The adipo-hepato-insular axis in glucose homeostasis

Peptides in Energy Balance and Obesity: Frontiers in Nutritional Science

Volumn , Issue , 2009, Pages 163-193

  Gómez Ambrosi, Javier ^a   Catalán, Victoria ^a   Frühbeck, Gema ^b  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84890627995     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (191)

1. Accili, D., Drago, J., Lee, E.J., Johnson, M.D., Cool, M.H., Salvatore, P., Asico, L.D., Jose, P.A., Taylor, S.I. and Westphal, H. (1996) Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genetics 12, 106-109.
2. Ahima, R.S., Qi, Y., Singhal, N.S., Jackson, M.B. and Scherer, P.E. (2006) Brain adipocytokine action and metabolic regulation. Diabetes 55 (Suppl. 2), S145-154.
3. Anderwald, C., Müller, G., Koca, G., Fürnsinn, C., Waldhäusl, W. and Roden, M. (2002) Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Molecular Endocrinology 16, 1612-1628.
4. Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T. and Matsuzawa, Y. (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 257, 79-83.
5. Arner, P. (2001) Free fatty acids - do they play a central role in type 2 diabetes? Diabetes, Obesity and Metabolism 3 (Suppl. 1), S11-19.
6. Arner, P. (2005) Resistin: yet another adipokine tells us that men are not mice. Diabetologia 48, 2203-2205.
7. Arner, P. (2006) Visfatin - a true or false trail to type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 91, 28-30.
8. Azuma, K., Katsukawa, F., Oguchi, S., Murata, M., Yamazaki, H., Shimada, A. and Saruta, T. (2003) Correlation between serum resistin level and adiposity in obese individuals. Obesity Research 11, 997-1001.
9. Banerjee, R.R., Rangwala, S.M., Shapiro, J.S., Rich, A.S., Rhoades, B., Qi, Y., Wang, J., Rajala, M.W., Pocai, A., Scherer, P.E., Steppan, C.M., Ahima, R.S., Obici, S., Rossetti, L. and Lazar, M.A. (2004) Regulation of fasted blood glucose by resistin. Science 303, 1195-1198.
10. Barzilai, N., She, L., Liu, B.Q., Vuguin, P., Cohen, P., Wang, J. and Rossetti, L. (1999) Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48, 94-98.
11. Bastard, J.P., Maachi, M., Van Nhieu, J.T., Jardel, C., Bruckert, E., Grimaldi, A., Robert, J.J., Capeau, J. and Hainque, B. (2002) Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. Journal of Clinical Endocrinology and Metabolism 87, 2084-2089.
12. Basu, R., Chandramouli, V., Dicke, B., Landau, B. and Rizza, R. (2005) Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis. Diabetes 54, 1942-1948.
13. Berg, A.H., Combs, T.P., Du, X., Brownlee, M. and Scherer, P.E. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Medicine 7, 947-953.
14. Berndt, J., Klöting, N., Kralisch, S., Kovacs, P., Fasshauer, M., Schön, M.R., Stumvoll, M. and Blüher, M. (2005) Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 54, 2911-2916.
15. Boden, G. (2003) Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes. Experimental and Clinical Endocrinology and Diabetes 111, 121-124.
16. Boden, G. (2005) Free fatty acids and insulin secretion in humans. Current Diabetes Report 5, 167-170.
17. Boden, G., She, P., Mozzoli, M., Cheung, P., Gumireddy, K., Reddy, P., Xiang, X., Luo, Z. and Ruderman, N. (2005) Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 54, 3458-3465.
18. Bokarewa, M., Nagaev, I., Dahlberg, L., Smith, U. and Tarkowski, A. (2005) Resistin, an adipokine with potent proinflammatory properties. Journal of Immunology 174, 5789-5795.
19. Broch, M., Vendrell, J., Ricart, W., Richart, C. and Fernández-Real, J.M. (2007) Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and non-obese subjects. Diabetes Care 30, 1802-1806.
20. Carey, A.L., Steinberg, G.R., Macaulay, S.L., Thomas, W.G., Holmes, A.G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M.J., James, D.E., Kemp, B.E., Pedersen, B.K. and Febbraio, M.A. (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMPactivated protein kinase. Diabetes 55, 2688-2697.
21. Carvalheira, J.B.C., Ribeiro, E.B., Folli, F., Velloso, L.A. and Saad, M.J. (2003) Interactions between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biological Chemistry 384, 151-159.
22. Cawthorn, W.P. and Sethi, J.K. (2008) TNF-alpha and adipocyte biology. FEBS Letters 582, 117-131.
23. Cawthorn, W.P., Heyd, F., Hegyi, K. and Sethi, J.K. (2007) Tumour necrosis factor-a inhibits adipogenesis via a ß-catenin/TCF4(TCF7L2)-dependent pathway. Cell Death and Differentiation 14, 1361-1373.
24. Ceddia, R.B. (2005) Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis. International Journal of Obesity 29, 1175-1183.
25. Ceddia, R.B., Koistinen, H.A., Zierath, J.R. and Sweeney, G. (2002) Analysis of paradoxical observations on the association between leptin and insulin resistance. The FASEB Journal 16, 1163-1176.
