Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo

FASEB Journal

Volumn 21, Issue 1, 2007, Pages 53-60

  Fishman, Sigal ^a   Muzumdar, Radhika H ^b   Atzmon, Gil ^a   Ma, Xiaohui ^a   Yang, Xiaoman ^a   Einstein, Francine H ^c   Barzilai, Nir ^a,c  

^a Diabetes Research and Training Center   (United States)

^b CHILDREN S HOSPITAL AT MONTEFIORE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Hepatic insulin action; Metabolic syndrome; Steatosis

Indexed keywords

INSULIN; LEPTIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FATTY LIVER; IN VIVO STUDY; INTRAABDOMINAL FAT; NONALCOHOLIC FATTY LIVER; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; ZUCKER DIABETIC FATTY RAT;

ANIMALS; FATTY LIVER; INSULIN; INSULIN RESISTANCE; LEPTIN; LIVER; MALE; MODELS, GENETIC; OBESITY; RATS; RATS, ZUCKER; TRIGLYCERIDES;

ANIMALIA;

EID: 33846105545     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6557com     Document Type: Article

References (39)

1. Clark, J. M., Brancati, F. L., and Diehl, A. M. (2002) Nonalcoholic fatty liver disease. Gastroenterology 122, 1649-1657
2. Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., and Parks, E. J. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1343-1351
3. Tamura, S., and Shimomura, I. (2005) Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1139-1142
4. Charlton, M., Sreekumar, R., Rasmussen, D., Lindor, K., and Nair, K. S. (2002) Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 35, 898-904
5. Diraison, F., Moulin, P., and Beylot, M. (2003) Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab. 29, 478-485
6. Bugianesi, E., McCullough, A. J., and Marchesini, G. (2005) Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42, 987-1000
7. Angulo, P. (2002) Nonalcoholic fatty liver disease. N. Engl. J. Med. 346, 1221-1231
8. Neuschwander-Tetri, B. A., and Caldwell, S. H. (2003) Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology 37, 1202-1219
9. Medina, J., Fernandez-Salazar, L. I., Garcia-Buey, L., and Moreno-Otero, R. (2004) Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis. Diabetes Care. 27, 2057-2066
10. Cohen, P., and Friedman, J. M. (2004) Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1). J. Nutr. 134, 2455S-2463S
11. Kusunoki, M., Tsutsumi, K., Hara, T., Ogawa, H., Nakamura, T., Miyata, T., Sakakibara, F., Fukuzawa, Y., Suga, T., Kakumu, S., and Nakaya, Y. (2002) Correlation between lipid and glycogen contents in liver and insulin resistance in high-fat-fed rats treated with the lipoprotein lipase activator NO-1886. Metabolism 51, 792-795
12. Samuel, V. T., Liu, Z. X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., and Shulman, G. I. (2004) Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J. Biol. Chem. 279, 32345-32353
13. Seppala-Lindroos, A., Vehkavaara, S., Hakkinen, A. M., Goto, T., Westerbacka, J., Sovijarvi, A., Halavaara, J., and Yki-Jarvinen, H. (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J. Clin. Endocrinol. Metab. 87, 3023-3028
14. Schaffler, A., Scholmerich, J., and Buchler, C. (2005) Mechanisms of disease: adipocytokines and visceral adipose tissue-emerging role in nonalcoholic fatty liver disease. Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 273-280
15. Musso, G., Gambino, R., Durazzo, M., Biroli, G., Carello, M., Faga, E., Pacini, G., De Michieli, F., Rabbione, L., Premoli, A., et al. (2005) Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease. Hepatology 42, 1175-1183
16. Atzmon, G., Yang, X. M., Muzumdar, R., Ma, X. H., Gabriely, I., and Barzilai, N. (2002) Differential gene expression between visceral and subcutaneous fat depots. Horm. Metab. Res. 34, 622-628
17. Barzilai, N., She, L., Liu, B. Q., Vuguin, P., Cohen, P., Wang, J., and Rossetti, L. (1999) Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48, 94-98
