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Volumn 28, Issue 1, 2014, Pages 1-14

Origins of aberrant DNA methylation in acute myeloid leukemia

Author keywords

AML; DNA methylation; epigenetics; pathogenesis; transcription factor

Indexed keywords

COHESIN; DNA METHYLTRANSFERASE 3A; REGULATOR PROTEIN; TRANSCRIPTION FACTOR;

EID: 84891842006     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.242     Document Type: Review
Times cited : (96)

References (137)
  • 1
    • 0016439429 scopus 로고
    • DNA modification mechanisms and gene activity during development
    • Holliday R, Pugh JE. DNA modification mechanisms and gene activity during development. Science 1975; 187: 226-232.
    • (1975) Science , vol.187 , pp. 226-232
    • Holliday, R.1    Pugh, J.E.2
  • 2
    • 0016692220 scopus 로고
    • X inactivation, differentiation, and DNA methylation
    • Riggs AD. X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet 1975; 14: 9-25.
    • (1975) Cytogenet Cell Genet , vol.14 , pp. 9-25
    • Riggs, A.D.1
  • 3
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004; 4: 143-153. (Pubitemid 38198742)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 4
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 2012; 13: 484-492.
    • (2012) Nat Rev Genet , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 6
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P et al. The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 2009; 41: 178-186.
    • (2009) Nat Genet , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5    Onyango, P.6
  • 8
    • 84864031521 scopus 로고    scopus 로고
    • Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
    • Akalin A, Garrett-Bakelman FE, Kormaksson M, Busuttil J, Zhang L, Khrebtukova I et al. Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet 2012; 8: e1002781.
    • (2012) PLoS Genet , vol.8
    • Akalin, A.1    Garrett-Bakelman, F.E.2    Kormaksson, M.3    Busuttil, J.4    Zhang, L.5    Khrebtukova, I.6
  • 9
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059-2074.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 10
    • 84872089137 scopus 로고    scopus 로고
    • DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding
    • Schoofs T, Rohde C, Hebestreit K, Klein HU, Gollner S, Schulze I et al. DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding. Blood 2013; 121: 178-187.
    • (2013) Blood , vol.121 , pp. 178-187
    • Schoofs, T.1    Rohde, C.2    Hebestreit, K.3    Klein, H.U.4    Gollner, S.5    Schulze, I.6
  • 13
  • 14
    • 84866378702 scopus 로고    scopus 로고
    • The role of mutations in epigenetic regulators in myeloid malignancies
    • Shih AH, Abdel-Wahab O, Patel JP, Levine RL. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer 2012; 12: 599-612.
    • (2012) Nat Rev Cancer , vol.12 , pp. 599-612
    • Shih, A.H.1    Abdel-Wahab, O.2    Patel, J.P.3    Levine, R.L.4
  • 16
    • 84865520089 scopus 로고    scopus 로고
    • IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
    • Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brustle A et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature 2012; 488: 656-659.
    • (2012) Nature , vol.488 , pp. 656-659
    • Sasaki, M.1    Knobbe, C.B.2    Munger, J.C.3    Lind, E.F.4    Brenner, D.5    Brustle, A.6
  • 17
    • 84868208186 scopus 로고    scopus 로고
    • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
    • Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet 2012; 44: 1179-1181.
    • (2012) Nat Genet , vol.44 , pp. 1179-1181
    • Busque, L.1    Patel, J.P.2    Figueroa, M.E.3    Vasanthakumar, A.4    Provost, S.5    Hamilou, Z.6
  • 18
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011; 43: 309-315.
    • (2011) Nat Genet , vol.43 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Zh, G.3    Pan, C.M.4    Lu, G.5    Shen, Y.6
  • 19
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010; 18: 553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 22
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • DOI 10.1038/nrc2253, PII NRC2253
    • Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 2007; 7: 823-833. (Pubitemid 350006257)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.11 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 24
    • 84867562009 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in tumorigenesis: Mechanistic insights and clinical perspectives
    • Yang H, Ye D, Guan KL, Xiong Y. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin Cancer Res 2012; 18: 5562-5571.
    • (2012) Clin Cancer Res , vol.18 , pp. 5562-5571
    • Yang, H.1    Ye, D.2    Guan, K.L.3    Xiong, Y.4
  • 28
    • 84655162785 scopus 로고    scopus 로고
    • Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains
    • Berman BP, Weisenberger DJ, Aman JF, Hinoue T, Ramjan Z, Liu Y et al. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet 2012; 44: 40-46.
