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Volumn 122, Issue 2, 2013, Pages 219-226

Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CELLULAR RETINOL BINDING PROTEIN 1; GLUTATHIONE PEROXIDASE 3; OSTEONECTIN; TRANSFORMING GROWTH FACTOR BETA1; AZACITIDINE; DRUG DERIVATIVE; SPARC PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

EID: 84884494098     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-03-487884     Document Type: Article
Times cited : (141)

References (50)
  • 1
    • 84860219443 scopus 로고    scopus 로고
    • The genetic architecture of multiple myeloma
    • Morgan GJ, Walker BA, Davies FE. The genetic architecture of multiple myeloma. Nat Rev Cancer. 2012;12(5):335-348.
    • (2012) Nat Rev Cancer , vol.12 , Issue.5 , pp. 335-348
    • Morgan, G.J.1    Walker, B.A.2    Davies, F.E.3
  • 2
    • 78751508049 scopus 로고    scopus 로고
    • Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma
    • Walker BA, Wardell CP, Chiecchio L, et al. Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma. Blood. 2011;117(2):553-562.
    • (2011) Blood , vol.117 , Issue.2 , pp. 553-562
    • Walker, B.A.1    Wardell, C.P.2    Chiecchio, L.3
  • 3
    • 74049162897 scopus 로고    scopus 로고
    • International Myeloma Working Group. International Myeloma Working Group molecular classification of multiple myeloma: Spotlight review
    • Fonseca R, Bergsagel PL, Drach J, et al; International Myeloma Working Group. International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia. 2009;23(12):2210-2221.
    • (2009) Leukemia , vol.23 , Issue.12 , pp. 2210-2221
    • Fonseca, R.1    Bergsagel, P.L.2    Drach, J.3
  • 4
    • 84866908944 scopus 로고    scopus 로고
    • LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types
    • Kim JH, Karnovsky A, Mahavisno V, et al. LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types. BMC Genomics. 2012;13:526.
    • (2012) BMC Genomics , vol.13 , pp. 526
    • Kim, J.H.1    Karnovsky, A.2    Mahavisno, V.3
  • 5
    • 81555214615 scopus 로고    scopus 로고
    • Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks
    • Deneberg S, Guardiola P, Lennartsson A, et al. Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks. Blood. 2011;118(20):5573-5582.
    • (2011) Blood , vol.118 , Issue.20 , pp. 5573-5582
    • Deneberg, S.1    Guardiola, P.2    Lennartsson, A.3
  • 6
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13(7):484-492.
    • (2012) Nat Rev Genet , vol.13 , Issue.7 , pp. 484-492
    • Jones, P.A.1
  • 7
    • 84857742284 scopus 로고    scopus 로고
    • DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory
    • Raynal NJ, Si J, Taby RF, et al. DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory. Cancer Res. 2012;72(5):1170-1181.
    • (2012) Cancer Res , vol.72 , Issue.5 , pp. 1170-1181
    • Raynal, N.J.1    Si, J.2    Taby, R.F.3
  • 8
    • 84868198427 scopus 로고    scopus 로고
    • Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
    • Kulis M, Heath S, Bibikova M, et al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet. 2012;44(11):1236-1242.
    • (2012) Nat Genet , vol.44 , Issue.11 , pp. 1236-1242
    • Kulis, M.1    Heath, S.2    Bibikova, M.3
  • 9
    • 84655162785 scopus 로고    scopus 로고
    • Regions of focal DNA hypermethylation and longrange hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains
    • Berman BP, Weisenberger DJ, Aman JF, et al. Regions of focal DNA hypermethylation and longrange hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet. 2012;44(1):40-46.
    • (2012) Nat Genet , vol.44 , Issue.1 , pp. 40-46
    • Berman, B.P.1    Weisenberger, D.J.2    Aman, J.F.3
  • 11
    • 70349263849 scopus 로고    scopus 로고
    • TGFbetaR2 aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma
    • de Carvalho F, Colleoni GW, Almeida MS, Carvalho AL, Vettore AL. TGFbetaR2 aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma. Int J Cancer. 2009;125(8):1985-1991.
