Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 5, 1997, Pages 633-636

  Mimaki, Yoshihiro ^a   Kuroda, Minpei ^a   Kameyama, Aiko ^a   Sashida, Yutaka ^a   Hirano, Toshiliko ^a   Oka, Kitaro ^a   Maekawa, Rhuji ^b   Wada, Toru ^b   Sugita, Kenji ^b   Beutler, John A ^c  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CHOLESTANE DERIVATIVE; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GLYCOSIDE; METHOTREXATE; MITOMYCIN C; PACLITAXEL;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL LINE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOSTASIS; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; LEUKEMIA P 388; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYTOCHEMISTRY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALIA; ORNITHOGALUM; ORNITHOGALUM SAUNDERSIAE;

EID: 0031552155     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00071-1     Document Type: Article

References (8)

1. 1. Fresh bulbs of O. saundersiae (16.2 kg) were purchased from Heiwaen, Japan. The plant specimen is on file in our laboratory.
2. 2. The assay was carried out according to a modified method of Sargent and Tayler. Sargent, J. M.; Tayler, C. G. Br. J. Cancer 1989, 60, 206.
3. 3. Kubo, S.; Mimaki, Y.; Terao, M.; Sashida, Y.; Nikaido, T.; Ohmoto T. Phytochemistry 1992, 31, 3969.
4. 4 (11 : 1) to remove exchangeable protons and minimize signal overlap.
5. 5. The monosaccharides were identified by converting them to the 1-[(S)-N-acetyl-α-methylbenzyl-amino]-1-deoxyalditol acetate derivatives followed by HPLC analysis. Oshima, R.; Yamauchi, Y.; Kumanotani, J. Carbohydr. Res. 1982, 107, 169.
6. 6. Boyd, M. R.; Paull, K. D.; Rubinstein, L. R. in Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development 1992, pp. 11 - 34, Kluwer Academic Publishers, Amsterdam.
7. 7. Boyd, M. R.; Paull, K. D. Drug Dev. Res. 1995, 34, 91.
8. 8. Pettit, G. R.; Inoue, M.; Kamano, Y.; Herald, D. L.; Arm, C.; Dufresne, C.; Christie, N. D.; Schmidt, J. M.; Doubek, D. L.; Krupa, T. S. J. Am. Chem. Soc. 1988, 110, 2006.