18. Stiles, B. L., Kuralwalla-Martinez, C., Guo, W., Gregorian, C., Wang, Y., Tian, J., Magnuson, M. A., and Wu, H. (2006) Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol. Cell. Biol. 26, 2772-2781
19. Javor, E. D., Ghany, M. G., Cochran, E. K., Oral, E. A., DePaoli, A. M., Premkumar, A., Kleiner, D. E., and Gorden, P. (2005) Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology 41, 753-760
20. Barzilai, N., Wang, J., Massilon, D., Vuguin, P., Hawkins, M., and Rossetti, L. (1997) Leptin selectively decreases visceral adiposity and enhances insulin action. J. Clin. Invest. 100, 3105-3110
21. Huang, W., Dedousis, N., Bandi, A., Lopaschuk, G. D., and O'Doherty R. M. (2005) Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology
22. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., and Burn, P. (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-549
23. Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., and Baskin, D. G. (1996) Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98, 1101-1106
24. Tartaglia, L. A., et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271
25. Cohen, B., Novick, D., and Rubinstein, M. (1996) Modulation of insulin activities by leptin. Science 274, 1185-1188
26. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., and Friedman, J. M. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546
27. Wang, J., Obici, S., Morgan, K., Barzilai, N., Feng, Z., and Rossetti, L. (2001) Overfeeding rapidly induces leptin and insulin resistance. Diabetes 50, 2786-2791
28. Sivitz, W. I., Walsh, S. A., Morgan, D. A., Thomas, M. J., and Haynes, W. G. (1997) Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138, 3395-3401
29. Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., and Goldstein, J. L. (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401, 73-76
30. Cefalu, W. T., Wang, Z. Q., Werbel, S., Bell-Farrow, A., Crouse III, J. R., Hinson, W. H., Terry, J. G., and Anderson, R. (1995) Contribution of visceral fat mass to the insulin resistance of aging. Metabolism 44, 954-959
31. Ferrannini, E., Natali, A., Capaldo, B., Lehtovirta, M., Jacob, S., and Yki-Jarvinen, H. (1997) Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. European Group for the Study of Insulin Resistance (EGIR). Hypertension 30, 1144-1149
32. Ma, X. H., Muzumdar, R., Yang, X. M., Gabriely, I., Berger, R., and Barzilai, N. (2002) Aging is associated with resistance to effects of leptin on fat distribution and insulin action. J. Gerontol. A Biol. Sci. Med. Sci. 57, B225-231
33. Shimokata, H., Tobin, J. D., Muller, D. C., Elahi, D., Coon, P. J., and Andres, R. (1989) Studies in the distribution of body fat: I. effects of age, sex, and obesity. J. Gerontol. 44, M66-73
34. Gabriely, I., Ma, X. H., Yang, X. M., Atzmon, G., Rajala, M. W., Berg, A. H., Scherer, P., Rossetti, L., and Barzilai, N. (2002) Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51, 2951-2958
35. Gabriely, I., Ma, X. H., Yang, X. M., Rossetti, L., and Barzilai, N. (2002) Leptin resistance during aging is independent of fat mass. Diabetes 51, 1016-1021
36. Barzilai, N., Hawkins, M., Angelov, I., Hu, M., and Rossetti, L. (1996) Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Diabetes 45, 1329-1335
37. Hughes, D. E., Stolz, D. B., Yu, S., Tan, Y., Reddy, J. K., Watkins, S. C., Diehl, A. M., and Costa, R. H. (2003) Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. Hepatology 37, 1414-1424
38. Levin, N., Nelson, C., Gurney, A., Vandlen, R., and de Sauvage, F. (1996) Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc. Natl. Acad. Sci. U. S. A. 93, 1726-1730
39. Deng, Q. G., She, H., Cheng, J. H., French, S. W., Koop, D. R., Xiong, S., and Tsukamoto, H. (2005) Steatohepatitis induced by intragastric overfeeding in mice. Hepatology 42, 905-914