메뉴 건너뛰기




Volumn , Issue , 2007, Pages 1-252

G Protein-Coupled Receptors: Molecular Pharmacology from Academic Concept to Pharmaceutical Research

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84891295931     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470516652     Document Type: Book
Times cited : (10)

References (142)
  • 1
    • 84951653316 scopus 로고
    • A study of adrenotopic receptors
    • Ahlquist R. (1948) A study of adrenotopic receptors. American Journal of Physiology, 153, 586-600.
    • (1948) American Journal of Physiology , vol.153 , pp. 586-600
    • Ahlquist, R.1
  • 3
    • 0034967910 scopus 로고    scopus 로고
    • Stimulation of Guanosine-5'-O-(3-[35S]thio)triphosphate binding in digitonin-permeabilized C6 rat glioma cells: evidence for an organized association of micro-opioid receptors and G protein
    • Alt, A., Mcfadyen, I. J., Fan, C. D., Woods, J. H. and Traynor, J. R. (2001) Stimulation of Guanosine-5'-O-(3-[35S]thio)triphosphate binding in digitonin-permeabilized C6 rat glioma cells: evidence for an organized association of micro-opioid receptors and G protein. Journal of Pharmacology & Experimental Therapeutics, 298, 116-121.
    • (2001) Journal of Pharmacology & Experimental Therapeutics , vol.298 , pp. 116-121
    • Alt, A.1    Mcfadyen, I.J.2    Fan, C.D.3    Woods, J.H.4    Traynor, J.R.5
  • 4
    • 0027511360 scopus 로고
    • Morphological and biochemical analysis of angiotensin II internalization in cultured rat aortic smooth muscle cells
    • Anderson, K. M., Murahashi, T., Dostal, D. E. and Peach, M. J. (1993) Morphological and biochemical analysis of angiotensin II internalization in cultured rat aortic smooth muscle cells. American Journal of Physiology-Cell Physiology, 264, C179-188.
    • (1993) American Journal of Physiology-Cell Physiology , vol.264
    • Anderson, K.M.1    Murahashi, T.2    Dostal, D.E.3    Peach, M.J.4
  • 5
    • 77049220618 scopus 로고
    • Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory
    • Ariens, E. J. (1954) Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory. Archives Internationales de Pharmacodynamie et de Therapie, 99, 32-49.
    • (1954) Archives Internationales de Pharmacodynamie et de Therapie , vol.99 , pp. 32-49
    • Ariens, E.J.1
  • 8
    • 33646494731 scopus 로고
    • Integrated methods for the construction of threedimensional models and computational probing of structure-function relations in G proteincoupled receptors
    • Ballesteros, J.A. and Weinstein, W. H. (1995) Integrated methods for the construction of threedimensional models and computational probing of structure-function relations in G proteincoupled receptors. Methods in Neuroscience, 153, 586-600.
    • (1995) Methods in Neuroscience , vol.153 , pp. 586-600
    • Ballesteros, J.A.1    Weinstein, W.H.2
  • 9
    • 0031815337 scopus 로고    scopus 로고
    • Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus
    • Berg, K. A., Maayani, S., Goldfarb, J., Scaramellini, C., Leff, P. and Clarke, W. P. (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Molecular Pharmacology, 54, 94-104.
    • (1998) Molecular Pharmacology , vol.54 , pp. 94-104
    • Berg, K.A.1    Maayani, S.2    Goldfarb, J.3    Scaramellini, C.4    Leff, P.5    Clarke, W.P.6
  • 10
    • 0031059468 scopus 로고    scopus 로고
    • Regulatory mechanisms that modulate signalling by G protein-coupled receptors
    • Bohm, S. K., Grady, E. F. and Bunnett, N. W. (1997) Regulatory mechanisms that modulate signalling by G protein-coupled receptors. Biochemical Journal, 322, 1-18.
    • (1997) Biochemical Journal , vol.322 , pp. 1-18
    • Bohm, S.K.1    Grady, E.F.2    Bunnett, N.W.3
  • 12
    • 0036174898 scopus 로고    scopus 로고
    • G protein-coupled receptor interacting proteins:emerging roles in localization and signal transduction
    • Brady, A. E. and Limbird, L. E. (2002) G protein-coupled receptor interacting proteins:emerging roles in localization and signal transduction. Cellular Signalling, 14, 297-309.
    • (2002) Cellular Signalling , vol.14 , pp. 297-309
    • Brady, A.E.1    Limbird, L.E.2
  • 13
    • 0033929371 scopus 로고    scopus 로고
    • Agonist-directed trafficking of porcine alpha 2A-adrenergic receptor signaling in Chinese Hamster ovary cells: l-Isoproterenol selectively activates Gs
    • Brink, C. B., Wade, S. M. and Neubig, R. R. (2000) Agonist-directed trafficking of porcine alpha 2A-adrenergic receptor signaling in Chinese Hamster ovary cells: l-Isoproterenol selectively activates Gs. Journal of Pharmacology and Experimental Therapeutics, 294, 539-547.
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.294 , pp. 539-547
    • Brink, C.B.1    Wade, S.M.2    Neubig, R.R.3
  • 14
    • 0032562288 scopus 로고    scopus 로고
    • Agonist occupation of an alpha 2A-Adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry
    • Burt, A. R., Sautel, M., Wilson, M. A., Rees, S., Wise, A. and Milligan, G. (1998) Agonist occupation of an alpha 2A-Adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry. Journal of Biological Chemistry, 273, 10367-10375.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 10367-10375
    • Burt, A.R.1    Sautel, M.2    Wilson, M.A.3    Rees, S.4    Wise, A.5    Milligan, G.6
  • 15
    • 0033019171 scopus 로고    scopus 로고
    • Human adrenoceptor polymorphisms: evolving recognition of clinical importance
    • Buscher, R., Herrmann, V. and Insel, P. A. (1999) Human adrenoceptor polymorphisms: evolving recognition of clinical importance. Trends in Pharmacological Sciences, 20, 94-99.
    • (1999) Trends in Pharmacological Sciences , vol.20 , pp. 94-99
    • Buscher, R.1    Herrmann, V.2    Insel, P.A.3
  • 16
    • 0035049091 scopus 로고    scopus 로고
    • Selective and non-selective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations
    • Carter, P. H., Petroni, B. D., Gensure, R. C., Schipani, E., Potts, J. T. Jr. and Gardella, T. J. (2001) Selective and non-selective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations. Endocrinology, 142, 1534-1545.
