
-
16
-
-
0034765167
-
Drug resistance in hematologic malignancies
-
Marie JP: Drug resistance in hematologic malignancies. Curr Opin Oncol 13:463-469, 2001
-
(2001)
Curr Opin Oncol
, vol.13
, pp. 463-469
-
-
Marie, J.P.1
-
17
-
-
0034009217
-
Novel mechanisms of drug resistance in leukemia
-
Ross DD: Novel mechanisms of drug resistance in leukemia. Leukemia 14:467-473, 2000
-
(2000)
Leukemia
, vol.14
, pp. 467-473
-
-
Ross, D.D.1
-
18
-
-
0033518874
-
Atypical multidrug resistance: Breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines
-
Ross DD, Yang W, Abruzzo LV, et al: Atypical multidrug resistance: Breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. J Natl Cancer Inst 91:429-433, 1999
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 429-433
-
-
Ross, D.D.1
Yang, W.2
Abruzzo, L.V.3
-
19
-
-
13144304081
-
Lung-resistance protein expression is a negative predictive factor for response to alkylating chemotherapy and survival in multiple myeloma
-
suppl
-
Lokhorts HM, Izquierdo MAI, Raaijmakers MGP, et al: Lung-resistance protein expression is a negative predictive factor for response to alkylating chemotherapy and survival in multiple myeloma. Blood 88:640a, 1996 (suppl)
-
(1996)
Blood
, vol.88
-
-
Lokhorts, H.M.1
Izquierdo, M.A.I.2
Raaijmakers, M.G.P.3
-
20
-
-
0032840591
-
The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma
-
Rimsza LM, Campbell K, Dalton WS, et al: The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma. Leuk Lymphoma 34:315-324, 1999
-
(1999)
Leuk Lymphoma
, vol.34
, pp. 315-324
-
-
Rimsza, L.M.1
Campbell, K.2
Dalton, W.S.3
-
21
-
-
0029974821
-
Pharmacological considerations in the modulation of multidrug resistance
-
abstr
-
Fisher GA, Lum BL, Hausdorff J, et al: Pharmacological considerations in the modulation of multidrug resistance. Eur J Cancer 32a:1082-1088, 1996 (abstr)
-
(1996)
Eur J Cancer
, vol.32 a
, pp. 1082-1088
-
-
Fisher, G.A.1
Lum, B.L.2
Hausdorff, J.3
-
22
-
-
0028816350
-
A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma: A Southwest Oncology Group study
-
Dalton WS, Crowley JJ, Salmon SS, et al: A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma: A Southwest Oncology Group study. Cancer 75:815-820, 1995
-
(1995)
Cancer
, vol.75
, pp. 815-820
-
-
Dalton, W.S.1
Crowley, J.J.2
Salmon, S.S.3
-
23
-
-
0036566201
-
Maintenance therapy with alternative-day prednisone improves survival in multiple myeloma patients
-
Berenson JR, Crowley JJ, Grogan TM, et al: Maintenance therapy with alternative-day prednisone improves survival in multiple myeloma patients. Blood 99:3163-3168, 2002
-
(2002)
Blood
, vol.99
, pp. 3163-3168
-
-
Berenson, J.R.1
Crowley, J.J.2
Grogan, T.M.3
-
24
-
-
0026634681
-
Modulation of multidrug resistant multiple myeloma by cyclosporin
-
Sonneveld P, Marier JP, Huisman C, et al: Modulation of multidrug resistant multiple myeloma by cyclosporin. Lancet 340:255-259, 1992
-
(1992)
Lancet
, vol.340
, pp. 255-259
-
-
Sonneveld, P.1
Marier, J.P.2
Huisman, C.3
-
25
-
-
0029549566
-
Analysis of the interactions of SDZ PSC 833 ([3′keto-BMTI)-Val2]cyclosporine), a multidrug resistance modulator, with P-glycoprotein
-
Archinal Mattheis A, Rzepka RW, Watanabe T, et al: Analysis of the interactions of SDZ PSC 833 ([3′keto-BMTI)-Val2]cyclosporine), a multidrug resistance modulator, with P-glycoprotein. Oncol Res 7:603-610, 1995
-
(1995)
Oncol Res
, vol.7
, pp. 603-610
-
-
Archinal Mattheis, A.1
Rzepka, R.W.2
Watanabe, T.3
-
26
-
-
0030069632
-
Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer
-
