Synthesis of a 35-member stereoisomer library of bistramide A: Evaluation of effects on actin state, cell cycle and tumor cell growth

Journal of Organic Chemistry

Volumn 74, Issue 5, 2009, Pages 1897-1916

  Wrona, Iwona E ^a   Lowe, Jason T ^a   Turbyville, Thomas J ^b,c   Johnson, Tanya R ^b   Beignet, Julien ^a   Beutler, John A ^b   Panek, James S ^a  

^a Boston University   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EVALUATIONS; CANCER CELL LINES; CELL CYCLES; CROTYLSILANE REAGENTS; LEWIS ACIDS; NATURAL PRODUCTS; ORGANOSILANE; PEPTIDE COUPLINGS; TETRAHYDROPYRAN; TUMOR CELLS;

AMINES; AMINO ACIDS; CELL CULTURE; GROWTH KINETICS; ISOMERS; ORGANIC ACIDS; SILANES; STEREOCHEMISTRY;

CELL GROWTH;

ACTIN; ANTINEOPLASTIC AGENT; BISTRAMIDE A; LEWIS ACID; NATURAL PRODUCT; SILANE DERIVATIVE; UNCLASSIFIED DRUG;

ANNULATION REACTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL GROWTH; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; ISOMER; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ACETAMIDES; ACTINS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRANS; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64249117392     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo802269q     Document Type: Article

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