    • (2001) Endocrinology , vol.142 , pp. 1534-1545
    • Carter, P.H.1    Petroni, B.D.2    Gensure, R.C.3    Schipani, E.4    Potts Jr., J.T.5    Gardella, T.J.6
  • 17
    • 0028988530 scopus 로고
    • Expression of the mu-opioid receptor in CHO cells: Ability of mu-opioid ligands to promote alphaazidoanilido [32P]GTP labeling of multiple G protein alpha subunits
    • Chakrabarti, S., Prather, P. L., Yu, L., Law, P. Y. and Loh, H. H. (1995) Expression of the mu-opioid receptor in CHO cells: Ability of mu-opioid ligands to promote alphaazidoanilido [32P]GTP labeling of multiple G protein alpha subunits. Journal of Neurochemistry, 64, 2534-2543.
    • (1995) Journal of Neurochemistry , vol.64 , pp. 2534-2543
    • Chakrabarti, S.1    Prather, P.L.2    Yu, L.3    Law, P.Y.4    Loh, H.H.5
  • 18
    • 0036688175 scopus 로고    scopus 로고
    • The use of constitutively active GPCRs in drug discovery and functional genomics
    • Chalmers, D. T. and Behan, D. P. (2002) The use of constitutively active GPCRs in drug discovery and functional genomics. Nature Reviews Drug Discovery, 1, 599-608.
    • (2002) Nature Reviews Drug Discovery , vol.1 , pp. 599-608
    • Chalmers, D.T.1    Behan, D.P.2
  • 19
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
    • Cheng, Y. and Prusoff, W. H. (1973) Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochemical Pharmacology, 22, 3099-3108.
    • (1973) Biochemical Pharmacology , vol.22 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 21
    • 0036490942 scopus 로고    scopus 로고
    • Allosteric binding sites on cell-surface receptors: novel targets for drug discovery
    • Christopoulos, A. (2002) Allosteric binding sites on cell-surface receptors: novel targets for drug discovery. Nature Reviews Drug Discovery, 1, 198-210.
    • (2002) Nature Reviews Drug Discovery , vol.1 , pp. 198-210
    • Christopoulos, A.1
  • 22
    • 0036258990 scopus 로고    scopus 로고
    • G protein-coupled receptor allosterism and complexing
    • Christopoulos, A. and Kenakin, T. (2002) G protein-coupled receptor allosterism and complexing. Pharmacological Reviews, 54, 323-374.
    • (2002) Pharmacological Reviews , vol.54 , pp. 323-374
    • Christopoulos, A.1    Kenakin, T.2
  • 23
    • 0030296744 scopus 로고    scopus 로고
    • G protein-coupled receptors:heterologous regulation of homologous desensitization and its implications
    • Chuang, T. T., Iacovelli, L., Sallese, M. and De Blasi, A. (1996) G protein-coupled receptors:heterologous regulation of homologous desensitization and its implications. Trends in Pharmacological Sciences, 17, 416-421.
    • (1996) Trends in Pharmacological Sciences , vol.17 , pp. 416-421
    • Chuang, T.T.1    Iacovelli, L.2    Sallese, M.3    De Blasi, A.4
  • 24
    • 0003779650 scopus 로고    scopus 로고
    • The Cell: A Molecular Approach
    • ASM Press, Washington D.C.
    • Cooper, G. M. (2007) The Cell: A Molecular Approach. ASM Press, Washington D.C.
    • (2007)
    • Cooper, G.M.1
  • 25
    • 33748325882 scopus 로고    scopus 로고
    • Drug-target residence time and its implication for lead optimization
    • Copeland, R., Pompliano, D. and Meek, T. (2006) Drug-target residence time and its implication for lead optimization. Nature Reviews Drug Discovery, 9, 730-739.
    • (2006) Nature Reviews Drug Discovery , vol.9 , pp. 730-739
    • Copeland, R.1    Pompliano, D.2    Meek, T.3
  • 26
    • 0019137579 scopus 로고
    • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
    • De Lean, A., Stadel, J. and Lefkowitz, R. (1980) A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. Journal of Biological Chemistry, 255, 7108-7117.
    • (1980) Journal of Biological Chemistry , vol.255 , pp. 7108-7117
    • De Lean, A.1    Stadel, J.2    Lefkowitz, R.3
  • 29
    • 0028287029 scopus 로고
    • Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs
    • Eason, M., Jacinto, M. and Liggett, S. (1994) Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs. Molecular Pharmacology, 45, 696-702.
    • (1994) Molecular Pharmacology , vol.45 , pp. 696-702
    • Eason, M.1    Jacinto, M.2    Liggett, S.3
  • 30
    • 0028977998 scopus 로고
    • The docking of Arg of angiotensin II with Asp of AT receptor is essential for full agonism
    • Feng, Y.-H., Noda, K., Saad, Y., Liu, X.-P., Husain, A. and Karnik, S. S. (1995) The docking of Arg of angiotensin II with Asp of AT receptor is essential for full agonism. Journal of Biological Chemistry, 270, 12846-12850.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 12846-12850
    • Feng, Y.-H.1    Noda, K.2    Saad, Y.3    Liu, X.-P.4    Husain, A.5    Karnik, S.S.6
  • 31
    • 0035101820 scopus 로고    scopus 로고
    • Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling
    • Ferguson, S. S. G. (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacological Reviews, 53, 1-24.
    • (2001) Pharmacological Reviews , vol.53 , pp. 1-24
    • Ferguson, S.S.G.1
  • 32
    • 0032970721 scopus 로고    scopus 로고
    • Binding of the antagonist [3H]candesartan to angiotensin II AT1 receptor-transfected Chinese hamster ovary cells
    • Fierens, F., Vanderheyden, P. M., De Backer, J. P. and Vauquelin, G. (1999a) Binding of the antagonist [3H]candesartan to angiotensin II AT1 receptor-transfected Chinese hamster ovary cells. European Journal of Pharmacology, 367, 413-422.
    • (1999) European Journal of Pharmacology , vol.367 , pp. 413-422
    • Fierens, F.1    Vanderheyden, P.M.2    De Backer, J.P.3    Vauquelin, G.4
  • 38
    • 0025802682 scopus 로고
    • Interactions of purified bovine brain A1- adenosine receptors with G proteins. Reciprocal modulation of agonist and antagonist binding
    • Freissmuth, M., Selzer, E. and Schutz, W. (1991) Interactions of purified bovine brain A1- adenosine receptors with G proteins. Reciprocal modulation of agonist and antagonist binding. Biochemical Journal, 275, 651-656.
    • (1991) Biochemical Journal , vol.275 , pp. 651-656
    • Freissmuth, M.1    Selzer, E.2    Schutz, W.3
  • 39
    • 0033152909 scopus 로고    scopus 로고
    • Structure of the integral membrane domain of the GLP1 receptor proteins
    • Frimurer, T.M., and Bywater, B. R. (1999) Structure of the integral membrane domain of the GLP1 receptor proteins. Structure, Function and Genetics, 35, 375-386.
