메뉴 건너뛰기




Volumn 13, Issue 7, 2013, Pages 497-510

Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; DNA; LAMIN ASSOCIATED DOMAIN PROTEIN; LARGE ORGANIZED CHROMATIN LYSINE MODIFICATION PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

EID: 84881086323     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3486     Document Type: Review
Times cited : (473)

References (196)
  • 1
    • 0015108960 scopus 로고
    • Isozymes in cancer
    • Weinhouse, S. Isozymes in cancer. Cancer Res. 31, 1166-1167 (1971).
    • (1971) Cancer Res. , vol.31 , pp. 1166-1167
    • Weinhouse, S.1
  • 2
    • 0020132123 scopus 로고
    • Isolation of a transforming sequence from a human bladder carcinoma cell line
    • Shih, C. & Weinberg, R. A. Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell 29, 161-169 (1982).
    • (1982) Cell , vol.29 , pp. 161-169
    • Shih, C.1    Weinberg, R.A.2
  • 3
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg, A. P. & Vogelstein, B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301, 89-92 (1983).
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 4
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson, A. G. Mutation and cancer: Statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA 68, 820-823 (1971).
    • (1971) Proc. Natl Acad. Sci. USA , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 5
    • 0024365892 scopus 로고
    • Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
    • Greger, V., Passarge, E., Hopping, W., Messmer, E. & Horsthemke, B. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum. Genet. 83, 155-158 (1989).
    • (1989) Hum. Genet. , vol.83 , pp. 155-158
    • Greger, V.1    Passarge, E.2    Hopping, W.3    Messmer, E.4    Horsthemke, B.5
  • 6
    • 0025891856 scopus 로고
    • Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene
    • Sakai, T. et al. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Amer. J. Hum. Genet. 48, 880-888 (1991).
    • (1991) Amer. J. Hum. Genet. , vol.48 , pp. 880-888
    • Sakai, T.1
  • 7
    • 79960927422 scopus 로고    scopus 로고
    • Increased methylation variation in epigenetic domains across cancer types
    • Hansen, K. D. et al. Increased methylation variation in epigenetic domains across cancer types. Nature Genet. 43, 768-775 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 768-775
    • Hansen, K.D.1
  • 10
    • 73949123695 scopus 로고    scopus 로고
    • The role of nuclear organization in cancer
    • Lever, E. & Sheer, D. The role of nuclear organization in cancer. J. Pathol. 220, 114-125 (2010).
    • (2010) J. Pathol. , vol.220 , pp. 114-125
    • Lever, E.1    Sheer, D.2
  • 11
    • 59149083658 scopus 로고    scopus 로고
    • Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells
    • Wen, B., Wu, H., Shinkai, Y., Irizarry, R. A. & Feinberg, A. P. Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nature Genet. 41, 246-250 (2009).
    • (2009) Nature Genet. , vol.41 , pp. 246-250
    • Wen, B.1    Wu, H.2    Shinkai, Y.3    Irizarry, R.A.4    Feinberg, A.P.5
  • 12
    • 84862639469 scopus 로고    scopus 로고
    • DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina
    • Zullo, J. M. et al. DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell 149, 1474-1487 (2012).
    • (2012) Cell , vol.149 , pp. 1474-1487
    • Zullo, J.M.1
  • 13
    • 84555208832 scopus 로고    scopus 로고
    • Large chromatin domains in pluripotent and differentiated cells
    • Hu, S., Cheng, L. & Wen, B. Large chromatin domains in pluripotent and differentiated cells. Acta Biochim. Biophys. Sin. (Shanghai) 44, 48-53 (2012).
    • (2012) Acta Biochim. Biophys. Sin. (Shanghai) , vol.44 , pp. 48-53
    • Hu, S.1    Cheng, L.2    Wen, B.3
  • 14
    • 77952576224 scopus 로고    scopus 로고
    • Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation
    • Peric-Hupkes, D. et al. Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol. Cell 38, 603-613 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 603-613
    • Peric-Hupkes, D.1
  • 15
    • 40749122641 scopus 로고    scopus 로고
    • Transcriptional repression mediated by repositioning of genes to the nuclear lamina
    • Reddy, K. L., Zullo, J. M., Bertolino, E. & Singh, H. Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 452, 243-247 (2008).
    • (2008) Nature , vol.452 , pp. 243-247
    • Reddy, K.L.1    Zullo, J.M.2    Bertolino, E.3    Singh, H.4
  • 16
    • 84857655359 scopus 로고    scopus 로고
    • The nuclear envelope environment and its cancer connections
    • Chow, K. H., Factor, R. E. & Ullman, K. S. The nuclear envelope environment and its cancer connections. Nature Rev. Cancer 12, 196-209 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 196-209
    • Chow, K.H.1    Factor, R.E.2    Ullman, K.S.3
  • 17
    • 77953809032 scopus 로고    scopus 로고
    • Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
    • Hawkins, R. D. et al. Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell 6, 479-491 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 479-491
    • Hawkins, R.D.1
  • 18
    • 84856528270 scopus 로고    scopus 로고
    • Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer
    • Hon, G. C. et al. Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res. 22, 246-258 (2012).
    • (2012) Genome Res. , vol.22 , pp. 246-258
    • Hon, G.C.1
  • 19
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-tomesenchymal transition
    • McDonald, O. G., Wu, H., Timp, W., Doi, A. & Feinberg, A. P. Genome-scale epigenetic reprogramming during epithelial-tomesenchymal transition. Nature Struct. Mol. Biol. 18, 867-874 (2011).
    • (2011) Nature Struct. Mol. Biol. , vol.18 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Timp, W.3    Doi, A.4    Feinberg, A.P.5
  • 20
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • Zhou, V. W., Goren, A. & Bernstein, B. E. Charting histone modifications and the functional organization of mammalian genomes. Nature Rev. Genet. 12, 7-18 (2011).
    • (2011) Nature Rev. Genet. , vol.12 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3
  • 21
    • 84867785414 scopus 로고    scopus 로고
    • Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions
    • Wen, B. et al. Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions. BMC Genomics 13, 566 (2012).
    • (2012) BMC Genomics , vol.13 , pp. 566
    • Wen, B.1
  • 22
    • 84655162785 scopus 로고    scopus 로고
    • Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains
    • Berman, B. P. et al. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nature Genet. 44, 40-46 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 40-46
    • Berman, B.P.1
  • 23
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich, M. DNA hypomethylation in cancer cells. Epigenomics 1, 239-259 (2009).
    • (2009) Epigenomics , vol.1 , pp. 239-259
    • Ehrlich, M.1
  • 24
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister, R. et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462, 315-322 (2009).
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1
  • 25
    • 79952264847 scopus 로고    scopus 로고
    • Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
    • Lister, R. et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 471, 68-73 (2011).
    • (2011) Nature , vol.471 , pp. 68-73
    • Lister, R.1
  • 26
    • 79961029908 scopus 로고    scopus 로고
    • DNA secondary structures and epigenetic determinants of cancer genome evolution
    • De, S. & Michor, F. DNA secondary structures and epigenetic determinants of cancer genome evolution. Nature Struct. Mol. Biol. 18, 950-955 (2011).