    • (2012) Nat Genet , vol.44 , pp. 40-46
    • Berman, B.P.1    Weisenberger, D.J.2    Aman, J.F.3    Hinoue, T.4    Ramjan, Z.5    Liu, Y.6
  • 29
    • 77952966794 scopus 로고    scopus 로고
    • Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping
    • Hsu PY, Hsu HK, Singer GA, Yan PS, Rodriguez BA, Liu JC et al. Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping. Genome Res 2010; 20: 733-744.
    • (2010) Genome Res , vol.20 , pp. 733-744
    • Hsu, P.Y.1    Hsu, H.K.2    Singer, G.A.3    Yan, P.S.4    Rodriguez, B.A.5    Liu, J.C.6
  • 30
    • 33646369393 scopus 로고    scopus 로고
    • Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band
    • Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA, Clark SJ. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet 2006; 38: 540-549.
    • (2006) Nat Genet , vol.38 , pp. 540-549
    • Frigola, J.1    Song, J.2    Stirzaker, C.3    Hinshelwood, R.A.4    Peinado, M.A.5    Clark, S.J.6
  • 33
  • 34
    • 84872806231 scopus 로고    scopus 로고
    • Genome-wide methylation profiles reveal quantitative views of human aging rates
    • Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 2013; 49: 359-367.
    • (2013) Mol Cell , vol.49 , pp. 359-367
    • Hannum, G.1    Guinney, J.2    Zhao, L.3    Zhang, L.4    Hughes, G.5    Sadda, S.6
  • 35
    • 84875965163 scopus 로고    scopus 로고
    • Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    • Beerman I, Bock C, Garrison BS, Smith ZD, Gu H, Meissner A et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 2013; 12: 413-425.
    • (2013) Cell Stem Cell , vol.12 , pp. 413-425
    • Beerman, I.1    Bock, C.2    Garrison, B.S.3    Smith, Z.D.4    Gu, H.5    Meissner, A.6
  • 36
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010; 468: 839-843.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3    Pape, U.J.4    Tahiliani, M.5    Bandukwala, H.S.6
  • 37
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: Roles in mammalian development
    • Smith ZD, Meissner A. DNA methylation: roles in mammalian development. Nat Rev Genet 2013; 14: 204-220.
    • (2013) Nat Rev Genet , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 38
    • 79960891281 scopus 로고    scopus 로고
    • DNA methylation as a pathogenic event and as a therapeutic target in AML
    • Schoofs T, Muller-Tidow C. DNA methylation as a pathogenic event and as a therapeutic target in AML. Cancer Treat Rev 2011; 37(Suppl 1): S13-S18.
    • (2011) Cancer Treat Rev , vol.37 , Issue.SUPPL. 1
    • Schoofs, T.1    Muller-Tidow, C.2
  • 39
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • DOI 10.1038/sj.onc.1205651
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 2002; 21: 5400-5413. (Pubitemid 34983477)
    • (2002) Oncogene , vol.21 , Issue.35 , pp. 5400-5413
    • Ehrlich, M.1
  • 40
    • 77449157068 scopus 로고    scopus 로고
    • Quantitative DNA methylation predicts survival in adult acute myeloid leukemia
    • Bullinger L, Ehrich M, Dohner K, Schlenk RF, Dohner H, Nelson MR et al. Quantitative DNA methylation predicts survival in adult acute myeloid leukemia. Blood 2010; 115: 636-642.
    • (2010) Blood , vol.115 , pp. 636-642
    • Bullinger, L.1    Ehrich, M.2    Dohner, K.3    Schlenk, R.F.4    Dohner, H.5    Nelson, M.R.6
  • 41
    • 77952331728 scopus 로고    scopus 로고
    • Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia
    • Deneberg S, Grovdal M, Karimi M, Jansson M, Nahi H, Corbacioglu A et al. Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia. Leukemia 2010; 24: 932-941.
