-
1
-
-
0028915934
-
Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute anticancer drug screen
-
ALVAREZ, M , PAULL, K , MONKS, A , HOSE, C , LEE, J-S , WEINSTEIN, J., GREVER. M , BATES, S & FOJO, T (1995). Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute anticancer drug screen. Journal of Clinical Investigation, 95, 2205.
-
(1995)
Journal of Clinical Investigation
, vol.95
, pp. 2205
-
-
Alvarez, M.1
Paull, K.2
Monks, A.3
Hose, C.4
Lee, J.-S.5
Weinstein, J.6
Grever, M.7
Bates, S.8
Fojo, T.9
-
2
-
-
0026069885
-
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytoxicity data
-
BAI, R.L., PAULL, K.D., HERALD, C.L , MALSPEIS, L., PETTIT, G R & HAMEL, E. (1991) Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytoxicity data. Journal of Biochemistry, 266, 15882.
-
(1991)
Journal of Biochemistry
, vol.266
, pp. 15882
-
-
Bai, R.L.1
Paull, K.D.2
Herald, C.L.3
Malspeis, L.4
Pettit, G.R.5
Hamel, E.6
-
3
-
-
0030888689
-
Antiproliferative activity in vitro and in vivo of the spicamycin analogue KRN5 500 with altered glycoprotein expression in vitro
-
BURGER, A , KAUR, G., HOLLINGSHEAD, M , FISCHER, R., NAGASHIMA, K., MALSPEIS, L , DUNCAN, K & SAUSVILLE, E. (1997). Antiproliferative activity in vitro and in vivo of the spicamycin analogue KRN5 500 with altered glycoprotein expression in vitro. Clinical Cancer Research, 3, 455,
-
(1997)
Clinical Cancer Research
, vol.3
, pp. 455
-
-
Burger, A.1
Kaur, G.2
Hollingshead, M.3
Fischer, R.4
Nagashima, K.5
Malspeis, L.6
Duncan, K.7
Sausville, E.8
-
4
-
-
0028968220
-
Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the COMPARE program
-
CLEVELAND, E.S., MONKS, A , VAIGRO-WOLFF A., ZAHAREVITZ, D.W., PAULL, K , ARDALAN, K., COONEY, D.A. & FORD, H., JR (1995) Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the COMPARE program. Biochemical Pharmacology, 49, 947.
-
(1995)
Biochemical Pharmacology
, vol.49
, pp. 947
-
-
Cleveland, E.S.1
Monks, A.2
Vaigro-Wolff, A.3
Zaharevitz, D.W.4
Paull, K.5
Ardalan, K.6
Cooney, D.A.7
Ford Jr., H.8
-
5
-
-
0027447244
-
In Vitro assessment of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance
-
FINLAY, G J, MARSHALL, E, MATTHEWS, J H., PAULL, K.D. & BAGULEY, B.D. (1993). In Vitro assessment of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance. Cancer Chemotherapy Pharmacology, 31, 401.
-
(1993)
Cancer Chemotherapy Pharmacology
, vol.31
, pp. 401
-
-
Finlay, G.J.1
Marshall, E.2
Matthews, J.H.3
Paull, K.D.4
Baguley, B.D.5
-
6
-
-
0029917028
-
Reductase enzyme expression across the National Cancer Institute tumor cell line panel: Correlation with sensitivity to mitomycin C and EO9
-
FITZSIMMONS, S , WORKMAN, P., GREVER, M., PAULL, K., CAMALIER, R., & LEWIS, A (1996). Reductase enzyme expression across the National Cancer Institute tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. Journal of the National Cancer Institute, 88, 259.
-
(1996)
Journal of the National Cancer Institute
, vol.88
, pp. 259
-
-
Fitzsimmons, S.1
Workman, P.2
Grever, M.3
Paull, K.4
Camalier, R.5
Lewis, A.6
-
7
-
-
0030897618
-
Identification of compounds with preferential inhibitory activity against low-Nm-23-expressing human breast carcinoma and melanoma cell lines
-
FREIJE, J., LAWRENCE, J., HOLLINGSHEAD, M., DE LA ROSA, A., NARAYANAN, V., GREVER, M., SAUSVILLE, E , PAULL, K. & STEEG, P. (1997). Identification of compounds with preferential inhibitory activity against low-Nm-23-expressing human breast carcinoma and melanoma cell lines. Nature Medicine, 3, 395.
