High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance

British Journal of Cancer

Volumn 85, Issue 11, 2001, Pages 1746-1752

  Cocker, H A ^a   Hobbs, S M ^a   Tiffin, N ^b   Pritchard Jones, K ^b   Pinkerton, C R ^b   Kelland, L R ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

mdm2; mdr 1; P glycoprotein; Resistance; Rhabdomyosarcoma

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; PROTEIN MDM2; PUROMYCIN; VALSPODAR; VINCRISTINE;

ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG SENSITIVITY; GENE OVEREXPRESSION; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; ONCOGENE; PRIORITY JOURNAL; RHABDOMYOSARCOMA;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CHILD; CISPLATIN; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITORY CONCENTRATION 50; NUCLEAR PROTEINS; P-GLYCOPROTEIN; PLASMIDS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RHABDOMYOSARCOMA; TRANSFECTION; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0035977168     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.2145     Document Type: Article

References (23)

1. Regulation of p53 stability
2. A 190-kDa protein overexpressed in non-P-glycoprotein containing multidrug resistant cells and its relationship to the MRP gene
3. Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma
4. Immunohistochemical detection of P-glycoprotein - Prognostic correlation in soft tissue sarcoma of childhood
5. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53
6. Characterization and modulation of drug resistance of human paediatric rhabdomyosarcoma cell lines
7. Development of a bicistronic vector driven by the human polypeptide chain elongation factor Iα-promotor for creation of stable mammalian cell lines that express very high levels of recombinant proteins
8. The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein
9. mdm2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line
10. P-Glycoprotein expression at diagnosis may not be a primary, mechanism of therapeutic failure in childhood rhabdomyosarcoma
11. The MDM2 C-terminal region binds to TAF(II)250 and is required for MDM2 regulation of the cyclin A promoter
12. Wild-type p53 gene increases MDR1 gene expression but decreases drug resistance in an MDR cell line KBV200
13. MDM2 amplification in a primary alveolar rhabdomyosarcoma displaying a t(2;13)(q35;q14)
14. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
15. New multidrug resistance reversing drugs. MS-209 and SDZ PSC833
16. Stabilization of the MDM2 oncoprotein by mutant p53
17. Effects of a new antioestrogen, idoxifene, on cisplatin- and doxorubicin-sensitive and resistant human ovarian carcinoma cell lines
18. Role of MDM2 overexpression in doxorubicin resistance of breast carcinoma
19. Mdm2 mRNA expression is associated with survival in ovarian cancer
20. p53 mutation and MDM2 amplification frequency in pediatric rhabdomyosarcoma tumors and cell lines
21. p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents
22. Elevated MDM2 protein expression in pediatric acute lymphoblastic leukemia (ALL) is associated with in vitro resistance to adriamycin and decreased duration of first remission (CR1)