    • (2010) Leukemia , vol.24 , pp. 932-941
    • Deneberg, S.1    Grovdal, M.2    Karimi, M.3    Jansson, M.4    Nahi, H.5    Corbacioglu, A.6
  • 42
    • 0034654269 scopus 로고    scopus 로고
    • Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: Potential prognostic implications
    • Wong IH, Ng MH, Huang DP, Lee JC. Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications. Blood 2000; 95: 1942-1949. (Pubitemid 30151630)
    • (2000) Blood , vol.95 , Issue.6 , pp. 1942-1949
    • Wong, I.H.N.1    Ng, M.H.L.2    Huang, D.P.3    Lee, J.C.K.4
  • 43
    • 18044374452 scopus 로고    scopus 로고
    • INK4b and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia
    • DOI 10.1016/j.leukres.2004.11.014
    • Shimamoto T, Ohyashiki JH, Ohyashiki K. Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia. Leuk Res 2005; 29: 653-659. (Pubitemid 40603565)
    • (2005) Leukemia Research , vol.29 , Issue.6 , pp. 653-659
    • Shimamoto, T.1    Ohyashiki, J.H.2    Ohyashiki, K.3
  • 45
    • 33847082188 scopus 로고    scopus 로고
    • DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia
    • Agrawal S, Unterberg M, Koschmieder S, zur Stadt U, Brunnberg U, Verbeek W et al. DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia. Cancer Res 2007; 67: 1370-1377.
    • (2007) Cancer Res , vol.67 , pp. 1370-1377
    • Agrawal, S.1    Unterberg, M.2    Koschmieder, S.3    Zur Stadt, U.4    Brunnberg, U.5    Verbeek, W.6
  • 46
    • 60849089645 scopus 로고    scopus 로고
    • Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
    • Jiang Y, Dunbar A, Gondek LP, Mohan S, Rataul M, O'Keefe C et al. Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood 2009; 113: 1315-1325.
    • (2009) Blood , vol.113 , pp. 1315-1325
    • Jiang, Y.1    Dunbar, A.2    Gondek, L.P.3    Mohan, S.4    Rataul, M.5    O'Keefe, C.6
  • 49
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC. Clonal evolution in cancer. Nature 2012; 481: 306-313.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 50
    • 84878900540 scopus 로고    scopus 로고
    • Clonal diversity of recurrently mutated genes in myelodysplastic syndromes
    • Walter MJ, Shen D, Shao J, Ding L, White BS, Kandoth C et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia 2013; 27: 1275-1282.
    • (2013) Leukemia , vol.27 , pp. 1275-1282
    • Walter, M.J.1    Shen, D.2    Shao, J.3    Ding, L.4    White, B.S.5    Kandoth, C.6
  • 52
  • 53
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 2012; 481: 506-510.
    • (2012) Nature , vol.481 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3    Miller, C.A.4    Koboldt, D.C.5    Welch, J.S.6
  • 54
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: Progress and promise
    • Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science 2011; 331: 1553-1558.
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 56
    • 84881086323 scopus 로고    scopus 로고
    • Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
    • Timp W, Feinberg AP. Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer 2013; 13: 497-510.
    • (2013) Nat Rev Cancer , vol.13 , pp. 497-510
    • Timp, W.1    Feinberg, A.P.2
  • 59
    • 70350654370 scopus 로고    scopus 로고
    • DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
    • Broske AM, Vockentanz L, Kharazi S, Huska MR, Mancini E, Scheller M et al. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet 2009; 41: 1207-1215.
    • (2009) Nat Genet , vol.41 , pp. 1207-1215
    • Broske, A.M.1    Vockentanz, L.2    Kharazi, S.3    Huska, M.R.4    Mancini, E.5    Scheller, M.6
  • 60
    • 77956902023 scopus 로고    scopus 로고
    • Comprehensive methylome map of lineage commitment from haematopoietic progenitors
    • Ji H, Ehrlich LI, Seita J, Murakami P, Doi A, Lindau P et al. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature 2010; 467: 338-342.
    • (2010) Nature , vol.467 , pp. 338-342
    • Ji, H.1    Ehrlich, L.I.2    Seita, J.3    Murakami, P.4    Doi, A.5    Lindau, P.6
  • 61
    • 0025145277 scopus 로고
    • 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes
    • Rideout 3rd WM, Coetzee GA, Olumi AF, Jones PA. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 1990; 249: 1288-1290.