26. Chen, M.P., Chung, F.M., Chang, D.M., Tsai, J.C., Huang, H.F., Shin, S.J. and Lee, Y.J. (2006) Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 91, 295-299.
27. Chen, N.G., Swick, A.G. and Romsos, D.R. (1997) Leptin constrains acetylcholineinduced insulin secretion from pancreatic islets of ob/ob mice. Journal of Clinical Investigation 100, 1174-1179.
28. Cho, Y.M., Youn, B.S., Lee, H., Lee, N., Min, S.S., Kwak, S.H., Lee, H.K. and Park, K.S. (2006) Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care 29, 2457-2461.
29. Clemmons, D.R. (2006a) Clinical utility of measurements of insulin-like growth factor 1. Nature Clinical Practice Endocrinology and Metabolism 2, 436-446.
30. Clemmons, D.R. (2006b) Involvement of insulin-like growth factor-I in the control of glucose homeostasis. Current Opinion in Pharmacology 6, 620-625.
31. Combs, T.P., Berg, A.H., Obici, S., Scherer, P.E. and Rossetti, L. (2001) Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. Journal of Clinical Investigation 108, 1875-1881.
32. Combs, T.P., Wagner, J.A., Berger, J., Doebber, T., Wang, W.J., Zhang, B.B., Tanen, M., Berg, A.H., O'Rahilly, S., Savage, D.B., Chatterjee, K., Weiss, S., Larson, P.J., Gottesdiener, K.M., Gertz, B.J., Charron, M.J., Scherer, P.E. and Moller, D.E. (2002) Induction of adipocyte complement-related protein of 30 kilodaltons by PPARγ agonists: a potential mechanism of insulin sensitization. Endocrinology 143, 998-1007.
33. Cong, L., Chen, K., Li, J., Gao, P., Li, Q., Mi, S., Wu, X. and Zhao, A.Z. (2007) Regulation of adiponectin and leptin secretion and expression by insulin through a PI3KPDE3B dependent mechanism in rat primary adipocytes. Biochemical Journal 403, 519-525.
34. Cota, D., Proulx, K. and Seeley, R.J. (2007) The role of CNS fuel sensing in energy and glucose regulation. Gastroenterology 132, 2158-2168.
35. Covey, S.D., Wideman, R.D., McDonald, C., Unniappan, S., Huynh, F., Asadi, A., Speck, M., Webber, T., Chua, S.C. and Kieffer, T.J. (2006) The pancreatic ß cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metabolism 4, 291-302.
36. Cryer, P.E. (2003) Glucose homeostasis and hypoglycemia. In: Larsen, P.R., Kronenberg, H.M., Melmed, S. and Polonsky, K.S. (eds) Williams Textbook of Endocrinology. Saunders, Philadelphia, Pennsylvania, pp. 1585-1618.
37. Danforth, E. Jr (2000) Failure of adipocyte differentiation causes type II diabetes mellitus?. Nature Genetics 26, 13.
38. Degawa-Yamauchi, M., Bovenkerk, J.E., Juliar, B.E., Watson, W., Kerr, K., Jones, R., Zhu, Q. and Considine, R.V. (2003) Serum resistin (FIZZ3) protein is increased in obese humans. Journal of Clinical Endocrinology and Metabolism 88, 5452-5455.
39. Dietze-Schroeder, D., Sell, H., Uhlig, M., Koenen, M. and Eckel, J. (2005) Autocrine action of adiponectin on human fat cells prevents the release of insulin resistanceinducing factors. Diabetes 54, 2003-2011.
40. Drucker, D.J. (2005) Biologic actions and therapeutic potential of the proglucagonderived peptides. Nature Clinical Practice Endocrinology and Metabolism 1, 22-31.
41. Dube, J.J., Bhatt, B.A., Dedousis, N., Bonen, A. and O'Doherty, R.M. (2007) Leptin, skeletal muscle lipids, and lipid-induced insulin resistance. American Journal of Physiology -Regulatory Integrative and Comparative Physiology 293, R642-650.
42. Duvillié, B., Cordonnier, N., Deltour, L., Dandoy-Dron, F., Itier, J.M., Monthioux, E., Jami, J., Joshi, R.L. and Bucchini, D. (1997) Phenotypic alterations in insulin-deficient mutant mice. Proceedings of the National Academy of Sciences of the United States of America 94, 5137-5140.
43. Engeli, S., Schling, P., Gorzelniak, K., Boschmann, M., Janke, J., Ailhaud, G., Teboul, M., Massiéra, F. and Sharma, A.M. (2003) The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?. International Journal of Biochemistry and Cell Biology 35, 807-825.
44. Farooqi, I.S., Jebb, S.A., Langmack, G., Lawrence, E., Cheetham, C.H., Prentice, A.M., Hughes, I.A., McCamish, M.A. and O'Rahilly, S. (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine 341, 879-884.
45. Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M. and Paschke, R. (2002) Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 290, 1084-1089.
46. Fehmann, H.C. and Heyn, J. (2002) Plasma resistin levels in patients with type 1 and type 2 diabetes mellitus and in healthy controls. Hormone and Metabolic Research 34, 671-673.