    • (2011) Nature Struct. Mol. Biol. , vol.18 , pp. 950-955
    • De, S.1    Michor, F.2
  • 27
    • 77954061853 scopus 로고    scopus 로고
    • Enzymatic approaches and bisulfite sequencing cannot distinguish between 5methylcytosine and 5hydroxymethylcytosine in DNA
    • Nestor, C., Ruzov, A., Meehan, R. & Dunican, D. Enzymatic approaches and bisulfite sequencing cannot distinguish between 5methylcytosine and 5hydroxymethylcytosine in DNA. Biotechniques 48, 317-319 (2010).
    • (2010) Biotechniques , vol.48 , pp. 317-319
    • Nestor, C.1    Ruzov, A.2    Meehan, R.3    Dunican, D.4
  • 28
    • 77954362183 scopus 로고    scopus 로고
    • Examination of the specificity of DNA methylation profiling techniques towards 5methylcytosine and 5hydroxymethylcytosine
    • Jin, S.G., Kadam, S. & Pfeifer, G. P. Examination of the specificity of DNA methylation profiling techniques towards 5methylcytosine and 5hydroxymethylcytosine. Nucleic Acids Res. 38, e125 (2010).
    • (2010) Nucleic Acids Res. , vol.38
    • Jin, S.G.1    Kadam, S.2    Pfeifer, G.P.3
  • 29
    • 84876944890 scopus 로고    scopus 로고
    • Quantification of 5methylcytosine and 5hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid chromatography/quadrupole TOF mass spectrometry
    • Chen, M.L. et al. Quantification of 5methylcytosine and 5hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid chromatography/quadrupole TOF mass spectrometry. Clin. Chem. 59, 824-832 (2013).
    • (2013) Clin. Chem. , vol.59 , pp. 824-832
    • Chen, M.L.1
  • 30
    • 84866419591 scopus 로고    scopus 로고
    • Loss of 5hydroxymethylcytosine is an epigenetic hallmark of melanoma
    • Lian, Christine, G. et al. Loss of 5hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150, 1135-1146 (2012).
    • (2012) Cell , vol.150 , pp. 1135-1146
    • Lian Christine, G.1
  • 31
    • 84875760285 scopus 로고    scopus 로고
    • Quantification of the sixth DNA base 5hydroxymethylcytosine in colorectal cancer tissue and C-26 cell line
    • Zhang, L.T. et al. Quantification of the sixth DNA base 5hydroxymethylcytosine in colorectal cancer tissue and C-26 cell line. Bioanalysis 5, 839-845 (2013).
    • (2013) Bioanalysis , vol.5 , pp. 839-845
    • Zhang, L.T.1
  • 32
    • 84861221693 scopus 로고    scopus 로고
    • Quantitative sequencing of 5methylcytosine and 5hydroxymethylcytosine at single-base resolution
    • Booth, M. J. et al. Quantitative sequencing of 5methylcytosine and 5hydroxymethylcytosine at single-base resolution. Science 336, 934-937 (2012).
    • (2012) Science , vol.336 , pp. 934-937
    • Booth, M.J.1
  • 33
    • 84874267510 scopus 로고    scopus 로고
    • High-resolution enzymatic mapping of genomic 5hydroxymethylcytosine in mouse embryonic stem cells
    • Sun, Z. et al. High-resolution enzymatic mapping of genomic 5hydroxymethylcytosine in mouse embryonic stem cells. Cell Rep. 3, 567-576 (2013).
    • (2013) Cell Rep. , vol.3 , pp. 567-576
    • Sun, Z.1
  • 34
    • 0020068934 scopus 로고
    • Studies of X chromosome DNA methylation in normal human cells
    • Wolf, S. F. & Migeon, B. R. Studies of X chromosome DNA methylation in normal human cells. Nature 295, 667-671 (1982).
    • (1982) Nature , vol.295 , pp. 667-671
    • Wolf, S.F.1    Migeon, B.R.2
  • 35
    • 0022000776 scopus 로고
    • A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA
    • Bird, A., Taggart, M., Frommer, M., Miller, O. J. & Macleod, D. A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell 40, 91-99 (1985).
    • (1985) Cell , vol.40 , pp. 91-99
    • Bird, A.1    Taggart, M.2    Frommer, M.3    Miller, O.J.4    Macleod, D.5
  • 36
    • 0021950948 scopus 로고
    • Hypomethylation of DNA from benign and malignant human colon neoplasms
    • Goelz, S. E., Vogelstein, B., Hamilton, S. R. & Feinberg, A. P. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228, 187-190 (1985).
    • (1985) Science , vol.228 , pp. 187-190
    • Goelz, S.E.1    Vogelstein, B.2    Hamilton, S.R.3    Feinberg, A.P.4
  • 37
    • 0023848637 scopus 로고
    • Reduced genomic 5methylcytosine content in human colonic neoplasia
    • Feinberg, A. P., Gehrke, C. W., Kuo, K. C. & Ehrlich, M. Reduced genomic 5methylcytosine content in human colonic neoplasia. Cancer Res. 48, 1159-1161 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 1159-1161
    • Feinberg, A.P.1    Gehrke, C.W.2    Kuo, K.C.3    Ehrlich, M.4
  • 38
    • 0020627846 scopus 로고
    • Hypomethylation of ras oncogenes in primary human cancers
    • Feinberg, A. P. & Vogelstein, B. Hypomethylation of ras oncogenes in primary human cancers. Biochem. Biophys. Res. Commun. 111, 47-54 (1983).
    • (1983) Biochem. Biophys. Res. Commun. , vol.111 , pp. 47-54
    • Feinberg, A.P.1    Vogelstein, B.2
  • 39
    • 0029957792 scopus 로고    scopus 로고
    • The activation of human gene MAGE1 in tumor cells is correlated with genome-wide demethylation
    • De Smet, C. et al. The activation of human gene MAGE1 in tumor cells is correlated with genome-wide demethylation. Proc. Natl Acad. Sci. USA 93, 7149-7153 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 7149-7153
    • De Smet, C.1
  • 40
    • 0037379406 scopus 로고    scopus 로고
    • Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
    • Iacobuzio-Donahue, C. A. et al. Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Amer. J. Pathol. 162, 1151-1162 (2003).
    • (2003) Amer. J. Pathol. , vol.162 , pp. 1151-1162
    • Iacobuzio-Donahue, C.A.1
  • 41
    • 1042263110 scopus 로고    scopus 로고
    • Promoter methylation of cyclin D2 gene in gastric carcinoma
    • Oshimo, Y. et al. Promoter methylation of cyclin D2 gene in gastric carcinoma. Int. J. Oncol. 23, 1663-1670 (2003).
    • (2003) Int. J. Oncol. , vol.23 , pp. 1663-1670
    • Oshimo, Y.1
  • 42
    • 0142182088 scopus 로고    scopus 로고
    • Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells
    • Akiyama, Y., Maesawa, C., Ogasawara, S., Terashima, M. & Masuda, T. Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells. Am. J. Pathol. 163, 1911-1919 (2003).
    • (2003) Am. J. Pathol. , vol.163 , pp. 1911-1919
    • Akiyama, Y.1    Maesawa, C.2    Ogasawara, S.3    Terashima, M.4    Masuda, T.5
  • 43
    • 0035902856 scopus 로고    scopus 로고
    • Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma
    • Cho, M. et al. Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma. Br. J. Cancer 85, 563-567 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 563-567
    • Cho, M.1
  • 44
    • 0032468051 scopus 로고    scopus 로고
    • Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines
    • Nakamura, N. & Takenaga, K. Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines. Clin. Exper. Metastasis 16, 471-479 (1998).
