메뉴 건너뛰기




Volumn 94, Issue 1, 2009, Pages 78-86

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

Author keywords

MMSET; Myeloma; WHSC1

Indexed keywords

BRCA1 PROTEIN; CASPASE 4; CHECKPOINT KINASE 1; INTERLEUKIN 1BETA CONVERTING ENZYME; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHRL1;

EID: 58149232433     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.13426     Document Type: Article
Times cited : (106)

References (38)
  • 1
    • 0036512435 scopus 로고    scopus 로고
    • Multiple myeloma: Evolving genetic events and host interactions
    • Kuehl WM, Bergsagel PL. Multiple myeloma: evolving genetic events and host interactions. Nat Rev Cancer 2002;2:175-87.
    • (2002) Nat Rev Cancer , vol.2 , pp. 175-187
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 3
    • 0030842266 scopus 로고    scopus 로고
    • A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
    • Richelda R, Ronchetti D, Baldini L, Cro L, Viggiano L, Marzella R, et al. A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene. Blood 1997;90:4062-70.
    • (1997) Blood , vol.90 , pp. 4062-4070
    • Richelda, R.1    Ronchetti, D.2    Baldini, L.3    Cro, L.4    Viggiano, L.5    Marzella, R.6
  • 4
    • 0035254612 scopus 로고    scopus 로고
    • Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
    • Chesi M, Brents LA, Ely SA, Bais C, Robbiani DF, Mesri EA, et al. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood 2001;97:729-36.
    • (2001) Blood , vol.97 , pp. 729-736
    • Chesi, M.1    Brents, L.A.2    Ely, S.A.3    Bais, C.4    Robbiani, D.F.5    Mesri, E.A.6
  • 5
    • 20844463416 scopus 로고    scopus 로고
    • Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients
    • Keats JJ, Maxwell CA, Taylor BJ, Hendzel MJ, Chesi M, Bergsagel PL, et al. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. Blood 2005;105:4060-9.
    • (2005) Blood , vol.105 , pp. 4060-4069
    • Keats, J.J.1    Maxwell, C.A.2    Taylor, B.J.3    Hendzel, M.J.4    Chesi, M.5    Bergsagel, P.L.6
  • 6
    • 0034142212 scopus 로고    scopus 로고
    • Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis
    • Plowright EE, Li Z, Bergsagel PL, Chesi M, Barber DL, Branch DR, et al. Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis. Blood 2000;95:992-8.
    • (2000) Blood , vol.95 , pp. 992-998
    • Plowright, E.E.1    Li, Z.2    Bergsagel, P.L.3    Chesi, M.4    Barber, D.L.5    Branch, D.R.6
  • 7
    • 0035858985 scopus 로고    scopus 로고
    • Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): Comparative analysis of Y373C, K650E and the novel G384D mutations
    • Ronchetti D, Greco A, Compasso S, Colombo G, Dell'Era P, Otsuki T, et al. Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations. Oncogene 2001;20:3553-62.
    • (2001) Oncogene , vol.20 , pp. 3553-3562
    • Ronchetti, D.1    Greco, A.2    Compasso, S.3    Colombo, G.4    Dell'Era, P.5    Otsuki, T.6
  • 8
    • 0037443417 scopus 로고    scopus 로고
    • A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript
    • Santra M, Zhan F, Tian E, Barlogie B, Shaughnessy J Jr. A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. Blood 2003;101:2374-6.
    • (2003) Blood , vol.101 , pp. 2374-2376
    • Santra, M.1    Zhan, F.2    Tian, E.3    Barlogie, B.4    Shaughnessy Jr, J.5
  • 10
    • 1942456800 scopus 로고    scopus 로고
    • Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma
    • Trudel S, Ely S, Farooqi Y, Affer M, Robbiani DF, Chesi M, et al. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood 2004;103:3521-8.
    • (2004) Blood , vol.103 , pp. 3521-3528
    • Trudel, S.1    Ely, S.2    Farooqi, Y.3    Affer, M.4    Robbiani, D.F.5    Chesi, M.6
  • 11
    • 0037441747 scopus 로고    scopus 로고
    • In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression
    • Keats JJ, Reiman T, Maxwell CA, Taylor BJ, Larratt LM, Mant MJ, et al. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. Blood 2003;101:1520-9.
    • (2003) Blood , vol.101 , pp. 1520-1529
    • Keats, J.J.1    Reiman, T.2    Maxwell, C.A.3    Taylor, B.J.4    Larratt, L.M.5    Mant, M.J.6
  • 12
    • 38349087546 scopus 로고    scopus 로고
