메뉴 건너뛰기




Volumn 111, Issue 3, 2003, Pages 121-124

Effects of free fatty acids (FFA) on glucose metabolism: Significance for insulin resistance and type 2 diabetes

Author keywords

FFA; Insulin secretion; Peripheral and hepatic insulin resistance

Indexed keywords

DIACYLGLYCEROL; FATTY ACID; GLUCOSE; INSULIN; PROTEIN KINASE C;

EID: 0037643536     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-39781     Document Type: Review
Times cited : (303)

References (51)
  • 2
    • 0029935227 scopus 로고    scopus 로고
    • Fuel metabolism in pregnancy and in gestational diabetes mellitus
    • Boden G. Fuel metabolism in pregnancy and in gestational diabetes mellitus. Obstet Gynecol Clin North Am 1996; 23: 1-10
    • (1996) Obstet Gynecol Clin North Am , vol.23 , pp. 1-10
    • Boden, G.1
  • 3
    • 0000246182 scopus 로고    scopus 로고
    • Free fatty acids (FFA), a link between obesity and insulin resistance
    • Boden G. Free fatty acids (FFA), a link between obesity and insulin resistance. Front Biosci 1998; 3: D169-D175
    • (1998) Front Biosci , vol.3
    • Boden, G.1
  • 4
    • 0031786726 scopus 로고    scopus 로고
    • Free fatty acids and insulin resistance during pregnancy
    • Boden G. Free fatty acids and insulin resistance during pregnancy. J Clin Endocrinol Metab 1998; 83: 2338-2342
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2338-2342
    • Boden, G.1
  • 5
    • 0034852786 scopus 로고    scopus 로고
    • Free fatty acids - The link between obesity and insulin resistance
    • Boden G. Free fatty acids - the link between obesity and insulin resistance. Endocr Pract 2001; 7: 44-51
    • (2001) Endocr Pract , vol.7 , pp. 44-51
    • Boden, G.1
  • 6
    • 0029084869 scopus 로고
    • Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes
    • Boden G, Chen X. Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 1995; 96: 1261-1268
    • (1995) J Clin Invest , vol.96 , pp. 1261-1268
    • Boden, G.1    Chen, X.2
  • 7
    • 0033009463 scopus 로고    scopus 로고
    • Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes
    • Boden G, Chen X. Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. Diabetes 1999; 48: 577-583
    • (1999) Diabetes , vol.48 , pp. 577-583
    • Boden, G.1    Chen, X.2
  • 8
    • 0031716376 scopus 로고    scopus 로고
    • Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects
    • Boden G, Chen X, Iqbal N. Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects. Diabetes 1998; 47: 1609-1612
    • (1998) Diabetes , vol.47 , pp. 1609-1612
    • Boden, G.1    Chen, X.2    Iqbal, N.3
  • 9
    • 0029046673 scopus 로고
    • Effects of a 48-h fat infusion on insulin secretion and glucose utilization
    • Boden G, Chen X, Rosner J, Barton M. Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 1995; 44: 1239-1242
    • (1995) Diabetes , vol.44 , pp. 1239-1242
    • Boden, G.1    Chen, X.2    Rosner, J.3    Barton, M.4
  • 10
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994: 93: 2438-2440
    • (1994) J Clin Invest , vol.93 , pp. 2438-2440
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 11
    • 0036293648 scopus 로고    scopus 로고
    • FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis
    • Boden G, Cheung P, Stein TP, Kresge K, Mozzoli M. FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am J Physiol 2002; 283: E12-E19
    • (2002) Am J Physiol , vol.283
    • Boden, G.1    Cheung, P.2    Stein, T.P.3    Kresge, K.4    Mozzoli, M.5
  • 13
    • 0035405847 scopus 로고    scopus 로고
    • Effects of acute changes of plasma FFA on intramuscular fat content and insulin resistance in healthy subjects
    • Boden, G, Lebed B, Schatz M, Homko C, Lemieux S. Effects of acute changes of plasma FFA on intramuscular fat content and insulin resistance in healthy subjects. Diabetes 2001; 50: 1612-1617
    • (2001) Diabetes , vol.50 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3    Homko, C.4    Lemieux, S.5
  • 15
    • 0032030866 scopus 로고    scopus 로고
    • Chronic exposure to free fatty acids reduced pancreatic β cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
    • Bollheimer LC, Skelly RH, Chester MW, McGarry DJ, Rhodes CJ. Chronic exposure to free fatty acids reduced pancreatic β cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 1998; 101: 1094-11,018
    • (1998) J Clin Invest , vol.101 , pp. 1094-11018
    • Bollheimer, L.C.1    Skelly, R.H.2    Chester, M.W.3    McGarry, D.J.4    Rhodes, C.J.5
  • 16
    • 0023951837 scopus 로고
    • Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA
    • Bronfman M, Morales MN, Orellano A. Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA. Biochem Biophys Res Commun 1988; 152: 987-992
    • (1988) Biochem Biophys Res Commun , vol.152 , pp. 987-992
    • Bronfman, M.1    Morales, M.N.2    Orellano, A.3
  • 17
    • 0027418067 scopus 로고
    • Overexpression of protein kinase C isoenzymes alpha, beta 1, gamma and episilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling
    • Chin JE, Dickens M, Tavare JM, Roth RA. Overexpression of protein kinase C isoenzymes alpha, beta 1, gamma and episilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. J Biol Chem 1993; 268: 6338-6347
    • (1993) J Biol Chem , vol.268 , pp. 6338-6347
    • Chin, J.E.1    Dickens, M.2    Tavare, J.M.3    Roth, R.A.4
  • 18
    • 0015882267 scopus 로고
    • Stimulation of insulin secretion by long-chain free fatty acids
    • Crespin SR, Greenough WB, Steinberg D. Stimulation of insulin secretion by long-chain free fatty acids. J Clin Invest 1973; 52: 1979-1984
    • (1973) J Clin Invest , vol.52 , pp. 1979-1984
    • Crespin, S.R.1    Greenough, W.B.2    Steinberg, D.3
  • 19
    • 0031465447 scopus 로고    scopus 로고
    • Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase
    • DeFea K, Roth RA. Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase. J Biol Chem 1997; 272: 31,400-31,406
    • (1997) J Biol Chem , vol.272 , pp. 31400-31406
    • DeFea, K.1    Roth, R.A.2
  • 23
    • 0003072414 scopus 로고    scopus 로고
    • Protein kinase C
    • Olefsky J, Taylor SE, LeRoit D (eds). Philadelphia: Lippincott
    • Farese RV. Protein kinase C. In: Olefsky J, Taylor SE, LeRoit D (eds). Diabetes Mellitus: A Fundamental and Clinical Text. Philadelphia: Lippincott, 2000: 239-251
    • (2000) Diabetes Mellitus: A Fundamental and Clinical Text , pp. 239-251
    • Farese, R.V.1
  • 24
    • 84941021274 scopus 로고
    • Effects of fat infusions on glucose tolerance and plasma insulin levels
    • Felber JP, Vanotti A. Effects of fat infusions on glucose tolerance and plasma insulin levels. Med Exp 1964; 10: 153-156
    • (1964) Med Exp , vol.10 , pp. 153-156
    • Felber, J.P.1    Vanotti, A.2
  • 25
    • 0021032715 scopus 로고
    • Effect of fatty acids on glucose production and utilization in man
    • Ferrannini E, Barrett E, Bevilacqua S, DeFronzo R. Effect of fatty acids on glucose production and utilization in man. J Clin Invest 1983: 72: 1737-1747
    • (1983) J Clin Invest , vol.72 , pp. 1737-1747
    • Ferrannini, E.1    Barrett, E.2    Bevilacqua, S.3    DeFronzo, R.4
  • 28
    • 0000847623 scopus 로고
    • Non-esterified fatty acids in blood of obese and lean subjects
    • Gorden ES. Non-esterified fatty acids in blood of obese and lean subjects. Am J Clin Nutr 1960: 8: 740-747
    • (1960) Am J Clin Nutr , vol.8 , pp. 740-747
    • Gorden, E.S.1
  • 29
    • 0036300538 scopus 로고    scopus 로고
    • Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IκB-α
    • Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IκB-α. Diabetes 2002; 51: 2005-2011
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 30
    • 0030720085 scopus 로고    scopus 로고
    • Tissue triglycerides, insulin resistance, and insulin production: Implications for hyperinsulinemia of obesity
    • Koyama K, Chen G, Lee Y, Unger RH. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am J Physiol 1997; 273: E708-E713
    • (1997) Am J Physiol , vol.273
    • Koyama, K.1    Chen, G.2    Lee, Y.3    Unger, R.H.4
  • 31
    • 0033399406 scopus 로고    scopus 로고
    • Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat
    • Laybutt DR, Schmitz-Peifffer C, Saha AK, Ruderman NB, Biden TJ, Kraegen EW. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. Am J Physiol 1999; 277: E1070-E1076
    • (1999) Am J Physiol , vol.277
    • Laybutt, D.R.1    Schmitz-Peifffer, C.2    Saha, A.K.3    Ruderman, N.B.4    Biden, T.J.5    Kraegen, E.W.6
  • 33
    • 0028267475 scopus 로고
    • Effect of fatty acids and their acyl-CoA esters on protein kinase C activity in fibroblasts: Possible implications in fatty acid oxidation defects
    • Nesher M, Boneh A. Effect of fatty acids and their acyl-CoA esters on protein kinase C activity in fibroblasts: possible implications in fatty acid oxidation defects. Biochim Biophys Acta 1994; 1221: 66-72
    • (1994) Biochim Biophys Acta , vol.1221 , pp. 66-72
    • Nesher, M.1    Boneh, A.2
  • 34