-
(1997)
Nature Medicine
, vol.3
, pp. 395
-
-
Freije, J.1
Lawrence, J.2
Hollingshead, M.3
De La Rosa, A.4
Narayanan, V.5
Grever, M.6
Sausville, E.7
Paull, K.8
Steeg, P.9
-
8
-
-
0026975774
-
Cytoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells
-
JAYARAM, H N , GHAREHBAGHI, K., RIESER, J., KROHN, K. & PAULL, K.D. (1992). Cytoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells. Biochemical and Biophysical Research Communications, 186, 1600.
-
(1992)
Biochemical and Biophysical Research Communications
, vol.186
, pp. 1600
-
-
Jayaram, H.N.1
Gharehbaghi, K.2
Rieser, J.3
Krohn, K.4
Paull, K.D.5
-
9
-
-
10544253077
-
Enhanced sensitivity to 1-β-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes
-
KOO, H-M , MONKS, A., MIKHEEV, A., RUBINSTEIN, L., GRAY-GOODRICH, M., MCWILLIAMS, M.J., ALVORD, W.G , OIE, H., GAZDAR, A., PAULL, K , ZARBI, H. & VAN DE WOUDE, G (1996). Enhanced sensitivity to 1-β-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes. Cancer Research, 56, 5211.
-
(1996)
Cancer Research
, vol.56
, pp. 5211
-
-
Koo, H.-M.1
Monks, A.2
Mikheev, A.3
Rubinstein, L.4
Gray-Goodrich, M.5
Mcwilliams, M.J.6
Alvord, W.G.7
Oie, H.8
Gazdar, A.9
Paull, K.10
Zarbi, H.11
Van De Woude, G.12
-
10
-
-
0028030228
-
Rhodamine efflux patterns predict p -glycoprotein substrates in the National Cancer Institute drug screen
-
LEE, J-S., PAULL, K., ALVAREZ, M , HOSE, C., MONKS, A., GREVER, M , FOJO, T & BATES, S. (1994). Rhodamine efflux patterns predict p -glycoprotein substrates in the National Cancer Institute drug screen. Molecular Pharmacology, 46, 627.
-
(1994)
Molecular Pharmacology
, vol.46
, pp. 627
-
-
Lee, J.-S.1
Paull, K.2
Alvarez, M.3
Hose, C.4
Monks, A.5
Grever, M.6
Fojo, T.7
Bates, S.8
-
11
-
-
0027933603
-
Topoisomerase II inhibition and cytoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen
-
LETEURTRE, F., KOHLHAGEN, G., PAULL, K.D. & POMMIER, Y (1994). Topoisomerase II inhibition and cytoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen. Journal of the National Cancer Institute, 86, 1239.
-
(1994)
Journal of the National Cancer Institute
, vol.86
, pp. 1239
-
-
Leteurtre, F.1
Kohlhagen, G.2
Paull, K.D.3
Pommier, Y.4
-
12
-
-
0025775062
-
Feasibility of a high-flux anticancer drug screen utilizing a diverse panel of human tumor cell lines in culture
-
MONKS, A., SCUDIERO, D., SKEHAN, P., SHOEMAKER, R , PAULL, K., VISTICA, D., HOSE, C., LANGLEY J., CRONISE, P., VAIGRO-WOLFF, A., GRAY-GOODRICH, M., CAMPBELL, H., MAYO, J. & BOYD, M.R (1991). Feasibility of a high-flux anticancer drug screen utilizing a diverse panel of human tumor cell lines in culture. Journal of the National Cancer Institute, 83, 757.
-
(1991)
Journal of the National Cancer Institute
, vol.83
, pp. 757
-
-
Monks, A.1
Scudiero, D.2
Skehan, P.3
Shoemaker, R.4
Paull, K.5
Vistica, D.6
Hose, C.7
Langley, J.8
Cronise, P.9
Vaigro-Wolff, A.10
Gray-Goodrich, M.11
Campbell, H.12
Mayo, J.13
Boyd, M.R.14
-
13
-
-
0028214608
-
Prognostic importance in the ras proto-oncogenes in de novo acute myeloid leukemia
-
NEUBAUER, A., DODGE, R.K., GEORGE, S.L., DAE,FR , SILVER, R.T., SCHIFFER, C.A , MAYER, R.J., BALL, E D., WURSTER-HILL, D., BLOOMFIELD, C.D. & LIU, E.T. (1994). Prognostic importance in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood, 83, 1603.
-
(1994)
Blood
, vol.83
, pp. 1603
-
-
Neubauer, A.1
Dodge, R.K.2
George, S.L.3
Dae, F.R.4
Silver, R.T.5
Schiffer, C.A.6
Mayer, R.J.7
Ball, E.D.8
Wurster-Hill, D.9
Bloomfield, C.D.10
Liu, E.T.11
-
14
-
-
0024312538
-
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development mean graph and COMPARE algorithm
-
PAULL, K.D., SHOEMAKER, R H , HODES, L., MONKS, A., SCUDIERO, D A., RUBINSTEIN, L., PLOWMAN, J & BOYD, M.R. (1989). Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development mean graph and COMPARE algorithm. Journal of the National Cancer Institute, 81, 1088.