    • The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity
    • Lauring J, Abukhdeir AM, Konishi H, Garay JP, Gustin JP, Wang Q, et al. The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. Blood 2008;111:856-64.
    • (2008) Blood , vol.111 , pp. 856-864
    • Lauring, J.1    Abukhdeir, A.M.2    Konishi, H.3    Garay, J.P.4    Gustin, J.P.5    Wang, Q.6
  • 13
    • 36148955443 scopus 로고    scopus 로고
    • Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma
    • Jenner MW, Leone PE, Walker BA, Ross FM, Johnson DC, Gonzalez D, et al. Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma. Blood 2007;110:3291-300.
    • (2007) Blood , vol.110 , pp. 3291-3300
    • Jenner, M.W.1    Leone, P.E.2    Walker, B.A.3    Ross, F.M.4    Johnson, D.C.5    Gonzalez, D.6
  • 14
    • 33748190743 scopus 로고    scopus 로고
    • Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma
    • Walker BA, Leone PE, Jenner MW, Li C, Gonzalez D, Johnson DC, et al. Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma. Blood 2006;108:1733-43.
    • (2006) Blood , vol.108 , pp. 1733-1743
    • Walker, B.A.1    Leone, P.E.2    Jenner, M.W.3    Li, C.4    Gonzalez, D.5    Johnson, D.C.6
  • 15
    • 0042121250 scopus 로고    scopus 로고
    • ChipInfo: Software for extracting gene annotation and gene ontology information for microarray analysis
    • Zhong S, Li C, Wong WH. ChipInfo: Software for extracting gene annotation and gene ontology information for microarray analysis. Nucleic Acids Res 2003;31:3483-6.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3483-3486
    • Zhong, S.1    Li, C.2    Wong, W.H.3
  • 16
    • 34547589578 scopus 로고    scopus 로고
    • Huang da W, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, et al. DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res 2007;35(Web Server issue):W169-75.
    • Huang da W, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, et al. DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res 2007;35(Web Server issue):W169-75.
  • 18
    • 0029087973 scopus 로고
    • Nuclear delivery of antisense oligodeoxynucleotides through reversible permeabilization of human leukemia cells with streptolysin O
    • Spring;
    • Spiller DG, Tidd DM. Nuclear delivery of antisense oligodeoxynucleotides through reversible permeabilization of human leukemia cells with streptolysin O. Antisense Res Dev 1995 Spring;5:13-21.
    • (1995) Antisense Res Dev , Issue.5 , pp. 13-21
    • Spiller, D.G.1    Tidd, D.M.2
  • 19
    • 41149088657 scopus 로고    scopus 로고
    • Streptolysin-O reversible permeabilisation is an effective method to transfect siRNAs into myeloma cells
    • Brito JL, Davies FE, Gonzalez D, Morgan GJ. Streptolysin-O reversible permeabilisation is an effective method to transfect siRNAs into myeloma cells. J Immunol Methods 2008;333:147-55.
    • (2008) J Immunol Methods , vol.333 , pp. 147-155
    • Brito, J.L.1    Davies, F.E.2    Gonzalez, D.3    Morgan, G.J.4
  • 21
    • 42449161943 scopus 로고    scopus 로고
    • The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor
    • Marango J, Shimoyama M, Nishio H, Meyer JA, Min DJ, Sirulnik A, et al. The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood 2008;111:3145-54.
    • (2008) Blood , vol.111 , pp. 3145-3154
    • Marango, J.1    Shimoyama, M.2    Nishio, H.3    Meyer, J.A.4    Min, D.J.5    Sirulnik, A.6
  • 23
    • 0036014969 scopus 로고    scopus 로고
    • The enigma of ectopic expression of FGFR3 in multiple myeloma: A critical initiating event or just a target for mutational activation during tumor progression
    • Chesi M, Bergsagel PL, Kuehl WM. The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression. Curr Opin Hematol 2002;9:288-93.
    • (2002) Curr Opin Hematol , vol.9 , pp. 288-293
    • Chesi, M.1    Bergsagel, P.L.2    Kuehl, W.M.3
  • 24
    • 0032212243 scopus 로고    scopus 로고
    • The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
    • Chesi M, Nardini E, Lim RS, Smith KD, Kuehl WM, Bergsagel PL. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood 1998;92:3025-34.
    • (1998) Blood , vol.92 , pp. 3025-3034