    • (1999) Structure, Function and Genetics , vol.35 , pp. 375-386
    • Frimurer, T.M.1    Bywater, B.R.2
  • 40
    • 0002355204 scopus 로고
    • On the use of -haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes
    • In N. J. Harper and A. B. Simmonds, Eds., Academic Press, London
    • Furchgott, R. R. (1966) On the use of -haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes. In N. J. Harper and A. B. Simmonds, Eds. Advances in Drug Research, Vol 3. Academic Press, London, p. 21-55.
    • (1966) Advances in Drug Research , vol.3 , pp. 21-55
    • Furchgott, R.R.1
  • 42
    • 0034464742 scopus 로고    scopus 로고
    • Uncovering molecular mechanisms involved in activation of G proteincoupled receptors
    • Gether, U. (2000) Uncovering molecular mechanisms involved in activation of G proteincoupled receptors. Endocrine Review, 21, 90-113.
    • (2000) Endocrine Review , vol.21 , pp. 90-113
    • Gether, U.1
  • 43
    • 0032541084 scopus 로고    scopus 로고
    • G protein-coupled Receptors. II. Mechanism of agonist activation
    • Gether, U. and Kobilka, B. K. (1998) G protein-coupled Receptors. II. Mechanism of agonist activation. Journal of Biological Chemistry, 273, 17979-17982.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 17979-17982
    • Gether, U.1    Kobilka, B.K.2
  • 44
    • 0030831364 scopus 로고    scopus 로고
    • A new approach to docking in the sdrenergic receptor that exploits the domain structure of G protein-coupled receptors
    • Gouldson, P. R., Snell, C. R. and Reynolds, C. A. (1997) A new approach to docking in the sdrenergic receptor that exploits the domain structure of G protein-coupled receptors. Journal of Medicinal Chemistry, 40, 3871-3886.
    • (1997) Journal of Medicinal Chemistry , vol.40 , pp. 3871-3886
    • Gouldson, P.R.1    Snell, C.R.2    Reynolds, C.A.3
  • 45
    • 0027503004 scopus 로고
    • Compartmentation of receptors and guanine nucleotidebinding proteins in NG108-15 cells: lack of cross talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors
    • Graeser, D. and Neubig, R. (1993) Compartmentation of receptors and guanine nucleotidebinding proteins in NG108-15 cells: lack of cross talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors. Molecular Pharmacology, 43, 434-443.
    • (1993) Molecular Pharmacology , vol.43 , pp. 434-443
    • Graeser, D.1    Neubig, R.2
  • 46
    • 0033669603 scopus 로고    scopus 로고
    • Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation
    • Hall, D. (2000) Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation. Molecular Pharmacology, 58, 1412-1423.
    • (2000) Molecular Pharmacology , vol.58 , pp. 1412-1423
    • Hall, D.1
  • 47
    • 0032702510 scopus 로고    scopus 로고
    • Allosteric regulation by oleamid of the binding properties of 5-hydroxytryptamine 7 receptors
    • Hedlund, P., Carson, M., Sutcliffe, J. and Thomas, E. (1999) Allosteric regulation by oleamid of the binding properties of 5-hydroxytryptamine 7 receptors. Biochemical Pharmacology, 58, 1807-1813.
    • (1999) Biochemical Pharmacology , vol.58 , pp. 1807-1813
    • Hedlund, P.1    Carson, M.2    Sutcliffe, J.3    Thomas, E.4
  • 48
    • 0038540318 scopus 로고    scopus 로고
    • Biochemical and pharmacological control of the multiplicity of coupling at G protein-coupled receptors
    • Hermans, E. (2003) Biochemical and pharmacological control of the multiplicity of coupling at G protein-coupled receptors. Pharmacology and Therapeutics, 99, 25-44.
    • (2003) Pharmacology and Therapeutics , vol.99 , pp. 25-44
    • Hermans, E.1
  • 49
    • 0036208442 scopus 로고    scopus 로고
    • Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors
    • Holloway, A. C., Qian, H., Pipolo, L., Ziogas, J., Miura, S.-I., Karnik, S., Southwell, B. R., Lew, M. J. and Thomas, W. G. (2002) Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. Molecular Pharmacology, 61, 768-777.
    • (2002) Molecular Pharmacology , vol.61 , pp. 768-777
    • Holloway, A.C.1    Qian, H.2    Pipolo, L.3    Ziogas, J.4    Miura, S.-I.5    Karnik, S.6    Southwell, B.R.7    Lew, M.J.8    Thomas, W.G.9
  • 51
    • 0032983090 scopus 로고    scopus 로고
    • The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm
    • Hulme, E., Lu, Z., Ward, S., Allman, K. and Curtis, C. (1999) The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm. European Journal of Pharmacology, 375, 247-260.
    • (1999) European Journal of Pharmacology , vol.375 , pp. 247-260
    • Hulme, E.1    Lu, Z.2    Ward, S.3    Allman, K.4    Curtis, C.5
  • 53
    • 0034327470 scopus 로고    scopus 로고
    • The molecular pharmacology of CGRP and related peptide receptor subtypes
    • Juaneda, C., Dumont, Y. and Quirion, R. (2000) The molecular pharmacology of CGRP and related peptide receptor subtypes. Trends in Pharmacological Sciences, 21, 432-438.
    • (2000) Trends in Pharmacological Sciences , vol.21 , pp. 432-438
    • Juaneda, C.1    Dumont, Y.2    Quirion, R.3
  • 54
    • 0033798153 scopus 로고    scopus 로고
    • The dopamine D3 receptor interacts with itself and the truncated D3 splice variant D3nf: D3-D3nf interaction causes mislocalization of D3 receptors
    • Karpa, K. D., Lin, R., Kabbani, N. and Levenson, R. (2000) The dopamine D3 receptor interacts with itself and the truncated D3 splice variant D3nf: D3-D3nf interaction causes mislocalization of D3 receptors. Molecular Pharmacology, 58, 677-683.
    • (2000) Molecular Pharmacology , vol.58 , pp. 677-683
    • Karpa, K.D.1    Lin, R.2    Kabbani, N.3    Levenson, R.4
  • 55
    • 0029061611 scopus 로고
    • Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity
    • Kenakin, T. (1995a) Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity. Trends in Pharmacological Sciences, 16, 188-192.
    • (1995) Trends in Pharmacological Sciences , vol.16 , pp. 188-192
    • Kenakin, T.1
  • 56
    • 0029054965 scopus 로고
    • Agonist-receptor efficacy II: agonist trafficking of receptor signals
    • Kenakin, T. (1995b) Agonist-receptor efficacy II: agonist trafficking of receptor signals. Trends in Pharmacological Sciences, 16, 232-238.
    • (1995) Trends in Pharmacological Sciences , vol.16 , pp. 232-238
    • Kenakin, T.1
  • 58
    • 0029812311 scopus 로고    scopus 로고
    • The classification of seven transmembrane receptors in recombinant expression systems
    • Kenakin, T. (1996) The classification of seven transmembrane receptors in recombinant expression systems. Pharmacological Reviews, 48, 413-463.