    • (1990) Science , vol.249 , pp. 1288-1290
    • Rideout III, W.M.1    Coetzee, G.A.2    Olumi, A.F.3    Jones, P.A.4
  • 62
    • 0025875679 scopus 로고
    • The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
    • de The H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 1991; 66: 675-684. (Pubitemid 121001703)
    • (1991) Cell , vol.66 , Issue.4 , pp. 675-684
    • De The, H.1    Lavau, C.2    Marchio, A.3    Chomienne, C.4    Degos, L.5    Dejean, A.6
  • 63
    • 0029019659 scopus 로고
    • AML1 and the 8 21 and 3;21 translocations in acute and chronic myeloid leukemia
    • Nucifora G, Rowley JD. AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 1995; 86: 1-14.
    • (1995) Blood , vol.86 , pp. 1-14
    • Nucifora, G.1    Rowley, J.D.2
  • 64
    • 0037315894 scopus 로고    scopus 로고
    • Disruption of differentiation in human cancer: AML shows the way
    • DOI 10.1038/nrc989
    • Tenen DG. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 2003; 3: 89-101. (Pubitemid 37328876)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.2 , pp. 89-101
    • Tenen, D.G.1
  • 65
    • 77955134007 scopus 로고    scopus 로고
    • Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: Report from the International Microarray Innovations in Leukemia Study Group
    • Haferlach T, Kohlmann A, Wieczorek L, Basso G, Kronnie GT, Bene MC et al. Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol 2010; 28: 2529-2537.
    • (2010) J Clin Oncol , vol.28 , pp. 2529-2537
    • Haferlach, T.1    Kohlmann, A.2    Wieczorek, L.3    Basso, G.4    Kronnie, G.T.5    Bene, M.C.6
  • 66
    • 15844394270 scopus 로고    scopus 로고
    • An MII-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
    • DOI 10.1016/S0092-8674(00)81269-6
    • Corral J, Lavenir I, Impey H, Warren AJ, Forster A, Larson TA et al. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell 1996; 85: 853-861. (Pubitemid 26192136)
    • (1996) Cell , vol.85 , Issue.6 , pp. 853-861
    • Corral, J.1    Lavenir, I.2    Impey, H.3    Warren, A.J.4    Forster, A.5    Larson, T.A.6    Bell, S.7    McKenzie, A.N.J.8    King, G.9    Rabbitts, T.H.10
  • 67
    • 0034665765 scopus 로고    scopus 로고
    • Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model
    • Rhoades KL, Hetherington CJ, Harakawa N, Yergeau DA, Zhou L, Liu LQ et al. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood 2000; 96: 2108-2115.
    • (2000) Blood , vol.96 , pp. 2108-2115
    • Rhoades, K.L.1    Hetherington, C.J.2    Harakawa, N.3    Yergeau, D.A.4    Zhou, L.5    Liu, L.Q.6
  • 68
    • 0037020837 scopus 로고    scopus 로고
    • AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency
    • DOI 10.1084/jem.20020824
    • Schwieger M, Lohler J, Friel J, Scheller M, Horak I, Stocking C. AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J Exp Med 2002; 196: 1227-1240. (Pubitemid 35304188)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.9 , pp. 1227-1240
    • Schwieger, M.1    Lohler, J.2    Friel, J.3    Scheller, M.4    Horak, I.5    Stocking, C.6
  • 70
    • 79953323643 scopus 로고    scopus 로고
    • PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice
    • Welch JS, Yuan W, Ley TJ. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest 2011; 121: 1636-1645.
    • (2011) J Clin Invest , vol.121 , pp. 1636-1645
    • Welch, J.S.1    Yuan, W.2    Ley, T.J.3
  • 71
    • 68749105680 scopus 로고    scopus 로고
    • PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors
    • Wojiski S, Guibal FC, Kindler T, Lee BH, Jesneck JL, Fabian A et al. PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors. Leukemia 2009; 23: 1462-1471.
    • (2009) Leukemia , vol.23 , pp. 1462-1471
    • Wojiski, S.1    Guibal, F.C.2    Kindler, T.3    Lee, B.H.4    Jesneck, J.L.5    Fabian, A.6
  • 73
    • 84872290502 scopus 로고    scopus 로고
    • Outcome of elderly patients with acute promyelocytic leukemia: Results of the German Acute Myeloid Leukemia Cooperative Group
    • Lengfelder E, Hanfstein B, Haferlach C, Braess J, Krug U, Spiekermann K et al. Outcome of elderly patients with acute promyelocytic leukemia: results of the German Acute Myeloid Leukemia Cooperative Group. Ann Hematol 2013; 92: 41-52.