    • (1998) Clin. Exper. Metastasis , vol.16 , pp. 471-479
    • Nakamura, N.1    Takenaga, K.2
  • 45
    • 0038365277 scopus 로고    scopus 로고
    • CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: Genomic hypomethylation correlates with carcinogenic progression
    • Badal, V. et al. CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: Genomic hypomethylation correlates with carcinogenic progression. J. Virol. 77, 6227-6234 (2003).
    • (2003) J. Virol. , vol.77 , pp. 6227-6234
    • Badal, V.1
  • 46
    • 0642345170 scopus 로고    scopus 로고
    • DNA demethylation is directly related to tumour progression: Evidence in normal, pre-malignant and malignant cells from uterine cervix samples
    • de Capoa, A. et al. DNA demethylation is directly related to tumour progression: Evidence in normal, pre-malignant and malignant cells from uterine cervix samples. Oncol. Rep. 10, 545-549 (2003).
    • (2003) Oncol. Rep. , vol.10 , pp. 545-549
    • De Capoa, A.1
  • 47
    • 0042674172 scopus 로고    scopus 로고
    • Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
    • Sato, N. et al. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res. 63, 4158-4166 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 4158-4166
    • Sato, N.1
  • 48
    • 0037306633 scopus 로고    scopus 로고
    • Race-and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States)
    • Piyathilake, C. J. et al. Race-and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States). Cancer Causes Control 14, 37-42 (2003).
    • (2003) Cancer Causes Control , vol.14 , pp. 37-42
    • Piyathilake, C.J.1
  • 49
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome-biological and translational implications
    • Baylin, S. B. & Jones, P. A. A decade of exploring the cancer epigenome-biological and translational implications. Nature Rev. Cancer 11, 726-734 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 50
    • 0025071834 scopus 로고
    • De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines
    • Jones, P. A. et al. De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines. Proc. Natl Acad. Sci. USA 87, 6117-6121 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 6117-6121
    • Jones, P.A.1
  • 51
    • 0037355506 scopus 로고    scopus 로고
    • Unanswered questions about the role of promoter methylation in carcinogenesis
    • Bestor, T. H. Unanswered questions about the role of promoter methylation in carcinogenesis. Ann. NY Acad. Sci. 983, 22-27 (2003).
    • (2003) Ann. NY Acad. Sci. , vol.983 , pp. 22-27
    • Bestor, T.H.1
  • 52
    • 70349956449 scopus 로고    scopus 로고
    • Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis
    • Hosoya, K. et al. Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis. Cancer Lett. 285, 182-189 (2009).
    • (2009) Cancer Lett. , vol.285 , pp. 182-189
    • Hosoya, K.1
  • 53
    • 80053927508 scopus 로고    scopus 로고
    • Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function
    • Levanon, D. et al. Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol. Med. 3, 593-604 (2011).
    • (2011) EMBO Mol. Med. , vol.3 , pp. 593-604
    • Levanon, D.1
  • 54
    • 33846973361 scopus 로고    scopus 로고
    • Inheritance of a cancer-associated MLH1 germ-line epimutation
    • Hitchins, M. P. et al. Inheritance of a cancer-associated MLH1 germ-line epimutation. N. Engl. J. Med. 356, 697-705 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , pp. 697-705
    • Hitchins, M.P.1
  • 55
    • 35649021295 scopus 로고    scopus 로고
    • Erasure of MLH1 methylation in spermatozoa-implications for epigenetic inheritance
    • Hitchins, M. P. & Ward, R. L. Erasure of MLH1 methylation in spermatozoa-implications for epigenetic inheritance. Nature Genet. 39, 1289 (2007).
    • (2007) Nature Genet. , vol.39 , pp. 1289
    • Hitchins, M.P.1    Ward, R.L.2
  • 56
    • 0037924433 scopus 로고    scopus 로고
    • Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
    • Bachman, K. E. et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell 3, 89-95 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 89-95
    • Bachman, K.E.1
  • 57
    • 79952716583 scopus 로고    scopus 로고
    • Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer
    • Sproul, D. et al. Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer. Proc. Natl Acad. Sci. USA 108, 4364-4369 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4364-4369
    • Sproul, D.1
  • 58
    • 84866844032 scopus 로고    scopus 로고
    • Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns
    • Sproul, D. et al. Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns. Genome Biol. 13, R84 (2012).
    • (2012) Genome Biol. , vol.13
    • Sproul, D.1
  • 59
    • 43149098062 scopus 로고    scopus 로고
    • Comprehensive high-throughput arrays for relative methylation (CHARM)
    • Irizarry, R. A. et al. Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res. 18, 780-790 (2008).
    • (2008) Genome Res. , vol.18 , pp. 780-790
    • Irizarry, R.A.1
  • 60
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry, R. A. et al. The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores. Nature Genet. 41, 178-186 (2009).
    • (2009) Nature Genet. , vol.41 , pp. 178-186
    • Irizarry, R.A.1
  • 61
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi, A. et al. Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature Genet. 41, 1350-1353 (2009).
    • (2009) Nature Genet. , vol.41 , pp. 1350-1353
    • Doi, A.1
  • 62
    • 84858828509 scopus 로고    scopus 로고
    • Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation
    • Teschendorff, A. et al. Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation. Genome Med. 4, 24 (2012).
    • (2012) Genome Med. , vol.4 , pp. 24
    • Teschendorff, A.1
  • 63
    • 84867637986 scopus 로고    scopus 로고
    • Gene expression anti-profiles as a basis for accurate universal cancer signatures
    • Corrada Bravo, H., Pihur, V., McCall, M., Irizarry, R. & Leek, J. Gene expression anti-profiles as a basis for accurate universal cancer signatures. BMC Bioinformatics 13, 272 (2012).
    • (2012) BMC Bioinformatics , vol.13 , pp. 272
    • Corrada Bravo, H.1    Pihur, V.2    McCall, M.3    Irizarry, R.4    Leek, J.5
  • 64
    • 34548544648 scopus 로고    scopus 로고
    • Chromatin remodeling and cancer, part II: ATP-dependent chromatin remodeling
    • Wang, G. G., Allis, C. D. & Chi, P. Chromatin remodeling and cancer, part II: ATP-dependent chromatin remodeling. Trends Mol. Med. 13, 373-380 (2007).
    • (2007) Trends Mol. Med. , vol.13 , pp. 373-380
    • Wang, G.G.1    Allis, C.D.2    Chi, P.3
  • 65
    • 34548526743 scopus 로고    scopus 로고
    • Chromatin remodeling and cancer, part I: Covalent histone modifications
    • Wang, G. G., Allis, C. D. & Chi, P. Chromatin remodeling and cancer, part I: Covalent histone modifications. Trends Mol. Med. 13, 363-372 (2007).
