메뉴 건너뛰기




Volumn , Issue , 2013, Pages 213-237

Natural products as tools for discovering new cancer targets

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84891130399     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-4654-5_9     Document Type: Chapter
Times cited : (4)

References (123)
  • 1
    • 0036905820 scopus 로고    scopus 로고
    • Receptor-dependence of the transcription read-out in a small-molecule three-hybrid system
    • Abida WM, Carter BT, Althoff EA et al (2002) Receptor-dependence of the transcription read-out in a small-molecule three-hybrid system. Chembiochem 3:887-895.
    • (2002) Chembiochem , vol.3 , pp. 887-895
    • Abida, W.M.1    Carter, B.T.2    Althoff, E.A.3
  • 2
    • 0028339110 scopus 로고
    • Anticancer specificity of some ellipticinium salts against human brain tumors in vitro
    • Acton EM, Narayanan VL, Risbood PA et al (1994) Anticancer specificity of some ellipticinium salts against human brain tumors in vitro. J Med Chem 37:2185-2189.
    • (1994) J Med Chem , vol.37 , pp. 2185-2189
    • Acton, E.M.1    Narayanan, V.L.2    Risbood, P.A.3
  • 3
    • 33644914163 scopus 로고    scopus 로고
    • A central strategy for converting natural products into fluorescent probes
    • Alexander MD, Burkart MD, Leonard MS et al (2006) A central strategy for converting natural products into fluorescent probes. Chembiochem 7:409-416.
    • (2006) Chembiochem , vol.7 , pp. 409-416
    • Alexander, M.D.1    Burkart, M.D.2    Leonard, M.S.3
  • 4
    • 33644946432 scopus 로고    scopus 로고
    • Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex
    • Aoki S, Watanabe Y, Sanagawa M et al (2006) Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex. J Am Chem Soc 128:3148-3149.
    • (2006) J Am Chem Soc , vol.128 , pp. 3148-3149
    • Aoki, S.1    Watanabe, Y.2    Sanagawa, M.3
  • 5
    • 0027482896 scopus 로고
    • Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin
    • Bai R, Cichacz ZA, Herald CL et al (1993) Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin. Mol Pharmacol 44:757-766.
    • (1993) Mol Pharmacol , vol.44 , pp. 757-766
    • Bai, R.1    Cichacz, Z.A.2    Herald, C.L.3
  • 6
    • 12244298884 scopus 로고    scopus 로고
    • An optimized dexamethasone-methotrexate yeast 3-hybrid system for high-throughput screening of small molecule-protein interactions
    • Baker K, Sengupta D, Salazar-Jimenez G et al (2003) An optimized dexamethasone-methotrexate yeast 3-hybrid system for high-throughput screening of small molecule-protein interactions. Anal Biochem 315:134-137.
    • (2003) Anal Biochem , vol.315 , pp. 134-137
    • Baker, K.1    Sengupta, D.2    Salazar-jimenez, G.3
  • 8
    • 70149117263 scopus 로고    scopus 로고
    • Natural products as a foundation for drug discovery
    • Beutler JA (2009) Natural products as a foundation for drug discovery. Curr Protoc Pharmacol 46:9.11.1-9.11.21.
    • (2009) Curr Protoc Pharmacol , vol.46 , pp. 9.11.1-9.11.21
    • Beutler, J.A.1
  • 9
    • 0032444190 scopus 로고    scopus 로고
    • Cytotoxic geranyl stilbenes from Macaranga schweinfurthii
    • Beutler JA, Shoemaker RH, Johnson T et al (1998) Cytotoxic geranyl stilbenes from Macaranga schweinfurthii. J Nat Prod 61:1509-1512.
    • (1998) J Nat Prod , vol.61 , pp. 1509-1512
    • Beutler, J.A.1    Shoemaker, R.H.2    Johnson, T.3
  • 10
    • 0034042055 scopus 로고    scopus 로고
    • Novel cytotoxic diterpenes from Casearia arborea
    • Beutler JA, McCall KL, Herbert K et al (2000) Novel cytotoxic diterpenes from Casearia arborea. J Nat Prod 63:657-661.
    • (2000) J Nat Prod , vol.63 , pp. 657-661
    • Beutler, J.A.1    McCall, K.L.2    Herbert, K.3
  • 11
    • 65249093662 scopus 로고    scopus 로고
    • Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition
    • Beutler JA, Kang M-I, Robert F et al (2009) Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. J Nat Prod 72:503-506.
    • (2009) J Nat Prod , vol.72 , pp. 503-506
    • Beutler, J.A.1    Kang, M.-I.2    Robert, F.3
  • 12
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A et al (2003) Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 63: 1270-1279.
    • (2003) Cancer Res , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3
  • 13
    • 0037040244 scopus 로고    scopus 로고
    • Mutations in subunit c of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site
    • Bowman BJ, Bowman EJ (2002) Mutations in subunit c of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site. J Biol Chem 277:3965-3972.
    • (2002) J Biol Chem , vol.277 , pp. 3965-3972
    • Bowman, B.J.1    Bowman, E.J.2
  • 14
    • 0242666433 scopus 로고    scopus 로고
    • Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases
    • Bowman EJ, Gustafson KR, Bowman BJ et al (2003) Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases. J Biol Chem 278:44147-44152.
    • (2003) J Biol Chem , vol.278 , pp. 44147-44152
    • Bowman, E.J.1    Gustafson, K.R.2    Bowman, B.J.3
  • 15
    • 0035078681 scopus 로고    scopus 로고
    • Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-ATPases
    • Boyd MR, Farina C, Belfiore P et al (2001) Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-ATPases. J Pharmacol Exp Ther 297:114-120.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 114-120
    • Boyd, M.R.1    Farina, C.2    Belfiore, P.3
  • 16
    • 54549105458 scopus 로고    scopus 로고
    • Gedunin, a novel hsp90 inhibitor: Semisynthesis of derivatives and preliminary structure-activity relationships
    • Brandt GE, Schmidt MD, Prisinzano TE et al (2008) Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J Med Chem 51: 6495-6502.
