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Volumn 25, Issue 6, 2011, Pages 1026-1035

Clinical and biological implications of MYC activation: A common difference between MGUS and newly diagnosed multiple myeloma

Author keywords

bortezomib; hyperdiploid; MGUS; MYC; myeloma

Indexed keywords

BORTEZOMIB; DEXAMETHASONE; MYC PROTEIN; RAS PROTEIN; SYNDECAN 1;

EID: 79958095463     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.53     Document Type: Article
Times cited : (230)

References (51)
  • 1
    • 67049114114 scopus 로고    scopus 로고
    • A monoclonal gammopathy precedes multiple myeloma in most patients
    • Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM. A monoclonal gammopathy precedes multiple myeloma in most patients. Blood 2009; 113: 5418-5422.
    • (2009) Blood , vol.113 , pp. 5418-5422
    • Weiss, B.M.1    Abadie, J.2    Verma, P.3    Howard, R.S.4    Kuehl, W.M.5
  • 2
    • 67049162188 scopus 로고    scopus 로고
    • Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: A prospective study
    • Landgren O, Kyle RA, Pfeiffer RM, Katzmann JA, Caporaso NE, Hayes RB et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood 2009; 113: 5412-5417.
    • (2009) Blood , vol.113 , pp. 5412-5417
    • Landgren, O.1    Kyle, R.A.2    Pfeiffer, R.M.3    Katzmann, J.A.4    Caporaso, N.E.5    Hayes, R.B.6
  • 3
    • 36749027626 scopus 로고    scopus 로고
    • Genetic events in the pathogenesis of multiple myeloma
    • DOI 10.1016/j.beha.2007.08.004, PII S1521692607000643, New Insights into the Biology and Advances in the Management of Multiple Myeloma
    • Chng WJ, Glebov O, Bergsagel PL, Kuehl WM. Genetic events in the pathogenesis of multiple myeloma. Best Pract Res Clin Haematol 2007; 20: 571-596. (Pubitemid 350215376)
    • (2007) Best Practice and Research in Clinical Haematology , vol.20 , Issue.4 , pp. 571-596
    • Chng, W.J.1    Glebov, O.2    Bergsagel, P.L.3    Kuehl, W.M.4
  • 9
    • 11144235574 scopus 로고    scopus 로고
    • Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors
    • DOI 10.1182/blood-2004-03-0833
    • Rasmussen T, Kuehl M, Lodahl M, Johnsen HE, Dahl IM. Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors. Blood 2005; 105: 317-323. (Pubitemid 40053099)
    • (2005) Blood , vol.105 , Issue.1 , pp. 317-323
    • Rasmussen, T.1    Kuehl, M.2    Lodahl, M.3    Johnsen, H.E.4    Dahl, I.M.S.5
  • 14
    • 50249133616 scopus 로고    scopus 로고
    • Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
    • Gurel B, Iwata T, Koh CM, Jenkins RB, Lan F, Van Dang C et al. Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis. Mod Pathol 2008; 21: 1156-1167.
    • (2008) Mod Pathol , vol.21 , pp. 1156-1167
    • Gurel, B.1    Iwata, T.2    Koh, C.M.3    Jenkins, R.B.4    Lan, F.5    Van Dang, C.6
  • 18
    • 33750619898 scopus 로고    scopus 로고
    • Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma
    • Chng WJ, Schop RF, Price-Troska T, Ghobrial I, Kay N, Jelinek DF et al. Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma. Blood 2006; 108: 2755-2763.
    • (2006) Blood , vol.108 , pp. 2755-2763
    • Chng, W.J.1    Schop, R.F.2    Price-Troska, T.3    Ghobrial, I.4    Kay, N.5    Jelinek, D.F.6
  • 19
    • 77649253330 scopus 로고    scopus 로고
    • Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
    • Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M et al. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci USA 2010; 107: 3534-3539.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3534-3539
    • Yustein, J.T.1    Liu, Y.C.2    Gao, P.3    Jie, C.4    Le Vuica-Ross A, M.5
  • 22
    • 12144289480 scopus 로고    scopus 로고
    • Identification of Epstein-Barr Virus (EBV) Nuclear Antigen 2 (EBNA2) Target Proteins by Proteome Analysis: Activation of EBNA2 in Conditionally Immortalized B Cells Reflects Early Events after Infection of Primary B Cells by EBV
    • DOI 10.1128/JVI.78.8.3941-3952.2004