47. Fishman, S., Muzumdar, R.H., Atzmon, G., Ma, X., Yang, X., Einstein, F.H. and Barzilai, N. (2007) Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo. FASEB Journal 21, 53-60.
48. Fruebis, J., Tsao, T.S., Javorschi, S., Ebbets Reed, D., Erickson, M.R., Yen, F.T., Bihain, B.E. and Lodish, H.F. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proceedings of the National Academy of Sciences of the United States of America 98, 2005-2010.
49. Frühbeck, G. (2006) Intracellular signalling pathways activated by leptin. Biochemical Journal 393, 7-20.
50. Frühbeck, G. and Gómez-Ambrosi, J. (2003) Control of body weight: a physiologic and transgenic perspective. Diabetologia 46, 143-172.
51. Frühbeck, G. and Gómez-Ambrosi, J. (2005) Adipose tissue. In: Caballero, B., Allen, L. and Prentice, A. (eds) Encyclopedia of Human Nutrition 2nd Edition, Volume 1. Elsevier Ltd., Oxford, UK, pp. 1-14.
52. Frühbeck, G. and Salvador, J. (2000) Relations between leptin and the regulation of glucose metabolism. Diabetologia 43, 3-12.
53. Frühbeck, G. and Salvador, J. (2004) Role of adipocytokines in metabolism and disease. Nutrition Research 24, 803-826.
54. Frühbeck, G., Aguado, M., Gómez-Ambrosi, J. and Martínez, J.A. (1998a) Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice. Biochemical and Biophysical Research Communications 250, 99-102.
55. Frühbeck, G., Jebb, S.A. and Prentice, A.M. (1998b) Leptin: physiology and pathophysiology. Clinical Physiology 18, 399-419.
56. Frühbeck, G., Gómez-Ambrosi, J. and Martínez, J.A. (1999) Pre- and postprandial expression of the leptin receptor splice variants OB-Ra and OB-Rb in murine peripheral tissues. Physiological Research 48, 189-195.
57. Frühbeck, G., Gómez-Ambrosi, J., Muruzábal, F.J. and Burrell, M.A. (2001) The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabo lism regulation. American Journal of Physiology -Endocrinology and Metabolism 280, E827-847.
58. Frystyk, J., Vestbo, E., Skjaerbaek, C., Mogensen, C.E. and Orskov, H. (1995) Free insulinlike growth factors in human obesity. Metabolism: Clinical and Experimental 44, 37-44.
59. Fu, Y., Luo, N., Klein, R.L. and Garvey, W.T. (2005) Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. Journal of Lipid Research 46, 1369-1379.
60. Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., Watanabe, E., Takagi, T., Akiyoshi, M., Ohtsubo, T., Kihara, S., Yamashita, S., Makishima, M., Funahashi, T., Yamanaka, S., Hiramatsu, R., Matsuzawa, Y. and Shimomura, I. (2005) Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307, 426-430.
61. Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., Watanabe, E., Takagi, T., Akiyoshi, M., Ohtsubo, T., Kihara, S., Yamashita, S., Makishima, M., Funahashi, T., Yamanaka, S., Hiramatsu, R., Matsuzawa, Y. and Shimomura, I. (2007) Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Retraction. Science 318, 565.
62. Gallardo, N., Bonzón-Kulichenko, E., Fernández-Agulloó, T., Moltó, E., Gómez-Alonso, S., Blanco, P., Carrascosa, J.M., Ros, M. and Andrés, A. (2007) Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Endocrinology 148, 5604-5610.
63. Garg, A. (2004) Acquired and inherited lipodystrophies. New England Journal of Medicine 350, 1220-1234.
64. Gavrila, A., Chan, J.L., Yiannakouris, N., Kontogianni, M., Miller, L.C., Orlova, C. and Mantzoros, C.S. (2003) Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. Journal of Clinical Endocrinology and Metabolism 88, 4823-4831.
65. Gómez-Ambrosi, J. and Frühbeck, G. (2001) Do resistin and resistin-like molecules also link obesity to inflammatory diseases?. Annals of Internal Medicine 135, 306-307.
66. Gómez-Ambrosi, J. and Frühbeck, G. (2005a) Resistin: a promising therapeutic target for the management of type 2 diabetes mellitus?. Drug Design Reviews -Online 2, 1-12.
67. Gómez-Ambrosi, J. and Frühbeck, G. (2005b) Evidence for the involvement of resistin in inflammation and cardiovascular disease. Current Diabetes Reviews 1, 227-234.
68. Gómez-Ambrosi, J., Rodríguez, A., Catalán, V., Ramírez, B., Silva, C., Rotellar, F., Gil, M.J., Salvador, J. and Frühbeck, G. (2008) Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus, but is reduced after relevant reductions in body fat following gastric bypass. Clinical Endocrinology 69, 208-215.
69. Graham, T.E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T.P., Henry, R.R., Wason, C.J., Oberbach, A., Jansson, P.A., Smith, U. and Kahn, B.B. (2006) Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. New England Journal of Medicine 354, 2552-2563.
70. Guilherme, A., Virbasius, J.V., Puri, V. and Czech, M.P. (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nature Reviews Molecular Cell Biology 9, 367-377.
