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Biochemistry

Volumn 40, Issue 33, 2001, Pages 9792-9798

A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin

(2) Kerrigan, J E a Pilch, D S b,c

a RUTGERS UNIVERSITY (United States)

b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL (United States)

c RUTGERS CANCER INSTITUTE OF NEW JERSEY (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TERNARY COMPLEX;

CROSSLINKING; CRYSTAL STRUCTURE; DNA; DRUG PRODUCTS; ENZYMES; HYDROGEN BONDS; MUTAGENESIS; X RAYS;

BIOCHEMISTRY;

CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA; DNA TOPOISOMERASE;

ARTICLE; CROSS LINKING; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA DRUG COMPLEX; ENZYME BINDING; GENE MUTATION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; INTERCALATION COMPLEX; MODEL; MOLECULAR STABILITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BASE SEQUENCE; CAMPTOTHECIN; COMPUTER SIMULATION; CROSS-LINKING REAGENTS; DNA; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING;

EID: 0035928802 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi010913l Document Type: Article

Times cited : (70)

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