Boote DJ, Dennis IF, Twentyman PR, et ai: Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer. J Clin Oncol 14:610-618, 1996
-
(1996)
J Clin Oncol
, vol.14
, pp. 610-618
-
-
Boote, D.J.1
Dennis, I.F.2
Twentyman, P.R.3
et ai4
-
27
-
-
0027518135
-
Clinical trials of modulation of resistance: Pharmacokinetics and pharmacodynamics considerations
-
Lum BL, Fisher GA, Brophy NA, et al: Clinical trials of modulation of resistance: Pharmacokinetics and pharmacodynamics considerations. Cancer 72:3502-3514, 1993
-
(1993)
Cancer
, vol.72
, pp. 3502-3514
-
-
Lum, B.L.1
Fisher, G.A.2
Brophy, N.A.3
-
28
-
-
0000419475
-
Treatment of refractory/ relapsed AML with PSC 833 plus mitoxantrone, etoposide, cytarabine (PSC-MEC vs MEC): Randomized phase III trial
-
abstr
-
Greenberg P, Advani R, Tallman L, et al: Treatment of refractory/ relapsed AML with PSC 833 plus mitoxantrone, etoposide, cytarabine (PSC-MEC vs MEC): Randomized phase III trial. Blood 94:383a, 1999 (abstr)
-
(1999)
Blood
, vol.94
-
-
Greenberg, P.1
Advani, R.2
Tallman, L.3
-
29
-
-
4243287600
-
Phase III study of the multidrug resistance (MDR) modulator PSC-833 in previously untreated acute myeloid leukemia (AML) patients 60 years old: Correlation of outcome with functional MDR
-
abstr
-
Baer MR, George SL, Dodge RK, et al: Phase III study of the multidrug resistance (MDR) modulator PSC-833 in previously untreated acute myeloid leukemia (AML) patients 60 years old: Correlation of outcome with functional MDR. Blood 98:461a, 2002 (abstr)
-
(2002)
Blood
, vol.98
-
-
Baer, M.R.1
George, S.L.2
Dodge, R.K.3
-
30
-
-
0025562606
-
Mechanism of multidrug resistance in human tumor cells: The role of P-glycoprotein, DNA topoisomerase II and other factors
-
Beck WT: Mechanism of multidrug resistance in human tumor cells: The role of P-glycoprotein, DNA topoisomerase II and other factors. Cancer Treat Rev 17:11-20, 1990
-
(1990)
Cancer Treat Rev
, vol.17
, pp. 11-20
-
-
Beck, W.T.1
-
31
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 100:57-70, 2000
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
32
-
-
0032189535
-
Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
-
Fulda S, Susin S, Kroemer G, et al: Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res 58:4453-4460, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 4453-4460
-
-
Fulda, S.1
Susin, S.2
Kroemer, G.3
-
33
-
-
0033820092
-
Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies
-
Solay E, Droin N, Bettaieb A, et al: Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies. Leukemia 14:1833-1849, 2000
-
(2000)
Leukemia
, vol.14
, pp. 1833-1849
-
-
Solay, E.1
Droin, N.2
Bettaieb, A.3
-
34
-
-
0029858387
-
TNF-alpha and cancer therapy-induced cell death
-
Wang CY, Mayo MW, Baldwin AS: TNF-alpha and cancer therapy-induced cell death. Science 274:784-787, 1996
-
(1996)
Science
, vol.274
, pp. 784-787
-
-
Wang, C.Y.1
Mayo, M.W.2
Baldwin, A.S.3
-
35
-
-
0029874138
-
The NF-kappa-B and iota-kappa-B proteins: New discoveries and insights
-
Baldwin AS: The NF-kappa-B and iota-kappa-B proteins: New discoveries and insights. Annu Rev Immunol 14:649-681, 1996
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 649-681
-
-
Baldwin, A.S.1
-
36
-
-
0033596127
-
Control of apoptosis by Rel/NF-kappa-B transcription factors
-
Barkett M, Gilmore T: Control of apoptosis by Rel/NF-kappa-B transcription factors. Oncogene 18:6910-6924, 1999
-
(1999)
Oncogene
, vol.18
, pp. 6910-6924
-
-
Barkett, M.1
Gilmore, T.2
-
37
-
-
0036009115
-
NF-B at the crossroad of life and death
-
Karin M, Lin A: NF-B at the crossroad of life and death. Nat Immunol 3:221-227, 2000