    • (2008) J Med Chem , vol.51 , pp. 6495-6502
    • Brandt, G.E.1    Schmidt, M.D.2    Prisinzano, T.E.3
  • 17
    • 44249098800 scopus 로고    scopus 로고
    • Natural products to drugs: Natural product-derived compounds in clinical trials
    • Butler MS (2008) Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep 25:475-516.
    • (2008) Nat Prod Rep , vol.25 , pp. 475-516
    • Butler, M.S.1
  • 18
    • 0034692370 scopus 로고    scopus 로고
    • Chondropsins A and B, novel tumor cell growth-inhibitory macrolide lactams from the marine sponge Chondropsis sp
    • Cantrell CL, Gustafson KR, Cecere MR et al (2000) Chondropsins A and B, novel tumor cell growth-inhibitory macrolide lactams from the marine sponge Chondropsis sp. J Am Chem Soc 122:8825-8829.
    • (2000) J Am Chem Soc , vol.122 , pp. 8825-8829
    • Cantrell, C.L.1    Gustafson, K.R.2    Cecere, M.R.3
  • 19
    • 70449120427 scopus 로고    scopus 로고
    • Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11
    • Cee VJ, Chen DY, Lee MR et al (2009) Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11. Angew Chem Int Ed Engl 48:8952-8957.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 8952-8957
    • Cee, V.J.1    Chen, D.Y.2    Lee, M.R.3
  • 20
    • 0016393711 scopus 로고
    • Variations in the antitumour constituents of Withania somnifera Dunal
    • Chakraborti SK, De BK, Bandyopadhyay T (1974) Variations in the antitumour constituents of Withania somnifera Dunal. Experientia 30:852-853.
    • (1974) Experientia , vol.30 , pp. 852-853
    • Chakraborti, S.K.1    De, B.K.2    Bandyopadhyay, T.3
  • 21
    • 1242341504 scopus 로고    scopus 로고
    • Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles
    • Chan J, Khan SN, Harvey I et al (2004) Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles. RNA 10:528-543.
    • (2004) RNA , vol.10 , pp. 528-543
    • Chan, J.1    Khan, S.N.2    Harvey, I.3
  • 22
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened
    • Chen JK, Taipale J, Cooper MK et al (2002) Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev 16:2743-2748.
    • (2002) Genes Dev , vol.16 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3
  • 23
    • 0016701762 scopus 로고
    • Mode of action of Withaferin A and Withanolide D
    • Chowdhury K, Neogy RK (1975) Mode of action of Withaferin A and Withanolide D. Biochem Pharmacol 24:919-920.
    • (1975) Biochem Pharmacol , vol.24 , pp. 919-920
    • Chowdhury, K.1    Neogy, R.K.2
  • 24
    • 70350271965 scopus 로고    scopus 로고
    • Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism
    • Cook KM, Hilton ST, Mecinovic J et al (2009) Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism. J Biol Chem 284:26831-26838.
    • (2009) J Biol Chem , vol.284 , pp. 26831-26838
    • Cook, K.M.1    Hilton, S.T.2    Mecinovic, J.3
  • 25
    • 1042266695 scopus 로고    scopus 로고
    • Multiple myeloma regression mediated by bruceantin
    • Cuendet M, Christov K, Lantvit DD et al (2004) Multiple myeloma regression mediated by bruceantin. Clin Cancer Res 10:1170-1179.
    • (2004) Clin Cancer Res , vol.10 , pp. 1170-1179
    • Cuendet, M.1    Christov, K.2    Lantvit, D.D.3
  • 26
    • 67649576730 scopus 로고    scopus 로고
    • Discovery of potent and practical antiangiogenic agents inspired by cortistatin A
    • Czakó B, Kürti L, Mammoto A et al (2009) Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. J Am Chem Soc 131:9014-9019.
    • (2009) J Am Chem Soc , vol.131 , pp. 9014-9019
    • Czakó, B.1    Kürti, L.2    Mammoto, A.3
  • 27
    • 0028219922 scopus 로고
    • The differential cytotoxicity of cardenolides from Thevetia ahouia
    • Decosterd LA, Gustafson KR, Cardellina JH II et al (1994) The differential cytotoxicity of cardenolides from Thevetia ahouia. Phytother Res 8:74-77.
    • (1994) Phytother Res , vol.8 , pp. 74-77
    • Decosterd, L.A.1    Gustafson, K.R.2    Cardellina, J.H.3
  • 28
    • 54049145429 scopus 로고    scopus 로고
    • Highly cytotoxic and neurotoxic acetogenins of the Annonaceae: New putative biological targets of squamocin detected by activity-based protein profiling
    • Derbre S, Gil S, Taverna M et al (2008) Highly cytotoxic and neurotoxic acetogenins of the Annonaceae: new putative biological targets of squamocin detected by activity-based protein profiling. Bioorg Med Chem Lett 18:5741-5744.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 5741-5744
    • Derbre, S.1    Gil, S.2    Taverna, M.3
  • 29
    • 36448991184 scopus 로고    scopus 로고
    • Cellular targets of natural products
    • Dixon N, Wong LS, Geerlings TH et al (2007) Cellular targets of natural products. Nat Prod Rep 24:1288-1310.
    • (2007) Nat Prod Rep , vol.24 , pp. 1288-1310
    • Dixon, N.1    Wong, L.S.2    Geerlings, T.H.3
  • 30
    • 0030711108 scopus 로고    scopus 로고
    • Salicylihalamides A and B, novel cytotoxic macrolides from the marine sponge Haliclona sp
    • Erickson KL, Beutler JA, Cardellina JH II et al (1997) Salicylihalamides A and B, novel cytotoxic macrolides from the marine sponge Haliclona sp. J Org Chem 62:8188-8192.
    • (1997) J Org Chem , vol.62 , pp. 8188-8192
    • Erickson, K.L.1    Beutler, J.A.2    Cardellina, J.H.3
  • 31
    • 0000150696 scopus 로고    scopus 로고
    • Structure revision and cytotoxic activity of the scabrosin esters, epidithiopiperazinediones from the lichen Xanthoparmelia scabrosa
    • Ernst-Russell MA, Chai CLL, Hurne AM et al (1999) Structure revision and cytotoxic activity of the scabrosin esters, epidithiopiperazinediones from the lichen Xanthoparmelia scabrosa. Aust J Chem 52:279-283.