    • (2013) Ann Hematol , vol.92 , pp. 41-52
    • Lengfelder, E.1    Hanfstein, B.2    Haferlach, C.3    Braess, J.4    Krug, U.5    Spiekermann, K.6
  • 74
    • 78650983952 scopus 로고    scopus 로고
    • Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1
    • Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJ, Li Y et al. Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood 2011; 117: 234-241.
    • (2011) Blood , vol.117 , pp. 234-241
    • Lugthart, S.1    Figueroa, M.E.2    Bindels, E.3    Skrabanek, L.4    Valk, P.J.5    Li, Y.6
  • 76
    • 41949133411 scopus 로고    scopus 로고
    • Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip
    • Hoemme C, Peerzada A, Behre G, Wang Y, McClelland M, Nieselt K et al. Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip. Blood 2008; 111: 2887-2895.
    • (2008) Blood , vol.111 , pp. 2887-2895
    • Hoemme, C.1    Peerzada, A.2    Behre, G.3    Wang, Y.4    McClelland, M.5    Nieselt, K.6
  • 79
    • 84867800489 scopus 로고    scopus 로고
    • Chromatin accessibility, p300, and histone acetylation define PML-RARalpha and AML1-ETO binding sites in acute myeloid leukemia
    • Saeed S, Logie C, Francoijs KJ, Frige G, Romanenghi M, Nielsen FG et al. Chromatin accessibility, p300, and histone acetylation define PML-RARalpha and AML1-ETO binding sites in acute myeloid leukemia. Blood 2012; 120: 3058-3068.
    • (2012) Blood , vol.120 , pp. 3058-3068
    • Saeed, S.1    Logie, C.2    Francoijs, K.J.3    Frige, G.4    Romanenghi, M.5    Nielsen, F.G.6
  • 80
    • 77957928566 scopus 로고    scopus 로고
    • DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia
    • Alvarez S, Suela J, Valencia A, Fernandez A, Wunderlich M, Agirre X et al. DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia. PLoS One 2010; 5: e12197.
    • (2010) PLoS One , vol.5
    • Alvarez, S.1    Suela, J.2    Valencia, A.3    Fernandez, A.4    Wunderlich, M.5    Agirre, X.6
  • 81
    • 84859402912 scopus 로고    scopus 로고
    • Targeting epigenetic programs in MLL-rearranged leukemias
    • Bernt KM, Armstrong SA. Targeting epigenetic programs in MLL-rearranged leukemias. Hematol Am Soc Hematol Educ Prog 2011; 2011: 354-360.
    • (2011) Hematol Am Soc Hematol Educ Prog , vol.2011 , pp. 354-360
    • Bernt, K.M.1    Armstrong, S.A.2
  • 83
    • 84859458145 scopus 로고    scopus 로고
    • Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs
    • Maiques-Diaz A, Chou FS, Wunderlich M, Gomez-Lopez G, Jacinto FV, Rodriguez-Perales S et al. Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs. Leukemia 2012; 26: 1329-1337.
    • (2012) Leukemia , vol.26 , pp. 1329-1337
    • Maiques-Diaz, A.1    Chou, F.S.2    Wunderlich, M.3    Gomez-Lopez, G.4    Jacinto, F.V.5    Rodriguez-Perales, S.6
  • 84
    • 84864886346 scopus 로고    scopus 로고
    • Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding
    • Ptasinska A, Assi SA, Mannari D, James SR, Williamson D, Dunne J et al. Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding. Leukemia 2012; 26: 1829-1841.
    • (2012) Leukemia , vol.26 , pp. 1829-1841
    • Ptasinska, A.1    Assi, S.A.2    Mannari, D.3    James, S.R.4    Williamson, D.5    Dunne, J.6
  • 86
    • 76249120854 scopus 로고    scopus 로고
    • PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia
    • Wang K, Wang P, Shi J, Zhu X, He M, Jia X et al. PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell 2010; 17: 186-197.
    • (2010) Cancer Cell , vol.17 , pp. 186-197
    • Wang, K.1    Wang, P.2    Shi, J.3    Zhu, X.4    He, M.5    Jia, X.6
  • 87
    • 84355163093 scopus 로고    scopus 로고
    • DNA-binding factors shape the mouse methylome at distal regulatory regions
    • Stadler MB, Murr R, Burger L, Ivanek R, Lienert F, Scholer A et al. DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature 2011; 480: 490-495.