71. Halleux, C.M., Takahashi, M., Delporte, M.L., Detry, R., Funahashi, T., Matsuzawa, Y. and Brichard, S.M. (2001) Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochemical and Biophysical Research Communications 288, 1102-1107.
72. Haque, W.A., Shimomura, I., Matsuzawa, Y. and Garg, A. (2002) Serum adiponectin and leptin levels in patients with lipodystrophies. Journal of Clinical Endocrinology and Metabolism 87, 2395-2398.
73. Heilbronn, L.K., Rood, J., Janderova, L., Albu, J.B., Kelley, D.E., Ravussin, E. and Smith, S.R. (2004) Relationship between serum resistin concentrations and insulin resistance in non-obese, obese, and obese diabetic subjects. Journal of Clinical Endocrinology and Metabolism 89, 1844-1848.
74. Hida, K., Wada, J., Eguchi, J., Zhang, H., Baba, M., Seida, A., Hashimoto, I., Okada, T., Yasuhara, A., Nakatsuka, A., Shikata, K., Hourai, S., Futami, J., Watanabe, E., Matsuki, Y., Hiramatsu, R., Akagi, S., Makino, H. and Kanwar, Y.S. (2005) Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proceedings of the National Academy of Sciences of the United States of America 102, 10610-10615.
75. Hotamisligil, G.S. (2006) Inflammation and metabolic disorders. Nature 444, 860-867.
76. Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., Nishida, M., Kihara, S., Sakai, N., Nakajima, T., Hasegawa, K., Muraguchi, M., Ohmoto, Y., Nakamura, T., Yamashita, S., Hanafusa, T. and Matsuzawa, Y. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis, Thrombosis, and Vascular Biology 20, 1595-1599.
77. Huan, J.N., Li, J., Han, Y., Chen, K., Wu, N. and Zhao, A.Z. (2003) Adipocyte-selective reduction of the leptin receptors induced by antisense-RNA leads to increased adiposity, dyslipidemia and insulin resistance. Journal of Biological Chemistry 278, 45638-45650.
78. Hug, C., Wang, J., Ahmad, N.S., Bogan, J.S., Tsao, T.S. and Lodish, H.F. (2004) T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proceedings of the National Academy of Sciences of the United States of America 101, 10308-10313.
79. Huypens, P., Moens, K., Heimberg, H., Ling, Z., Pipeleers, D. and Van de Casteele, M. (2005) Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells. Life Sciences 77, 1273-1282.
80. Ishizuka, K., Usui, I., Kanatani, Y., Bukhari, A., He, J., Fujisaka, S., Yamazaki, Y., Suzuki, H., Hiratani, K., Ishiki, M., Iwata, M., Urakaze, M., Haruta, T. and Kobayashi, M. (2007) Chronic tumor necrosis factor-a treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes. Endocrinology 148, 2994-3003.
81. Janke, J., Engeli, S., Boschmann, M., Adams, F., Bohnke, J., Luft, F.C., Sharma, A.M. and Jordan, J. (2006) Retinol-binding protein 4 in human obesity. Diabetes 55, 2805-2810.
82. Jiang, G. and Zhang, B.B. (2003) Glucagon and regulation of glucose metabolism. American Journal of Physiology -Endocrinology and Metabolism 284, E671-678.
83. Kadowaki, T. and Yamauchi, T. (2005) Adiponectin and adiponectin receptors. Endocrine Reviews 26, 439-451.
84. Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K., Ueki, K. and Tobe, K. (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Journal of Clinical Investigation 116, 1784-1792.
85. Kahn, B.B., Alquier, T., Carling, D. and Hardie, D.G. (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism 1, 15-25.
86. Kahn, S.E., Hull, R.L. and Utzschneider, K.M. (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840-846.
87. Kaser, S., Kaser, A., Sandhofer, A., Ebenbichler, C.F., Tilg, H. and Patsch, J.R. (2003) Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochemical and Biophysical Research Communications 309, 286-290.
88. Katovich, M.J. and Pachori, A. (2000) Effects of inhibition of the renin-angiotensin system on the cardiovascular actions of insulin. Diabetes, Obesity and Metabolism 2, 3-14.
89. Kazumi, T., Kawaguchi, A., Sakai, K., Hirano, T. and Yoshino, G. (2002) Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure. Diabetes Care 25, 971-976.
90. Kellerer, M., Koch, M., Metzinger, E., Mushack, J., Capp, E. and Haring, H.U. (1997) Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40, 1358-1362.
91. Kharroubi, I., Rasschaert, J., Eizirik, D.L. and Cnop, M. (2003) Expression of adiponectin receptors in pancreatic ß cells. Biochemical and Biophysical Research Communications 312, 1118-1122.
92. Kieffer, T.J. and Habener, J.F. (2000) The adipoinsular axis: effects of leptin on pancreatic ß-cells. American Journal of Physiology -Endocrinology and Metabolism 278, E1-E14.
93. Kieffer, T.J., Heller, R.S. and Habener, J.F. (1996) Leptin receptors expressed on pancreatic ß-cells. Biochemical and Biophysical Research Communications 224, 522-527.
