New determinants of receptor-effector coupling: Trafficking and compartmentation in membrane microdomains

Molecular Pharmacology

Volumn 61, Issue 3, 2002, Pages 473-476

  Ostrom, Rennolds S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

BINDING AFFINITY; CAVEOLA; CELL COMPARTMENTALIZATION; HUMAN; MEMBRANE TRANSPORT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL TRANSPORT; CAVEOLAE; CELL COMPARTMENTATION; CELL MEMBRANE; HUMANS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 0036180964     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.3.473     Document Type: Review

References (34)

1. The caveolae membrane system
2. Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes
3. Regulated endocytosis of G-protein-coupled receptors by a biochemically and functionally distinct subpopulation of clathrin-coated pits
4. Epinephrine-induced sequestration of the beta-adrenergic receptor in cultured S49 WT and cyc- lymphoma cells
5. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase
6. Bradykinin sequesters B2 bradykinin receptors and the receptor-coupled Gα subunits Gαq and Gαi in caveolae in DDT1 MF-2 smooth muscle cells
7. Biochemical and molecular pharmacology of kinin receptors
8. Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction
9. Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: Lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors
10. Agonist-induced redistribution of bradykinin B2 receptor in caveolae
11. Compartmentation of second messenger action: Immunocytochemical and biochemical evidence
12. Functional compartments in cyclic nucleotide action
13. Desensitization of the beta-adrenergic receptor-coupled adenylate cyclase in cultured mammalian cells. Receptor sequestration versus receptor function
14. The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification
15. Agonist-promoted trafficking of human bradykinin receptors: Arrestin- and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells
16. Activated cardiac adenosine A1 receptors translocate out of caveolae
17. Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae
18. B1 and B2 kinin receptors mediate distinct patterns of intracellular Ca2+ signaling in single cultured vascular smooth muscle cells
19. Membrane organization in G-protein mechanisms
20. Segregation of heterotrimeric G proteins in cell surface microdomains G(q) binds caveolin to concentrate in caveolae, whereas g(i) and g(s) target lipid rafts by default
21. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane
22. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase
23. Stoichiometry and compartmentation in G protein-coupled receptor signaling implications for therapeutic interventions involving Gs
24. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains
25. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover
26. Bradykinin-induced internalization of the human B2 receptor requires phosphorylation of three serine and two threonine residues at its carboxyl tail
27. The role of calcium and phosphorylation of cytosolic phospholipase A2 in regulating arachidonic acid release in macrophages
28. Differential targeting of beta-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway
29. 1 receptor to caveolae-related rafts
30. Role of plasmalemmal caveolae in signal transduction
31. Compartmentation of g protein-coupled signaling pathways in cardiac myocytes
32. Role of extracellular signal-regulated kinase and PKC alpha in cytosolic PLA2 activation by bradykinin in MDCK-D1 cells
33. Spacial compartmentalization of Ca2+ signaling complexes in pancreatic acini
34. Regulation of inducible bradykinin B1 receptor gene expression through absence of internalization and resensitization