    • (2011) Nature , vol.480 , pp. 490-495
    • Stadler, M.B.1    Murr, R.2    Burger, L.3    Ivanek, R.4    Lienert, F.5    Scholer, A.6
  • 88
    • 44049086446 scopus 로고    scopus 로고
    • Cooperating gene mutations in acute myeloid leukemia: A review of the literature
    • DOI 10.1038/leu.2008.19, PII LEU200819
    • Renneville A, Roumier C, Biggio V, Nibourel O, Boissel N, Fenaux P et al. Cooperating gene mutations in acute myeloid leukemia: a review of the literature. Leukemia 2008; 22: 915-931. (Pubitemid 351709343)
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 915-931
    • Renneville, A.1    Roumier, C.2    Biggio, V.3    Nibourel, O.4    Boissel, N.5    Fenaux, P.6    Preudhomme, C.7
  • 90
    • 15044358998 scopus 로고    scopus 로고
    • CEBPA point mutations in hematological malignancies
    • DOI 10.1038/sj.leu.2403614
    • Leroy H, Roumier C, Huyghe P, Biggio V, Fenaux P, Preudhomme C. CEBPA point mutations in hematological malignancies. Leukemia 2005; 19: 329-334. (Pubitemid 40409478)
    • (2005) Leukemia , vol.19 , Issue.3 , pp. 329-334
    • Leroy, H.1    Roumier, C.2    Huyghe, P.3    Biggio, V.4    Fenaux, P.5    Preudhomme, C.6
  • 91
    • 2442478144 scopus 로고    scopus 로고
    • PML-RARA-RXR Oligomers Mediate Retinoid and Rexinoid/cAMP Cross-Talk in Acute Promyelocytic Leukemia Cell Differentiation
    • DOI 10.1084/jem.20032226
    • Kamashev D, Vitoux D, De The H. PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation. J Exp Med 2004; 199: 1163-1174. (Pubitemid 38619912)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.8 , pp. 1163-1174
    • Kamashev, D.1    Vitoux, D.2    De The, H.3
  • 93
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010; 17: 225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6
  • 95
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011; 19: 17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6
  • 96
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011; 333: 1300-1303.
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6
  • 97
    • 84555189745 scopus 로고    scopus 로고
    • DNA methylation: TET proteins-guardians of CpG islands
    • Williams K, Christensen J, Helin K. DNA methylation: TET proteins-guardians of CpG islands EMBO Rep 2012; 13: 28-35.
    • (2012) EMBO Rep , vol.13 , pp. 28-35
    • Williams, K.1    Christensen, J.2    Helin, K.3
  • 98
    • 80052933429 scopus 로고    scopus 로고
    • DNA demethylation dynamics
    • Bhutani N, Burns DM, Blau HM. DNA demethylation dynamics. Cell 2011; 146: 866-872.
    • (2011) Cell , vol.146 , pp. 866-872
    • Bhutani, N.1    Burns, D.M.2    Blau, H.M.3
  • 99
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    • Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 2011; 20: 11-24.
    • (2011) Cancer Cell , vol.20 , pp. 11-24
    • Moran-Crusio, K.1    Reavie, L.2    Shih, A.3    Abdel-Wahab, O.4    Ndiaye-Lobry, D.5    Lobry, C.6
  • 100
    • 84875496294 scopus 로고    scopus 로고
    • (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
    • Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 2013; 339: 1621-1625.
    • (2013) Science , vol.339 , pp. 1621-1625
    • Losman, J.A.1    Looper, R.E.2    Koivunen, P.3    Lee, S.4    Schneider, R.K.5    McMahon, C.6
  • 101
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • DOI 10.1146/annurev.biochem.74.010904.153721
    • Goll MG, Bestor TH. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 2005; 74: 481-514. (Pubitemid 40995515)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 102
    • 84866077973 scopus 로고    scopus 로고
    • Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation
    • Holz-Schietinger C, Matje DM, Reich NO. Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation. J Biol Chem 2012; 287: 30941-30951.