    • (1999) Aust J Chem , vol.52 , pp. 279-283
    • Ernst-russell, M.A.1    Chai, C.L.L.2    Hurne, A.M.3
  • 32
    • 33645235842 scopus 로고    scopus 로고
    • Actin filament aggregation induced by withferin A is mediated by annexin II
    • Falsey RR, Marron MT, Gunaherath GMKB et al (2006) Actin filament aggregation induced by withferin A is mediated by annexin II. Nat Chem Biol 2:33-38.
    • (2006) Nat Chem Biol , vol.2 , pp. 33-38
    • Falsey, R.R.1    Marron, M.T.2    Gunaherath, G.M.K.B.3
  • 33
    • 77249176062 scopus 로고    scopus 로고
    • Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol
    • Fischer JD, Liao L, Carvalho PC et al (2010) Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. J Proteomics 73(5):1018-1027.
    • (2010) J Proteomics , vol.73 , Issue.5 , pp. 1018-1027
    • Fischer, J.D.1    Liao, L.2    Carvalho, P.C.3
  • 34
    • 77249142404 scopus 로고    scopus 로고
    • The art of the chemical probe
    • Frye SV (2010) The art of the chemical probe. Nat Chem Biol 6:159-161.
    • (2010) Nat Chem Biol , vol.6 , pp. 159-161
    • Frye, S.V.1
  • 35
    • 14644401085 scopus 로고    scopus 로고
    • Structure-activity relationships of quassinoids for eukaryotic protein synthesis
    • Fukamiya N, Lee KH, Muhammad I et al (2005) Structure-activity relationships of quassinoids for eukaryotic protein synthesis. Cancer Lett 220:37-48.
    • (2005) Cancer Lett , vol.220 , pp. 37-48
    • Fukamiya, N.1    Lee, K.H.2    Muhammad, I.3
  • 36
    • 0027973669 scopus 로고
    • Cucurbitacins; differential cytotoxicity, dereplication and first isolation from Gonystylus keithii
    • Fuller RW, Cardellina JH II, Cragg GM et al (1994) Cucurbitacins; differential cytotoxicity, dereplication and first isolation from Gonystylus keithii. J Nat Prod 57:1442-1445.
    • (1994) J Nat Prod , vol.57 , pp. 1442-1445
    • Fuller, R.W.1    Cardellina, J.H.2    Cragg, G.M.3
  • 37
    • 0028171012 scopus 로고
    • TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I
    • Funabashi Y, Horiguchi T, Iinuma S et al (1994) TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I. J Antibiot 47: 1202-1218.
    • (1994) J Antibiot , vol.47 , pp. 1202-1218
    • Funabashi, Y.1    Horiguchi, T.2    Iinuma, S.3
  • 38
    • 0000720183 scopus 로고
    • Studies on the antitumor effect of cucurbitacins
    • Gitter S, Gallily R, Shohat B et al (1961) Studies on the antitumor effect of cucurbitacins. Cancer Res 21:516-521.
    • (1961) Cancer Res , vol.21 , pp. 516-521
    • Gitter, S.1    Gallily, R.2    Shohat, B.3
  • 39
    • 69049109766 scopus 로고    scopus 로고
    • Resveratrol and chemoprevention
    • Goswami SK, Das DK (2009) Resveratrol and chemoprevention. Cancer Lett 284:1-6.
    • (2009) Cancer Lett , vol.284 , pp. 1-6
    • Goswami, S.K.1    Das, D.K.2
  • 40
    • 0033535077 scopus 로고    scopus 로고
    • On the relationship of OSW-1 to the cephalostatins
    • Guo C, LaCour TG, Fuchs PL (1999) On the relationship of OSW-1 to the cephalostatins. BioMed Chem Lett 9:419-424.
    • (1999) BioMed Chem Lett , vol.9 , pp. 419-424
    • Guo, C.1    LaCour, T.G.2    Fuchs, P.L.3
  • 41
    • 0022521980 scopus 로고
    • Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis)
    • Gupta RS, Chopra A, Stetsko DK (1986) Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis). J Cell Physiol 127:197-206.
    • (1986) J Cell Physiol , vol.127 , pp. 197-206
    • Gupta, R.S.1    Chopra, A.2    Stetsko, D.K.3
  • 42
    • 0031562074 scopus 로고    scopus 로고
    • Novel thiodiketopiperazine fungal metabolites as epidermal growth factor receptor antagonists
    • Hegde VR, Dai P, Patel M et al (1997) Novel thiodiketopiperazine fungal metabolites as epidermal growth factor receptor antagonists. Tetrahedron Lett 38:911-914.
    • (1997) Tetrahedron Lett , vol.38 , pp. 911-914
    • Hegde, V.R.1    Dai, P.2    Patel, M.3
  • 44
    • 33749433916 scopus 로고    scopus 로고
    • Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
    • Hieronymus H, Lamb J, Ross KN et al (2006) Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell 10:321-330.
    • (2006) Cancer Cell , vol.10 , pp. 321-330
    • Hieronymus, H.1    Lamb, J.2    Ross, K.N.3
  • 45
    • 70449380987 scopus 로고    scopus 로고
    • From teratogens to potential therapeutics: Natural inhibitors of the Hedgehog signaling network come of age
    • Hovhannisyan A, Matz M, Gebhardt R (2009) From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age. Planta Med 75:1371-1380.
    • (2009) Planta Med , vol.75 , pp. 1371-1380
    • Hovhannisyan, A.1    Matz, M.2    Gebhardt, R.3
  • 46
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang YH, Hertzberg R, Hecht S et al (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 260:14873-14878.
    • (1985) J Biol Chem , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3
  • 47
    • 0037199964 scopus 로고    scopus 로고
    • Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins
    • Hurne AM, Chai CL, Moerman K et al (2002) Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins. J Biol Chem 277:31631-31638.