    • (2009) Int J Cancer , vol.125 , Issue.8 , pp. 1985-1991
    • De Carvalho, F.1    Colleoni, G.W.2    Almeida, M.S.3    Carvalho, A.L.4    Vettore, A.L.5
  • 14
    • 84871437541 scopus 로고    scopus 로고
    • DNA methylation in multiple myeloma is weakly associated with gene transcription
    • Jung S, Kim S, Gale M, et al. DNA methylation in multiple myeloma is weakly associated with gene transcription. PLoS ONE. 2012;7(12):e52626.
    • (2012) PLoS ONE , vol.7 , Issue.12
    • Jung, S.1    Kim, S.2    Gale, M.3
  • 15
    • 78650174738 scopus 로고    scopus 로고
    • Haematological oncology clinical study group. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC myeloma IX): A randomised controlled trial
    • National Cancer Research Institute
    • Morgan GJ, Davies FE, Gregory WM, et al; National Cancer Research Institute Haematological Oncology Clinical Study Group. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Lancet. 2010;376(9757):1989-1999.
    • (2010) Lancet , vol.376 , Issue.9757 , pp. 1989-1999
    • Morgan, G.J.1    Davies, F.E.2    Gregory, W.M.3
  • 16
    • 84887924545 scopus 로고    scopus 로고
    • Longterm follow-up of patients with multiple myeloma receiving bisphosphonates in conjunction with antimyeloma therapy: MRC Myeloma IX study
    • June. Amsterdam
    • Morgan GJ, Graham J, Davies FE, et al. Longterm follow-up of patients with multiple myeloma receiving bisphosphonates in conjunction with antimyeloma therapy: MRC Myeloma IX study. 17th Congress of European Hematology Association. June 14-17, 2012. Amsterdam.
    • (2012) 17th Congress of European Hematology Association , pp. 14-17
    • Morgan, G.J.1    Graham, J.2    Davies, F.E.3
  • 17
    • 84856706335 scopus 로고    scopus 로고
    • NCRI Haematology Oncology Studies Group. A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: Analysis of patients treated in the MRC Myeloma IX trial
    • Boyd KD, Ross FM, Chiecchio L, et al; NCRI Haematology Oncology Studies Group. A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial. Leukemia. 2012;26(2):349-355.
    • (2012) Leukemia , vol.26 , Issue.2 , pp. 349-355
    • Boyd, K.D.1    Ross, F.M.2    Chiecchio, L.3
  • 18
    • 77949686098 scopus 로고    scopus 로고
    • Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcome
    • Dickens NJ, Walker BA, Leone PE, et al. Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcome. Clin Cancer Res. 2010;16(6): 1856-1864.
    • (2010) Clin Cancer Res , vol.16 , Issue.6 , pp. 1856-1864
    • Dickens, N.J.1    Walker, B.A.2    Leone, P.E.3
  • 19
    • 79955583542 scopus 로고    scopus 로고
    • Mapping and analysis of chromatin state dynamics in nine human cell types
    • Ernst J, Kheradpour P, Mikkelsen TS, et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature. 2011; 473(7345):43-49.
    • (2011) Nature , vol.473 , Issue.7345 , pp. 43-49
    • Ernst, J.1    Kheradpour, P.2    Mikkelsen, T.S.3
  • 21
    • 74949107707 scopus 로고    scopus 로고
    • Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma
    • Chen L, Wang S, Zhou Y, et al. Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma. Blood. 2010;115(1):61-70.
    • (2010) Blood , vol.115 , Issue.1 , pp. 61-70
    • Chen, L.1    Wang, S.2    Zhou, Y.3
  • 23
    • 80054115013 scopus 로고    scopus 로고
    • Significant biological role of sp1 transactivation in multiple myeloma
    • Fulciniti M, Amin S, Nanjappa P, et al. Significant biological role of sp1 transactivation in multiple myeloma. Clin Cancer Res. 2011;17(20): 6500-6509.