    • (2012) J Biol Chem , vol.287 , pp. 30941-30951
    • Holz-Schietinger, C.1    Matje, D.M.2    Reich, N.O.3
  • 104
    • 34247337999 scopus 로고    scopus 로고
    • De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
    • DOI 10.1084/jem.20060750
    • Tadokoro Y, Ema H, Okano M, Li E, Nakauchi H. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med 2007; 204: 715-722. (Pubitemid 46631602)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.4 , pp. 715-722
    • Tadokoro, Y.1    Ema, H.2    Okano, M.3    Li, E.4    Nakauchi, H.5
  • 105
  • 106
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 107
    • 63549135460 scopus 로고    scopus 로고
    • Meta-analysis of age-related gene expression profiles identifies common signatures of aging
    • de Magalhaes JP, Curado J, Church GM. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 2009; 25: 875-881.
    • (2009) Bioinformatics , vol.25 , pp. 875-881
    • De Magalhaes, J.P.1    Curado, J.2    Church, G.M.3
  • 109
    • 70149099610 scopus 로고    scopus 로고
    • Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    • Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 2009; 5: e1000602.
    • (2009) PLoS Genet , vol.5
    • Christensen, B.C.1    Houseman, E.A.2    Marsit, C.J.3    Zheng, S.4    Wrensch, M.R.5    Wiemels, J.L.6
  • 110
    • 84860572791 scopus 로고    scopus 로고
    • Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
    • Bell JT, Tsai PC, Yang TP, Pidsley R, Nisbet J, Glass D et al. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 2012; 8: e1002629.
    • (2012) PLoS Genet , vol.8
    • Bell, J.T.1    Tsai, P.C.2    Yang, T.P.3    Pidsley, R.4    Nisbet, J.5    Glass, D.6
  • 114
    • 70549104872 scopus 로고    scopus 로고
    • Dynamic DNA methylation programs persistent adverse effects of early-life stress
    • Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmuhl Y, Fischer D et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009; 12: 1559-1566.
    • (2009) Nat Neurosci , vol.12 , pp. 1559-1566
    • Murgatroyd, C.1    Patchev, A.V.2    Wu, Y.3    Micale, V.4    Bockmuhl, Y.5    Fischer, D.6
  • 115
    • 60749094831 scopus 로고    scopus 로고
    • Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    • Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N et al. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 2009; 323: 1074-1077.
    • (2009) Science , vol.323 , pp. 1074-1077
    • Ma, D.K.1    Jang, M.H.2    Guo, J.U.3    Kitabatake, Y.4    Chang, M.L.5    Pow-Anpongkul, N.6
  • 116
    • 84866740172 scopus 로고    scopus 로고
    • Environmental epigenetics: Prospects for studying epigenetic mediation of exposure-response relationships
    • Cortessis VK, Thomas DC, Levine AJ, Breton CV, Mack TM, Siegmund KD et al. Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet 2012; 131: 1565-1589.
    • (2012) Hum Genet , vol.131 , pp. 1565-1589
    • Cortessis, V.K.1    Thomas, D.C.2    Levine, A.J.3    Breton, C.V.4    MacK, T.M.5    Siegmund, K.D.6
  • 118
    • 77649271805 scopus 로고    scopus 로고
    • Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity
    • Coolen MW, Stirzaker C, Song JZ, Statham AL, Kassir Z, Moreno CS et al. Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol 2010; 12: 235-246.
    • (2010) Nat Cell Biol , vol.12 , pp. 235-246
    • Coolen, M.W.1    Stirzaker, C.2    Song, J.Z.3    Statham, A.L.4    Kassir, Z.5    Moreno, C.S.6
  • 119
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • DOI 10.1038/ng1598
    • Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, Lam WL et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 2005; 37: 853-862. (Pubitemid 41077111)
    • (2005) Nature Genetics , vol.37 , Issue.8 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5    Lam, W.L.6    Schubeler, D.7
  • 120
    • 84872382158 scopus 로고    scopus 로고
    • Epigenetic abnormalities in cancer find a home on the range
    • Easwaran H, Baylin SB. Epigenetic abnormalities in cancer find a "home on the range". Cancer Cell 2013; 23: 1-3.