    • (2007) Trends Mol. Med. , vol.13 , pp. 363-372
    • Wang, G.G.1    Allis, C.D.2    Chi, P.3
  • 66
    • 1042290351 scopus 로고    scopus 로고
    • The SWI/SNF complex-chromatin and cancer
    • Roberts, C. W. & Orkin, S. H. The SWI/SNF complex-chromatin and cancer. Nature Rev. Cancer 4, 133-142 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 133-142
    • Roberts, C.W.1    Orkin, S.H.2
  • 67
    • 62649085538 scopus 로고    scopus 로고
    • The DNA-encoded nucleosome organization of a eukaryotic genome
    • Kaplan, N. et al. The DNA-encoded nucleosome organization of a eukaryotic genome. Nature 458, 362-366 (2009).
    • (2009) Nature , vol.458 , pp. 362-366
    • Kaplan, N.1
  • 68
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 69
    • 27144510368 scopus 로고    scopus 로고
    • Genome-scale profiling of histone H3.3 replacement patterns
    • Mito, Y., Henikoff, J. G. & Henikoff, S. Genome-scale profiling of histone H3.3 replacement patterns. Nature Genet. 37, 1090-1097 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 1090-1097
    • Mito, Y.1    Henikoff, J.G.2    Henikoff, S.3
  • 70
    • 70349292569 scopus 로고    scopus 로고
    • Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs
    • Zofall, M. et al. Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs. Nature 461, 419-422 (2009).
    • (2009) Nature , vol.461 , pp. 419-422
    • Zofall, M.1
  • 71
    • 79955473684 scopus 로고    scopus 로고
    • Operating on chromatin, a colorful language where context matters
    • Gardner, K. E., Allis, C. D. & Strahl, B. D. Operating on chromatin, a colorful language where context matters. J. Mol. Biol. 409, 36-46 (2011).
    • (2011) J. Mol. Biol. , vol.409 , pp. 36-46
    • Gardner, K.E.1    Allis, C.D.2    Strahl, B.D.3
  • 72
    • 34547624303 scopus 로고    scopus 로고
    • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • Mikkelsen, T. S. et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448, 553-560 (2007).
    • (2007) Nature , vol.448 , pp. 553-560
    • Mikkelsen, T.S.1
  • 73
    • 71049122240 scopus 로고    scopus 로고
    • High throughput characterization of combinatorial histone codes
    • Young, N. L. et al. High throughput characterization of combinatorial histone codes. Mol. Cell. Proteomics 8, 2266-2284 (2009).
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 2266-2284
    • Young, N.L.1
  • 74
    • 84867009687 scopus 로고    scopus 로고
    • Asymmetrically modified nucleosomes
    • Voigt, P. et al. Asymmetrically modified nucleosomes. Cell 151, 181-193 (2012).
    • (2012) Cell , vol.151 , pp. 181-193
    • Voigt, P.1
  • 75
    • 33846569960 scopus 로고    scopus 로고
    • A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm, J. E. et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nature Genet. 39, 237-242 (2007).
    • (2007) Nature Genet. , vol.39 , pp. 237-242
    • Ohm, J.E.1
  • 76
    • 33846576622 scopus 로고    scopus 로고
    • Epigenetic stem cell signature in cancer
    • Widschwendter, M. et al. Epigenetic stem cell signature in cancer. Nature Genet. 39, 157-158 (2007).
    • (2007) Nature Genet. , vol.39 , pp. 157-158
    • Widschwendter, M.1
  • 77
    • 77954659099 scopus 로고    scopus 로고
    • Relationship between nucleosome positioning and DNA methylation
    • Chodavarapu, R. K. et al. Relationship between nucleosome positioning and DNA methylation. Nature 466, 388-392 (2010).
    • (2010) Nature , vol.466 , pp. 388-392
    • Chodavarapu, R.K.1
  • 78
    • 77951118936 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • Gupta, R. A. et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464, 1071-1076 (2010).
    • (2010) Nature , vol.464 , pp. 1071-1076
    • Gupta, R.A.1
  • 79
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • Yu, W. et al. Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 451, 202-206 (2008).
    • (2008) Nature , vol.451 , pp. 202-206
    • Yu, W.1
  • 80
    • 84869052718 scopus 로고    scopus 로고
    • Cis-acting noncoding RNAs: Friends and foes
    • Guil, S. & Esteller, M. Cis-acting noncoding RNAs: Friends and foes. Nature Struct. Mol. Biol. 19, 1068-1075 (2012).
    • (2012) Nature Struct. Mol. Biol. , vol.19 , pp. 1068-1075
    • Guil, S.1    Esteller, M.2
  • 81
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer
    • Forbes, S. A. et al. COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 39, D945-D950 (2011).
    • (2011) Nucleic Acids Res. , vol.39
    • Forbes, S.A.1
  • 82
    • 84866410479 scopus 로고    scopus 로고
    • Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
    • Imielinski, M. et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150, 1107-1120 (2012).
    • (2012) Cell , vol.150 , pp. 1107-1120
    • Imielinski, M.1
  • 83
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801-1806 (2008).
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1
  • 84
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao, Y. et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 331, 1199-1203 (2011).
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1
  • 85
    • 84862777348 scopus 로고    scopus 로고
    • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    • Schwartzentruber, J. et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482, 226-231 (2012).
    • (2012) Nature , vol.482 , pp. 226-231
    • Schwartzentruber, J.1
  • 86
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov, A. V. & Armstrong, S. A. MLL translocations, histone modifications and leukaemia stem-cell development. Nature Rev. Cancer 7, 823-833 (2007).
    • (2007) Nature Rev. Cancer , vol.7 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 87
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan, X. J. et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nature Genet. 43, 309-315 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 309-315
    • Yan, X.J.1
  • 88
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley, T. J. et al. DNMT3A mutations in acute myeloid leukemia. N. Engl. J. Med. 363, 2424-2433 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2424-2433
    • Ley, T.J.1
  • 89
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa, M. E. et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553-567 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1
  • 90
    • 73149094518 scopus 로고    scopus 로고
    • TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia
    • Kosmider, O. et al. TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. Haematologica 94, 1676-1681 (2009).
    • (2009) Haematologica , vol.94 , pp. 1676-1681
    • Kosmider, O.1
  • 91
    • 79952430906 scopus 로고    scopus 로고
    • Inactivating mutations of acetyltransferase genes in Bcell lymphoma
    • Pasqualucci, L. et al. Inactivating mutations of acetyltransferase genes in Bcell lymphoma. Nature 471, 189-195 (2011).
    • (2011) Nature , vol.471 , pp. 189-195
    • Pasqualucci, L.1
  • 92
    • 80052269038 scopus 로고    scopus 로고
    • Analysis of the coding genome of diffuse large Bcell lymphoma
    • Pasqualucci, L. et al. Analysis of the coding genome of diffuse large Bcell lymphoma. Nature Genet. 43, 830-837 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 830-837
    • Pasqualucci, L.1
  • 93
    • 79960044951 scopus 로고    scopus 로고
    • MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
    • Bernt, K. M. et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 20, 66-78 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 66-78
    • Bernt, K.M.1
  • 94
    • 79952381408 scopus 로고    scopus 로고
    • CREBBP mutations in relapsed acute lymphoblastic leukaemia
    • Mullighan, C. G. et al. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 471, 235-239 (2011).
    • (2011) Nature , vol.471 , pp. 235-239
    • Mullighan, C.G.1
  • 95
    • 84862777410 scopus 로고    scopus 로고
    • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    • Wu, G. et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nature Genet. 44, 251-253 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 251-253
    • Wu, G.1
  • 96
    • 77957731999 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma
    • Jones, S. et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science 330, 228-231 (2010).