94. Kieffer, T.J., Heller, R.S., Leech, C.A., Holz, G.G. and Habener, J.F. (1997) Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic ß-cells. Diabetes 46, 1087-1093.
95. Kim, H.J., Higashimori, T., Park, S.Y., Choi, H., Dong, J., Kim, Y.J., Noh, H.L., Cho, Y.R., Cline, G., Kim, Y.B. and Kim, J.K. (2004a) Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 53, 1060-1067.
96. Kim, J.B., Sarraf, P., Wright, M., Yao, K.M., Mueller, E., Solanes, G., Lowell, B.B. and Spiegelman, B.M. (1998) Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. Journal of Clinical Investigation 101, 1-9.
97. Kim, K.H., Zhao, L., Moon, Y., Kang, C. and Sul, H.S. (2004b) Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America 101, 6780-6785.
98. Klöting, N., Berndt, J., Kralisch, S., Kovacs, P., Fasshauer, M., Schön, M.R., Stumvoll, M. and Blüher, M. (2006) Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochemical and Biophysical Research Communications 339, 430-436.
99. Koeslag, J.H., Saunders, P.T. and Terblanche, E. (2003) A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex. Journal of Physiology 549, 333-346.
100. Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., Eto, K., Yamashita, T., Kamon, J., Satoh, H., Yano, W., Froguel, P., Nagai, R., Kimura, S., Kadowaki, T. and Noda, T. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. Journal of Biological Chemistry 277, 25863-25866.
101. Kusminski, C.M., McTernan, P.G. and Kumar, S. (2005) Role of resistin in obesity, insulin resistance and type II diabetes. Clinical Science 109, 243-256.
102. Kusminski, C.M., da Silva, N.F., Creely, S.J., Fisher, F.M., Harte, A.L., Baker, A.R., Kumar, S. and McTernan, P.G. (2007) The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes. Journal of Clinical Endocrinology and Metabolism 92, 270-276.
103. Le Lay, S., Boucher, J., Rey, A., Castan-Laurell, I., Krief, S., Ferré, P., Valet, P. and Dugail, I. (2001) Decreased resistin expression in mice with different sensitivities to a high-fat diet. Biochemical and Biophysical Research Communications 289, 564-567.
104. Le Marchand-Brustel, Y., Heydrick, S.J., Jullien, D., Gautier, N. and Van Obberghen, E. (1995) Effect of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice. Metabolism: Clinical and Experimental 44, 18-23.
105. Lee, J.H., Chan, J.L., Yiannakouris, N., Kontogianni, M., Estrada, E., Seip, R., Orlova, C. and Mantzoros, C.S. (2003) Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. Journal of Clinical Endocrinology and Metabolism 88, 4848-4856.
106. Lehrke, M., Reilly, M.P., Millington, S.C., Iqbal, N., Rader, D.J. and Lazar, M.A. (2004) An inflammatory cascade leading to hyperresistinemia in humans. PLoS Medicine 1, e45.
107. Licinio, J., Caglayan, S., Ozata, M., Yildiz, B.O., de Miranda, P.B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., Krauss, R.M., Veldhuis, J.D., Wagner, A.J., DePaoli, A.M., McCann, S.M. and Wong, M.L. (2004) Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proceedings of the National Academy of Sciences of the United States of America 101, 4531-4536.
108. Lin, J., Handschin, C. and Spiegelman, B.M. (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism 1, 361-370.
109. Long, Y.C. and Zierath, J.R. (2006) AMP-activated protein kinase signaling in metabolic regulation. Journal of Clinical Investigation 116, 1776-1783.
110. McTernan, P.G., Fisher, F.M., Valsamakis, G., Chetty, R., Harte, A., McTernan, C.L., Clark, P.M., Smith, S.A., Barnett, A.H. and Kumar, S. (2003) Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. Journal of Clinical Endocrinology and Metabolism 88, 6098-6106.
111. McTernan, P.G., Kusminski, C.M. and Kumar, S. (2006) Resistin. Current Opinion in Lipidology 17, 170-175.
112. Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., Komuro, R., Ouchi, N., Kihara, S., Tochino, Y., Okutomi, K., Horie, M., Takeda, S., Aoyama, T., Funahashi, T. and Matsuzawa, Y. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ ACRP30. Nature Medicine 8, 731-737.
113. Mallamaci, F., Zoccali, C., Cuzzola, F., Tripepi, G., Cutrupi, S., Parlongo, S., Tanaka, S., Ouchi, N., Kihara, S., Funahashi, T. and Matsuzawa, Y. (2002) Adiponectin in essential hypertension. Journal of Nephrology 15, 507-511.
114. Matsubara, M., Maruoka, S. and Katayose, S. (2002a) Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. European Journal of Endocrinology 147, 173-180.
115. Matsubara, M., Maruoka, S. and Katayose, S. (2002b) Decreased plasma adiponectin concentrations in women with dyslipidemia. Journal of Clinical Endocrinology and Metabolism 87, 2764-2769.
116. Matsuzawa, Y., Funahashi, T., Kihara, S. and Shimomura, I. (2004) Adiponectin and metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 29-33.
117. Minokoshi, Y., Kim, Y.B., Peroni, O.D., Fryer, L.G., Muller, C., Carling, D. and Kahn, B.B. (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415, 339-343.