    • Schlee M, Krug T, Gires O, Zeidler R, Hammerschmidt W, Mailhammer R et al. Identification of Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) target proteins by proteome analysis: activation of EBNA2 in conditionally immortalized B cells reflects early events after infection of primary B cells by EBV. J Virol 2004; 78: 3941-3952. (Pubitemid 38437200)
    • (2004) Journal of Virology , vol.78 , Issue.8 , pp. 3941-3952
    • Schlee, M.1    Krug, T.2    Gires, O.3    Zeidler, R.4    Hammerschmidt, W.5    Mailhammer, R.6    Laux, G.7    Sauer, G.8    Lovric, J.9    Bornkamm, G.W.10
  • 24
    • 70350506572 scopus 로고    scopus 로고
    • The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis
    • Klapproth K, Sander S, Marinkovic D, Baumann B, Wirth T. The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis. Blood 2009; 114: 2448-2458.
    • (2009) Blood , vol.114 , pp. 2448-2458
    • Klapproth, K.1    Sander, S.2    Marinkovic, D.3    Baumann, B.4    Wirth, T.5
  • 27
    • 0037184102 scopus 로고    scopus 로고
    • Wang CY. c-Myc sensitizes cells to tumor necrosis factor-mediated apoptosis by inhibiting nuclear factor kappa B transactivation
    • You Z, Madrid LV, Saims D, Sedivy J, Wang CY. c-Myc sensitizes cells to tumor necrosis factor-mediated apoptosis by inhibiting nuclear factor kappa B transactivation. J Biol Chem 2002; 277: 36671-36677.
    • (2002) J Biol Chem , vol.277 , pp. 36671-36677
    • You, Z.1    Madrid, L.V.2    Saims, D.3    Sedivy, J.4
  • 30
    • 0036512435 scopus 로고    scopus 로고
    • Multiple myeloma: Evolving genetic events and host interactions
    • Kuehl WM, Bergsagel PL. Multiple myeloma: evolving genetic events and host interactions. Nat Rev Cancer 2002; 2: 175-187. (Pubitemid 37328787)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.3 , pp. 175-187
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 33
    • 0034306997 scopus 로고    scopus 로고
    • Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
    • Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000; 14: 2501-2514.
    • (2000) Genes Dev , vol.14 , pp. 2501-2514
    • Sears, R.1    Nuckolls, F.2    Haura, E.3    Taya, Y.4    Tamai, K.5    Nevins, J.R.6
  • 34
    • 0033082892 scopus 로고    scopus 로고
    • Ras enhances Myc protein stability
    • DOI 10.1016/S1097-2765(00)80308-1
    • Sears R, Leone G, DeGregori J, Nevins JR. Ras enhances Myc protein stability. Mol Cell 1999; 3: 169-179. (Pubitemid 29292618)
    • (1999) Molecular Cell , vol.3 , Issue.2 , pp. 169-179
    • Sears, R.1    Leone, G.2    DeGregori, J.3    Nevins, J.R.4
  • 35
    • 77949423427 scopus 로고    scopus 로고
    • Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling
    • Gutierrez NC, Sarasquete ME, Misiewicz-Krzeminska I, Delgado M, De Las Rivas J, Ticona FV et al. Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling. Leukemia 2010; 24: 627-637.
    • (2010) Leukemia , vol.24 , pp. 627-637
    • Gutierrez, N.C.1    Sarasquete, M.E.2    Misiewicz-Krzeminska, I.3    Delgado, M.4    De Las Rivas, J.5    Ticona, F.V.6
  • 36
    • 73949101367 scopus 로고    scopus 로고
    • Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma
    • Lionetti M, Biasiolo M, Agnelli L, Todoerti K, Mosca L, Fabris S et al. Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma. Blood 2009; 114: e20-e26.
    • (2009) Blood , vol.114
    • Lionetti, M.1    Biasiolo, M.2    Agnelli, L.3    Todoerti, K.4    Mosca, L.5    Fabris, S.6
  • 38
    • 57749102689 scopus 로고    scopus 로고
    • IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1
    • Shi Y, Frost PJ, Hoang BQ, Benavides A, Sharma S, Gera JF et al. IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1. Cancer Res 2008; 68: 10215-10222.
    • (2008) Cancer Res , vol.68 , pp. 10215-10222
    • Shi, Y.1    Frost, P.J.2    Hoang, B.Q.3    Benavides, A.4    Sharma, S.5    Gera, J.F.6
  • 39
    • 78650962515 scopus 로고    scopus 로고
    • IL-6- induced enhancement of c-Myc translation in multiple myeloma cells: Critical role of cytoplasmic localization of the rna-binding protein hnRNP A1