-
(2000)
Nat Immunol
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
-
38
-
-
0032588170
-
NF-kappa-B function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition
-
Hinz M, Krappman D, Eichten A, et al: NF-kappa-B function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19:2690-2698, 1999
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2690-2698
-
-
Hinz, M.1
Krappman, D.2
Eichten, A.3
-
39
-
-
0033767858
-
The role of human and viral cytokines in the pathogenesis of multiple myeloma
-
Berenson JR, Sjak-Shie N, Vescio RA: The role of human and viral cytokines in the pathogenesis of multiple myeloma. Semin Cancer Biol 10:383-391, 2000
-
(2000)
Semin Cancer Biol
, vol.10
, pp. 383-391
-
-
Berenson, J.R.1
Sjak-Shie, N.2
Vescio, R.A.3
-
40
-
-
0031897632
-
NF-B and Rel proteins: Evolutionarily conserved mediators of immune responses
-
Ghosh S, May M, Kopp E: NF-B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260, 1998
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 225-260
-
-
Ghosh, S.1
May, M.2
Kopp, E.3
-
41
-
-
0033031799
-
Matrix metalloproteinase 9 expression in induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2
-
Takeshita H, Yashizaki T, Miller WE, et al: Matrix metalloproteinase 9 expression in induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2. J Virol 73:5548-5555, 1999
-
(1999)
J Virol
, vol.73
, pp. 5548-5555
-
-
Takeshita, H.1
Yashizaki, T.2
Miller, W.E.3
-
42
-
-
0027097806
-
Interleukin-8 as a macrophage-derived mediator of angiogenesis
-
Koch AE, Polverini PJ, Kunkel SL, et al: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258:1798-1801, 1992
-
(1992)
Science
, vol.258
, pp. 1798-1801
-
-
Koch, A.E.1
Polverini, P.J.2
Kunkel, S.L.3
-
43
-
-
0034306969
-
Blockade of NF-kappa-B signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin-8
-
Huang S, Robinson JB, Deguzman A, et al: Blockade of NF-kappa-B signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin-8. Cancer Res 60:5334-5339, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 5334-5339
-
-
Huang, S.1
Robinson, J.B.2
Deguzman, A.3
-
44
-
-
0026642195
-
Induction of apoptosis in fibroblasts by c-myc protein
-
Evan GL, Wyllie AH, Gilber CS, et al: Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119-128, 1992
-
(1992)
Cell
, vol.69
, pp. 119-128
-
-
Evan, G.L.1
Wyllie, A.H.2
Gilber, C.S.3
-
45
-
-
0036190344
-
Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappa-B and AP-1 activation and enhances myocardial damage
-
Zingarelli B, Hake PW, Yang Z, et al: Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappa-B and AP-1 activation and enhances myocardial damage. FASEB J 16:327-342, 2002
-
(2002)
FASEB J
, vol.16
, pp. 327-342
-
-
Zingarelli, B.1
Hake, P.W.2
Yang, Z.3
-
46
-
-
0033537739
-
Severe liver degeneration in mice lacking the iota-kappa-B kinase 2 gene
-
Li Q, Van Antwerp D, Mercurio F, et al: Severe liver degeneration in mice lacking the iota-kappa-B kinase 2 gene. Science 284:321-325, 1999
-
(1999)
Science
, vol.284
, pp. 321-325
-
-
Li, Q.1
Van Antwerp, D.2
Mercurio, F.3
-
47
-
-
0030882666
-
Oncogenic Ha-Kas-induced signaling activates NF-kappa-B transcriptional activity which is required for cellular transformation
-
Finco T, Westwick JK, Norris JL, et al: Oncogenic Ha-Kas-induced signaling activates NF-kappa-B transcriptional activity which is required for cellular transformation. J Biol Chem 272:24113-24116, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 24113-24116
-
-
Finco, T.1
Westwick, J.K.2
Norris, J.L.3
-
48
-
-
0037342894
-
Proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma cells to chemotherapeutic agents
-
Ma HM, Parker KM, Manyak S, et al: Proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma cells to chemotherapeutic agents. Clin Cancer Res 9:1136-1144, 2003
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1136-1144
-
-
Ma, H.M.1
Parker, K.M.2
Manyak, S.3
-
49
-
-
0032885416
-
The proteasome inhibitor PS-341 in cancer therapy
-
Teicher BA, Ara G, Herbst R, et al: The proteasome inhibitor PS-341 in cancer therapy. Clin Cancer Res 5:2638-2645, 1999
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2638-2645
-
-
Teicher, B.A.1
Ara, G.2
Herbst, R.3
-
50
-
-
0033152760
-
Proteasome inhibitors: A novel class of potent and effective antitumor agents
-
Adams J, Palombella VJ, Sausville EA, et al: Proteasome inhibitors: A novel class of potent and effective antitumor agents. Cancer Res 59:2615-2622, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 2615-2622
-
-
Adams, J.1
Palombella, V.J.2
Sausville, E.A.3
-
51
-
-
0032189685
-
Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor
-
Orlowski RZ, Eswara JR, Lafond-Walker A, et al: Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor. Cancer Res 58:4342-4348, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 4342-4348
-
-
Orlowski, R.Z.1
Eswara, J.R.2
Lafond-Walker, A.3
-
52
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, et al: The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 61:3071-3076, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
-
53
-
-
79960971463
-
Proteasome inhibitor PS-341 inhibits human multiple myeloma cell growth in a murine model
-
abstr
-
LeBlanc R, Catley L, Hideshima T, et al: Proteasome inhibitor PS-341 inhibits human multiple myeloma cell growth in a murine model. Blood 98:774a, 2001 (abstr)
-
(2001)
Blood
, vol.98
-
-
LeBlanc, R.1
Catley, L.2
Hideshima, T.3
-
54
-
-
0034062989
-
Proteasome inhibition: A new strategy in cancer treatment
-
Adams J, Palombella VJ, Elliott PJ: Proteasome inhibition: A new strategy in cancer treatment. Invest New Drugs 18:109-121, 2000
-
(2000)
Invest New Drugs
, vol.18
, pp. 109-121
-
-
Adams, J.1
Palombella, V.J.2
Elliott, P.J.3
-
55
-
-
0037973279
-
Phase II study of bortezomib in relapsed, refractory myeloma
-
Richardson, PG, Berenson J, Irwin D, et al: Phase II study of bortezomib in relapsed, refractory myeloma. N Engl J Med 348:2609-2617, 2003
-
(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Berenson, J.2
Irwin, D.3
-
56
-
-
18844465632
-
Constitutive activation of NF-kappa-B-RelA is required for proliferation and survival of Hodgkin's disease tumor cells
-
Bargou R, Emmerich F, Krappmann D, et al: Constitutive activation of NF-kappa-B-RelA is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 100:2961-2969, 1997
-
(1997)
J Clin Invest
, vol.100
, pp. 2961-2969
-
-
Bargou, R.1
Emmerich, F.2
Krappmann, D.3
-
57
-
-
0031440245
-
Aberrant nuclear factor-B/Rel expression and the pathogenesis of breast cancer
-
Sovak MA, Bellas RE, Kim DW, et al: Aberrant nuclear factor-B/Rel expression and the pathogenesis of breast cancer. J Clin Invest 100:2952-2960, 1997
-
(1997)
J Clin Invest
, vol.100
, pp. 2952-2960
-
-
Sovak, M.A.1
Bellas, R.E.2
Kim, D.W.3
-
58
-
-
0029814063
-
Inhibition of NF-B/Rel induces apoptosis of murine B cells
-
Wu M, Lee H, Bellas RE, et al: Inhibition of NF-B/Rel induces apoptosis of murine B cells. EMBO 15:4682-4690, 1996
-
(1996)
EMBO
, vol.15
, pp. 4682-4690
-
-
Wu, M.1
Lee, H.2
Bellas, R.E.3
-
59
-
-
0033177897
-
NF-kappa-B and chemoresistance potentiation of cancer chemotherapy via inhibition of NF-kappa-B