    • Chesi, M.1    Nardini, E.2    Lim, R.S.3    Smith, K.D.4    Kuehl, W.M.5    Bergsagel, P.L.6
  • 25
    • 0033887241 scopus 로고    scopus 로고
    • Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts
    • Malgeri U, Baldini L, Perfetti V, Fabris S, Vignarelli MC, Colombo G, et al. Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts. Cancer Res 2000;60:4058-61.
    • (2000) Cancer Res , vol.60 , pp. 4058-4061
    • Malgeri, U.1    Baldini, L.2    Perfetti, V.3    Fabris, S.4    Vignarelli, M.C.5    Colombo, G.6
  • 26
    • 39749106551 scopus 로고    scopus 로고
    • Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells
    • Evans R, Naber C, Steffler T, Checkland T, Keats J, Maxwell C, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma 2008;49:559-69.
    • (2008) Leuk Lymphoma , vol.49 , pp. 559-569
    • Evans, R.1    Naber, C.2    Steffler, T.3    Checkland, T.4    Keats, J.5    Maxwell, C.6
  • 27
    • 3843103732 scopus 로고    scopus 로고
    • Caspase-1zeta, a new splice variant of the caspase-1 gene
    • Feng Q, Li P, Leung PC, Auersperg N. Caspase-1zeta, a new splice variant of the caspase-1 gene. Genomics 2004;84:587-91.
    • (2004) Genomics , vol.84 , pp. 587-591
    • Feng, Q.1    Li, P.2    Leung, P.C.3    Auersperg, N.4
  • 28
    • 0029078965 scopus 로고
    • Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases
    • Kamens J, Paskind M, Hugunin M, Talanian RV, Allen H, Banach D, et al. Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases. J Biol Chem 1995;270:15250-6.
    • (1995) J Biol Chem , vol.270 , pp. 15250-15256
    • Kamens, J.1    Paskind, M.2    Hugunin, M.3    Talanian, R.V.4    Allen, H.5    Banach, D.6
  • 29
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-68.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 31
    • 0037031828 scopus 로고    scopus 로고
    • Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization
    • Tran NL, Adams DG, Vaillancourt RR, Heimark RL. Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization. J Biol Chem 2002;277:32905-14.
    • (2002) J Biol Chem , vol.277 , pp. 32905-32914
    • Tran, N.L.1    Adams, D.G.2    Vaillancourt, R.R.3    Heimark, R.L.4
  • 33
    • 33645745595 scopus 로고    scopus 로고
    • ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin
    • Karadag A, Zhou M, Croucher PI. ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin. Blood 2006;107:3271-8.
    • (2006) Blood , vol.107 , pp. 3271-3278
    • Karadag, A.1    Zhou, M.2    Croucher, P.I.3
  • 34
    • 0034811643 scopus 로고    scopus 로고
    • MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin
    • Zhou M, Graham R, Russell G, Croucher PI. MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin. Biochem Biophys Res Commun 2001;280:574-80.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 574-580
    • Zhou, M.1    Graham, R.2    Russell, G.3    Croucher, P.I.4
  • 35
    • 34047099312 scopus 로고    scopus 로고
    • Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes
    • Brennan D, Hu Y, Joubeh S, Choi YW, Whitaker-Menezes D, O'Brien T, et al. Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes. J Cell Sci 2007;120:758-71.
    • (2007) J Cell Sci , vol.120 , pp. 758-771
    • Brennan, D.1    Hu, Y.2    Joubeh, S.3    Choi, Y.W.4    Whitaker-Menezes, D.5    O'Brien, T.6
  • 37
    • 0033767214 scopus 로고    scopus 로고
    • Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma
    • Gado K, Domjan G, Hegyesi H, Falus A. Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma. Cell Biol Int 2000;24:195-209.
    • (2000) Cell Biol Int , vol.24 , pp. 195-209
    • Gado, K.1    Domjan, G.2    Hegyesi, H.3    Falus, A.4
  • 38
    • 10544241191 scopus 로고    scopus 로고
    • Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop
    • Gu ZJ, Costes V, Lu ZY, Zhang XG, Pitard V, Moreau JF, et al. Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop. Blood 1996;88:3972-86.
    • (1996) Blood , vol.88 , pp. 3972-3986
    • Gu, Z.J.1    Costes, V.2    Lu, Z.Y.3    Zhang, X.G.4    Pitard, V.5    Moreau, J.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.