The cholecystokinin(B) receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins

Journal of Neurochemistry

Volumn 73, Issue 1, 1999, Pages 281-288

  Pommier, Blandine ^a   Da Nascimento, Sophie ^a   Dumont, Stéphanie ^a   Bellier, Bruno ^a   Million, Emmanuelle ^a   Garbay, Christiane ^a   Roques, Bernard P ^a,b   Noble, Florence ^a  

^a Laboratoire de Pharmacochimie   (France)

^b CNRS   (France)

Author keywords

Arachidonic acid; Chinese hamster ovary cell line; Cholecystokinin; Cholecystokinin(B) receptor; Inositol phosphate; Second messenger

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PHOSPHOLIPASE A2; ARACHIDONIC ACID; BORDETELLA VIRULENCE FACTOR; CHOLECYSTOKININ RECEPTOR; INOSITOL PHOSPHATE; PHOSPHOLIPASE A; PHOSPHOLIPASE C; RECOMBINANT PROTEIN;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CHO CELL; NONHUMAN; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; RAT; RECEPTOR AFFINITY; SECOND MESSENGER; ANIMAL; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; HAMSTER; KINETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ARACHIDONIC ACID; CHO CELLS; CRICETINAE; GTP-BINDING PROTEINS; INOSITOL PHOSPHATES; KINETICS; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PHOSPHOLIPASES A; PROTEIN CONFORMATION; RATS; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0032586989     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0730281.x     Document Type: Article

References (49)

