Agonist-directed trafficking of porcine α(2A)-adrenergic receptor signaling in chinese hamster ovary cells: I-isoproterenol selectively activates G(s)

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 2, 2000, Pages 539-547

  Brink, Christina B ^a,c   Wade, Susan M ^a   Neubig, Richard R ^a,b,d  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NORTH WEST UNIVERSITY   (South Africa)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALPHA 2A ADRENERGIC RECEPTOR; AZEPEXOLE; BENEXTRAMINE; BRIMONIDINE; CLONIDINE; GUANABENZ; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; NORADRENALIN; OXYMETAZOLINE; TALIPEXOLE; XYLAZINE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME REGULATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SEROTONINERGIC NERVE CELL; SIGNAL TRANSDUCTION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-AGONISTS; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; DRUG INTERACTIONS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; ISOPROTERENOL; KINETICS; OXYMETAZOLINE; PINDOLOL; PROTEIN BINDING; QUINOXALINES; RECEPTORS, ADRENERGIC, ALPHA-2; SEROTONIN ANTAGONISTS; SIGNAL TRANSDUCTION; SWINE; YOHIMBINE;

EID: 0033929371     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. 1B binding sites in rat brain membranes. Neurochem Res 14:835-843.
2. Berg KA, Clarke WP, Sailstad C, Saltzman A and Maayani S (1994) Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems. Mol Pharmacol 46:477-484.
3. Berg KA, Maayani S. Goldfarb J, Scaramellini C, Leff P and Clarke WP (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 54:94-104.
4. Bonhaus DW, Chang LK, Kwan J and Martin GR (1998) Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: Evidence for agonist-specific trafficking of intracellular responses. J Pharmacol Exp Ther 287: 884-888.
5. 2-adrenergic receptors by pyrextramine and benextramine in the isolated guinea pig ileum. Life Sci 38:1633-1640.
6. 2A-adrenergic receptor to multiple G-proteins. J Biol Chem 269:5730-5734.
7. s. Mol Pharmacol 45: 696-702.
8. 2A-adrenergic receptors to two G proteins with opposing effects. J Biol Chem 267:15795-15801.
9. i coupling domains. J Biol Chem 271:12826-12832.
10. Furchgott RF (1966) The use of β-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes, in Advances in Drug Research (Harper NJ and Simmonds AB eds) vol 3, pp 21-55, Academic Press, New York.
11. Galitzky J, Mauriege P, Berlan M and Lafontan M (1989) Human fat cell alpha-2 adrenoceptors. I. Functional exploration and pharmacological definition with selected alpha-2 agonists and antagonists. J Pharmacol Exp Ther 249:583-591.
12. i subtypes couple to a single effector mechanism. Mol Pharmacol 40:707-711.
13. 1B receptor on CHO cells: Functional responses in the absence of radio-ligand binding. Br J Pharmacol 117:1119-1126.
14. Karlsson JOG, Andersson RGG and Grundström N (1989) Characterization of pigment aggregating α2-adrenoceptors of fish melanophores by use of different agonists after partial irreversible receptor inactivation. Br J Pharmacol 97:222-228.
15. Kenakin T (1995) Agonist-receptor efficacy. II: Agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238.
16. Leff P, Scaramelli C, Law C and McKechnie K (1997) A three-state model of agonist action. Trends Pharmacol Sci 18:355-362.
17. Melchiorre C (1981) Tetramine disulfides: A new tool in α-adrenergic pharmacology. Trends Pharmacol Sci 2:209-211.
18. Salomon Y, Londos C and Rodbell M (1974) A highly sensitive adenylate cyclase assay. Anal Biochem 58:475-486.
19. 1D receptors. Eur J Pharmacol 196:213-216.
20. 2-adrenergic receptors by benextramine. Mol Pharmacol 31:89-96.
21. 2-adrenoceptor mediated vasoconstriction in pitched rats. Naunyn-Schmiedeberg's Arch Pharmacol 329:404-413.
22. Van den Brink FG (1977) General theory of drug-receptor interactions, in Kinetics of Drug Action (Van Rossum JM ed) pp 169-254, Springer-Verlag, Berlin.
23. Van Rossum JM (1966) Limitations of molecular pharmacology, in Advances in Drug Research (Harper NJ and Simmonds AB eds) vol 3, pp 189-234, Academic Press, New York.
24. Venter DP (1997) Efficacy. I: A new method for estimating relative efficacy of full agonists via an efficacy related parameter. Eur J Pharmacol 320:223-231.
25. s activation. Mol Pharmacol 56:1005-1013.
26. i1α fusion protein. FEBS Lett 419:141-146.
27. Yang Q and Lanier SM (1999) Influence of G protein type on agonist efficacy. Mol Pharmacol 56:651-656.