    • (1996) Pharmacological Reviews , vol.48 , pp. 413-463
    • Kenakin, T.1
  • 59
    • 0043235844 scopus 로고    scopus 로고
    • Ligand-selective receptor conformations revisited: the promise and the problem
    • Kenakin, T. (2003) Ligand-selective receptor conformations revisited: the promise and the problem. Trends in Pharmacological Sciences, 24, 346-354.
    • (2003) Trends in Pharmacological Sciences , vol.24 , pp. 346-354
    • Kenakin, T.1
  • 60
    • 1942517868 scopus 로고    scopus 로고
    • Principles: receptor theory in pharmacology
    • Kenakin, T. (2004) Principles: receptor theory in pharmacology. Trends in Pharmacological Sciences, 25, 186-192.
    • (2004) Trends in Pharmacological Sciences , vol.25 , pp. 186-192
    • Kenakin, T.1
  • 62
    • 0026592357 scopus 로고
    • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation
    • Kjelsberg, M., Cotecchia, S., Ostrowski, J., Caron, M. & Lefkowitz, R. (1992) Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. Journal of Biological Chemistry, 267, 1430-1433.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 1430-1433
    • Kjelsberg, M.1    Cotecchia, S.2    Ostrowski, J.3    Caron, M.4    Lefkowitz, R.5
  • 63
    • 0013863816 scopus 로고
    • Comparison of experimental binding data and theoretical models in proteins containing subunits
    • Koshland, D. E., Jr., Nemethy, G. and Filmer, D. (1966) Comparison of experimental binding data and theoretical models in proteins containing subunits. Biochemistry, 5, 365-385.
    • (1966) Biochemistry , vol.5 , pp. 365-385
    • Koshland Jr., D.E.1    Nemethy, G.2    Filmer, D.3
  • 64
    • 0028204451 scopus 로고
    • Solution structure and dynamics of Ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy
    • Kraulis, P. J., Domaille, P. J., Campbell-Burk, S. L., Van Aken, T. and Laue, E. D. (1994) Solution structure and dynamics of Ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy. Biochemistry, 33, 3515-3531.
    • (1994) Biochemistry , vol.33 , pp. 3515-3531
    • Kraulis, P.J.1    Domaille, P.J.2    Campbell-Burk, S.L.3    Van Aken, T.4    Laue, E.D.5
  • 65
    • 0030610845 scopus 로고    scopus 로고
    • The stability of the agonist beta 2-adrenergic receptor-Gs complex: evidence for agonist-specific states
    • Krumins, A. M. and Barber, R. (1997) The stability of the agonist beta 2-adrenergic receptor-Gs complex: evidence for agonist-specific states. Molecular Pharmacology, 52, 144-154.
    • (1997) Molecular Pharmacology , vol.52 , pp. 144-154
    • Krumins, A.M.1    Barber, R.2
  • 66
    • 0035577682 scopus 로고    scopus 로고
    • Modelling of promiscuous receptor-Gi/Gs-protein coupling and effector response
    • Kukkonen, J. P., Nasman, J. and Akerman, K. E. O. (2001) Modelling of promiscuous receptor-Gi/Gs-protein coupling and effector response. Trends in Pharmacological Sciences, 22, 616-622.
    • (2001) Trends in Pharmacological Sciences , vol.22 , pp. 616-622
    • Kukkonen, J.P.1    Nasman, J.2    Akerman, K.E.O.3
  • 67
    • 0020475449 scopus 로고
    • A simple method for displaying the hydropathic character of a protein
    • Kyte, J. and Doolittle, R. F. (1982) A simple method for displaying the hydropathic character of a protein. Journal of Molecular Biology, 157, 105-132.
    • (1982) Journal of Molecular Biology , vol.157 , pp. 105-132
    • Kyte, J.1    Doolittle, R.F.2
  • 68
    • 0037189515 scopus 로고    scopus 로고
    • Angiotensin IV is a potent agonist for constitutive active human AT1 receptors. Distinct roles of the N- and C-terminal residues of angiotensin II during AT1 receptor activation
    • Le, M. T., Vanderheyden, P. M. L., Szaszak, M., Hunyady, L. and Vauquelin, G. (2002) Angiotensin IV is a potent agonist for constitutive active human AT1 receptors. Distinct roles of the N- and C-terminal residues of angiotensin II during AT1 receptor activation. Journal of Biological Chemistry, 277, 23107-23110.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 23107-23110
    • Le, M.T.1    Vanderheyden, P.M.L.2    Szaszak, M.3    Hunyady, L.4    Vauquelin, G.5
  • 69
    • 0033924207 scopus 로고    scopus 로고
    • Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell
    • Lee, S. P., O'dowd, B. F., Ng, G. Y. K., Varghese, G., Akil, H., Mansour, A., Nguyen, T. and George, S. R. (2000) Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell. Molecular Pharmacology, 58, 120-128.
    • (2000) Molecular Pharmacology , vol.58 , pp. 120-128
    • Lee, S.P.1    O'dowd, B.F.2    Ng, G.Y.K.3    Varghese, G.4    Akil, H.5    Mansour, A.6    Nguyen, T.7    George, S.R.8
  • 71
    • 0031799559 scopus 로고    scopus 로고
    • Characterization of the allosteric interactions between and amiloride analogues at the human alpha2-adrenergic receptor
    • Leppik, R., Lazareno, S., Mynett, A. and Birdsall, N. (1998) Characterization of the allosteric interactions between and amiloride analogues at the human alpha2-adrenergic receptor. Molecular Pharmacology, 53, 916-925.
    • (1998) Molecular Pharmacology , vol.53 , pp. 916-925
    • Leppik, R.1    Lazareno, S.2    Mynett, A.3    Birdsall, N.4
  • 73
    • 0036473397 scopus 로고    scopus 로고
    • The role of beta-arrestins in the termination and transduction of G protein-coupled receptor signals
    • Luttrell, L. M. and Lefkowitz, R. J. (2002) The role of beta-arrestins in the termination and transduction of G protein-coupled receptor signals. Journal of Cell Science, 115, 455-465.
    • (2002) Journal of Cell Science , vol.115 , pp. 455-465
    • Luttrell, L.M.1    Lefkowitz, R.J.2
  • 76
    • 0035498937 scopus 로고    scopus 로고
    • Receptor activation: what does the rhodopsin structure tell us?
    • Meng, E. C. and Bourne, H. R. (2001) Receptor activation: what does the rhodopsin structure tell us? Trends in Pharmacological Sciences, 22, 587-593.
    • (2001) Trends in Pharmacological Sciences , vol.22 , pp. 587-593
    • Meng, E.C.1    Bourne, H.R.2
  • 77
    • 0033049565 scopus 로고    scopus 로고
    • Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features
    • Mhaouty-Kodja, S., Barak, L. S., Scheer, A., Abuin, L., Diviani, D., Caron, M. G. and Cotecchia, S. (1999) Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features. Molecular Pharmacology, 55, 339-347.