    • (2002) J Biol Chem , vol.277 , pp. 31631-31638
    • Hurne, A.M.1    Chai, C.L.2    Moerman, K.3
  • 48
    • 0031723219 scopus 로고    scopus 로고
    • The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
    • Incardona JP, Gaffield W, Kapur RP et al (1998) The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125:3553-3562.
    • (1998) Development , vol.125 , pp. 3553-3562
    • Incardona, J.P.1    Gaffield, W.2    Kapur, R.P.3
  • 49
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemopreventative activity of resveratrol, a natural product derived from grapes
    • Jang M, Cai L, Udeani GO et al (1997) Cancer chemopreventative activity of resveratrol, a natural product derived from grapes. Science 275:218-220.
    • (1997) Science , vol.275 , pp. 218-220
    • Jang, M.1    Cai, L.2    Udeani, G.O.3
  • 50
    • 0019824829 scopus 로고
    • 3J-O-Methylevomonoside: A new cytotoxic cardiac glycoside from Thevetia ahouia A.DC (Apocynaceae)
    • Jolad SD, Hoffman JJ, Cole JR et al (1981) 3J-O-Methylevomonoside: a new cytotoxic cardiac glycoside from Thevetia ahouia A.DC (Apocynaceae). J Org Chem 46:1946-1947.
    • (1981) J Org Chem , vol.46 , pp. 1946-1947
    • Jolad, S.D.1    Hoffman, J.J.2    Cole, J.R.3
  • 51
    • 0014245807 scopus 로고
    • Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopean effects of steroidal alkaloids from the plant and structurally related compounds from other sources
    • Keeler RF, Binns W (1968) Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopean effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology 1:5-10.
    • (1968) Teratology , vol.1 , pp. 5-10
    • Keeler, R.F.1    Binns, W.2
  • 52
    • 0035928802 scopus 로고    scopus 로고
    • A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin
    • Kerrigan JE, Pilch DS (2001) A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin. Biochemistry 40:9792-9798.
    • (2001) Biochemistry , vol.40 , pp. 9792-9798
    • Kerrigan, J.E.1    Pilch, D.S.2
  • 53
    • 0034097869 scopus 로고    scopus 로고
    • Characterization of anticancer agents by their growthinhibitory activity and relationships to mechanism of action and structure
    • Keskin O, Bahar I, Jernigan RL et al (2000) Characterization of anticancer agents by their growthinhibitory activity and relationships to mechanism of action and structure. Anticancer Drug Design 15:79-98.
    • (2000) Anticancer Drug Design , vol.15 , pp. 79-98
    • Keskin, O.1    Bahar, I.2    Jernigan, R.L.3
  • 54
    • 16044370146 scopus 로고    scopus 로고
    • Aplyronine A, a potent antitumor substance of marine origin, aplyronines B and C and artificial analogues: Total synthesis and structure-cytotoxicity relationships
    • Kigoshi H, Suenaga K, Mutou T et al (1996) Aplyronine A, a potent antitumor substance of marine origin, aplyronines B and C and artificial analogues: total synthesis and structure-cytotoxicity relationships. J Org Chem 61:5326-5351.
    • (1996) J Org Chem , vol.61 , pp. 5326-5351
    • Kigoshi, H.1    Suenaga, K.2    Mutou, T.3
  • 55
    • 34548104659 scopus 로고    scopus 로고
    • Splicing factor SF3b as a target of the antitumor natural product pladienolide
    • Kotake Y, Sagane K, Owa T et al (2007) Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol 3:570-575.
    • (2007) Nat Chem Biol , vol.3 , pp. 570-575
    • Kotake, Y.1    Sagane, K.2    Owa, T.3
  • 56
    • 66449122592 scopus 로고    scopus 로고
    • Synthesis and biological activity of a fluorescent schweinfurthin analogue
    • Kuder CH, Neighbors JD, Hohl RJ et al (2009) Synthesis and biological activity of a fluorescent schweinfurthin analogue. Bioorg Med Chem 17:4718-4723.
    • (2009) Bioorg Med Chem , vol.17 , pp. 4718-4723
    • Kuder, C.H.1    Neighbors, J.D.2    Hohl, R.J.3
  • 57
    • 3142622930 scopus 로고    scopus 로고
    • Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
    • Kung AL, Zabludoff SD, France DS et al (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6:33-43.
    • (2004) Cancer Cell , vol.6 , pp. 33-43
    • Kung, A.L.1    Zabludoff, S.D.2    France, D.S.3
  • 58
    • 0015921169 scopus 로고
    • Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica
    • Kupchan SM, Britton RW, Ziegler MF et al (1973) Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica. J Org Chem 38:178-179.
    • (1973) J Org Chem , vol.38 , pp. 178-179
    • Kupchan, S.M.1    Britton, R.W.2    Ziegler, M.F.3
  • 59
    • 33645473657 scopus 로고    scopus 로고
    • Study of the interaction between actin and antitumor substance aplyronine A with a novel fluorescent photoaffinity probe
    • Kuroda T, Suenaga K, Sakakura A et al (2006) Study of the interaction between actin and antitumor substance aplyronine A with a novel fluorescent photoaffinity probe. Bioconjug Chem 17:524-529.
    • (2006) Bioconjug Chem , vol.17 , pp. 524-529
    • Kuroda, T.1    Suenaga, K.2    Sakakura, A.3
  • 60
    • 33845876254 scopus 로고    scopus 로고
    • The Connectivity Map: A new tool for biomedical research
    • Lamb J (2007) The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 7:54-60.
    • (2007) Nat Rev Cancer , vol.7 , pp. 54-60
    • Lamb, J.1
  • 61
    • 85028574799 scopus 로고    scopus 로고
    • Accessed 23 Feb 2010
    • Lamb J (2010) Connectivity Map 02. http://www.broadinstitute.org/cmap/. Accessed 23 Feb 2010.
