Modelling of promiscuous receptor-Gi/Gs-protein coupling and effector response

Trends in Pharmacological Sciences

Volumn 22, Issue 12, 2001, Pages 616-622

  Kukkonen, Jyrki P ^a   Näsman, Johnny ^a   Åkerman, Karl E O ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CHOLERA TOXIN; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN;

ALLOSTERISM; CONCENTRATION RESPONSE; ENZYME REGULATION; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR AFFINITY; REVIEW; STOICHIOMETRY;

ANIMALS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; MODELS, BIOLOGICAL;

EID: 0035577682     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01864-2     Document Type: Review

References (40)

1. Diversity and selectivity of receptor-G protein interaction
2. Chimeric mutagenesis of putative G-protein coupling domains of the α2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains
3. The second intracellular loop of the alpha2-adrenergic receptors determines subtype-specific coupling to cAMP production
4. Molecular basis of receptor/G-protein-coupling selectivity
5. Site-directed mutations in the third intracellular loop of the serotonin 5-HT(1A) receptor alter G protein coupling from G(i) to G(s) in a ligand-dependent manner
6. Simultaneous coupling of α2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of α2C10, α2C4, and α2C2 adrenergic receptors to Gi and Gs
7. The cloned human 5-HT1E receptor couples to inhibition and activation of adenylyl cyclase via two distinct pathways in transfected BS-C-1 cells
8. Role of G protein availability in differential signalling by α2-adrenoceptors
9. Coupling of human α2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells
10. 2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line
11. Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: Evidence for agonist-specific trafficking of intracellular responses
12. Multiple Gi protein subtypes regulate a single effector mechanism
13. Contribution of ligand structure to activation of α2-adrenergic receptor subtype coupling to Gs
14. Selective inhibition of adenylyl cyclase by octopamine via a human cloned α2A-adrenoceptor
15. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
16. Influence of G protein type on agonist efficacy
17. Agonist trafficking of Gi/o-mediated α2A-adrenoceptor responses in HEL 92.1.7 cells
18. Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: Isoproterenol selectively activates G(s)
19. Agonist-receptor efficacy. II. Agonist trafficking of receptor signals
20. A three-state receptor model of agonist action
21. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
22. Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity
23. Rethinking receptor-G protein-effector interactions
24. Membrane organization in G-protein mechanisms
25. Biochemistry by numbers: Simulation of biochemical pathways with Gepasi 3
26. The stability of the agonist β2-adrenergic receptor-Gs complex: Evidence for agonist-specific states
27. Stoichiometry and compartmentation in G protein-coupled receptor signaling: Implications for therapeutic interventions involving G(s)
28. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system
29. A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: Crossover from G protein-coupled inhibition to stimulation
30. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases
31. Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by β-adrenergic receptors in reconstituted phospholipid vesicles
32. Insulation of a G protein-coupled receptor on the plasmalemmal surface of the pancreatic acinar cell
33. Regulation of lateral mobility and cellular trafficking of the CCK receptor by a partial agonist
34. Binding of agonist but not antagonist leads to fluorescence resonance energy transfer between intrinsically fluorescent gonadotropin-releasing hormone receptors
35. Evidence for the role of epinephrine binding frequency in activation of adenylate cyclase
36. Analysis of receptor-mediated activation of GTP-binding protein/adenylate cyclase using the encounter coupling model
37. Quantification of signalling components and amplification in the β adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes
38. Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles
39. Reconstitution of β2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells - High coupling efficiency in a β2-adrenoceptor-G(sα) fusion protein
40. Insights into ligand pharmacology using receptor-G-protein fusion proteins