118. Morioka, T., Asilmaz, E., Hu, J., Dishinger, J.F., Kurpad, A.J., Elias, C.F., Li, H., Elmquist, J.K., Kennedy, R.T. and Kulkarni, R.N. (2007) Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. Journal of Clinical Investigation 117, 2860-2868.
119. Moschen, A.R., Kaser, A., Enrich, B., Mosheimer, B., Theurl, M., Niederegger, H. and Tilg, H. (2007) Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. Journal of Immunology 178, 1748-1758.
120. Mueller, W.M., Gregoire, F.M., Stanhope, K.L., Mobbs, C.V., Mizuno, T.M., Warden, C.H., Stern, J.S. and Havel, P.J. (1998) Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139, 551-558.
121. Muoio, D.M. and Newgard, C.B. (2008) Molecular and metabolic mechanisms of insulin resistance and ß-cell failure in type 2 diabetes. Nature Reviews Molecular Cell Biology 9, 193-205.
122. Murakami, T., Otani, S., Honjoh, T., Doi, T. and Shima, K. (2001) Influence of the presence of OB-Re on leptin radioimmunoassay. Journal of Endocrinology 168, 79-86.
123. Murphy, L.J. (2003) The role of the insulin-like growth factors and their binding proteins in glucose homeostasis. Experimental Diabetes Research 4, 213-224.
124. Muse, E.D., Obici, S., Bhanot, S., Monia, B.P., McKay, R.A., Rajala, M.W., Scherer, P.E. and Rossetti, L. (2004) Role of resistin in diet-induced hepatic insulin resistance. Journal of Clinical Investigation 114, 232-239.
125. Muzumdar, R., Ma, X., Yang, X., Atzmon, G., Bernstein, J., Karkanias, G. and Barzilai, N. (2003) Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. The FASEB Journal 17, 1130-1132.
126. Myers, M.G., Cowley, M.A. and Münzberg, H. (2008) Mechanisms of leptin action and leptin resistance. Annual Review of Physiology 70, 537-556.
127. Nemecz, M., Preininger, K., Englisch, R., Fürnsinn, C., Schneider, B., Waldhäusl, W. and Roden, M. (1999) Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 29, 166-172.
128. Nolan, C.J., Madiraju, M.S., Delghingaro-Augusto, V., Peyot, M.L. and Prentki, M. (2006) Fatty acid signaling in the ß-cell and insulin secretion. Diabetes 55 (Suppl. 2), S16-23.
129. Ookuma, M., Ookuma, K. and York, D.A. (1998) Effects of leptin on insulin secretion from isolated rat pancreatic islets. Diabetes 47, 219-223.
130. Oral, E.A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A.J., DePaoli, A.M., Reitman, M.L., Taylor, S.I., Gorden, P. and Garg, A. (2002) Leptin-replacement therapy for lipodystrophy. New England Journal of Medicine 346, 570-578.
131. Orci, L., Cook, W.S., Ravazzola, M., Wang, M.Y., Park, B.H., Montesano, R. and Unger, R.H. (2004) Rapid transformation of white adipocytes into fat-oxidizing machines. Proceedings of the National Academy of Sciences of the United States of America 101, 2058-2063.
132. Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., Yamashita, S., Funahashi, T. and Matsuzawa, Y. (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100, 2473-2476.
133. Pérez, C., Fernández-Galaz, C., Fernández-Agullo, T., Arribas, C., Andrés, A., Ros, M. and Carrascosa, J.M. (2004) Leptin impairs insulin signaling in rat adipocytes. Diabetes 53, 347-353.
134. Petersen, K.F., Oral, E.A., Dufour, S., Befroy, D., Ariyan, C., Yu, C., Cline, G.W., DePaoli, A.M., Taylor, S.I., Gorden, P. and Shulman, G.I. (2002) Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. Journal of Clinical Investigation 109, 1345-1350.
135. Qi, Y., Nie, Z., Lee, Y.-S., Singhal, N.S., Scherer, P.E., Lazar, M.A. and Ahima, R.S. (2006) Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes 55, 3083-3090.
136. Rajala, M.W., Obici, S., Scherer, P.E. and Rossetti, L. (2003) Adipose-derived resistin and gut-derived resistin-like molecule-ß selectively impair insulin action on glucose production. Journal of Clinical Investigation 111, 225-230.
137. Rajala, M.W., Qi, Y., Patel, H.R., Takahashi, N., Banerjee, R., Pajvani, U.B., Sinha, M.K., Gingerich, R.L., Scherer, P.E. and Ahima, R.S. (2004) Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes 53, 1671-1679.
138. Rakatzi, I., Mueller, H., Ritzeler, O., Tennagels, N. and Eckel, J. (2004) Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1. Diabetologia 47, 249-258.
139. Rangwala, S.M., Rich, A.S., Rhoades, B., Shapiro, J.S., Obici, S., Rossetti, L. and Lazar, M.A. (2004) Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes 53, 1937-1941.
140. Reilly, M.P., Lehrke, M., Wolfe, M.L., Rohatgi, A., Lazar, M.A. and Rader, D.J. (2005) Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111, 932-939.