    • (2010) Connectivity Map 02
    • Lamb, J.1
  • 62
    • 33749335282 scopus 로고    scopus 로고
    • The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
    • Lamb J, Crawford ED, Peck D et al (2006) The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313:1929-1935.
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1    Crawford, E.D.2    Peck, D.3
  • 63
    • 37049041251 scopus 로고
    • Constituents of Withania somnifera Dun. Part IV. The structure of withaferin A
    • Lavie D, Glotter E, Shvo Y (1965) Constituents of Withania somnifera Dun. Part IV. The structure of withaferin A. J Chem Soc 50:7517-7531.
    • (1965) J Chem Soc , vol.50 , pp. 7517-7531
    • Lavie, D.1    Glotter, E.2    Shvo, Y.3
  • 64
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: End of an era or an endless frontier?
    • Li JW, Vederas JC (2009) Drug discovery and natural products: end of an era or an endless frontier? Science 325:161-165.
    • (2009) Science , vol.325 , pp. 161-165
    • Li, J.W.1    Vederas, J.C.2
  • 65
    • 33644901007 scopus 로고    scopus 로고
    • Multiple biological activities of curcumin: A short review
    • Maheshwari RK, Singh AK, Gaddipati J et al (2006) Multiple biological activities of curcumin: a short review. Life Sci 78:2081-2087.
    • (2006) Life Sci , vol.78 , pp. 2081-2087
    • Maheshwari, R.K.1    Singh, A.K.2    Gaddipati, J.3
  • 66
    • 0029859750 scopus 로고    scopus 로고
    • Cytotoxic triterpenes from a marine sponge, Stelletta sp
    • McCormick JL, McKee TC, Cardellina JH II et al (1996) Cytotoxic triterpenes from a marine sponge, Stelletta sp. J Nat Prod 59:1047-1050.
    • (1996) J Nat Prod , vol.59 , pp. 1047-1050
    • McCormick, J.L.1    McKee, T.C.2    Cardellina, J.H.3
  • 68
    • 0032582588 scopus 로고    scopus 로고
    • The lobatamides, novel cytotoxic macrolides from southwestern Pacific tunicates
    • McKee TC, Galinis DL, Pannell LK et al (1998) The lobatamides, novel cytotoxic macrolides from southwestern Pacific tunicates. J Org Chem 63:7805-7810.
    • (1998) J Org Chem , vol.63 , pp. 7805-7810
    • McKee, T.C.1    Galinis, D.L.2    Pannell, L.K.3
  • 69
    • 34548306962 scopus 로고    scopus 로고
    • Cardiotonic steroids on the road to anti-cancer therapy
    • Mijatovic T, Van QE, Delest B et al (2007) Cardiotonic steroids on the road to anti-cancer therapy. Biochim Biophys Acta 1776:32-57.
    • (2007) Biochim Biophys Acta , vol.1776 , pp. 32-57
    • Mijatovic, T.1    Van, Q.E.2    Delest, B.3
  • 70
    • 0031552155 scopus 로고    scopus 로고
    • Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs
    • Mimaki Y, Kuroda M, Kameyama A et al (1997) Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs. BioMed Chem Lett 7:633-636.
    • (1997) BioMed Chem Lett , vol.7 , pp. 633-636
    • Mimaki, Y.1    Kuroda, M.2    Kameyama, A.3
  • 71
    • 1842865013 scopus 로고    scopus 로고
    • Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities
    • Mizui Y, Sakai T, Iwata M et al (2004) Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities. J Antibiot 57:188-196.
    • (2004) J Antibiot , vol.57 , pp. 188-196
    • Mizui, Y.1    Sakai, T.2    Iwata, M.3
  • 72
    • 0043094087 scopus 로고    scopus 로고
    • Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388D1 cells
    • Moerman KL, Chai CL, Waring P (2003) Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388D1 cells. Toxicol Appl Pharmacol 190:232-240.
    • (2003) Toxicol Appl Pharmacol , vol.190 , pp. 232-240
    • Moerman, K.L.1    Chai, C.L.2    Waring, P.3
  • 73
    • 0030832842 scopus 로고    scopus 로고
    • The NCI anti-cancer drug screen: A smart screen to identify effectors of novel targets
    • Monks A, Scudiero DA, Johnson GS et al (1997) The NCI anti-cancer drug screen: a smart screen to identify effectors of novel targets. Anticancer Drug Des 12:533-541.
    • (1997) Anticancer Drug Des , vol.12 , pp. 533-541
    • Monks, A.1    Scudiero, D.A.2    Johnson, G.S.3
  • 74
    • 0032503953 scopus 로고    scopus 로고
    • Mode of action of the anticancer quassinoids-inhibition of the plasma membrane NADH oxidase
    • Morre DJ, Grieco PA, Morre DM (1998) Mode of action of the anticancer quassinoids-inhibition of the plasma membrane NADH oxidase. Life Sci 63:595-604.
    • (1998) Life Sci , vol.63 , pp. 595-604
    • Morre, D.J.1    Grieco, P.A.2    Morre, D.M.3
  • 75
    • 33645801979 scopus 로고    scopus 로고
    • Natural products from invertebrates and microbes as modulators of antitumor targets
    • Newman DJ, Cragg GM (2006) Natural products from invertebrates and microbes as modulators of antitumor targets. Curr Drug Targets 7:279-304.
    • (2006) Curr Drug Targets , vol.7 , pp. 279-304
    • Newman, D.J.1    Cragg, G.M.2
  • 76
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461-477.
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 77
    • 0028825869 scopus 로고
    • A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and p-glycoprotein
    • Ojima I, Duclose O, Dormán G et al (1995) A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and p-glycoprotein. J Med Chem 38:3891-3894.
    • (1995) J Med Chem , vol.38 , pp. 3891-3894
    • Ojima, I.1    Duclose, O.2    Dormán, G.3
  • 78
    • 8744250329 scopus 로고    scopus 로고
    • MPC1001 and its analogues: New antitumor agents from the fungus Cladorrhinum species
    • Onodera H, Hasegawa A, Tsumagari N et al (2004) MPC1001 and its analogues: new antitumor agents from the fungus Cladorrhinum species. Org Lett 6:4101-4104.
