Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11

Angewandte Chemie - International Edition

Volumn 48, Issue 47, 2009, Pages 8952-8957

  Cee, Victor J ^a   Chen, David Y K ^b   Lee, Matthew R ^a   Nicolaou, K C ^c,d  

^a AMGEN INC   (United States)

^b INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; CDK; Cortistatin a; Kinases; ROCK

Indexed keywords

ANGIOGENESIS; ANTI-PROLIFERATIVE; CDK; COILED COIL; CORTISTATIN A; CRYSTALLOGRAPHIC STRUCTURE; CYCLIN-DEPENDENT KINASE; CYCLIN-DEPENDENT KINASE 11; HIGH AFFINITY LIGANDS; HOMOLOGY MODELS; KINASES; PROTEIN KINASE;

LIGANDS;

ROCKS;

CDC2L2 PROTEIN, HUMAN; CORTISTATIN A; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 8; ISOQUINOLINE DERIVATIVE; LIGAND; POLYCYCLIC HYDROCARBON; RHO KINASE;

ANIMAL; ARTICLE; BINDING SITE; CELL LINE; CHEMISTRY; COMPUTER SIMULATION; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; SPONGE (PORIFERA); X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CELL LINE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 8; CYCLIN-DEPENDENT KINASES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ISOQUINOLINES; LIGANDS; POLYCYCLIC COMPOUNDS; PORIFERA; PROTEIN STRUCTURE, TERTIARY; RHO-ASSOCIATED KINASES;

EID: 70449120427     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200904778     Document Type: Article

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