    • (2010) Science , vol.330 , pp. 228-231
    • Jones, S.1
  • 97
    • 77957946398 scopus 로고    scopus 로고
    • ARID1A mutations in endometriosis-associated ovarian carcinomas
    • Wiegand, K. C. et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N. Engl. J. Med. 363, 1532-1543 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1532-1543
    • Wiegand, K.C.1
  • 98
    • 85027932742 scopus 로고    scopus 로고
    • Methylation-mediated deamination of 5methylcytosine appears to give rise to mutations causing human inherited disease in CpNpG trinucleotides, as well as in CpG dinucleotides
    • Cooper, D. N., Mort, M., Stenson, P. D., Ball, E. V. & Chuzhanova, N. A. Methylation-mediated deamination of 5methylcytosine appears to give rise to mutations causing human inherited disease in CpNpG trinucleotides, as well as in CpG dinucleotides. Hum. Genomics 4, 406-410 (2010).
    • (2010) Hum. Genomics , vol.4 , pp. 406-410
    • Cooper, D.N.1    Mort, M.2    Stenson, P.D.3    Ball, E.V.4    Chuzhanova, N.A.5
  • 99
    • 33947101019 scopus 로고    scopus 로고
    • Patterns of somatic mutation in human cancer genomes
    • Greenman, C. et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158 (2007).
    • (2007) Nature , vol.446 , pp. 153-158
    • Greenman, C.1
  • 100
    • 84865248380 scopus 로고    scopus 로고
    • Chromatin organization is a major influence on regional mutation rates in human cancer cells
    • Schuster-Bockler, B. & Lehner, B. Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature 488, 504-507 (2012).
    • (2012) Nature , vol.488 , pp. 504-507
    • Schuster-Bockler, B.1    Lehner, B.2
  • 101
    • 70449388892 scopus 로고    scopus 로고
    • Common fragile sites are characterized by histone hypoacetylation
    • Jiang, Y. et al. Common fragile sites are characterized by histone hypoacetylation. Hum. Mol. Genet. 18, 4501-4512 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 4501-4512
    • Jiang, Y.1
  • 102
    • 83255165727 scopus 로고    scopus 로고
    • High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
    • Fudenberg, G., Getz, G., Meyerson, M. & Mirny, L. A. High order chromatin architecture shapes the landscape of chromosomal alterations in cancer. Nature Biotech. 29, 1109-1113 (2011).
    • (2011) Nature Biotech. , vol.29 , pp. 1109-1113
    • Fudenberg, G.1    Getz, G.2    Meyerson, M.3    Mirny, L.A.4
  • 104
    • 18644382388 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 is involved in progression of prostate cancer
    • Varambally, S. et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624-629 (2002).
    • (2002) Nature , vol.419 , pp. 624-629
    • Varambally, S.1
  • 105
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NFκB, Lin28, Let7 microRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos, D., Hirsch, H. A. & Struhl, K. An epigenetic switch involving NFκB, Lin28, Let7 microRNA, and IL6 links inflammation to cell transformation. Cell 139, 693-706 (2009).
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 106
    • 84862528505 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: Past, present, and future
    • Yamanaka, S. Induced pluripotent stem cells: Past, present, and future. Cell Stem Cell 10, 678-684 (2012).
    • (2012) Cell Stem Cell , vol.10 , pp. 678-684
    • Yamanaka, S.1
  • 107
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • Suvà, M. L., Riggi, N. & Bernstein, B. E. Epigenetic reprogramming in cancer. Science 339, 1567-1570 (2013).
    • (2013) Science , vol.339 , pp. 1567-1570
    • Suvà, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 108
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • Minucci, S. & Pelicci, P. G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nature Rev. Cancer 6, 38-51 (2006).
    • (2006) Nature Rev. Cancer , vol.6 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 110
    • 2942718723 scopus 로고    scopus 로고
    • Control of stochasticity in eukaryotic gene expression
    • Raser, J. M. & O'Shea, E. K. Control of stochasticity in eukaryotic gene expression. Science 304, 1811-1814 (2004).
    • (2004) Science , vol.304 , pp. 1811-1814
    • Raser, J.M.1    O'Shea, E.K.2
  • 111
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 6-21
    • Bird, A.1
  • 112
    • 33847208871 scopus 로고    scopus 로고
    • Timescales of genetic and epigenetic inheritance
    • Rando, O. J. & Verstrepen, K. J. Timescales of genetic and epigenetic inheritance. Cell 128, 655-668 (2007).
    • (2007) Cell , vol.128 , pp. 655-668
    • Rando, O.J.1    Verstrepen, K.J.2
  • 113
    • 76549135113 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease
    • Feinberg, A. P. & Irizarry, R. A. Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease. Proc. Natl Acad. Sci. USA 107 (Suppl. 1), 1757-1764 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.SUPPL. 1 , pp. 1757-1764
    • Feinberg, A.P.1    Irizarry, R.A.2
  • 114
    • 79953737588 scopus 로고    scopus 로고
    • Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis
    • Alvarez, H. et al. Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis. PLoS Genet. 7, e1001356 (2011).
    • (2011) PLoS Genet. , vol.7
    • Alvarez, H.1
  • 115
    • 77955038710 scopus 로고    scopus 로고
    • DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis
    • Shah, M. Y. et al. DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res. 70, 5840-5850 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 5840-5850
    • Shah, M.Y.1
  • 116
    • 0017144189 scopus 로고
    • Natural selection and random genetic drift in phenotypic evolution
    • Lande, R. Natural selection and random genetic drift in phenotypic evolution. Evolution 30, 314-334 (1976).
    • (1976) Evolution , vol.30 , pp. 314-334
    • Lande, R.1
  • 117
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: The next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 118
    • 29244447111 scopus 로고    scopus 로고
    • Loss of imprinting of IGF2: A common epigenetic modifier of intestinal tumor risk
    • Kaneda, A. & Feinberg, A. P. Loss of imprinting of IGF2: A common epigenetic modifier of intestinal tumor risk. Cancer Res. 65, 11236-11240 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 11236-11240
    • Kaneda, A.1    Feinberg, A.P.2
  • 119
    • 59449098943 scopus 로고    scopus 로고
    • A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction
    • Timp, W., Levchenko, A. & Feinberg, A. P. A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction. Cell Cycle 8, 383-390 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 383-390
    • Timp, W.1    Levchenko, A.2    Feinberg, A.P.3
  • 120
    • 0842278570 scopus 로고    scopus 로고
    • Epigenetic changes in colorectal cancer
    • Kondo, Y. & Issa, J. P. Epigenetic changes in colorectal cancer. Cancer Metastasis Rev. 23, 29-39 (2004).
    • (2004) Cancer Metastasis Rev. , vol.23 , pp. 29-39
    • Kondo, Y.1    Issa, J.P.2
  • 122
    • 84872806231 scopus 로고    scopus 로고
    • Genome-wide methylation profiles reveal quantitative views of human aging rates
    • Hannum, G. et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol. Cell 49, 359-367 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 359-367
    • Hannum, G.1
  • 123
    • 0037436509 scopus 로고    scopus 로고
    • Loss of IGF2 imprinting: A potential marker of colorectal cancer risk
    • Cui, H. et al. Loss of IGF2 imprinting: A potential marker of colorectal cancer risk. Science 299, 1753-1755 (2003).
