The Physiology of Cellular Liporegulation

Annual Review of Physiology

Volumn 65, Issue , 2003, Pages 333-347

  Unger, Roger H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

Apoptosis; Ceramide; Leptin; Lipotoxicity; Metabolic syndrome

Indexed keywords

LEPTIN;

ADIPOCYTE; AGING; APOPTOSIS; CALORIC INTAKE; CELL ACTIVITY; CELL DEATH; CUSHING DISEASE; DIET; HOMEOSTASIS; HUMAN; LIPID DIET; LIPID STORAGE; LIPODYSTROPHY; LIPOGENESIS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; ADIPOSE TISSUE; ANIMAL; CYTOLOGY; LIPID METABOLISM; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADIPOSE TISSUE; ANIMALS; HUMANS; LEPTIN; LIPID METABOLISM; OBESITY;

EID: 0037636366     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.65.092101.142622     Document Type: Review

References (52)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-32
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, et al. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-46
3. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, et al. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-43
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-49
5. Unger RH, Zhou YT, Orci L. 1999. Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc. Natl. Acad. Sci. USA 96:2327-32
6. Unger RH. 2000. Leptin physiology: A second look. Regul. Pep. 92:87-95
7. Unger RH. 2002. Lipotoxic diseases. Annu. Rev. Med. 53:319-36
8. Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, et al. 1997. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc. Natl. Acad. Sci. USA 94:4637-41
9. Muoio DM, Dohm GL, Fiedorek FT Jr, Tapscott EB, Coleman RA, et al. 1997. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46:1360-63
10. Ceddia RB, William WM Jr, Curi R. 2001. The response of skeletal muscle to leptin. Front. Biosci. 6:D90-97
11. Neel JV. 1999. The "thrifty genotype" in 1998. Nutr. Rev. 57:82-9
12. Seip M, Trygstad O. 1996. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr. Suppl. 413:2-28
13. Klar A, Brand A, Hurvitz H, Gross-Kieselstein E, Branski D. 1993. Cardiomyopathy in lipodystrophy and the specificity spillover hypothesis. Isr. J. Med. Sci. 29:50-52
14. Kaplan BS. 1970. Congenital generalized lipodystrophy. S. Afr. Med. J. 44:945-48
15. Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. 1999. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401:13-16
16. Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, et al. 2002. Leptin replacement therapy for lipodystrophy. N. Engl. J. Med. 346:570-78
17. Lee Y, Wang MY, Kakuma T, Wang ZW, Babcock E, et al. 2001. Liporegulation in diet-induced obesity: the antisteatotic role of hyperleptinemia. J. Biochem. 276:5629-35
18. Kakuma T, Lee Y, Higa M, Wang ZW, Pan W, et al. 2000. Leptin, troglitazone and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc. Natl. Acad. Sci. USA 97:8536-411
19. Zhou YT, Shimobukuro M, Koyama K, Lee Y, Wang MY, et al. 1997. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc. Natl. Acad. Sci. USA 94:6386-90
20. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, et al. 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415:339-43
21. McGarry JD, Mannaerts GP, Foster DW. 1977. A possible role for malonyl CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J. Clin. Invest. 60: 265-70
22. Kakuma T, Wang ZW, Pan W, Unger RH, Zhou YT. 2000. Role of leptin in peroxisome proliferator-activated receptor γ coactivator-1 expression. Endocrinology 141:4576-82
23. Puigserver P, Wu Z, Park CW, Graves R, Wright M, et al. 1998. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-39
24. Zhou YT, Shimabukuro M, Lee Y, Koyama K, Higa M, et al. 1998. Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker Diabetic Fatty rats: role in the pathogenesis of lipotoxic diabetes. Diabetes 47:1904-8
25. Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, et al. 2000. Lipotoxic heart disease in obese rats: implications for human obesity. Proc. Natl. Acad. Sci. USA 97:1784-89
26. Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, et al. 2001. A novel mouse model of lipotoxic cardiomyopathy. J. Clin. Invest. 107:813-22
27. Gabrilova O, Marcus-Samuels B, Graham D, Kim JD, Shulman GI, et al. 2000. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J. Clin. Invest. 105:271-78
28. Montague CT, Farrooqi IS, Whitehead JP, Soos MA, Rau H, et al. 1997. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387:903-8
29. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. 1995. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270: 26746-49
30. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, et al. 1996. Substitution at codon 269 (glutamine → proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker Fatty (fa/fa) rat. Biochem. Biophys. Res. Commun. 224:597-604
31. Wang MY, Koyama K, Shimabukuro M, Newgard CB, Unger RH. 1998. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. Proc. Natl. Acad. Sci. USA 95:714-18
32. Dhalla NS, Xu YJ, Sheu SS, Tappia PS, Panagia AV. 1997. Phosphatidic acid: a potential signal transducer for cardiac hypertrophy. J. Mol. Cell. Cardiol. 29:2865-71
33. 2 expression. Proc. Natl. Acad. Sci. USA 95: 9558-61
34. Shimabukuro M, Zhou YT, Levi M, Unger RH. 1998. Fatty acid-induced β-cell apoptosis: a link between obesity and diabetes. Proc. Natl. Acad. Sci. USA 95:2498-502
35. Weiss B, Stoffel W. 1997. Human and murine serine palmitoyl CoA transferase -cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur. J. Biochem. 249:239-47
36. Aikawa R, Nawano M, Gu Y, Katagiri H, Asano T, et al. 2000. Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of P13 kinase/Akt. Circulation 102:2873-79
37. Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, et al. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB). Science 292:1728-31
38. Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, et al. 1997. The PD-kinase/Akt signaling pathway delivers an antiapoptotic signal. Genes Dev. 11:701-13
39. Navarro P, Valverde AM, Rohn JL, Benito M, Lorenzo M. 2000. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth Horm. IGF Res. 10:256-66
40. Basu S, Bayoumy S, Zhang Y, Lozano J, Kolesnick R. 1998. BAD enables ceramide to signal apoptosis via Ras and Raf-1. J. Biol. Chem. 273:30419-26
41. DiPaola M, Cocco T, Lorusso M. 2000. Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry 39:6660-68
42. Sabeh G, Alley RA, Robbins TJ, Narduzzi JV, Kenny FM, et al. 1969. Adrenocortical indices during fasting in obesity. J. Clin. Endocrinol. Metab. 29:373-76
43. Hankin ME, Theile HM, Steinbeck AW. 1972. Cortisol and aldosterone excretion and plasma cortisol concentrations in normal and obese female subjects. Clin. Sci. 43:289-98
44. O'Connell M, Danforth E Jr, Horton ES, Salans L, Sims EA. 1973. Experimental obesity in man. 3. Adrenocortical function. J. Clin. Endocrinol. Metab. 36:323-29
45. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, et al. 2001. A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166-70
46. Ogawa A, Johnson JH, Ohneda M, McAlister CT, Inman L, et al. 1992. Roles of insulin resistance and β-cell dysfunction in dexamethasone-induced diabetes. J. Clin. Invest. 90:497-504
47. Madiehe AM, Lin L, White C, Braymer HD, Bray GA, York DA. 2001. Constitutive activation of STAT-3 and downregulation of SOCS-3 expression induced by adrenalectomy. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R2048-R58
48. Cheng A, Uetani N, Simoncic PD, Chaubey VP, Lee-Loy A, et al. 2002. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase IB. Dev. Cell 2:497-503
49. Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, et al. 2002. PTP1B regulates leptin signal transduction in vivo. Dev. Cell 2:489-95
50. Cook WS, Unger RH. 2002. Protein tyrosine phosphatase IB: a potential leptin resistance factor of obesity. Dev. Cell 2:385-87
51. LI C, Friedman JM. 1999. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc. Natl. Acad. Sci. USA 96:9677-82
52. Chung CD, Liao J, Liu B, Rao X, Jay P, et al. 1997. Specific inhibition of STAT-3 signal transduction by PIAS3. Science 278:1803-5