-
(1989)
Journal of the National Cancer Institute
, vol.81
, pp. 1088
-
-
Paull, K.D.1
Shoemaker, R.H.2
Hodes, L.3
Monks, A.4
Scudiero, D.A.5
Rubinstein, L.6
Plowman, J.7
Boyd, M.R.8
-
15
-
-
0026752669
-
Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data
-
PAULL, K D., LIN, C.M., MALSPEIS, L. & HAMEL, E. (1992). Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data. Cancer Research, 52, 3982.
-
(1992)
Cancer Research
, vol.52
, pp. 3982
-
-
Paull, K.D.1
Lin, C.M.2
Malspeis, L.3
Hamel, E.4
-
16
-
-
0003154873
-
Prediction of biochemical mechanisms of action from the in vitro antitumor screen of the National Cancer Institute
-
Foye, W. (ed.), ACS Professional Reference Book, ACS: Washington, DC
-
PAULL, K D , HAMEL, E. & MAISPEIS, L. (1995). Prediction of biochemical mechanisms of action from the in vitro antitumor screen of the National Cancer Institute. In Cancer Chemotherapeutic Agents. Foye, W. (ed.), p. 9. ACS Professional Reference Book, ACS: Washington, DC.
-
(1995)
Cancer Chemotherapeutic Agents
, pp. 9
-
-
Paull, K.D.1
Hamel, E.2
Maispeis, L.3
-
17
-
-
0028152064
-
Levels of mRNA coding for DNA topoisomerase II isoforms do not correlate with in vitro drug sensitivity
-
PETERS, A , SMYTHE, A., WU, L., MONKS, A , BOYD, M & SHOEMAKER, R. (1994). Levels of mRNA coding for DNA topoisomerase II isoforms do not correlate with in vitro drug sensitivity. Oncology Reports, 1, 907.
-
(1994)
Oncology Reports
, vol.1
, pp. 907
-
-
Peters, A.1
Smythe, A.2
Wu, L.3
Monks, A.4
Boyd, M.5
Shoemaker, R.6
-
18
-
-
0029807115
-
Flavopiridol (L86 8275: NSC 649890), a new kinase inhibitor for tumor therapy
-
SEDLACEK, H , CZECH, J., NAIK, R., KAUR, G , WORLAND, P., LOSIEWICZ, M., PARKER, B., CARLSON, B , SMITH, A , SENDEROWITZ, A & SAUSVILLE, E. (1996). Flavopiridol (L86 8275: NSC 649890), a new kinase inhibitor for tumor therapy. International Journal of Oncology, 9, 1143.
-
(1996)
International Journal of Oncology
, vol.9
, pp. 1143
-
-
Sedlacek, H.1
Czech, J.2
Naik, R.3
Kaur, G.4
Worland, P.5
Losiewicz, M.6
Parker, B.7
Carlson, B.8
Smith, A.9
Senderowitz, A.10
Sausville, E.11
-
19
-
-
0028306807
-
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue
-
SEYNAEVE, C , KAZANIETZ, M., BLUMBERG, P. SAUSVILLE, E & WORLAND, P (1994). Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Molecular Pharmacology, 45, 1207.
-
(1994)
Molecular Pharmacology
, vol.45
, pp. 1207
-
-
Seynaeve, C.1
Kazanietz, M.2
Blumberg, P.3
Sausville, E.4
Worland, P.5
-
20
-
-
0029895281
-
Glutathione associated enzymes in the human cell lines of the National Cancer Institute drug screening program
-
TEW, K , MONKS, A., BARONE, L., ROSSER, D., AKERMAN, G., MONTALI, J , WHEATLEY, J. & SCHMIDT, D (1996). Glutathione associated enzymes in the human cell lines of the National Cancer Institute drug screening program. Molecular Pharmacology, 50, 149.
-
(1996)
Molecular Pharmacology
, vol.50
, pp. 149
-
-
Tew, K.1
Monks, A.2
Barone, L.3
Rosser, D.4
Akerman, G.5
Montali, J.6
Wheatley, J.7
Schmidt, D.8
-
21
-
-
0026498426
-
Neural computing in cancer drug development: Predicting mechanism of action
-
WEINSTEIN, J., KOHN, K., GREVER, M., VISWANADHAM, V., RUBINSTEIN, L., MONKS, A , SCUDIERO, D , WELCH, L., KOUTSOUKOS, A , CHIAUSA, A. & PAULL, K. (1992). Neural computing in cancer drug development: predicting mechanism of action. Science, 258, 447.