-
Cusack J, Liu R, Baldwin A: NF-kappa-B and chemoresistance potentiation of cancer chemotherapy via inhibition of NF-kappa-B. Drug Resist Updat 2:271-273, 1999
-
(1999)
Drug Resist Updat
, vol.2
, pp. 271-273
-
-
Cusack, J.1
Liu, R.2
Baldwin, A.3
-
60
-
-
0032905030
-
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappa-B
-
Wang CY, Cusack J, Liu R, et al.: Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappa-B. Nat Med 4:412-417, 1999
-
(1999)
Nat Med
, vol.4
, pp. 412-417
-
-
Wang, C.Y.1
Cusack, J.2
Liu, R.3
-
61
-
-
0006213882
-
Inducible chemoresistance to CPT-11 in colorectal cancer cells and a xenograft model is overcome by inhibition of NF-kappa-B
-
Cusack J, Liu R, Baldwin A: Inducible chemoresistance to CPT-11 in colorectal cancer cells and a xenograft model is overcome by inhibition of NF-kappa-B. Cancer Res 60:1323-1330, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 1323-1330
-
-
Cusack, J.1
Liu, R.2
Baldwin, A.3
-
62
-
-
0034662496
-
NF-kappa-B/IB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells
-
Huang Y, Johnson K, Norris J, et al: NF-kappa-B/IB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res 60:4426-4432, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 4426-4432
-
-
Huang, Y.1
Johnson, K.2
Norris, J.3
-
63
-
-
0031132604
-
Glucocorticosteroids and ambroxol inhibit secretion of inflammatory cytokines in tracheobronchial epithelial cells: Possible role of the NF-kappa B transcription factor
-
Betz R: Glucocorticosteroids and ambroxol inhibit secretion of inflammatory cytokines in tracheobronchial epithelial cells: Possible role of the NF-kappa B transcription factor. Pneumologie 51:491-492, 1997
-
(1997)
Pneumologie
, vol.51
, pp. 491-492
-
-
Betz, R.1
-
64
-
-
0034680928
-
Inhibition of NF-kappa-B activation by arsenite through reaction with critical cysteine in the activation loop of iota-kappa-B kinase
-
Kapahi P, Takahashi T, Natoli G, et al: Inhibition of NF-kappa-B activation by arsenite through reaction with critical cysteine in the activation loop of iota-kappa-B kinase. J Biol Chem 275:36062-36066, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 36062-36066
-
-
Kapahi, P.1
Takahashi, T.2
Natoli, G.3
-
65
-
-
0035877967
-
Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis
-
Sordet O, Rebe C, Leroy I, et al: Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis. Blood 97:3931-3940, 2001
-
(2001)
Blood
, vol.97
, pp. 3931-3940
-
-
Sordet, O.1
Rebe, C.2
Leroy, I.3
-
66
-
-
0003298249
-
Arsenic compounds induce apoptosis in multiple myeloma (MM), activate pro-caspase-3 but not affect BCL2 family members
-
suppl 1
-
Tang B, Bajenova O, Feinman-Siegal R, et al: Arsenic compounds induce apoptosis in multiple myeloma (MM), activate pro-caspase-3 but not affect BCL2 family members. Blood 92:638a, 1998 (suppl 1)
-
(1998)
Blood
, vol.92
-
-
Tang, B.1
Bajenova, O.2
Feinman-Siegal, R.3
-
67
-
-
0035895082
-
Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2- infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage
-
Mahieux R, Pise-Maison C, Gessain A, et al: Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2- infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage. Blood 98:3762-3769, 2001
-
(2001)
Blood
, vol.98
, pp. 3762-3769
-
-
Mahieux, R.1
Pise-Maison, C.2
Gessain, A.3
-
68
-
-
0030610687
-
3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients
-
3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89:3354-3360, 1997
-
(1997)
Blood
, vol.89
, pp. 3354-3360
-
-
Shen, Z.X.1
Chen, G.Q.2
Ni, J.H.3
-
69
-
-
