β-arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation

Journal of Biological Chemistry

Volumn 277, Issue 11, 2002, Pages 9429-9436

  Tohgo, Akira ^a   Pierce, Kristen L ^a   Choy, Eric W ^a   Lefkowitz, Robert J ^b   Luttrell, Louis M ^a,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR TRANSLOCATION;

CELLS; FLUORESCENCE; HYDROLYSIS; MICROSCOPIC EXAMINATION; PHOSPHOLIPIDS;

PROTEINS;

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1A RECEPTOR; BETA ARRESTIN; BETA ARRESTIN 1; BETA ARRESTIN 2; CELL PROTEIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN; PROTEIN CRAF 1; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FRACTIONATION; CELL STRAIN COS7; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; IMMUNOFLUORESCENCE MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; ARRESTINS; COS CELLS; CYTOSOL; GTP-BINDING PROTEINS; HYDROLYSIS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROTEINS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; RECEPTORS, CELL SURFACE; TNF RECEPTOR-ASSOCIATED FACTOR 3; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0037088585     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106457200     Document Type: Article

References (34)