    • (2011) Clin Cancer Res , vol.17 , Issue.20 , pp. 6500-6509
    • Fulciniti, M.1    Amin, S.2    Nanjappa, P.3
  • 24
    • 84863337757 scopus 로고    scopus 로고
    • Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
    • Tsai HC, Li H, Van Neste L, et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell. 2012;21(3):430-446.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 430-446
    • Tsai, H.C.1    Li, H.2    Van Neste, L.3
  • 26
    • 67650381828 scopus 로고    scopus 로고
    • Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma
    • Nojima M, Maruyama R, Yasui H, et al. Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma. Clin Cancer Res. 2009;15(13): 4356-4364.
    • (2009) Clin Cancer Res , vol.15 , Issue.13 , pp. 4356-4364
    • Nojima, M.1    Maruyama, R.2    Yasui, H.3
  • 27
    • 79958140475 scopus 로고    scopus 로고
    • TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells
    • Wen G, Partridge MA, Li B, et al. TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells. Cancer Lett. 2011;308(1):23-32.
    • (2011) Cancer Lett , vol.308 , Issue.1 , pp. 23-32
    • Wen, G.1    Partridge, M.A.2    Li, B.3
  • 29
    • 84862808609 scopus 로고    scopus 로고
    • TGFBI promoter hypermethylation correlating with paclitaxel chemoresistance in ovarian cancer
    • Wang N, Zhang H, Yao Q, Wang Y, Dai S, Yang X. TGFBI promoter hypermethylation correlating with paclitaxel chemoresistance in ovarian cancer. J Exp Clin Cancer Res. 2012;31:6.
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 6
    • Wang, N.1    Zhang, H.2    Yao, Q.3    Wang, Y.4    Dai, S.5    Yang, X.6
  • 31
    • 84863105129 scopus 로고    scopus 로고
    • Blockade of SOX4 mediated DNA repair by SPARC enhances radioresponse in medulloblastoma
    • Chetty C, Dontula R, Gujrati M, Dinh DH, Lakka SS. Blockade of SOX4 mediated DNA repair by SPARC enhances radioresponse in medulloblastoma. Cancer Lett. 2012;323(2): 188-198.
    • (2012) Cancer Lett , vol.323 , Issue.2 , pp. 188-198
    • Chetty, C.1    Dontula, R.2    Gujrati, M.3    Dinh, D.H.4    Lakka, S.S.5
  • 32
    • 84860477076 scopus 로고    scopus 로고
    • SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT
    • Bhoopathi P, Gorantla B, Sailaja GS, et al. SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT. PLoS ONE. 2012;7(5):e36093.
    • (2012) PLoS ONE , vol.7 , Issue.5
    • Bhoopathi, P.1    Gorantla, B.2    Sailaja, G.S.3
  • 33
    • 34548128327 scopus 로고    scopus 로고
    • Common deleted genes in the 5q-syndrome: Thrombocytopenia and reduced erythroid colony formation in SPARC null mice
    • DOI 10.1038/sj.leu.2404852, PII 2404852
    • Lehmann S, O'Kelly J, Raynaud S, Funk SE, Sage EH, Koeffler HP. Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice. Leukemia. 2007;21(9):1931-1936. (Pubitemid 47299966)
    • (2007) Leukemia , vol.21 , Issue.9 , pp. 1931-1936
    • Lehmann, S.1    O'Kelly, J.2    Raynaud, S.3    Funk, S.E.4    Sage, E.H.5    Koeffler, H.P.6
  • 36
    • 84860875552 scopus 로고    scopus 로고
    • P53-induced gene 3 mediates cell death induced by glutathione peroxidase 3
    • Wang H, Luo K, Tan LZ, et al. p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3. J Biol Chem. 2012;287(20): 16890-16902.
    • (2012) J Biol Chem , vol.287 , Issue.20 , pp. 16890-16902
    • Wang, H.1    Luo, K.2    Tan, L.Z.3
  • 37
    • 79959838676 scopus 로고    scopus 로고
    • GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response
    • Chen B, Rao X, House MG, Nephew KP, Cullen KJ, Guo Z. GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response. Cancer Lett. 2011;309(1):37-45.
    • (2011) Cancer Lett , vol.309 , Issue.1 , pp. 37-45
    • Chen, B.1    Rao, X.2    House, M.G.3    Nephew, K.P.4    Cullen, K.J.5    Guo, Z.6
  • 39
    • 70149089770 scopus 로고    scopus 로고
    • RARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma
    • Wang S, Tricot G, Shi L, et al. RARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma. Blood. 2009;114(3): 600-607.