84871469041
-
Arsenic trioxide cause apoptosis, growth inhibition and increased sensitivity of chemotherapeutic agents in multiple myeloma cells through inhibition of nuclear factor (NF)-kappa-B activity
-
Friedman JM, Ma MH, Manyak S, et al: Arsenic trioxide cause apoptosis, growth inhibition and increased sensitivity of chemotherapeutic agents in multiple myeloma cells through inhibition of nuclear factor (NF)-kappa-B activity. Proc Am Assoc Cancer Res 43:4585, 2002
-
(2002)
Proc Am Assoc Cancer Res
, vol.43
, pp. 4585
-
-
Friedman, J.M.1
Ma, M.H.2
Manyak, S.3
-
71
-
-
0035229427
-
The mitochondrion in apoptosis: How Pandora's box opens
-
Zamzami N, Kroemer G: The mitochondrion in apoptosis: How Pandora's box opens. Nat Rev Mol Cell Biol 2:67-71, 2001
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 67-71
-
-
Zamzami, N.1
Kroemer, G.2
-
73
-
-
0032575688
-
The bcl-2 protein family: Arbiters of cell survival
-
Adams JM, Cory S: The bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326, 1998
-
(1998)
Science
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
74
-
-
0026527344
-
Expression of bcl-2 gene in human multiple myeloma cell lines and normal plasma cells
-
Pettersson M, Jernberg-Wiklund H, Larssin L-G, et al: Expression of bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood 79:495-502, 1992
-
(1992)
Blood
, vol.79
, pp. 495-502
-
-
Pettersson, M.1
Jernberg-Wiklund, H.2
Larssin, L.-G.3
-
75
-
-
79960971606
-
Bcl-2 antisense oligonucleotide (ASO) enhances apoptosis and cytotoxicity in drug-resistant myeloma cells
-
abstr
-
Gazitti Y, Liu Q, Vesole D, et al: Bcl-2 antisense oligonucleotide (ASO) enhances apoptosis and cytotoxicity in drug-resistant myeloma cells. Blood 98:641a, 2001 (abstr)
-
(2001)
Blood
, vol.98
-
-
Gazitti, Y.1
Liu, Q.2
Vesole, D.3
-
76
-
-
0032734301
-
Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, mutation stage, and cytogenetics
-
Wuchter C, Karawajew L, Ruppert V, et al: Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, mutation stage, and cytogenetics. Leukemia 13:1943-1953, 1999
-
(1999)
Leukemia
, vol.13
, pp. 1943-1953
-
-
Wuchter, C.1
Karawajew, L.2
Ruppert, V.3
-
77
-
-
0032481131
-
Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53
-
Herrmann JL, Briones F Jr, Brisbay S, et al: Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53. Oncogens 3:2889-2899, 1998
-
(1998)
Oncogens
, vol.3
, pp. 2889-2899
-
-
Herrmann, J.L.1
Briones Jr, F.2
Brisbay, S.3
-
78
-
-
0032429122
-
Novel dipeptidyl proteasome inhibitors overcomes Bcl-2 protective function and selective accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed but not normal human fibroblasts
-
An B, Goldfarb RH, Siman R, et al: Novel dipeptidyl proteasome inhibitors overcomes Bcl-2 protective function and selective accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed but not normal human fibroblasts. Cell Death Differ 12:1062-1075, 1998
-
(1998)
Cell Death Differ
, vol.12
, pp. 1062-1075
-
-
An, B.1
Goldfarb, R.H.2
Siman, R.3
-
79
-
-
79960970830
-
Proteasome inhibitor PS341 inhibits constitutive NF-B activity and bypasses the anti-apoptotic bcl-2 signal in human multiple myeloma cells
-
abstr
-
Feinman R, Gangurde P, Miller S, et al: Proteasome inhibitor PS341 inhibits constitutive NF-B activity and bypasses the anti-apoptotic bcl-2 signal in human multiple myeloma cells. Blood 98:640a, 2001 (abstr)
-
(2001)
Blood
, vol.98
-
-
Feinman, R.1
Gangurde, P.2
Miller, S.3
-
80
-
-
0031029911
-
Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells
-