141. Roden, M., Price, T.B., Perseghin, G., Petersen, K.F., Rothman, D.L., Cline, G.W. and Shulman, G.I. (1996) Mechanism of free fatty acid-induced insulin resistance in humans. Journal of Clinical Investigation 97, 2859-2865.
142. Rosen, E.D. and Spiegelman, B.M. (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444, 847-853.
143. Rother, E., Könner, A.C. and Brüning, J. (2008) Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism. American Journal of Physiology -Endocrinology and Metabolism 294, E810-816.
144. Saltiel, A.R. and Kahn, C.R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806.
145. Satoh, H., Nguyen, M.T., Miles, P.D., Imamura, T., Usui, I. and Olefsky, J.M. (2004) Adenovirus-mediated chronic 'hyper-resistinemia' leads to in vivo insulin resistance in normal rats. Journal of Clinical Investigation 114, 224-231.
146. Schäffler, A., Schölmerich, J. and Büchler, C. (2005) Mechanisms of disease: adipocytokines and visceral adipose tissue -emerging role in non-alcoholic fatty liver disease. Nature Clinical Practice Gastroenterology and Hepatology 2, 273-280.
147. Segal, K.R., Landt, M. and Klein, S. (1996) Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45, 988-991.
148. Sell, H., Dietze-Schroeder, D. and Eckel, J. (2006) The adipocyte-myocyte axis in insulin resistance. Trends in Endocrinology and Metabolism 17, 416-422.
149. Senn, J.J., Klover, P.J., Nowak, I.A., Zimmers, T.A., Koniaris, L.G., Furlanetto, R.W. and Mooney, R.A. (2003) Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. Journal of Biological Chemistry 278, 13740-13746.
150. Sethi, J.K. and Vidal-Puig, A. (2005) Visfatin: the missing link between intra-abdominal obesity and diabetes?. Trends in Molecular Medicine 11, 344-347.
151. Seufert, J. (2004) Leptin effects on pancreatic ß-cell gene expression and function. Diabetes 53 (Suppl. 1), S152-158.
152. Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S. and Goldstein, J.L. (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401, 73-76.
153. Siegrist-Kaiser, C.A., Pauli, V., Juge-Aubry, C.E., Boss, O., Pernin, A., Chin, W.W., Cusin, I., Rohner-Jeanrenaud, F., Burger, A.G., Zapf, J. and Meier, C.A. (1997) Direct effects of leptin on brown and white adipose tissue. Journal of Clinical Investigation 100, 2858-2864.
154. Silha, J.V., Krsek, M., Skrha, J.V., Sucharda, P., Nyomba, B.L. and Murphy, L.J. (2003) Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. European Journal of Endocrinology 149, 331-335.
155. Silswal, N., Singh, A.K., Aruna, B., Mukhopadhyay, S., Ghosh, S. and Ehtesham, N.Z. (2005) Human resistin stimulates the pro-inflammatory cytokines TNF-a and IL-12 in macrophages by NF-κB-dependent pathway. Biochemical and Biophysical Research Communications 334, 1092-1101.
156. Spranger, J., Kroke, A., Mohlig, M., Bergmann, M.M., Ristow, M., Boeing, H. and Pfeiffer, A.F. (2003) Adiponectin and protection against type 2 diabetes mellitus. Lancet 361, 226-228.
157. Steinberg, G.R., Dyck, D.J., Calles-Escandon, J., Tandon, N.N., Luiken, J.J., Glatz, J.F. and Bonen, A. (2002a) Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle. Journal of Biological Chemistry 277, 8854-8860.
158. Steinberg, G.R., Parolin, M.L., Heigenhauser, G.J.F. and Dyck, D.J. (2002b) Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. American Journal of Physiology -Endocrinology and Metabolism 283, E187-192.
159. Steinberg, G.R., Michell, B.J., van Denderen, B.J., Watt, M.J., Carey, A.L., Fam, B.C., Andrikopoulos, S., Proietto, J., Gorgun, C.Z., Carling, D., Hotamisligil, G.S., Febbraio, M.A., Kay, T.W. and Kemp, B.E. (2006) Tumor necrosis factor a-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metabolism 4, 465-474.
160. Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S. and Lazar, M.A. (2001) The hormone resistin links obesity to diabetes. Nature 409, 307-312.
161. Stumvoll, M., Goldstein, B.J. and van Haeften, T.W. (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365, 1333-1346.
162. Szanto, I. and Kahn, C.R. (2000) Selective interaction between leptin and insulin signaling pathways in a hepatic cell line. Proceedings of the National Academy of Sciences of the United States of America 97, 2355-2360.
163. Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G.J., Campfield, L.A., Clark, F.T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K.J., Smutko, J.S., Mays, G.G., Woolf, E.A., Monroe, C.A. and Tepper, R.I. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271.
164. Tilg, H. and Moschen, A.R. (2008) Inflammatory mechanisms in the regulation of insulin resistance. Molecular Medicine 14, 222-231.
165. Tomas, E., Tsao, T.S., Saha, A.K., Murrey, H.E., Zhang Cc, C., Itani, S.I., Lodish, H.F. and Ruderman, N.B. (2002) Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proceedings of the National Academy of Sciences of the United States of America 99, 16309-16313.
