Distinct binding properties of the AT1 receptor antagonist [3H]candesartan to intact cells and membrane preparations

Biochemical Pharmacology

Volumn 63, Issue 7, 2002, Pages 1273-1279

  Fierens, Frederik L P ^a   Vanderheyden, Patrick M L ^a   Roggeman, Chantal ^a   Vande Gucht, Pascal ^a   De Backer, Jean Paul ^a   Vauquelin, Georges ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Angiotensin AT1 receptor; Candesartan; CHO cells; Dissociation; Memberanes; Non peptide antagonist

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENOSINE TRIPHOSPHATE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CANDESARTAN; COLCHICINE; COMPACTIN; CYTOCHALASIN B; CYTOCHALASIN D; LOSARTAN POTASSIUM; PACLITAXEL; POTASSIUM CHLORIDE; PROTEIN KINASE C; SAPONIN; SODIUM NITRATE; TRITIUM; VINBLASTINE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; CYTOSKELETON; DISSOCIATION CONSTANT; DRUG HALF LIFE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; ENTHALPY; ENTROPY; MICROTUBULE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

ANIMALS; BENZIMIDAZOLES; BINDING SITES; CELL MEMBRANE; CHO CELLS; CRICETINAE; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; TETRAZOLES; THERMODYNAMICS; TRITIUM;

EID: 0036536907     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00859-6     Document Type: Article

References (41)

1. Nomenclature for angiotensin receptors: A report of the Nomenclature Committee of the Council for high blood pressure research
2. Angiotensin II receptors and functional correlates
3. The renin-angiotensin system
4. Different types of angiotensin II receptor antagonism induced by BIBS 222 in the rat portal vein and rabbit aorta: The influence of receptor reserve
5. Different types of receptor interaction of peptide and non-peptide angiotensin II antagonists revealed by receptor binding and functional studies
6. 1 receptor
7. 1 receptors
8. 1 receptor-transfected Chinese hamster ovary cells
9. 3H]candesartan is independent of receptor internalisation
10. Non-peptide angiotensin receptor antagonists. XI. Pharmacology of EXP3174: An active metabolite of DuP 753, an orally active antihypertensice agent
11. 50) of an enzymatic reaction
12. Drugs that influence tubulin polymerization modulate thyrotropin hormone receptor number in AtT-20 cells
13. Colchicine inhibits GABAa receptors independently of microtubule depolymerization
14. Mechanism of action of Taxol
15. Regulation of intracellular actin polymerization by prenylated cellular proteins
16. Cytoskeletal and phosphoinositide requirements for muscarinic receptor signalling to focal ahesion kinase and paxillin
17. Mevalonate controls cytoskeleton organisation and cell morphology in thyroid epithelial cells
18. ATP-Depletion affects the phosphorylation state, ligand binding and nuclear transport of the 4S polycyclic aromatic hydrocarbon binding protein in rat hepatoma cells
19. The bisindolmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
20. Role of the cytoplasmic tail of the type 1A angiotensin II receptor in agonist and phorbol ester-induced desensitisation
21. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist (TCV-116)
22. Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms
23. Pharmacological properties of KT3-671, a novel non-peptide angiotensin II receptor antagonist
24. Insurmountable angiotensin AT1 receptor antagonists: The role of tight antagonist binding
25. A two-state receptor model for the interaction between angiotensin II type 1 receptors and non-peptide antagonists
26. Insurmountable AT1 receptor antagonism: The need for different antagonist binding states of the receptor
27. Mechanisms and functions of AT(1) angiotensin receptor internalisation
28. Is signal transduction modulated by an interaction between heterotrimeric G-proteins and tubulin?
29. Molecular mechanisms of angiotensin II receptor internalisation
30. Cytoskeleton-dependent endocytosis is required for apical type 1 angiotensin II receptor mediated phospholipase C activation in cultured rat proximal tubule cells
31. Effect of cytochalasin B on the metabolism of polyphosphoinositides in adrenocortical cells
32. Gamma-aminobutyric acid A receptor function is inhibited by microtubule depolymerization
33. Microtubule depolymerization inhibits ethanol-induced enhancement of GABAa-responses in stably transfected cells
34. 3H]irbsartan to human recombinant angiotensin type 1 receptors
35. Role of basic amino acids of the human angiotensin type 1 receptor in the binding of the non-peptide antagonist candesartan
36. Structural chemistry and drug design
37. Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor
38. Can thermodynamic measurements of receptor binding yield information on drug affinity and efficacy?
39. Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors
40. b receptors show different binding profiles in intact cells and cell membrane preparations