Chauhan D, Kharbands S, Ogata A, et al: Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood 89:227-234, 1997
-
(1997)
Blood
, vol.89
, pp. 227-234
-
-
Chauhan, D.1
Kharbands, S.2
Ogata, A.3
-
81
-
-
0031225483
-
IL-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade
-
Ogata A, Chauhan D, Teoh G, et al: IL-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade. J Immunol 159: 2212-2221, 1997
-
(1997)
J Immunol
, vol.159
, pp. 2212-2221
-
-
Ogata, A.1
Chauhan, D.2
Teoh, G.3
-
82
-
-
0029019664
-
Interleukin-6 inhibits apoptosis of malignant plasma cells
-
Lichtenstein A, Tu Y, Fady C, et al: Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol 162:248-255, 1995
-
(1995)
Cell Immunol
, vol.162
, pp. 248-255
-
-
Lichtenstein, A.1
Tu, Y.2
Fady, C.3
-
83
-
-
0036242247
-
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
-
Wang W, Chen JX, Liao R: Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 22:3389-3403, 2002
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3389-3403
-
-
Wang, W.1
Chen, J.X.2
Liao, R.3
-
84
-
-
0032530301
-
Apoptotic regulation in primitive hematopoietic precursors
-
Peters R, Leyvraz S, Perey L: Apoptotic regulation in primitive hematopoietic precursors. Blood 92:2041-2052, 1998
-
(1998)
Blood
, vol.92
, pp. 2041-2052
-
-
Peters, R.1
Leyvraz, S.2
Perey, L.3
-
85
-
-
85014210290
-
Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes
-
Wierenga AT, Schuringa JJ, Eggen BJ: Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Leukemia 16:675-682, 2002
-
(2002)
Leukemia
, vol.16
, pp. 675-682
-
-
Wierenga, A.T.1
Schuringa, J.J.2
Eggen, B.J.3
-
86
-
-
0035136846
-
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
-
Epling-Burnette PK, Liu JH, Catlett-Falcone R: Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 107:351-362, 2001
-
(2001)
J Clin Invest
, vol.107
, pp. 351-362
-
-
Epling-Burnette, P.K.1
Liu, J.H.2
Catlett-Falcone, R.3
-
87
-
-
0032984589
-
Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
Catlett-Falcone R, Landowski TH, Oshiro MM, et al: Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10:105-115, 1999
-
(1999)
Immunity
, vol.10
, pp. 105-115
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
-
88
-
-
0033105537
-
Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
-
Damiano JS, Cress AE, Hazlehurst LA, et al: Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 93:1658-1667, 1999
-
(1999)
Blood
, vol.93
, pp. 1658-1667
-
-
Damiano, J.S.1
Cress, A.E.2
Hazlehurst, L.A.3
-
89
-
-
0034009920
-
Integrin-mediated drug resistance in multiple myeloma
-
Damiano JS, Dalton WS: Integrin-mediated drug resistance in multiple myeloma. Leuk Lymphoma 38:71-81, 2000
-
(2000)
Leuk Lymphoma
, vol.38
, pp. 71-81
-
-
Damiano, J.S.1
Dalton, W.S.2
-
90
-
-
0026787347
-
Characterization of adhesion molecules on human myeloma cell lines
-
Uchiyama H, Barut BA, Chauhan D, et al: Characterization of adhesion molecules on human myeloma cell lines. Blood 80:2306-2314, 1992
-
(1992)
Blood
, vol.80
, pp. 2306-2314
-
-
Uchiyama, H.1
Barut, B.A.2
Chauhan, D.3
-
91
-
-
0029946652
-
Regulation of leukocyte integrin function: Affinity vs. avidity
-
Stewart MP, Hogg N: Regulation of leukocyte integrin function: Affinity vs. avidity. J Cell Biochem 61:554-561, 1996
-
(1996)
J Cell Biochem
, vol.61
, pp. 554-561
-
-
Stewart, M.P.1
Hogg, N.2
-
92
-
-
0032498543
-
LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain
-
Stewart MP, McDowell A, Hogg N: LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain. J Cell Biol 140:699-707, 1998
-
(1998)
J Cell Biol
, vol.140
, pp. 699-707
-
-
Stewart, M.P.1
McDowell, A.2
Hogg, N.3
|