166. Trujillo, M.E. and Scherer, P.E. (2005) Adiponectin -journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. Journal of Internal Medicine 257, 167-175.
167. Trujillo, M.E. and Scherer, P.E. (2006) Adipose tissue-derived factors: impact on health and disease. Endocrine Reviews 27, 762-778.
168. Unger, R.H. (2003) The physiology of cellular liporegulation. Annual Review of Physiology 65, 333-347.
169. Utzschneider, K.M., Carr, D.B., Tong, J., Wallace, T.M., Hull, R.L., Zraika, S., Xiao, Q., Mistry, J.S., Retzlaff, B.M., Knopp, R.H. and Kahn, S.E. (2005) Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia 48, 2330-2333.
170. Walder, K., Filippis, A., Clark, S., Zimmet, P. and Collier, G.R. (1997) Leptin inhibits insulin binding in isolated rat adipocytes. Journal of Endocrinology 155, R5-7.
171. Wallenius, V., Wallenius, K., Ahren, B., Rudling, M., Carlsten, H., Dickson, S.L., Ohlsson, C. and Jansson, J.O. (2002) Interleukin-6-deficient mice develop mature-onset obesity. Nature Medicine 8, 75-79.
172. Wang, A.Y., Hickman, I.J., Richards, A.A., Whitehead, J.P., Prins, J.B. and Macdonald, G.A. (2005a) High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infection. American Journal of Gastroenterology 100, 2717-2723.
173. Wang, J.L., Chinookoswong, N., Scully, S., Qi, M. and Shi, Z.Q. (1999a) Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology 140, 2117-2124.
174. Wang, M.Y., Lee, Y. and Unger, R.H. (1999b) Novel form of lipolysis induced by leptin. Journal of Biological Chemistry 274, 17541-17544.
175. Wang, M.Y., Orci, L., Ravazzola, M. and Unger, R.H. (2005b) Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proceedings of the National Academy of Sciences of the United States of America 102, 18011-18016.
176. Wang, M.Y., Grayburn, P., Chen, S., Ravazzola, M., Orci, L. and Unger, R.H. (2008a) Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America 105, 6139-6144.
177. Wang, P.Y., Caspi, L., Lam, C.K., Chari, M., Li, X., Light, P.E., Gutierrez-Juarez, R., Ang, M., Schwartz, G.J. and Lam, T.K. (2008b) Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. Nature 452, 1012-1016.
178. Way, J.M., Görgün, C.Z., Tong, Q., Uysal, K.T., Brown, K.K., Harrington, W.W., Oliver, W.R. Jr, Willson, T.M., Kliewer, S.A. and Hotamisligil, G.S. (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. Journal of Biological Chemistry 276, 25651-25653.
179. Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R.E. and Tataranni, P.A. (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism 86, 1930-1935.
180. Winzell, M.S., Nogueiras, R., Dieguez, C. and Ahrén, B. (2004) Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochemical and Biophysical Research Communications 321, 154-160.
181. Wu, X., Motoshima, H., Mahadev, K., Stalker, T.J., Scalia, R. and Goldstein, B.J. (2003) Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52, 1355-1363.
182. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M.L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P. and Kadowaki, T. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 7, 941-946.
183. Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., Eto, K., Akanuma, Y., Froguel, P., Foufelle, F., Ferre, P., Carling, D., Kimura, S., Nagai, R., Kahn, B.B. and Kadowaki, T. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 8, 1288-1295.
184. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki, T., Uchida, S., Takekawa, S., Waki, H., Tsuno, N.H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R. and Kadowaki, T. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762-769.
185. Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., Ito, Y., Kamon, J., Tsuchida, A., Kumagai, K., Kozono, H., Hada, Y., Ogata, H., Tokuyama, K., Tsunoda, M., Ide, T., Murakami, K., Awazawa, M., Takamoto, I., Froguel, P., Hara, K., Tobe, K., Nagai, R., Ueki, K. and Kadowaki, T. (2007) Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine 13, 332-339.
186. Yang, Q., Graham, T.E., Mody, N., Preitner, F., Peroni, O.D., Zabolotny, J.M., Kotani, K., Quadro, L. and Kahn, B.B. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436, 356-362.
187. Yang, W.S., Lee, W.J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.L., Chen, C.L., Tai, T.Y. and Chuang, L.M. (2001) Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. Journal of Clinical Endocrinology and Metabolism 86, 3815-3819.
188. Yaspelkis, B.B., 3rd, Singh, M.K., Krisan, A.D. and Collins, D.E. (2004) Chronic leptin administration enhances insulin-stimulated glucose disposal in skeletal muscle of high-fat fed rodents. Life Sciences 74, 1801-1816.
189. Yoon, M.J., Lee, G.Y., Chung, J.J., Ahn, Y.H., Hong, S.H. and Kim, J.B. (2006) Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 55, 2562-2570.
190. Youn, B.S., Klöting, N., Kratzsch, J., Lee, N., Park, J.W., Song, E.S., Ruschke, K., Oberbach, A., Fasshauer, M., Stumvoll, M. and Blüher, M. (2008) Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes 57, 372-377.
191. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J.M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.