    • (2004) Org Lett , vol.6 , pp. 4101-4104
    • Onodera, H.1    Hasegawa, A.2    Tsumagari, N.3
  • 79
    • 33746753342 scopus 로고    scopus 로고
    • Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast
    • Parsons AB, Lopez A, Givoni IE et al (2006) Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell 126:611-625.
    • (2006) Cell , vol.126 , pp. 611-625
    • Parsons, A.B.1    Lopez, A.2    Givoni, I.E.3
  • 80
    • 0024312538 scopus 로고
    • Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development of mean graph and COMPARE algorithm
    • Paull KD, Shoemaker RH, Hodes L et al (1989) Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J Natl Cancer Inst 81:1088-1092.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 1088-1092
    • Paull, K.D.1    Shoemaker, R.H.2    Hodes, L.3
  • 81
    • 0026752669 scopus 로고
    • Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data
    • Paull KD, Lin CM, Malspeis L et al (1992) Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data. Cancer Res 52:3892-3900.
    • (1992) Cancer Res , vol.52 , pp. 3892-3900
    • Paull, K.D.1    Lin, C.M.2    Malspeis, L.3
  • 82
    • 0036281057 scopus 로고    scopus 로고
    • Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis
    • Perkins S, Verschoyle RD, Hill K et al (2002) Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev 11:535-540.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 535-540
    • Perkins, S.1    Verschoyle, R.D.2    Hill, K.3
  • 83
    • 0023864515 scopus 로고
    • Isolation and structure of the powerful cell growth inhibitor cephalostatin 1
    • Pettit GR, Inoue M, Kamano Y et al (1988) Isolation and structure of the powerful cell growth inhibitor cephalostatin 1. J Am Chem Soc 110:2006-2007.
    • (1988) J Am Chem Soc , vol.110 , pp. 2006-2007
    • Pettit, G.R.1    Inoue, M.2    Kamano, Y.3
  • 84
    • 0027171060 scopus 로고
    • Isolation and structure of the remarkable human cancer cell growth inhibitors spongistatins and 3 from an eastern Indian Ocean Spongia sp
    • Pettit GR, Cichacz ZA, Gao F et al (1993a) Isolation and structure of the remarkable human cancer cell growth inhibitors spongistatins and 3 from an eastern Indian Ocean Spongia sp. J Chem Soc Chem Commun 14:1166-1168.
    • (1993) J Chem Soc Chem Commun , vol.14 , pp. 1166-1168
    • Pettit, G.R.1    Cichacz, Z.A.2    Gao, F.3
  • 85
    • 0027155835 scopus 로고
    • Isolation and structure of spongistatin 1
    • Pettit GR, Cichacz ZA, Gao F et al (1993b) Isolation and structure of spongistatin 1. J Org Chem 58:1302-1304.
    • (1993) J Org Chem , vol.58 , pp. 1302-1304
    • Pettit, G.R.1    Cichacz, Z.A.2    Gao, F.3
  • 86
    • 77149121747 scopus 로고    scopus 로고
    • Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2
    • Qi H, Wei L, Han Y et al (2010) Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2. Int J Oncol 36:725-735.
    • (2010) Int J Oncol , vol.36 , pp. 725-735
    • Qi, H.1    Wei, L.2    Han, Y.3
  • 87
    • 0032489634 scopus 로고    scopus 로고
    • Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
    • Redinbo MR, Stewart L, Kuhn P et al (1998) Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science 279:1504-1513.
    • (1998) Science , vol.279 , pp. 1504-1513
    • Redinbo, M.R.1    Stewart, L.2    Kuhn, P.3
  • 88
    • 12744274771 scopus 로고    scopus 로고
    • Quassinoids can induce mitochondrial membrane depolarisation and caspase 3 activation in human cells
    • Rosati A, Quaranta E, Ammirante M et al (2004) Quassinoids can induce mitochondrial membrane depolarisation and caspase 3 activation in human cells. Cell Death Differ 11:S216-S218.
    • (2004) Cell Death Differ , vol.11 , pp. S216-S218
    • Rosati, A.1    Quaranta, E.2    Ammirante, M.3
  • 89
    • 0029742550 scopus 로고    scopus 로고
    • Novel actin depolymerizing macrolide aplyronine A
    • Saito S, Watabe S, Ozaki H et al (1996) Novel actin depolymerizing macrolide aplyronine A. J Biochem 120:552-555.
    • (1996) J Biochem , vol.120 , pp. 552-555
    • Saito, S.1    Watabe, S.2    Ozaki, H.3
  • 90
    • 61349139994 scopus 로고    scopus 로고
    • Development and application of high-performance affinity beads: Toward chemical biology and drug discovery
    • Sakamoto S, Kabe Y, Hatakeyama M et al (2009) Development and application of high-performance affinity beads: toward chemical biology and drug discovery. Chem Rec 9:66-85.
    • (2009) Chem Rec , vol.9 , pp. 66-85
    • Sakamoto, S.1    Kabe, Y.2    Hatakeyama, M.3
  • 91
    • 51649114209 scopus 로고    scopus 로고
    • Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP
    • Schyschka L, Rudy A, Jeremias I et al (2008) Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP. Leukemia 22:1737-1745.
    • (2008) Leukemia , vol.22 , pp. 1737-1745
    • Schyschka, L.1    Rudy, A.2    Jeremias, I.3
  • 92
    • 0031911557 scopus 로고    scopus 로고
    • Mining the National Cancer Institute anticancer drug discovery database: Cluster analysis of ellipticine analogs with p53-Inverse and central nervous system-selective patterns of activity
    • Shi LM, Myers TG, Fan Y et al (1998) Mining the National Cancer Institute anticancer drug discovery database: cluster analysis of ellipticine analogs with p53-Inverse and central nervous system-selective patterns of activity. Mol Pharmacol 53:241-251.
    • (1998) Mol Pharmacol , vol.53 , pp. 241-251
    • Shi, L.M.1    Myers, T.G.2    Fan, Y.3
  • 93
    • 33749011163 scopus 로고    scopus 로고
    • The NCI60 human tumour cell line anticancer drug screen
    • Shoemaker RH (2006) The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 6:813-823.