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 1997; 46: 1768-1774
    • (1997) Diabetes , vol.46 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilleri, S.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 36
    • 0014251318 scopus 로고
    • Effect of acute elevation of plasma glycerol, triglyceride and FFA levels on glucose utilization and plasma insulin
    • Pelkonen R, Miettinen A, Taskinen M-R, Nikkila EA. Effect of acute elevation of plasma glycerol, triglyceride and FFA levels on glucose utilization and plasma insulin. Diabetes 1968; 17: 76-82
    • (1968) Diabetes , vol.17 , pp. 76-82
    • Pelkonen, R.1    Miettinen, A.2    Taskinen, M.-R.3    Nikkila, E.A.4
  • 37
    • 0029787329 scopus 로고    scopus 로고
    • Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
    • Phillips DIW, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 1996; 45: 947-950
    • (1996) Metabolism , vol.45 , pp. 947-950
    • Phillips, D.I.W.1    Caddy, S.2    Ilic, V.3    Fielding, B.A.4    Frayn, K.N.5    Borthwick, A.C.6    Taylor, R.7
  • 38
    • 50549202600 scopus 로고
    • The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1: 785-789
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 39
    • 0035793592 scopus 로고    scopus 로고
    • Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
    • Ravichandran LV, Esposito DL, Chen J, Quon MJ. Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin. J Biol Chem 2000; 276: 3543-3549
    • (2000) J Biol Chem , vol.276 , pp. 3543-3549
    • Ravichandran, L.V.1    Esposito, D.L.2    Chen, J.3    Quon, M.J.4
  • 40
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 41
    • 0024244339 scopus 로고
    • Measurement of plasma glucose, free fatty acid, lactate and insulin for 24 h in patients with NIDDM
    • Reaven GM, Hollenbeck C, Jeng C-Y, Wu MS, Chen YD. Measurement of plasma glucose, free fatty acid, lactate and insulin for 24 h in patients with NIDDM. Diabetes 1988; 37: 1020-1024
    • (1988) Diabetes , vol.37 , pp. 1020-1024
    • Reaven, G.M.1    Hollenbeck, C.2    Jeng, C.-Y.3    Wu, M.S.4    Chen, Y.D.5
  • 43
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999; 34: 115-120
    • (1999) N Engl J Med , vol.34 , pp. 115-120
    • Ross, R.1
  • 44
    • 0024995157 scopus 로고
    • A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation
    • Sako Y, Grill VE. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 1990; 127: 1580-1589
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.E.2
  • 45
    • 0032829745 scopus 로고    scopus 로고
    • Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and non-diabetic subjects
    • Santomauro A, Boden G, Silva M, Rocha DM, Santos RF, Ursich MJM, Strassman PG, Wajchengerg BL. Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and non-diabetic subjects. Diabetes 1999; 48: 1836-1841
    • (1999) Diabetes , vol.48 , pp. 1836-1841
    • Santomauro, A.1    Boden, G.2    Silva, M.3    Rocha, D.M.4    Santos, R.F.5    Ursich, M.J.M.6    Strassman, P.G.7    Wajchengerg, B.L.8
  • 46
    • 0028987309 scopus 로고
    • Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women
    • Simoneau JA, Colberg SR, Thaete FL, Kelley DE. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J 1995; 9: 273-278
    • (1995) FASEB J , vol.9 , pp. 273-278
    • Simoneau, J.A.1    Colberg, S.R.2    Thaete, F.L.3    Kelley, D.E.4
  • 48
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and ω-3 fatty acids in muscle phospholipid
    • Storlien LH, Jenks AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and ω-3 fatty acids in muscle phospholipid. Diabetes 1991; 40: 280-289
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenks, A.B.2    Chisholm, D.J.3    Pascoe, W.S.4    Khouri, S.5    Kraegen, E.W.6
  • 49
    • 0028872833 scopus 로고
    • Uptake and release of glucose by the human kidney: Postabsorptive rates and responses to epinephrine
    • Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J. Uptake and release of glucose by the human kidney: postabsorptive rates and responses to epinephrine. J Clin Invest 1995; 96: 2528-2533
    • (1995) J Clin Invest , vol.96 , pp. 2528-2533
    • Stumvoll, M.1    Chintalapudi, U.2    Perriello, G.3    Welle, S.4    Gutierrez, O.5    Gerich, J.6
  • 51
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou Y-P, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994; 93: 870-876
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.-P.1    Grill, V.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.