A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

Apoptosis

Volumn 13, Issue 3, 2008, Pages 413-422

  Xu, G Wei ^a   Mawji, Imtiaz A ^a   Macrae, Chloe J ^a   Koch, C Anne ^a   Datti, Alessandro ^b   Wrana, Jeffrey L ^b   Dennis, James W ^b   Schimmer, Aaron D ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Ellipticine; High throughput screen; p53

Indexed keywords

DOUBLE STRANDED DNA; ELLIPTICINE; GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL; CELL MATURATION; CELL NUCLEUS; CELL STRAIN HCT116; CYTOPLASM; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; NUCLEAR LOCALIZATION SIGNAL; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SCREENING;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DRUG EVALUATION, PRECLINICAL; ELLIPTICINES; GREEN FLUORESCENT PROTEINS; HUMANS; LEUPEPTINS; OSTEOSARCOMA; RECOMBINANT FUSION PROTEINS; THAPSIGARGIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 40049089626     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0175-4     Document Type: Article

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