    • (2006) Nat Rev Cancer , vol.6 , pp. 813-823
    • Shoemaker, R.H.1
  • 94
    • 40849130043 scopus 로고    scopus 로고
    • Proteomic methods for drug target discovery
    • Sleno L, Emili A (2008) Proteomic methods for drug target discovery. Curr Opin Chem Biol 12:46-54.
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 46-54
    • Sleno, L.1    Emili, A.2
  • 95
    • 0031552092 scopus 로고    scopus 로고
    • Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs
    • Suenaga K, Kamei N, Okugawa Y et al (1997) Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. BioMed Chem Lett 7:269-274.
    • (1997) BioMed Chem Lett , vol.7 , pp. 269-274
    • Suenaga, K.1    Kamei, N.2    Okugawa, Y.3
  • 96
    • 0035213907 scopus 로고    scopus 로고
    • A new antibiotic CJ-17,665 from Aspergillus ochraceus
    • Sugie Y, Hirai H, Inagaki T et al (2001) A new antibiotic CJ-17,665 from Aspergillus ochraceus. J Antibiot 54:911-916.
    • (2001) J Antibiot , vol.54 , pp. 911-916
    • Sugie, Y.1    Hirai, H.2    Inagaki, T.3
  • 97
    • 18844370367 scopus 로고    scopus 로고
    • Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
    • Sun J, Blaskovich MA, Jove R et al (2005) Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 24:3236-3245.
    • (2005) Oncogene , vol.24 , pp. 3236-3245
    • Sun, J.1    Blaskovich, M.A.2    Jove, R.3
  • 98
    • 65749118391 scopus 로고    scopus 로고
    • A metabolomic analysis of the toxicity of Aconitum sp. alkaloids in rats using gas chromatography/mass spectrometry
    • Sun B, Wu S, Li L et al (2009) A metabolomic analysis of the toxicity of Aconitum sp. alkaloids in rats using gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom 23: 1221-1228.
    • (2009) Rapid Commun Mass Spectrom , vol.23 , pp. 1221-1228
    • Sun, B.1    Wu, S.2    Li, L.3
  • 99
    • 0034738979 scopus 로고    scopus 로고
    • Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine
    • Taipale J, Chen JK, Cooper MK et al (2000) Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine. Nature 406:1005-1009.
    • (2000) Nature , vol.406 , pp. 1005-1009
    • Taipale, J.1    Chen, J.K.2    Cooper, M.K.3
  • 100
    • 0036255935 scopus 로고    scopus 로고
    • Vacuolar H(+)-ATPase: Functional mechanisms and potential as a target for cancer chemotherapy
    • Torigoe T, Izumi H, Ise T et al (2002) Vacuolar H(+)-ATPase: functional mechanisms and potential as a target for cancer chemotherapy. Anticancer Drugs 13:237-243.
    • (2002) Anticancer Drugs , vol.13 , pp. 237-243
    • Torigoe, T.1    Izumi, H.2    Ise, T.3
  • 101
    • 0034795339 scopus 로고    scopus 로고
    • Use of isogenic human cancer cells for highthroughput screening and drug discovery
    • Torrance CJ, Agrawal V, Vogelstein B et al (2001) Use of isogenic human cancer cells for highthroughput screening and drug discovery. Nat Biotechnol 19:940-945.
    • (2001) Nat Biotechnol , vol.19 , pp. 940-945
    • Torrance, C.J.1    Agrawal, V.2    Vogelstein, B.3
  • 102
    • 77952151244 scopus 로고    scopus 로고
    • Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in an NF1-GRD dependent manner
    • Turbyville TJ, Gürsel DB, Tuskan RG et al (2010) Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in an NF1-GRD dependent manner. Mol Cancer Ther 9(5):1234-1243.
    • (2010) Mol Cancer Ther , vol.9 , Issue.5 , pp. 1234-1243
    • Turbyville, T.J.1    Gürsel, D.B.2    Tuskan, R.G.3
  • 103
    • 75849156898 scopus 로고    scopus 로고
    • Structural analogues of schweinfurthin F: Probing the steric, electronic and hydrophobic properties of the D-ring substructure
    • Ulrich NC, Kodet JG, Mente NR et al (2010) Structural analogues of schweinfurthin F: probing the steric, electronic and hydrophobic properties of the D-ring substructure. Bioorg Med Chem 18:1676-1683.
    • (2010) Bioorg Med Chem , vol.18 , pp. 1676-1683
    • Ulrich, N.C.1    Kodet, J.G.2    Mente, N.R.3
  • 104
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 105
    • 70349431230 scopus 로고    scopus 로고
    • In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: It is the time to combine
    • Vidalin O, Muslmani M, Estienne C et al (2009) In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: it is the time to combine. Curr Opin Pharmacol 9:669-676.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 669-676
    • Vidalin, O.1    Muslmani, M.2    Estienne, C.3
  • 106
    • 0028232102 scopus 로고
    • Cellular uptake as a determinant of cytotoxicity of quaternized ellipticines to human brain tumor cells
    • Vistica DT, Kenney S, Hursey ML et al (1994) Cellular uptake as a determinant of cytotoxicity of quaternized ellipticines to human brain tumor cells. Biochem Biophys Res Commun 200: 1762-1768.
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 1762-1768
    • Vistica, D.T.1    Kenney, S.2    Hursey, M.L.3
  • 107
    • 0030440926 scopus 로고    scopus 로고
    • Role of membrane potential in the accumulation of quaternized ellipticines by human tumor cell lines
    • Vistica DT, Kenney S, Hursey ML et al (1996) Role of membrane potential in the accumulation of quaternized ellipticines by human tumor cell lines. J Pharmacol Exp Ther 279:1018-1025.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1018-1025
    • Vistica, D.T.1    Kenney, S.2    Hursey, M.L.3
  • 109
    • 33646718613 scopus 로고
    • Chaetomin, a new antibiotic substance produced by chaetomium cochliodes: I. Formation and properties
    • Waksman SA, Bugie E (1944) Chaetomin, a new antibiotic substance produced by chaetomium cochliodes: I. Formation and properties. J Bacteriol 48:527-530.