    • (1999) Molecular Pharmacology , vol.55 , pp. 339-347
    • Mhaouty-Kodja, S.1    Barak, L.S.2    Scheer, A.3    Abuin, L.4    Diviani, D.5    Caron, M.G.6    Cotecchia, S.7
  • 78
    • 0033916687 scopus 로고    scopus 로고
    • From agonist to antagonist:fab fragments of an agonist-like monoclonal anti-beta 2-adrenoceptor antibody behave as antagonists
    • Mijares, A., Lebesgue, D., Wallukat, G. and Hoebeke, J. (2000) From agonist to antagonist:fab fragments of an agonist-like monoclonal anti-beta 2-adrenoceptor antibody behave as antagonists. Molecular Pharmacology, 58, 373-379.
    • (2000) Molecular Pharmacology , vol.58 , pp. 373-379
    • Mijares, A.1    Lebesgue, D.2    Wallukat, G.3    Hoebeke, J.4
  • 79
    • 0037305047 scopus 로고    scopus 로고
    • Principles: extending the utility of [35S]GTP gamma S binding assays
    • Milligan, G. (2003) Principles: extending the utility of [35S]GTP gamma S binding assays. Trends in Pharmacol Sciences, 24, 87-91.
    • (2003) Trends in Pharmacol Sciences , vol.24 , pp. 87-91
    • Milligan, G.1
  • 80
    • 0035478746 scopus 로고    scopus 로고
    • Protein-protein interactions at G protein-coupled receptors
    • Milligan, G. and White, J. H. (2001) Protein-protein interactions at G protein-coupled receptors. Trends in Pharmacological Sciences, 22, 513-518.
    • (2001) Trends in Pharmacological Sciences , vol.22 , pp. 513-518
    • Milligan, G.1    White, J.H.2
  • 82
    • 78651189765 scopus 로고
    • On the nature of allosteric transitions: a plausible model
    • Monod, J., Wyman, J. and Changeux, J. (1965) On the nature of allosteric transitions: a plausible model. Journal of Molecular Biology, 12, 88-118.
    • (1965) Journal of Molecular Biology , vol.12 , pp. 88-118
    • Monod, J.1    Wyman, J.2    Changeux, J.3
  • 83
    • 0003690341 scopus 로고
    • Biochemistry. A Case-Oriented Approach
    • The C.V. Mosby Company, St. Louis.
    • Montgomery, R., Conway, T. W. and Spector, A. A. (1990) Biochemistry. A Case-Oriented Approach. The C.V. Mosby Company, St. Louis.
    • (1990)
    • Montgomery, R.1    Conway, T.W.2    Spector, A.A.3
  • 85
    • 0035479917 scopus 로고    scopus 로고
    • Role of G protein availability in differential signaling by alpha 2-adrenoceptors
    • Nasman, J., Kukkonen, J. P., Ammoun, S. and Akerman, K. E. O. (2001) Role of G protein availability in differential signaling by alpha 2-adrenoceptors. Biochemical Pharmacology, 62, 913-922.
    • (2001) Biochemical Pharmacology , vol.62 , pp. 913-922
    • Nasman, J.1    Kukkonen, J.P.2    Ammoun, S.3    Akerman, K.E.O.4
  • 86
    • 33947204210 scopus 로고    scopus 로고
    • Principles of Biochemistry
    • New York, Freeman and Company.
    • Nelson, D. L. and Cox, M. M. (2000) Principles of Biochemistry. New York, Freeman and Company.
    • (2000)
    • Nelson, D.L.1    Cox, M.M.2
  • 87
    • 0004026407 scopus 로고    scopus 로고
    • Lehninger, Principles of Biochemistry
    • New York, W. H. Freeman and Company
    • Nelson, D. L. and Cox, M. M. (2005) Lehninger, Principles of Biochemistry. New York, W. H. Freeman and Company, p. 372.
    • (2005) , pp. 372
    • Nelson, D.L.1    Cox, M.M.2
  • 88
    • 0035164003 scopus 로고    scopus 로고
    • Segregation of heterotrimeric G proteins in cell surface microdomains. Gq binds caveolin to concentrate in caveolae, whereas Gi and Gs target lipid rafts by default
    • Oh, P. and Schnitzer, J. E. (2001) Segregation of heterotrimeric G proteins in cell surface microdomains. Gq binds caveolin to concentrate in caveolae, whereas Gi and Gs target lipid rafts by default. Molecular Biology of the Cell, 12, 685-698.
    • (2001) Molecular Biology of the Cell , vol.12 , pp. 685-698
    • Oh, P.1    Schnitzer, J.E.2
  • 89
    • 0032489443 scopus 로고    scopus 로고
    • Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane
    • Okamoto, T., Schlegel, A., Scherer, P. E. and Lisanti, M. P. (1998) Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane. Journal of Biological Chemistry, 273, 5419-5422.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 5419-5422
    • Okamoto, T.1    Schlegel, A.2    Scherer, P.E.3    Lisanti, M.P.4
  • 90
    • 0036180964 scopus 로고    scopus 로고
    • New determinants of receptor-effector coupling: trafficking and compartmentation in membrane microdomains
    • Ostrom, R. S. (2002) New determinants of receptor-effector coupling: trafficking and compartmentation in membrane microdomains. Molecular Pharmacology, 61, 473-476.
    • (2002) Molecular Pharmacology , vol.61 , pp. 473-476
    • Ostrom, R.S.1
  • 91
    • 0035834749 scopus 로고    scopus 로고
    • Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase
    • Ostrom, R. S., Gregorian, C., Drenan, R. M., Xiang, Y., Regan, J. W. and Insel, P. A. (2001) Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. Journal of Biological Chemistry, 276, 42063-42069.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 42063-42069
    • Ostrom, R.S.1    Gregorian, C.2    Drenan, R.M.3    Xiang, Y.4    Regan, J.W.5    Insel, P.A.6
  • 92
    • 0033943654 scopus 로고    scopus 로고
    • Stochiometry and compartmentation in G protein-coupled receptor signaling: implications for therapetic interventions involving G(s)
    • Ostrom, R. S., Post, R. and Insel, P. (2000) Stochiometry and compartmentation in G protein-coupled receptor signaling: implications for therapetic interventions involving G(s). Journal of Pharmacology and Experimental Therapeutics, 294, 407-412.
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.294 , pp. 407-412
    • Ostrom, R.S.1    Post, R.2    Insel, P.3
  • 94
    • 0034691035 scopus 로고    scopus 로고
    • Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay
    • Parnot, C., Bardin, S., Miserey-Lenkei, S., Guedin, D., Corvol, P. and Clauser, E. (2000) Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay. Proceedings of the National Academy of Sciences, 97, 7615-7620.