    • (2009) Blood , vol.114 , Issue.3 , pp. 600-607
    • Wang, S.1    Tricot, G.2    Shi, L.3
  • 40
    • 0032757641 scopus 로고    scopus 로고
    • Inhibition of myeloma cell growth by all-trans retinoic acid is associated with upregulation of p21WAF1 and dephosphorylation of the retinoblastoma protein
    • Lavelle D, Chen YH, Hankewych M, Desimone J. Inhibition of myeloma cell growth by all-trans retinoic acid is associated with upregulation of p21WAF1 and dephosphorylation of the retinoblastoma protein. Leuk Lymphoma. 1999; 35(3-4):261-268.
    • (1999) Leuk Lymphoma , vol.35 , Issue.3-4 , pp. 261-268
    • Lavelle, D.1    Chen, Y.H.2    Hankewych, M.3    Desimone, J.4
  • 41
    • 33846940740 scopus 로고    scopus 로고
    • Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid
    • DOI 10.3324/haematol.10300
    • Sanda T, Iida S, Kayukawa S, Ueda R. Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007;92(1):115-120. (Pubitemid 46232665)
    • (2007) Haematologica , vol.92 , Issue.1 , pp. 115-120
    • Sanda, T.1    Iida, S.2    Kayukawa, S.3    Ueda, R.4
  • 42
    • 84867501402 scopus 로고    scopus 로고
    • A retinoic acid-rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(1) T cells
    • Guo Y, Pino-Lagos K, Ahonen CA, et al. A retinoic acid-rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(1) T cells. Cancer Res. 2012;72(20):5230-5239.
    • (2012) Cancer Res , vol.72 , Issue.20 , pp. 5230-5239
    • Guo, Y.1    Pino-Lagos, K.2    Ahonen, C.A.3
  • 45
    • 0842301527 scopus 로고    scopus 로고
    • Prognostic significance of surface markers expressed in multiple myeloma: CD56 and other antigens
    • DOI 10.1080/1042819031000149377
    • Sahara N, Takeshita A. Prognostic significance of surface markers expressed in multiple myeloma: CD56 and other antigens. Leuk Lymphoma. 2004; 45(1):61-65. (Pubitemid 38181394)
    • (2004) Leukemia and Lymphoma , vol.45 , Issue.1 , pp. 61-65
    • Sahara, N.1    Takeshita, A.2
  • 47
    • 83255188897 scopus 로고    scopus 로고
    • Polycombrepressed genes have permissive enhancers that initiate reprogramming
    • Taberlay PC, Kelly TK, Liu CC, et al. Polycombrepressed genes have permissive enhancers that initiate reprogramming. Cell. 2011;147(6): 1283-1294.
    • (2011) Cell , vol.147 , Issue.6 , pp. 1283-1294
    • Taberlay, P.C.1    Kelly, T.K.2    Liu, C.C.3
  • 48
    • 84866370627 scopus 로고    scopus 로고
    • A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors
    • Vicente-Duenãs C, Romero-Camarero I, González-Herrero I, et al. A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors. EMBO J. 2012; 31(18):3704-3717.
    • (2012) EMBO J , vol.31 , Issue.18 , pp. 3704-3717
    • Vicente-Duenãs, C.1    Romero-Camarero, I.2    González-Herrero, I.3
  • 49
    • 80051589767 scopus 로고    scopus 로고
    • Selfrenewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia
    • Kikushige Y, Ishikawa F, Miyamoto T, et al. Selfrenewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell. 2011;20(2): 246-259.
    • (2011) Cancer Cell , vol.20 , Issue.2 , pp. 246-259
    • Kikushige, Y.1    Ishikawa, F.2    Miyamoto, T.3
  • 50
    • 84867709361 scopus 로고    scopus 로고
    • The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
    • Dominguez-Sola D, Victora GD, Ying CY, et al. The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol. 2012;13(11):1083-1091.
    • (2012) Nat Immunol , vol.13 , Issue.11 , pp. 1083-1091
    • Dominguez-Sola, D.1    Victora, G.D.2    Ying, C.Y.3


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