-
(1992)
Science
, vol.258
, pp. 447
-
-
Weinstein, J.1
Kohn, K.2
Grever, M.3
Viswanadham, V.4
Rubinstein, L.5
Monks, A.6
Scudiero, D.7
Welch, L.8
Koutsoukos, A.9
Chiausa, A.10
Paull, K.11
-
22
-
-
0031035181
-
An information-intensive approach to the molecular pharmacology of cancer
-
WEINSTEIN, J., MYERS, T., O'CONNOR, P , FRIEND, S , FORNACE, A , KOHN, K., FOJO, T , BATES, S , RUBINSTEIN, L , ANDERSON, N.L., BUOLAMWINI, J , VAN OSDOL, W., MONKS, A , SCUDIERO, D , SAUSVILLE, E., ZAHAREVITZ, D , BUNOW, B , VISWANADHAN, V., JOHNSON, G., WITTE, R &. PAULL, K (1997). An information-intensive approach to the molecular pharmacology of cancer. Science, 275, 343.
-
(1997)
Science
, vol.275
, pp. 343
-
-
Weinstein, J.1
Myers, T.2
O'Connor, P.3
Friend, S.4
Fornace, A.5
Kohn, K.6
Fojo, T.7
Bates, S.8
Rubinstein, L.9
Anderson, N.L.10
Buolamwini, J.11
Van Osdol, W.12
Monks, A.13
Scudiero, D.14
Sausville, E.15
Zaharevitz, D.16
Bunow, B.17
Viswanadhan, V.18
Johnson, G.19
Witte, R.20
Paull, K.21
more..
-
23
-
-
0031408620
-
Diversity of metallothionein content and subcellular localization in the National Cancer Institute tumor panel
-
in press
-
WOO, E , MONKS, A , WATKINS, S , WANG, A. & LAZO, J (1997). Diversity of metallothionein content and subcellular localization in the National Cancer Institute tumor panel. Cancer Chemical Pharmacology, in press.
-
(1997)
Cancer Chemical Pharmacology
-
-
Woo, E.1
Monks, A.2
Watkins, S.3
Wang, A.4
Lazo, J.5
-
24
-
-
9844231174
-
Use of EGF receptor, c-erbB2 and TGFα gene expression profiles in the National Cancer Institute anticancer drug screen to identify EGF receptor and c-erbB2 pathway inhibitors
-
in press
-
WOSIKOWSKI, K , SCHUURHUIS, D., JOHNSON, K., PAULL, K., MYERS, T., WEINSTEIN, J. & BATES, S. (1997). Use of EGF receptor, c-erbB2 and TGFα gene expression profiles in the National Cancer Institute anticancer drug screen to identify EGF receptor and c-erbB2 pathway inhibitors. Journal of the National Cancer Institute, in press.
-
(1997)
Journal of the National Cancer Institute
-
-
Wosikowski, K.1
Schuurhuis, D.2
Johnson, K.3
Paull, K.4
Myers, T.5
Weinstein, J.6
Bates, S.7
-
25
-
-
0026766576
-
Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening
-
WU, L., SMYTHE, A M., STINSON, S.F , MULLENDORE, L.A., MONKS, A , SCUDIERO, D.A., PAULL, K.D., KOUTSOUKOS, A.D., RUBINSTEIN, L.V., BOYD, M.R. & SHOEMAKER, R.H. (1992). Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. Cancer Research, 52, 3029.
-
(1992)
Cancer Research
, vol.52
, pp. 3029
-
-
Wu, L.1
Smythe, A.M.2
Stinson, S.F.3
Mullendore, L.A.4
Monks, A.5
Scudiero, D.A.6
Paull, K.D.7
Koutsoukos, A.D.8
Rubinstein, L.V.9
Boyd, M.R.10
Shoemaker, R.H.11
-
26
-
-
0013962211
-
The chemotherapy program of the National Cancer Institute: History, analysis and plans
-
ZUBROD, C., SCHEPARTZ, S., J. LEITER, K.M., ENDICOTT, L M & BAKER, C.G. (1966). The chemotherapy program of the National Cancer Institute: history, analysis and plans. Cancer Chemotherapy Reports, 50, 349.
-
(1966)
Cancer Chemotherapy Reports
, vol.50
, pp. 349
-
-
Zubrod, C.1
Schepartz, S.J.2
Leiter, K.M.3
Endicott, L.M.4
Baker, C.G.5
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