    • (2000) Proceedings of the National Academy of Sciences , vol.97 , pp. 7615-7620
    • Parnot, C.1    Bardin, S.2    Miserey-Lenkei, S.3    Guedin, D.4    Corvol, P.5    Clauser, E.6
  • 96
    • 0041878682 scopus 로고    scopus 로고
    • The distinct role of mGlu1 receptors in post-ischemic neuronal death
    • Pellegrini-Giampietro, D. E. (2003) The distinct role of mGlu1 receptors in post-ischemic neuronal death. Trends in Pharmacological Sciences, 24, 461-470.
    • (2003) Trends in Pharmacological Sciences , vol.24 , pp. 461-470
    • Pellegrini-Giampietro, D.E.1
  • 97
    • 0041494100 scopus 로고    scopus 로고
    • Lipid rafts: bringing order to chaos
    • Pike, L. J. (2003) Lipid rafts: bringing order to chaos. Journal of Lipid Research, 44, 655-667.
    • (2003) Journal of Lipid Research , vol.44 , pp. 655-667
    • Pike, L.J.1
  • 98
    • 0038662595 scopus 로고    scopus 로고
    • Evolution, structure, and activation mechanism of family 3/C G protein-coupled receptors
    • Pin, J.-P., Galvez, T. and Prezeau, L. (2003) Evolution, structure, and activation mechanism of family 3/C G protein-coupled receptors. Pharmacology & Therapeutics, 98, 325-354.
    • (2003) Pharmacology & Therapeutics , vol.98 , pp. 325-354
    • Pin, J.-P.1    Galvez, T.2    Prezeau, L.3
  • 99
    • 0032586989 scopus 로고    scopus 로고
    • The cholecystokinin B receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins
    • Pommier, B., Da Nascimento, S., Dumont, S., Bellier, B., Million, E., Garbay, C., Roques, B. P. and Noble, F. (1999) The cholecystokinin B receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins. Journal of Neurochemistry, 73, 281-288.
    • (1999) Journal of Neurochemistry , vol.73 , pp. 281-288
    • Pommier, B.1    Da Nascimento, S.2    Dumont, S.3    Bellier, B.4    Million, E.5    Garbay, C.6    Roques, B.P.7    Noble, F.8
  • 100
    • 0037101774 scopus 로고    scopus 로고
    • Homo-and hetero-oligomeric interactions between G protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences
    • Ramsay, D., Kellett, E., Mcvey, M., Rees, S. and Milligan, G. (2002) Homo- and hetero-oligomeric interactions between G protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences. Biochemical Journal, 365, 429-440.
    • (2002) Biochemical Journal , vol.365 , pp. 429-440
    • Ramsay, D.1    Kellett, E.2    Mcvey, M.3    Rees, S.4    Milligan, G.5
  • 101
    • 0035577569 scopus 로고    scopus 로고
    • Developments in whole-body molecular imaging of live subjects
    • Reader, A. J. and Zweit, J. (2001) Developments in whole-body molecular imaging of live subjects. Trends in Pharmacological Sciences, 22, 604-607.
    • (2001) Trends in Pharmacological Sciences , vol.22 , pp. 604-607
    • Reader, A.J.1    Zweit, J.2
  • 102
    • 0003812214 scopus 로고
    • Medical Physiology
    • Philadelphia, Lipincott Williams & Wilkins (A Wolters Kluwer Company), (Fi.g 3-20 A).
    • Rhoades, R. A. and Tanner, G. A. (1995) Medical Physiology. Philadelphia, Lipincott Williams & Wilkins (A Wolters Kluwer Company), p.49 (Fi.g 3-20 A).
    • (1995) , pp. 49
    • Rhoades, R.A.1    Tanner, G.A.2
  • 103
    • 0035726693 scopus 로고    scopus 로고
    • G protein-coupled receptor dimerization:modulation of receptor function
    • Rios, C. D., Jordan, B. A., Gomes, I. and Devi, L. A. (2001) G protein-coupled receptor dimerization:modulation of receptor function. Pharmacology and Therapeutics, 92, 71-87.
    • (2001) Pharmacology and Therapeutics , vol.92 , pp. 71-87
    • Rios, C.D.1    Jordan, B.A.2    Gomes, I.3    Devi, L.A.4
  • 105
    • 0027513982 scopus 로고
    • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
    • Samama, P., Cotecchia, S., Costa, T. and Lefkowitz, R. (1993) A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. Journal of Biological Chemistry, 268, 4625-4636.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 4625-4636
    • Samama, P.1    Cotecchia, S.2    Costa, T.3    Lefkowitz, R.4
  • 106
    • 84969001783 scopus 로고
    • The attraction of proteins to small molecules and ions
    • Scatchard, G. (1949) The attraction of proteins to small molecules and ions. Annals of the New York Academy of Sciences, 51, 600-672.
    • (1949) Annals of the New York Academy of Sciences , vol.51 , pp. 600-672
    • Scatchard, G.1
  • 107
    • 11944268922 scopus 로고
    • Molecular mechanism of action of non-peptide ligands for peptide receptors
    • Schwartz, T., Gether, U., Schambye, H. and Hjort, T. (1995) Molecular mechanism of action of non-peptide ligands for peptide receptors. Current Pharmaceutical Design, 1, 325-342.
    • (1995) Current Pharmaceutical Design , vol.1 , pp. 325-342
    • Schwartz, T.1    Gether, U.2    Schambye, H.3    Hjort, T.4
  • 108
    • 33745130304 scopus 로고    scopus 로고
    • Anatomy & Physiology
    • Boston, McGraw Hill.
    • Seeley, R. R., Stephens,T.D. and Tate, P. (2000) Anatomy & Physiology. Boston, McGraw Hill.
    • (2000)
    • Seeley, R.R.1    Stephens, T.D.2    Tate, P.3
  • 109
    • 0015514472 scopus 로고
    • The fluid mosaic model of the structure of cell membranes
    • Singer, S. J. and Nicolson, G. L. (1972) The fluid mosaic model of the structure of cell membranes. Science, 175, 720-731.
    • (1972) Science , vol.175 , pp. 720-731
    • Singer, S.J.1    Nicolson, G.L.2
  • 112
    • 0034213071 scopus 로고    scopus 로고
    • LNB-TM7, a group of seven-transmembrane proteins related to family-B G protein-coupled receptors
    • Stacey, M., Lin, H.-H., Gordon, S. and Mcknight, A. J. (2000) LNB-TM7, a group of seven-transmembrane proteins related to family-B G protein-coupled receptors. Trends in Biochemical Sciences, 25, 284-289.
    • (2000) Trends in Biochemical Sciences , vol.25 , pp. 284-289
    • Stacey, M.1    Lin, H.-H.2    Gordon, S.3    Mcknight, A.J.4
  • 114
    • 2242457698 scopus 로고
    • The beta-adrenergic receptors and G proteins in The Molecular Biology of Receptor Techniques and Applications of Receptor Research
    • Weinheim, VCH Publisher
    • Strosberg, A. D. (1987) The beta-adrenergic receptors and G proteins in The Molecular Biology of Receptor Techniques and Applications of Receptor Research. Weinheim, VCH Publisher, p. 139-163.