    • Shi Y, Frost P, Hoang B, Benavides A, Gera J, Lichtenstein A. IL-6- induced enhancement of c-Myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the rna-binding protein hnRNP A1. J Biol Chem 2011; 286: 67-78.
    • (2011) J Biol Chem , vol.286 , pp. 67-78
    • Shi, Y.1    Frost, P.2    Hoang, B.3    Benavides, A.4    Gera, J.5    Lichtenstein, A.6
  • 40
    • 67650745974 scopus 로고    scopus 로고
    • Loss of 1p and rearrangement ofMYC are associated with progression of smouldering myeloma to myeloma: Sequential analysis of a single case
    • Chiecchio L, Dagrada GP, Protheroe RK, Stockley DM, Smith AG, Orchard KH et al. Loss of 1p and rearrangement ofMYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case. Haematologica 2009; 94: 1024-1028.
    • (2009) Haematologica , vol.94 , pp. 1024-1028
    • Chiecchio, L.1    Dagrada, G.P.2    Protheroe, R.K.3    Stockley, D.M.4    Smith, A.G.5    Orchard, K.H.6
  • 41
    • 22044440425 scopus 로고    scopus 로고
    • Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
    • DOI 10.1182/blood-2005-01-0034
    • Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy Jr. J. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 2005; 106: 296-303. (Pubitemid 40967205)
    • (2005) Blood , vol.106 , Issue.1 , pp. 296-303
    • Bergsagel, P.L.1    Kuehl, W.M.2    Zhan, F.3    Sawyer, J.4    Barlogie, B.5    Shaughnessy Jr., J.6
  • 43
    • 0032905924 scopus 로고    scopus 로고
    • C-Myc target genes involved in cell growth, apoptosis, and metabolism
    • Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999; 19: 1-11. (Pubitemid 29018404)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.1 , pp. 1-11
    • Dang, C.V.1
  • 44
    • 2342645571 scopus 로고    scopus 로고
    • The role of c-myc in regulation of translation initiation
    • DOI 10.1038/sj.onc.1207548
    • Schmidt EV. The role of c-myc in regulation of translation initiation. Oncogene 2004; 23: 3217-3221. (Pubitemid 38638833)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3217-3221
    • Schmidt, E.V.1
  • 45
    • 0033539555 scopus 로고    scopus 로고
    • Eisenman RN. c-Myc enhances protein synthesis and cell size during B lymphocyte development
    • Iritani BM, Eisenman RN. c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc Natl Acad Sci USA 1999; 96: 13180-13185.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13180-13185
    • Iritani, B.M.1
  • 47
    • 0027162858 scopus 로고
    • Consensus review of the clinical utility of DNA flow cytometry in neoplastic hematopathology
    • Duque RE, Andreeff M, Braylan RC, Diamond LW, Peiper SC. Consensus review of the clinical utility of DNA flow cytometry in neoplastic hematopathology. Cytometry 1993; 14: 492-496. (Pubitemid 23191958)
    • (1993) Cytometry , vol.14 , Issue.5 , pp. 492-496
    • Duque, R.E.1    Andreeff, M.2    Braylan, R.C.3    Diamond, L.W.4    Peiper, S.C.5
  • 48
    • 43549087444 scopus 로고    scopus 로고
    • PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor
    • Zhao WL, Liu YY, Zhang QL, Wang L, Leboeuf C, Zhang YW et al. PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor. Blood 2008; 111: 3867-3871.
    • (2008) Blood , vol.111 , pp. 3867-3871
    • Zhao, W.L.1    Liu, Y.Y.2    Zhang, Q.L.3    Wang, L.4    Leboeuf, C.5    Zhang, Y.W.6
  • 50
    • 34447137342 scopus 로고    scopus 로고
    • Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
    • DOI 10.1038/nm1606, PII NM1606
    • Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med 2007; 13: 820-827. (Pubitemid 47038193)
    • (2007) Nature Medicine , vol.13 , Issue.7 , pp. 820-827
    • Goga, A.1    Yang, D.2    Tward, A.D.3    Morgan, D.O.4    Bishop, J.M.5
  • 51
    • 66649127621 scopus 로고    scopus 로고
    • Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
    • Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q et al. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature 2009; 459: 717-721.
    • (2009) Nature , vol.459 , pp. 717-721
    • Compagno, M.1    Lim, W.K.2    Grunn, A.3    Nandula, S.V.4    Brahmachary, M.5    Shen, Q.6


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