    • (2003) Science , vol.299 , pp. 1753-1755
    • Cui, H.1
  • 124
    • 20144374299 scopus 로고    scopus 로고
    • Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice
    • Sakatani, T. et al. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 307, 1976-1978 (2005).
    • (2005) Science , vol.307 , pp. 1976-1978
    • Sakatani, T.1
  • 125
    • 84861752999 scopus 로고    scopus 로고
    • Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions
    • Teschendorff, A. E. & Widschwendter, M. Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions. Bioinformatics 28, 1487-1494 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 1487-1494
    • Teschendorff, A.E.1    Widschwendter, M.2
  • 126
    • 0032580358 scopus 로고    scopus 로고
    • The BRCA2 is a histone acetyltransferase
    • Siddique, H., Zou, J. P., Rao, V. N. & Reddy, E. The BRCA2 is a histone acetyltransferase. Oncogene 16, 2283 (1998).
    • (1998) Oncogene , vol.16 , pp. 2283
    • Siddique, H.1    Zou, J.P.2    Rao, V.N.3    Reddy, E.4
  • 127
    • 0032512067 scopus 로고    scopus 로고
    • BRCA2 associates with acetyltransferase activity when bound to P/CAF
    • Fuks, F., Milner, J. & Kouzarides, T. BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene 17, 2531 (1998).
    • (1998) Oncogene , vol.17 , pp. 2531
    • Fuks, F.1    Milner, J.2    Kouzarides, T.3
  • 128
    • 12844286057 scopus 로고    scopus 로고
    • Human maintenance DNA (cytosine5)-methyltransferase and p53 modulate expression of p53repressed promoters
    • Esteve, P. O., Chin, H. G. & Pradhan, S. Human maintenance DNA (cytosine5)-methyltransferase and p53 modulate expression of p53repressed promoters. Proc. Natl Acad. Sci. USA 102, 1000-1005 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1000-1005
    • Esteve, P.O.1    Chin, H.G.2    Pradhan, S.3
  • 129
    • 2342603414 scopus 로고    scopus 로고
    • Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis
    • Zhu, P. et al. Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell 5, 455-463 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 455-463
    • Zhu, P.1
  • 130
    • 0037272898 scopus 로고    scopus 로고
    • Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway
    • Campbell, P. M. & Szyf, M. Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway. Carcinogenesis 24, 17-24 (2003).
    • (2003) Carcinogenesis , vol.24 , pp. 17-24
    • Campbell, P.M.1    Szyf, M.2
  • 131
    • 34548388292 scopus 로고    scopus 로고
    • Phosphatidylinositol 3kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation
    • Sun, L. et al. Phosphatidylinositol 3kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation. Cell. Signal. 19, 2255-2263 (2007).
    • (2007) Cell. Signal. , vol.19 , pp. 2255-2263
    • Sun, L.1
  • 132
    • 39749180354 scopus 로고    scopus 로고
    • DNA methylation biomarkers for blood-based colorectal cancer screening
    • Lofton-Day, C. et al. DNA methylation biomarkers for blood-based colorectal cancer screening. Clin. Chem. 54, 414-423 (2008).
    • (2008) Clin. Chem. , vol.54 , pp. 414-423
    • Lofton-Day, C.1
  • 133
    • 83355163991 scopus 로고    scopus 로고
    • Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer
    • Warren, J. D. et al. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med. 9, 133 (2011).
    • (2011) BMC Med. , vol.9 , pp. 133
    • Warren, J.D.1
  • 134
    • 38849196779 scopus 로고    scopus 로고
    • Highly methylated genes in colorectal neoplasia: Implications for screening
    • Zou, H. et al. Highly methylated genes in colorectal neoplasia: Implications for screening. Cancer Epidemiol. Biomarkers Prev. 16, 2686-2696 (2007).
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 2686-2696
    • Zou, H.1
  • 135
    • 0028152397 scopus 로고
    • Cytidine methylation of regulatory sequences near the piclass glutathione Stransferase gene accompanies human prostatic carcinogenesis
    • Lee, W. H. et al. Cytidine methylation of regulatory sequences near the piclass glutathione Stransferase gene accompanies human prostatic carcinogenesis. Proc. Natl Acad. Sci. USA 91, 11733-11737 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 11733-11737
    • Lee, W.H.1
  • 136
    • 84859166725 scopus 로고    scopus 로고
    • The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer
    • Zhuang, J. et al. The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer. PLoS Genet. 8, e1002517 (2012).
    • (2012) PLoS Genet. , vol.8
    • Zhuang, J.1
  • 137
    • 70249147655 scopus 로고    scopus 로고
    • Sensitive digital quantification of DNA methylation in clinical samples
    • Li, M. et al. Sensitive digital quantification of DNA methylation in clinical samples. Nature Biotech. 27, 858-863 (2009).
    • (2009) Nature Biotech. , vol.27 , pp. 858-863
    • Li, M.1
  • 138
    • 84859789534 scopus 로고    scopus 로고
    • O6-Methylguanine-DNA methyltransferase in glioma therapy: Promise and problems
    • Silber, J. R., Bobola, M. S., Blank, A. & Chamberlain, M. C. O6-Methylguanine-DNA methyltransferase in glioma therapy: Promise and problems. Biochim. Biophys. Acta 1826, 71-82 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1826 , pp. 71-82
    • Silber, J.R.1    Bobola, M.S.2    Blank, A.3    Chamberlain, M.C.4
  • 139
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodriguez-Paredes, M. & Esteller, M. Cancer epigenetics reaches mainstream oncology. Nature Med. 17, 330-339 (2011).
    • (2011) Nature Med. , vol.17 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 140
    • 84867632489 scopus 로고    scopus 로고
    • A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    • Knutson, S. K. et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nature Chem. Biol. 8, 890-896 (2012).
    • (2012) Nature Chem. Biol. , vol.8 , pp. 890-896
    • Knutson, S.K.1
  • 141
    • 70350494322 scopus 로고    scopus 로고
    • Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
    • Fiskus, W. et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 114, 2733-2743 (2009).
    • (2009) Blood , vol.114 , pp. 2733-2743
    • Fiskus, W.1
  • 142
    • 84867355390 scopus 로고    scopus 로고
    • Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2HG in vivo
    • Popovici-Muller, J. et al. Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2HG in vivo. ACS Med. Chem. Lett. 3, 850-855 (2012).
    • (2012) ACS Med. Chem. Lett. , vol.3 , pp. 850-855
    • Popovici-Muller, J.1
  • 143
    • 79960058024 scopus 로고    scopus 로고
    • Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
    • Daigle, S. R. et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 20, 53-65 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 53-65
    • Daigle, S.R.1
  • 144
    • 84867053264 scopus 로고    scopus 로고
    • Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia
    • Hull, M. A. Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia. Recent Results Cancer Res. 191, 143-156 (2013).
    • (2013) Recent Results Cancer Res. , vol.191 , pp. 143-156
    • Hull, M.A.1
  • 145
    • 84867060067 scopus 로고    scopus 로고
    • COX2 active agents in the chemoprevention of colorectal cancer
    • Kraus, S., Naumov, I. & Arber, N. COX2 active agents in the chemoprevention of colorectal cancer. Recent Results Cancer Res. 191, 95-103 (2013).