    • (1987) , pp. 139-163
    • Strosberg, A.D.1
  • 115
    • 0034734253 scopus 로고    scopus 로고
    • Crystallographic analysis of protein conformational changes in the bacteriorhodopsin photocycle
    • Subramaniam, S. and Hendersson, R. (2000) Crystallographic analysis of protein conformational changes in the bacteriorhodopsin photocycle. Biochimica et Biophysica Acta, 1460, 157-165.
    • (2000) Biochimica et Biophysica Acta , vol.1460 , pp. 157-165
    • Subramaniam, S.1    Hendersson, R.2
  • 116
    • 0013886529 scopus 로고
    • The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones
    • Sutherland, E. W. and Robison, G. A. (1966) The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones. Pharmacological Reviews, 18, 145-161.
    • (1966) Pharmacological Reviews , vol.18 , pp. 145-161
    • Sutherland, E.W.1    Robison, G.A.2
  • 117
    • 4544381198 scopus 로고    scopus 로고
    • Biochemical mechanisms of drug action: what does it take for success
    • Swinney, D. (2004) Biochemical mechanisms of drug action: what does it take for success. Nature Reviews Drug Discovery, 3, 801-808.
    • (2004) Nature Reviews Drug Discovery , vol.3 , pp. 801-808
    • Swinney, D.1
  • 119
    • 0028176054 scopus 로고
    • Determinanans of alpha 2- adrenergic receptor activation of G proteins: evidence for a precoupled receptor/G proetin state
    • Tian, W. N., Duzic, E., Lanier, S. M. and Deth, R. C. (1994) Determinanans of alpha 2- adrenergic receptor activation of G proteins: evidence for a precoupled receptor/G proetin state. Molecular Pharmacology, 45, 524-531.
    • (1994) Molecular Pharmacology , vol.45 , pp. 524-531
    • Tian, W.N.1    Duzic, E.2    Lanier, S.M.3    Deth, R.C.4
  • 121
    • 0037088585 scopus 로고    scopus 로고
    • Beta -Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation
    • Tohgo, A., Pierce, K. L., Choy, E. W., Lefkowitz, R. J. and Luttrell, L. M. (2002) beta -Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. Journal of Biological Chemistry, 277, 9429-9436.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 9429-9436
    • Tohgo, A.1    Pierce, K.L.2    Choy, E.W.3    Lefkowitz, R.J.4    Luttrell, L.M.5
  • 122
    • 0018125541 scopus 로고
    • Model of coupling between the beta-adrenergic receptor and adnylate cyclase in turkey erythrocyte membranes
    • Tolkovsky, A. and Levitzki, R. (1978) Model of coupling between the beta-adrenergic receptor and adnylate cyclase in turkey erythrocyte membranes. Biochemistry, 17, 3795-3810.
    • (1978) Biochemistry , vol.17 , pp. 3795-3810
    • Tolkovsky, A.1    Levitzki, R.2
  • 123
    • 0034643287 scopus 로고    scopus 로고
    • Further evidence for the presence of "septide-sensitive" tachykinin binding sites in tissues possessing solely NK1 tachykinin receptors
    • Torrens, Y., Beaujouan, J.-C., Saffroy, M. and Glowinski, J. (2000) Further evidence for the presence of "septide-sensitive" tachykinin binding sites in tissues possessing solely NK1 tachykinin receptors. Biochemical and Biophysical Research Communications, 270, 665-672.
    • (2000) Biochemical and Biophysical Research Communications , vol.270 , pp. 665-672
    • Torrens, Y.1    Beaujouan, J.-C.2    Saffroy, M.3    Glowinski, J.4
  • 124
    • 0034760504 scopus 로고    scopus 로고
    • Positive allosteric modulation of native and recombinant gamma -aminobutyric acid B receptors by 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501
    • Urwyler, S., Mosbacher, J., Lingenhoehl, K., Heid, J., Hofstetter, K., Froestl, W., Bettler, B. and Kaupmann, K. (2001) Positive allosteric modulation of native and recombinant gamma -aminobutyric acid B receptors by 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Molecular Pharmacology, 60, 963-971.
    • (2001) Molecular Pharmacology , vol.60 , pp. 963-971
    • Urwyler, S.1    Mosbacher, J.2    Lingenhoehl, K.3    Heid, J.4    Hofstetter, K.5    Froestl, W.6    Bettler, B.7    Kaupmann, K.8
  • 125
    • 0026699804 scopus 로고
    • Multiple beta adrenergic receptor subclasses mediate the l-isoproterenol-induced lipolytic response in rat adipocytes
    • Van Liefde, I., Van Witzenburg, A. and Vauquelin, G. (1992) Multiple beta adrenergic receptor subclasses mediate the l-isoproterenol-induced lipolytic response in rat adipocytes. Journal of Pharmacology and Experimental Therapeutics, 262, 552-558.
    • (1992) Journal of Pharmacology and Experimental Therapeutics , vol.262 , pp. 552-558
    • Van Liefde, I.1    Van Witzenburg, A.2    Vauquelin, G.3
  • 126
    • 0032478359 scopus 로고    scopus 로고
    • Human neuropeptide YY1 receptors exert unequal control of the extracellular acidification rate in different cell lines
    • Van Liefde, I., Vanderheyden, P. M. L., Fraeyman, N., De Backer, J. P. and Vauquelin, G. (1998) Human neuropeptide YY1 receptors exert unequal control of the extracellular acidification rate in different cell lines. European Journal of Pharmacology, 346, 87-95.
    • (1998) European Journal of Pharmacology , vol.346 , pp. 87-95
    • Van Liefde, I.1    Vanderheyden, P.M.L.2    Fraeyman, N.3    De Backer, J.P.4    Vauquelin, G.5
  • 127
    • 0032942443 scopus 로고    scopus 로고
    • Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors
    • Vanderheyden, P. M. L., Fierens, F. L. P., De Backer, J. P., Fraeyman, N. and Vauquelin, G. (1999) Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors. British Journal of Pharmacology, 126, 1057-1065.
    • (1999) British Journal of Pharmacology , vol.126 , pp. 1057-1065
    • Vanderheyden, P.M.L.1    Fierens, F.L.P.2    De Backer, J.P.3    Fraeyman, N.4    Vauquelin, G.5
  • 128
    • 0018895294 scopus 로고
    • Inactivation of beta-adrenergic receptors by N-ethylmalmeimide: permissive role of beta-adrenergic agents in relation to adenylate cyclase activation
    • Vauquelin, G., Bottari, S. and Strosberg, A. D. (1980) Inactivation of beta-adrenergic receptors by N-ethylmalmeimide: permissive role of beta-adrenergic agents in relation to adenylate cyclase activation. Molecular Pharmacology, 17, 163-171.