1. Beinfeld M. C. (1983) Cholecystokinin in the central nervous system: a minireview. Neuropeptides 3, 411-427.
2. Beinfeld M. C., Meyer D. K., Eskay R. U., Jensen R. T., and Brownstein M. J. (1981) The distribution of cholecystokinin immunoreactivity in the central nervous system of the rat as determined by radioimmunoassay. Brain Res. 212, 51-57.
3. Bellier B., McCort I., Ducos B., Da Nascimento S., Meudal H., Noble F., Garbay C., and Roques B. P. (1997) Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor. J. Med. Chem. 40, 3947-3956.
4. IB-like receptor function via arachidonic acid metabolism. Mol. Pharmacol. 50, 1017-1023.
5. Berg K. A., Maayani S., Goldfarb J., Scaramellini C., Leff P., and Clarke W. P. (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol. Pharmacol. 54, 94-104.
6. Berridge M. J. (1983) Inositol triphosphate and calcium signaling. Nature 361, 315-325.
7. Blommaert A. G. S., Dhotel H., Ducos B., Durieux C., Goudreau N., Bado A., Garbay C., and Roques B. P. (1997) Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor. J. Med. Chem. 40, 647-658.
8. Brown B. L., Albano J. D. M., Ekins R. P., Sgherzi A. M., and Tampion W. (1971) A simple and sensitive saturation assay method for measurement of adenosine 3′,5′-cyclic monophosphate. Biochem. J. 121, 561-562.
9. Charpentier B., Durieux C., Pélaprat D., Dor A., Reibaud M., Blanchard J. C., and Roques B. P. (1988) Enzyme-resistant CCK analogs with high affinities for central receptors. Peptides 9, 835-841.
10. Charpentier B., Dor A., Roy P., England P., Pham H., Durieux C., and Roques B. P. (1989) Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors. J. Med. Chem. 31, 1184-1190.
11. Crawley J. N. and Corwin R. L. (1994) Biological actions of Cholecystokinin. Peptides 15, 731-755.
12. Derrien M., McCort I., Ducos B., Roques B. P., and Durieux C. (1994) Heterogeneity of CCK-B receptors involved in animal models of anxiety. Pharmacol. Biochem. Behav. 49, 133-141.
13. Detjen K., Yule D., Tseng M. J., Williams J. A., and Logsdon C. D. (1997) CCK-B receptors produce similar signals but have opposite growth effects in CHO and Swiss 3T3 cells. Am. J. Physiol. 273, C1449-C1457.
14. 2 and adenylyl cyclase in CHO cells expressing bovine rhodopsin. Exp. Cell Res. 216, 46-50.
15. Dixon J. F. and Hokin L. E. (1984) Secretogogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates AA, stearic acid and glycerol by sequential actions of phospholipase C and diglyceride lipase. J. Biol. Chem. 259, 14418-14425.
16. B type receptors on human T lymphoblastoid Jurkat cells. Am. J. Physiol. 268, G522-G529.
17. Durieux C., Coppey M., Zajac J. M., and Roques B. P. (1986) Occurrence of two cholecystokinin binding sites in guinea-pig brain cortex. Biochem. Biophys. Res. Commun. 137, 1167-1173.
18. 3H]SNF 8702. Mol. Pharmacol. 41, 1089-1095.
19. Galas M. C., Bernard N., and Martinez J. (1992) Pharmacological studies on CCK-B receptors in guinea pig synaptosomes. Eur. J. Pharmacol 226, 35-41.
20. Harper E. A., Roberts S. P., Shankley N. P., and Black J. W. (1996) Analysis of variation in L365,260 competition curves in radioligand binding assays. Br. J. Pharmacol. 118, 1717-1726.
21. Hou W., Arita Y., and Morisset J. (1996) Caerulein-stimulated AA release in rat pancreatic acini: a diacylglycerol lipase affair. Am. J. Physiol. 271, C1735-C1742.
22. Huang S. C., Fortune K. P., Wank S. A., Kopin A. S., and Gardner J. D. (1994) Multiple affinity states of different cholecystokinin receptors. J. Biol. Chem. 269, 26121-26126.
23. Ito M., Matsui T., Taniguchi T., Tsukamoto T., Murayama T., Arima N., Nakata H., Chiba T., and Chihara K. (1993) Functional characterization of a human brain CCK-B receptor. J. Biol. Chem. 268, 18300-18305.
24. Jagerschmidt A., Guillaume N., Goudreau N., Maigret B., and Roques B. P. (1995) Mutation of Asp 100 in the second transmembrane domain of the cholecystokinin B receptor increases antagonist binding and reduces signal transduction. Mol. Pharmacol. 48, 783-789.
25. Johnson P. S., Wang J. B., Wang W. F., and Uhl G. R. (1994) Expressed mu opiate receptor couples to adenylate cyclase and phosphatidylinositol turnover. Neuroreport 5, 507-509.
26. 2, PLC and PLD in bradykinin-induced release of arachidonic acid in MDCK cells. Am. J. Physiol. 271, C1064-C1072.
27. 26-33): evidence for CCK-B receptor heterogeneity. J. Pharmacol. Exp. Ther. 255, 1278-1286.
28. 2+ levels in a pituitary cell line. Peptides 14, 801-805.
29. Ladurelle N., Sebret A., Garbay C., Roques B. P., and Daugé V. (1998) Opposite effects of CCKB agonists in grooming behaviour in rats: further evidence for two CCKB subsites. Br. J. Pharmacol. 124, 1091-1098.
30. Lee Y. M., Beinborn M., McBride E. W., Lu M., Kolakowski L. F., and Kopin A. S. (1993) The human brain cholecystokinin B/gastrin receptor. Cloning and characterization. J. Biol. Chem. 268, 8164-8169.
31. Leff P., Scaramellini C., Law C., and McKechnie K. (1997) A three-state receptor model of agonist action. Trends Pharmacol. Sci. 18, 355-362.
32. Léna I., Roques B. P., and Durieux C. (1997) Dual modulation of dopamine release from anterior nucleus accumbens through cholecystokinin-B receptor subsites. J. Neurochem. 68, 162-168.
33. Million M. E., Lena I., Da Nascimento S., Noble F., Daugé V., Garbay C., and Roques B. P. (1997) Development of new potent agonists able to interact with two postulated subsites of the cholecystokinin CCK-B receptor. Lett. Pept. Sci. 4, 407-410.
34. Moran T. H., Robinson P. H., Goldrich M. S., and Mettugh P. R. (1986) Two brain cholecystokinin receptors: implication for behavioural actions. Brain Res. 362, 175-179.
35. Noble F. and Roques B. P. (1999) CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology. Prog. Neurobiol. (in press).
36. Perez D., Hwa J., Gaiwin R., Mathur M., Brown F., and Graham R. (1996) Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor. Mol. Pharmacol. 49, 112-122.
37. 1D-adrenergic receptors to multiple signaling pathways is both G protein and cell type specific. Mol. Pharmacol. 44, 784-795.
38. 2 receptor synergism. Nature 353, 164-167.
39. α subunit and is similar to that of other opioid receptors. Mol. Brain Res. 29, 336-346.
40. Rehfeld J. F. (1978) Immunological studies of CCK: distribution and molecular heterogeneity of cholecystokinin in the CNS and small intestine of man and hog. J. Biol. Chem. 253, 4022-4030.
41. Rehfeld J. F. and Nielsen F. C. (1995) Molecular forms and regional distribution of cholecystokinin in the central nervous system, in Cholecystokinin and Anxiety: From Neuron to Behaviour (Bradwejn J. and Vasar E., eds), pp. 33-56. R. G. Landes Company, Austin.
42. Rodriguez M., Lignon M. F., Galas M. C., Amblard M., and Martinez J. (1990) Cyclic cholecystokinin analogues that are highly selective for rat and guinea pig central cholecystokinin receptors. Mol. Pharmacol. 38, 333-341.
43. Sokolosky M. (1995) Endothelin receptor subtypes and their role in transmembrane signaling mechanisms. Pharmacol. Ther. 68, 435-471.
44. Sutherland C. A. and Amin D. (1982) Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. J. Biol. Chem. 257, 14006-14010.
45. Talkad V. D., Patto R. J., Metz D. C., Turner R. J., Fortune K. P., Bhat S. I., and Gardner J. D. (1994) Characterization of the three different states of the cholecystokinin (CCK) receptor in pancreatic acini. Biochim. Biophys. Acta 1224, 103-116.
46. q protein in pancreatic acini. Biochem. Biophys. Res. Commun. 211, 648-655.
47. Wank S. A. (1995) Cholecystokinin receptors. Am. J. Physiol. 269, G628-G646.
48. Wank S. A., Harkins R., Jensen R. T., Shapira H., de Weerth A., and Slatterly T. (1992) Purification, molecular cloning and functional expression of the cholecystokinin receptor from rat pancreas. Proc. Natl. Acad. Sci. USA 89, 3125-3129.
49. Zhang L. J., Lu X. Y., and Han J. S. (1992) Influences of cholecystokinin octapeptide on phosphoinositide turnover in neonatal-rat brain cells. Biochem. J. 285, 847-850.