    • (2013) Recent Results Cancer Res. , vol.191 , pp. 95-103
    • Kraus, S.1    Naumov, I.2    Arber, N.3
  • 146
    • 84863464543 scopus 로고    scopus 로고
    • A pointbypoint response to recent arguments against the use of statins in primary prevention: This statement is endorsed by the American Society for Preventive Cardiology
    • Joshi, P. H. et al. A pointbypoint response to recent arguments against the use of statins in primary prevention: This statement is endorsed by the American Society for Preventive Cardiology. Clin. Cardiol. 35, 404-409 (2012).
    • (2012) Clin. Cardiol. , vol.35 , pp. 404-409
    • Joshi, P.H.1
  • 147
    • 84867039742 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk
    • Yuasa, Y. et al. Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. Int. J. Cancer 131, 2596-2603 (2012).
    • (2012) Int. J. Cancer , vol.131 , pp. 2596-2603
    • Yuasa, Y.1
  • 148
    • 38049170553 scopus 로고    scopus 로고
    • Enhanced sensitivity to IGFII signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk
    • Kaneda, A. et al. Enhanced sensitivity to IGFII signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc. Natl Acad. Sci. USA 104, 20926-20931 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 20926-20931
    • Kaneda, A.1
  • 149
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom, T. et al. The consensus coding sequences of human breast and colorectal cancers. Science 314, 268-274 (2006).
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1
  • 150
    • 80052029516 scopus 로고    scopus 로고
    • Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
    • Morin, R. D. et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 476, 298-303 (2011).
    • (2011) Nature , vol.476 , pp. 298-303
    • Morin, R.D.1
  • 151
    • 0037456636 scopus 로고    scopus 로고
    • Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers
    • Kanai, Y., Ushijima, S., Nakanishi, Y., Sakamoto, M. & Hirohashi, S. Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers. Cancer Lett. 192, 75-82 (2003).
    • (2003) Cancer Lett. , vol.192 , pp. 75-82
    • Kanai, Y.1    Ushijima, S.2    Nakanishi, Y.3    Sakamoto, M.4    Hirohashi, S.5
  • 152
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • Tefferi, A. et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia 23, 905-911 (2009).
    • (2009) Leukemia , vol.23 , pp. 905-911
    • Tefferi, A.1
  • 153
    • 67649876132 scopus 로고    scopus 로고
    • Acquired mutations in TET2 are common in myelodysplastic syndromes
    • Langemeijer, S. M. et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nature Genet. 41, 838-842 (2009).
    • (2009) Nature Genet. , vol.41 , pp. 838-842
    • Langemeijer, S.M.1
  • 154
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan, H. et al. IDH1 and IDH2 mutations in gliomas. New Engl. J. Med. 360, 765-773 (2009).
    • (2009) New Engl. J. Med. , vol.360 , pp. 765-773
    • Yan, H.1
  • 155
    • 80052158097 scopus 로고    scopus 로고
    • The mutational landscape of head and neck squamous cell carcinoma
    • Stransky, N. et al. The mutational landscape of head and neck squamous cell carcinoma. Science 333, 1157-1160 (2011).
    • (2011) Science , vol.333 , pp. 1157-1160
    • Stransky, N.1
  • 156
    • 80052266351 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
    • Gui, Y. et al. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nature Genet. 43, 875-878 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 875-878
    • Gui, Y.1
  • 158
    • 77955660663 scopus 로고    scopus 로고
    • Diverse somatic mutation patterns and pathway alterations in human cancers
    • Kan, Z. et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 466, 869-873 (2010).
    • (2010) Nature , vol.466 , pp. 869-873
    • Kan, Z.1
  • 159
    • 19944426043 scopus 로고    scopus 로고
    • Mutations and deletions of the CBP gene in human lung cancer
    • Kishimoto, M. et al. Mutations and deletions of the CBP gene in human lung cancer. Clin. Cancer Res. 11, 512-519 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 512-519
    • Kishimoto, M.1
  • 160
    • 79951497419 scopus 로고    scopus 로고
    • The genomic complexity of primary human prostate cancer
    • Berger, M. F. et al. The genomic complexity of primary human prostate cancer. Nature 470, 214-220 (2011).
    • (2011) Nature , vol.470 , pp. 214-220
    • Berger, M.F.1
  • 161
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • Dalgliesh, G. L. et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463, 360-363 (2010).
    • (2010) Nature , vol.463 , pp. 360-363
    • Dalgliesh, G.L.1
  • 162
    • 84866170767 scopus 로고    scopus 로고
    • Identification of somatic mutations in parathyroid tumors using whole-exome sequencing
    • Cromer, M. K. et al. Identification of somatic mutations in parathyroid tumors using whole-exome sequencing. J. Clin. Endocrinol. Metab. 97, E1774-E1781 (2012).
    • (2012) J. Clin. Endocrinol. Metab. , vol.97
    • Cromer, M.K.1
  • 163
    • 84864492215 scopus 로고    scopus 로고
    • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    • Pugh, T. J. et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 488, 106-110 (2012).
    • (2012) Nature , vol.488 , pp. 106-110
    • Pugh, T.J.1
  • 164
    • 79251629946 scopus 로고    scopus 로고
    • The genetic landscape of the childhood cancer medulloblastoma
    • Parsons, D. W. et al. The genetic landscape of the childhood cancer medulloblastoma. Science 331, 435-439 (2011).
    • (2011) Science , vol.331 , pp. 435-439
    • Parsons, D.W.1
  • 165
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large Bcell lymphomas of germinal-center origin
    • Morin, R. D. et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large Bcell lymphomas of germinal-center origin. Nature Genet. 42, 181-185 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 181-185
    • Morin, R.D.1
  • 166
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst, T. et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nature Genet. 42, 722-726 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 722-726
    • Ernst, T.1
  • 167
    • 79954435405 scopus 로고    scopus 로고
    • EZH2 Y641 mutations in follicular lymphoma
    • Bodor, C. et al. EZH2 Y641 mutations in follicular lymphoma. Leukemia 25, 726-729 (2011).
    • (2011) Leukemia , vol.25 , pp. 726-729
    • Bodor, C.1
  • 168
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • Guichard, C. et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nature Genet. 44, 694-698 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 694-698
    • Guichard, C.1
  • 169
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Network, T. C.G. A. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
    • Network, T.C.G.A.1
  • 170
    • 84861576201 scopus 로고    scopus 로고
    • The landscape of cancer genes and mutational processes in breast cancer
    • Stephens, P. J. et al. The landscape of cancer genes and mutational processes in breast cancer. Nature 486, 400-404 (2012).
    • (2012) Nature , vol.486 , pp. 400-404
    • Stephens, P.J.1
  • 171
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012).
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1
  • 172
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
    • (2011) Nature , vol.469 , pp. 539-542
    • Varela, I.1
  • 173
    • 0032940605 scopus 로고    scopus 로고
    • Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors
    • Biegel, J. A. et al. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res. 59, 74-79 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 74-79
    • Biegel, J.A.1
  • 174
    • 1542318319 scopus 로고    scopus 로고
    • Loss of insulin-like growth factorII imprinting and the presence of screen-detected colorectal adenomas in women
    • Woodson, K. et al. Loss of insulin-like growth factorII imprinting and the presence of screen-detected colorectal adenomas in women. J. Natl Cancer Inst. 96, 407-410 (2004).