    • (1980) Molecular Pharmacology , vol.17 , pp. 163-171
    • Vauquelin, G.1    Bottari, S.2    Strosberg, A.D.3
  • 129
    • 0025013047 scopus 로고
    • Identification of alpha2 adrenergic receptors in human frontal cortex membranes by binding of [3H]RX 821002, the 2-methoxy analog of [3H]idazoxan
    • Vauquelin, G, DeVos, H., De Backer, J.P. and Ebinger, G (1990) Identification of alpha2 adrenergic receptors in human frontal cortex membranes by binding of [3H]RX 821002, the 2-methoxy analog of [3H]idazoxan. Neurochemistry International, 17, 537-546.
    • (1990) Neurochemistry International , vol.17 , pp. 537-546
    • Vauquelin, G.1    DeVos, H.2    De Backer, J.P.3    Ebinger, G.4
  • 130
    • 34548510529 scopus 로고    scopus 로고
    • Mechanisms of Angiotensin II Antagonism. Competitive vs. Non-Competitive Inhibition in Angiotensin II Receptor Antagonists
    • Philadelphia, Harley & Belfus Inc.
    • Vauquelin, G., Fierens, F. and Vanderheyden, P. (2002) Mechanisms of Angiotensin II Antagonism. Competitive vs. Non-Competitive Inhibition in Angiotensin II Receptor Antagonists. Philadelphia, Harley & Belfus Inc., p. 105-118.
    • (2002) , pp. 105-118
    • Vauquelin, G.1    Fierens, F.2    Vanderheyden, P.3
  • 131
    • 84862905783 scopus 로고
    • Agonistmediated activation of adrenergic receptors
    • In C. Melchiorre andM. Gianella, Eds., Amsterdam, Elsevier Science Publishers B.V.
    • Vauquelin, G., Severne, Y., Convents, A., Nerme, V. and Abrahamsson, T. (1988) Agonistmediated activation of adrenergic receptors. In C. Melchiorre andM. Gianella, Eds. Recent Advances in Receptor Chemistry. Amsterdam, Elsevier Science Publishers B.V., p. 43-61.
    • (1988) Recent Advances in Receptor Chemistry. , pp. 43-61
    • Vauquelin, G.1    Severne, Y.2    Convents, A.3    Nerme, V.4    Abrahamsson, T.5
  • 133
    • 0028987618 scopus 로고
    • Anti-beta 1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: mapping of epitopes in the first and second extracellular loops
    • Wallukat, G., Wollenberger, A., Morwinski, R. and Pitschner, H. F. (1995) Anti-beta 1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: mapping of epitopes in the first and second extracellular loops. Journal of Molecular & Cellular Cardiology, 27, 397-406.
    • (1995) Journal of Molecular & Cellular Cardiology , vol.27 , pp. 397-406
    • Wallukat, G.1    Wollenberger, A.2    Morwinski, R.3    Pitschner, H.F.4
  • 134
    • 0037184945 scopus 로고    scopus 로고
    • Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3
    • Wang, Q. and Limbird, L. E. (2002) Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3. Journal of Biological Chemistry, 277, 50589-50596.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 50589-50596
    • Wang, Q.1    Limbird, L.E.2
  • 135
    • 0030596736 scopus 로고    scopus 로고
    • The cubic ternary complex receptor-occupancy model III. Resurrecting efficacy
    • Weiss, J. M., Morgan, P. H., Lutz, M. W. and Kenakin, T. P. (1996) The cubic ternary complex receptor-occupancy model III. Resurrecting efficacy. Journal of Theoretical Biology, 181, 381-397.
    • (1996) Journal of Theoretical Biology , vol.181 , pp. 381-397
    • Weiss, J.M.1    Morgan, P.H.2    Lutz, M.W.3    Kenakin, T.P.4
  • 136
    • 0033794067 scopus 로고    scopus 로고
    • Molecular analysis of beta 2-adrenoceptor coupling to Gs-, Gi-, and Gq-proteins
    • Wenzel-Seifert, K. and Seifert, R. (2000) Molecular analysis of beta 2-adrenoceptor coupling to Gs-, Gi-, and Gq-proteins. Molecular Pharmacology, 58, 954-966.
    • (2000) Molecular Pharmacology , vol.58 , pp. 954-966
    • Wenzel-Seifert, K.1    Seifert, R.2
  • 137
    • 0032402450 scopus 로고    scopus 로고
    • Molecular basis of receptor/G protein-coupling selectivity
    • Wess, J. (1998) Molecular basis of receptor/G protein-coupling selectivity. Pharmacology and Therapeutics, 80, 231-264.
    • (1998) Pharmacology and Therapeutics , vol.80 , pp. 231-264
    • Wess, J.1
  • 139
    • 0004121367 scopus 로고
    • Human Pharmacology: Molecular to Clinical
    • London, Wolfe Publishing Ltd., (Fig. 18-2).
    • Wingard, L. B., Brody, T. M., Larner, J. and Schwartz, A. (1991) Human Pharmacology: Molecular to Clinical. London, Wolfe Publishing Ltd., p. 234 (Fig. 18-2).
    • (1991) , pp. 234
    • Wingard, L.B.1    Brody, T.M.2    Larner, J.3    Schwartz, A.4
  • 140
    • 0034897325 scopus 로고    scopus 로고
    • Analytical pharmacology of G protein-coupled receptors by stoichiometric expression of the receptor and G(alpha) protein subunits
    • Wurch, T. and Pauwels, P. J. (2001) Analytical pharmacology of G protein-coupled receptors by stoichiometric expression of the receptor and G(alpha) protein subunits. Journal of Pharmacological and Toxicological Methods, 45, 3-16.
    • (2001) Journal of Pharmacological and Toxicological Methods , vol.45 , pp. 3-16
    • Wurch, T.1    Pauwels, P.J.2
  • 141
    • 0037452545 scopus 로고    scopus 로고
    • A conformational trigger for activation of a G protein by a G protein-coupled receptor
    • Yeagle, P. L. and Albert, A. D. (2003) A conformational trigger for activation of a G protein by a G protein-coupled receptor. Biochemistry, 42, 1365-1368.
    • (2003) Biochemistry , vol.42 , pp. 1365-1368
    • Yeagle, P.L.1    Albert, A.D.2
  • 142
    • 0345393601 scopus 로고
    • Biochemistry, Volume two: Catabolism and Biosynthesis
    • Oxford, Wim. C. Brown Publishers, (Part of Table 24.3).
    • Zubay (1993) Biochemistry, Volume two: Catabolism and Biosynthesis. Oxford, Wim. C. Brown Publishers, p. 667 (Part of Table 24.3).
    • (1993) , pp. 667
    • Zubay1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.