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Chemical shifts of the dioxopiperazine ring in 5 were compared to similar structures such as (a) dithiosivation (Kawahara, N.; Nozawa, K.; Nakajima, S.; Kawai, K. J. Chem. Soc., Perkin Trans. 1 1987, 2099-2101) and (b) a synthetic intermediate of gliotoxin (Fukuyama, T.; Nakatsuka, S.; Kishi, Y. Tetrahedron 1981, 37, 2045-2078).
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0019463984
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Chemical shifts of the dioxopiperazine ring in 5 were compared to similar structures such as (a) dithiosivation (Kawahara, N.; Nozawa, K.; Nakajima, S.; Kawai, K. J. Chem. Soc., Perkin Trans. 1 1987, 2099-2101) and (b) a synthetic intermediate of gliotoxin (Fukuyama, T.; Nakatsuka, S.; Kishi, Y. Tetrahedron 1981, 37, 2045-2078).
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8744235113
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note
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Molecular modeling study of 6 using MM2 deduced a dihedral angle between C-4 and H-5a of about 90°, which resulted in the small coupling.
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12
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8744233174
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Chemical shifts of the trioxopiperazine ring in 6 were compared to similar structures such as (a) neoechinuline (Cardillo, R.; Fuganti, C.; Gatti, G.; Ghiringhelli, D.; Grasselli, P. Tetrahedron Lett. 1974, 36, 3163-3166) and (b) a compound 1 (Mulliez, M.; Royer, J. Tetrahedron 1984, 40, 5143-5151).
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13
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0000080114
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Chemical shifts of the trioxopiperazine ring in 6 were compared to similar structures such as (a) neoechinuline (Cardillo, R.; Fuganti, C.; Gatti, G.; Ghiringhelli, D.; Grasselli, P. Tetrahedron Lett. 1974, 36, 3163-3166) and (b) a compound 1 (Mulliez, M.; Royer, J. Tetrahedron 1984, 40, 5143-5151).
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Ueno, Y.; Umemori, K.; Niimi, E.; Tanuma, S.; Nagata, S.; Sugamata, M.; Ihara, T.; Sekijima, M.; Kawai, K.; Ueno, I.; Tashiro, F. Nat. Toxins 1995, 3, 129-137.
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(a) Neuss, N.; Boeck, L. D.; Brannon, D. R.; Cline, J. C.; DeLong, D. C.; Gorman, M.; Huckstep, L. L.; Lively, D. H.; Mabe, J.; Marsh, M. M.; Molloy, B. B.; Nagarajan, R.; Nelson, J. D.; Stark, W. M. Antimicrob. Agents Chemother. 1968, 8, 213-219.
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