    • (1944) J Bacteriol , vol.48 , pp. 527-530
    • Waksman, S.A.1    Bugie, E.2
  • 110
    • 0026498426 scopus 로고
    • Neural computing in cancer drug development: Predicting mechanism of action
    • Weinstein JN, Kohn KW, Grever MR et al (1992) Neural computing in cancer drug development: predicting mechanism of action. Science 258:447-451.
    • (1992) Science , vol.258 , pp. 447-451
    • Weinstein, J.N.1    Kohn, K.W.2    Grever, M.R.3
  • 111
    • 0031035181 scopus 로고    scopus 로고
    • An information-intensive approach to the molecular pharmacology of cancer
    • Weinstein JN, Myers TG, O'Connor PM et al (1997) An information-intensive approach to the molecular pharmacology of cancer. Science 275:343-349.
    • (1997) Science , vol.275 , pp. 343-349
    • Weinstein, J.N.1    Myers, T.G.2    O'Connor, P.M.3
  • 112
    • 0032564593 scopus 로고    scopus 로고
    • Ambewelamides A and B, antineoplastic epidithiapiperazinediones isolated from the lichen Usnea sp
    • Williams DE, Bombuwala K, Lobkovsky E et al (1998) Ambewelamides A and B, antineoplastic epidithiapiperazinediones isolated from the lichen Usnea sp. Tetrahedron Lett 39:9579-9582.
    • (1998) Tetrahedron Lett , vol.39 , pp. 9579-9582
    • Williams, D.E.1    Bombuwala, K.2    Lobkovsky, E.3
  • 113
    • 0020324821 scopus 로고
    • Phase II trial of bruceantin in metastatic breast carcinoma
    • Wiseman CL, Yap HY, Bedikian AY et al (1982) Phase II trial of bruceantin in metastatic breast carcinoma. Am J Clin Oncol 5:389-391.
    • (1982) Am J Clin Oncol , vol.5 , pp. 389-391
    • Wiseman, C.L.1    Yap, H.Y.2    Bedikian, A.Y.3
  • 114
    • 0030828009 scopus 로고    scopus 로고
    • Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns
    • Wosikowski K, Schuurhuis D, Johnson K et al (1997) Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns. J Natl Cancer Inst 89:1505-1515.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1505-1515
    • Wosikowski, K.1    Schuurhuis, D.2    Johnson, K.3
  • 115
    • 64249117392 scopus 로고    scopus 로고
    • Synthesis of a 35-member stereoisomer library of bistramide A: Evaluation of effects on actin state, cell cycle and tumor cell growth
    • Wrona IE, Lowe JT, Turbyville TJ et al (2009) Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth. J Org Chem 74:1897-1916.
    • (2009) J Org Chem , vol.74 , pp. 1897-1916
    • Wrona, I.E.1    Lowe, J.T.2    Turbyville, T.J.3
  • 116
    • 0026766576 scopus 로고
    • Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening
    • Wu L, Smythe AM, Stinson SF et al (1992) Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. Cancer Res 52: 3029-3034.
    • (1992) Cancer Res , vol.52 , pp. 3029-3034
    • Wu, L.1    Smythe, A.M.2    Stinson, S.F.3
  • 117
    • 36448960196 scopus 로고    scopus 로고
    • The natural product avrainvillamide binds to the oncoprotein nucleophosmin
    • Wulff JE, Siegrist R, Myers AG (2007) The natural product avrainvillamide binds to the oncoprotein nucleophosmin. J Am Chem Soc 129:14444-14451.
    • (2007) J Am Chem Soc , vol.129 , pp. 14444-14451
    • Wulff, J.E.1    Siegrist, R.2    Myers, A.G.3
  • 118
    • 40049089626 scopus 로고    scopus 로고
    • A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization
    • Xu GW, Mawji IA, Macrae CJ et al (2008) A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis 13:413-422.
    • (2008) Apoptosis , vol.13 , pp. 413-422
    • Xu, G.W.1    Mawji, I.A.2    Macrae, C.J.3
  • 119
    • 0027763552 scopus 로고
    • Aplyronine A, a potent antitumor substance, and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodai
    • Yamada K, Ojika M, Ishigaki T et al (1993) Aplyronine A, a potent antitumor substance, and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodai. J Am Chem Soc 115:11020-11021.
    • (1993) J Am Chem Soc , vol.115 , pp. 11020-11021
    • Yamada, K.1    Ojika, M.2    Ishigaki, T.3
  • 120
    • 33846454701 scopus 로고    scopus 로고
    • The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry"
    • Yang H, Shi G, Dou QP (2007) The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry". Mol Pharmacol 71:426-437.
    • (2007) Mol Pharmacol , vol.71 , pp. 426-437
    • Yang, H.1    Shi, G.2    Dou, Q.P.3
  • 121
    • 34247254877 scopus 로고    scopus 로고
    • Cytotoxic prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rain forest
    • Yoder B, Norris A, Miller JS et al (2006) Cytotoxic prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rain forest. J Nat Prod 70:342-346.
    • (2006) J Nat Prod , vol.70 , pp. 342-346
    • Yoder, B.1    Norris, A.2    Miller, J.S.3
  • 122
    • 71549153791 scopus 로고    scopus 로고
    • Withaferin A targets heat shock protein 90 in pancreatic cancer cells
    • Yu Y, Hamza A, Zhang T et al (2010) Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochem Pharmacol 79:542-551.
    • (2010) Biochem Pharmacol , vol.79 , pp. 542-551
    • Yu, Y.1    Hamza, A.2    Zhang, T.3
  • 123
    • 64849111865 scopus 로고    scopus 로고
    • Targeting STAT3 in cancer: How successful are we?
    • Yue P, Turkson J (2009) Targeting STAT3 in cancer: how successful are we? Expert Opin Investig Drugs 18:45-56.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 45-56
    • Yue, P.1    Turkson, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.