    • (2004) J. Natl Cancer Inst. , vol.96 , pp. 407-410
    • Woodson, K.1
  • 175
    • 0033037809 scopus 로고    scopus 로고
    • Analysis of IGF2 gene imprinting in breast and colorectal cancer by allele specific-PCR
    • Yun, K., Soejima, H., Merrie, A. E. H., McCall, J. L. & Reeve, A. E. Analysis of IGF2 gene imprinting in breast and colorectal cancer by allele specific-PCR. J. Pathol. 187, 518-522 (1999).
    • (1999) J. Pathol. , vol.187 , pp. 518-522
    • Yun, K.1    Soejima, H.2    Merrie, A.E.H.3    McCall, J.L.4    Reeve, A.E.5
  • 176
    • 38449100788 scopus 로고    scopus 로고
    • Expression profile of class I histone deacetylases in human cancer tissues
    • Nakagawa, M. et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncol. Rep. 18, 769-774 (2007).
    • (2007) Oncol. Rep. , vol.18 , pp. 769-774
    • Nakagawa, M.1
  • 177
    • 0035676731 scopus 로고    scopus 로고
    • Expression profile of histone deacetylase 1 in gastric cancer tissues
    • Choi, J. H. et al. Expression profile of histone deacetylase 1 in gastric cancer tissues. Jpn J. Cancer Res. 92, 1300-1304 (2001).
    • (2001) Jpn J. Cancer Res. , vol.92 , pp. 1300-1304
    • Choi, J.H.1
  • 178
    • 1842631408 scopus 로고    scopus 로고
    • Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer
    • Halkidou, K. et al. Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate 59, 177-189 (2004).
    • (2004) Prostate , vol.59 , pp. 177-189
    • Halkidou, K.1
  • 179
    • 0142122363 scopus 로고    scopus 로고
    • Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha
    • Kawai, H., Li, H., Avraham, S., Jiang, S. & Avraham, H. K. Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. Int. J. Cancer 107, 353-358 (2003).
    • (2003) Int. J. Cancer , vol.107 , pp. 353-358
    • Kawai, H.1    Li, H.2    Avraham, S.3    Jiang, S.4    Avraham, H.K.5
  • 180
    • 59449084559 scopus 로고    scopus 로고
    • Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment
    • Lin, Z. et al. Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Clin. Cancer Res. 15, 570-577 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 570-577
    • Lin, Z.1
  • 181
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer, C. G. et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl Acad. Sci. USA 100, 11606-11611 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 11606-11611
    • Kleer, C.G.1
  • 182
    • 33744954457 scopus 로고    scopus 로고
    • Differential expression of selected histone modifier genes in human solid cancers
    • Ozdag, H. et al. Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics 7, 90 (2006).
    • (2006) BMC Genomics , vol.7 , pp. 90
    • Ozdag, H.1
  • 183
    • 17144378591 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1
    • Huang, B. H. et al. Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. Cell Death Differ. 12, 395-404 (2005).
    • (2005) Cell Death Differ. , vol.12 , pp. 395-404
    • Huang, B.H.1
  • 184
    • 33744956666 scopus 로고    scopus 로고
    • Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer
    • Wilson, A. J. et al. Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. J. Biol. Chem. 281, 13548-13558 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 13548-13558
    • Wilson, A.J.1
  • 185
    • 6044271613 scopus 로고    scopus 로고
    • HDAC6 expression is correlated with better survival in breast cancer
    • Zhang, Z. et al. HDAC6 expression is correlated with better survival in breast cancer. Clin. Cancer Res. 10, 6962-6968 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6962-6968
    • Zhang, Z.1
  • 186
    • 63649125404 scopus 로고    scopus 로고
    • Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
    • Jung-Hynes, B., Nihal, M., Zhong, W. & Ahmad, N. Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J. Biol. Chem. 284, 3823-3832 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 3823-3832
    • Jung-Hynes, B.1    Nihal, M.2    Zhong, W.3    Ahmad, N.4
  • 187
    • 33750212896 scopus 로고    scopus 로고
    • Altered sirtuin expression is associated with node-positive breast cancer
    • Ashraf, N. et al. Altered sirtuin expression is associated with node-positive breast cancer. Br. J. Cancer 95, 1056-1061 (2006).
    • (2006) Br. J. Cancer , vol.95 , pp. 1056-1061
    • Ashraf, N.1
  • 188
    • 0038748632 scopus 로고    scopus 로고
    • A novel gene (PLU1) containing highly conserved putative DNA/chromatin binding motifs is specifically upregulated in breast cancer
    • Lu, P. J. et al. A novel gene (PLU1) containing highly conserved putative DNA/chromatin binding motifs is specifically upregulated in breast cancer. J. Biol. Chem. 274, 15633-15645 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 15633-15645
    • Lu, P.J.1
  • 189
    • 42549095632 scopus 로고    scopus 로고
    • Enhanced methyltransferase activity of SMYD3 by the cleavage of its Nterminal region in human cancer cells
    • Silva, F. P. et al. Enhanced methyltransferase activity of SMYD3 by the cleavage of its Nterminal region in human cancer cells. Oncogene 27, 2686-2692 (2008).
    • (2008) Oncogene , vol.27 , pp. 2686-2692
    • Silva, F.P.1
  • 190
    • 63449115501 scopus 로고    scopus 로고
    • Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
    • Northcott, P. A. et al. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nature Genet. 41, 465-472 (2009).
    • (2009) Nature Genet. , vol.41 , pp. 465-472
    • Northcott, P.A.1
  • 191
    • 33745627069 scopus 로고    scopus 로고
    • DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas
    • Peng, D. F. et al. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis 27, 1160-1168 (2006).
    • (2006) Carcinogenesis , vol.27 , pp. 1160-1168
    • Peng, D.F.1
  • 192
    • 0037598752 scopus 로고    scopus 로고
    • Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas
    • Saito, Y. et al. Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int. J. Cancer 105, 527-532 (2003).
    • (2003) Int. J. Cancer , vol.105 , pp. 527-532
    • Saito, Y.1
  • 193
    • 17144413410 scopus 로고    scopus 로고
    • DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis
    • Nakagawa, T. et al. DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis. J. Urol. 173, 1767-1771 (2005).
    • (2005) J. Urol. , vol.173 , pp. 1767-1771
    • Nakagawa, T.1
  • 194
    • 24044493602 scopus 로고    scopus 로고
    • Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer
    • Agoston, A. T. et al. Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. J. Biol. Chem. 280, 18302-18310 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 18302-18310
    • Agoston, A.T.1
  • 195
    • 33846034825 scopus 로고    scopus 로고
    • Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours
    • Butcher, D. T. & Rodenhiser, D. I. Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours. Eur. J. Cancer 43, 210-219 (2007).
    • (2007) Eur. J. Cancer , vol.43 , pp. 210-219
    • Butcher, D.T.1    Rodenhiser, D.I.2
  • 196
    • 10744225444 scopus 로고    scopus 로고
    • High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia
    • McCarthy, H. et al. High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia. Blood 101, 4903-4908 (2003).
    • (2003) Blood , vol.101 , pp. 4903-4908
    • McCarthy, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.