    • (2013) Cancer Cell , vol.23 , pp. 1-3
    • Easwaran, H.1    Baylin, S.B.2
  • 121
    • 0035316574 scopus 로고    scopus 로고
    • Chromosome territories, nuclear architecture and gene regulation in mammalian cells
    • DOI 10.1038/35066075
    • Cremer T, Cremer C. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat Rev Genet 2001; 2: 292-301. (Pubitemid 33674777)
    • (2001) Nature Reviews Genetics , vol.2 , Issue.4 , pp. 292-301
    • Cremer, T.1    Cremer, C.2
  • 125
    • 78751693154 scopus 로고    scopus 로고
    • Replication timing-related and gene body-specific methylation of active human genes
    • Aran D, Toperoff G, Rosenberg M, Hellman A. Replication timing-related and gene body-specific methylation of active human genes. Hum Mol Genet 2011; 20: 670-680.
    • (2011) Hum Mol Genet , vol.20 , pp. 670-680
    • Aran, D.1    Toperoff, G.2    Rosenberg, M.3    Hellman, A.4
  • 126
  • 127
    • 84873702853 scopus 로고    scopus 로고
    • Cohesin, a chromatin engagement ring
    • Remeseiro S, Losada A. Cohesin, a chromatin engagement ring. Curr Opin Cell Biol 2013; 25: 63-71.
    • (2013) Curr Opin Cell Biol , vol.25 , pp. 63-71
    • Remeseiro, S.1    Losada, A.2
  • 128
    • 84862859738 scopus 로고    scopus 로고
    • The specific contributions of cohesin-SA1 to cohesion and gene expression: Implications for cancer and development
    • Cuadrado A, Remeseiro S, Gomez-Lopez G, Pisano DG, Losada A. The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development. Cell Cycle 2012; 11: 2233-2238.
    • (2012) Cell Cycle , vol.11 , pp. 2233-2238
    • Cuadrado, A.1    Remeseiro, S.2    Gomez-Lopez, G.3    Pisano, D.G.4    Losada, A.5
  • 131
    • 84884180546 scopus 로고    scopus 로고
    • Perspectives and future directions for epigenetics in hematology
    • Goodell MA, Godley LA. Perspectives and future directions for epigenetics in hematology. Blood 2013; 121: 5131-5137.
    • (2013) Blood , vol.121 , pp. 5131-5137
    • Goodell, M.A.1    Godley, L.A.2
  • 133
    • 84890437337 scopus 로고    scopus 로고
    • Towards personalized therapy in AML: In vivo benefit of targeting aberrant epigenetics in MLL-PTD-associated AML
    • Bernot KM, Siebenaler RF, Whitman SP, Zorko NA, Marcucci GG, Santhanam R et al. Towards personalized therapy in AML: in vivo benefit of targeting aberrant epigenetics in MLL-PTD-associated AML. Leukemia 2013; 27: 2379-2382.
    • (2013) Leukemia , vol.27 , pp. 2379-2382
    • Bernot, K.M.1    Siebenaler, R.F.2    Whitman, S.P.3    Zorko, N.A.4    Marcucci, G.G.5    Santhanam, R.6
  • 134
    • 84871769515 scopus 로고    scopus 로고
    • Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia-A randomised SAL pilot study
    • Krug U, Koschmieder A, Schwammbach D, Gerss J, Tidow N, Steffen B et al. Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia-a randomised SAL pilot study. PLoS ONE 2012; 7: e52695.
    • (2012) PLoS ONE , vol.7
    • Krug, U.1    Koschmieder, A.2    Schwammbach, D.3    Gerss, J.4    Tidow, N.5    Steffen, B.6
  • 135
    • 84862777766 scopus 로고    scopus 로고
    • Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
    • Schenk T, Chen WC, Gollner S, Howell L, Jin L, Hebestreit K et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 2012; 18: 605-611.
    • (2012) Nat Med , vol.18 , pp. 605-611
    • Schenk, T.1    Chen, W.C.2    Gollner, S.3    Howell, L.4    Jin, L.5    Hebestreit, K.6
  • 137
    • 79951681879 scopus 로고    scopus 로고
    • Genome-wide functions of PMLRARalpha in acute promyelocytic leukaemia
    • Saeed S, Logie C, Stunnenberg HG, Martens JH. Genome-wide functions of PMLRARalpha in acute promyelocytic leukaemia. Br J Cancer 2011; 104: 554-558.
    • (2011) Br J Cancer , vol.104 , pp. 554-558
    • Saeed, S.1    Logie, C.2    Stunnenberg, H.G.3    Martens, J.H.4


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