-
1
-
-
0035850402
-
The continuing epidemics of obesity and diabetes in the United States
-
Mokdad AN, Bowman BA, Ford ES: The continuing epidemics of obesity and diabetes in the United States. JAMA 286:1195-1200, 2001
-
(2001)
JAMA
, vol.286
, pp. 1195-1200
-
-
Mokdad, A.N.1
Bowman, B.A.2
Ford, E.S.3
-
2
-
-
15944408334
-
A burning question: Does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?
-
Tataranni PA, Ortega E: A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes? Diabetes 54:917-927, 2005
-
(2005)
Diabetes
, vol.54
, pp. 917-927
-
-
Tataranni, P.A.1
Ortega, E.2
-
3
-
-
32044434817
-
Free fatty acids as target for therapy
-
Boden G: Free fatty acids as target for therapy. Curr Opin Endocrinol Diab 11:258-263, 2004
-
(2004)
Curr Opin Endocrinol Diab
, vol.11
, pp. 258-263
-
-
Boden, G.1
-
4
-
-
0029084869
-
Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes
-
Boden G, Chen X: Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96:1261-1268, 1995
-
(1995)
J Clin Invest
, vol.96
, pp. 1261-1268
-
-
Boden, G.1
Chen, X.2
-
5
-
-
0032954778
-
Effects of fatty acids on glucose transport and IRS-1 associated phosphatidylinositol 3-kinase activity
-
Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI: Effects of fatty acids on glucose transport and IRS-1 associated phosphatidylinositol 3-kinase activity. J Clin Invest 103:253-259, 1999
-
(1999)
J Clin Invest
, vol.103
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Marcucci, M.3
Griffin, M.E.4
Dufour, S.5
Cline, G.W.6
Slezak, L.A.7
Andersen, D.K.8
Hundal, R.S.9
Rothman, D.L.10
Petersen, K.F.11
Shulman, G.I.12
-
6
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α
-
Itani SI, Ruderman NB, Schmieder, Boden G: Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α. Diabetes 51:2005-2011, 2002
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder3
Boden, G.4
-
7
-
-
3543029821
-
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
-
Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI: Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279:32345-32353, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 32345-32353
-
-
Samuel, V.T.1
Liu, Z.X.2
Qu, X.3
Elder, B.D.4
Bilz, S.5
Befroy, D.6
Romanelli, A.J.7
Shulman, G.I.8
-
8
-
-
0036785633
-
Free fatty acid-induced hepatic insulin resistance: A potential role for protein kinase C-δ
-
Lam TKT, Yoshii H, Haber A, Bogdanovic Lam L, Fantus G, Giacca A: Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-δ. Am J Physiol 283:E682-E691, 2002
-
(2002)
Am J Physiol
, vol.283
-
-
Lam, T.K.T.1
Yoshii, H.2
Haber, A.3
Bogdanovic Lam, L.4
Fantus, G.5
Giacca, A.6
-
9
-
-
0036310157
-
Extreme insulin resistance of the central adipose depot in vivo
-
Mittleman SD, Van Citters GW, Kirkman EL, Bergman RN: Extreme insulin resistance of the central adipose depot in vivo. Diabetes 51:755-761, 2002
-
(2002)
Diabetes
, vol.51
, pp. 755-761
-
-
Mittleman, S.D.1
Van Citters, G.W.2
Kirkman, E.L.3
Bergman, R.N.4
-
10
-
-
0028257939
-
A multicompartment body composition technique based on computerized tomography
-
Chowdhury B, Sjostrom L, Alpsten M, Kostanty J, Kvist H, Lofgren R: A multicompartment body composition technique based on computerized tomography. Int J Obes Relat Metab Disord 18:219-234, 1994
-
(1994)
Int J Obes Relat Metab Disord
, vol.18
, pp. 219-234
-
-
Chowdhury, B.1
Sjostrom, L.2
Alpsten, M.3
Kostanty, J.4
Kvist, H.5
Lofgren, R.6
-
11
-
-
0345375262
-
Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion
-
Cheung P, Yang G, Boden G: Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion. Metabolism 52:1496-1500, 2003
-
(2003)
Metabolism
, vol.52
, pp. 1496-1500
-
-
Cheung, P.1
Yang, G.2
Boden, G.3
-
12
-
-
77049274176
-
Measurement of size and turnover rate of body glucose pool by the isotope dilution method
-
Steele R, Wall JS, DeBodo RC, Altszuler N: Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 187:15-24, 1956
-
(1956)
Am J Physiol
, vol.187
, pp. 15-24
-
-
Steele, R.1
Wall, J.S.2
DeBodo, R.C.3
Altszuler, N.4
-
13
-
-
0022970190
-
Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells
-
Preiss J, Loomis CR, Bishop WR, Stein R, Niedel JE, Bell RM: Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J Biol Chem 261:8597-8600, 1986
-
(1986)
J Biol Chem
, vol.261
, pp. 8597-8600
-
-
Preiss, J.1
Loomis, C.R.2
Bishop, W.R.3
Stein, R.4
Niedel, J.E.5
Bell, R.M.6
-
14
-
-
0037059013
-
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
-
Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang C, Itani SI, Lodish HF, Ruderman NB: Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A 99:16309-16313, 2002
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 16309-16313
-
-
Tomas, E.1
Tsao, T.S.2
Saha, A.K.3
Murrey, H.E.4
Zhang, C.5
Itani, S.I.6
Lodish, H.F.7
Ruderman, N.B.8
-
15
-
-
0037129380
-
Nonalcoholic fatty liver disease
-
Angulo P: Nonalcoholic fatty liver disease. N Engl J Med 346:1221-1231, 2002
-
(2002)
N Engl J Med
, vol.346
, pp. 1221-1231
-
-
Angulo, P.1
-
16
-
-
2542441798
-
Rat proinflammatory cytokine and cytokine related mRNA quantitation by real-time polymerase chain reaction using SYBR Green
-
Peinnequin A, Mouret C, Birot O, Alonso A, Mathieu J, Clarencon D, Agay D, Chancerelle Y, Multon E: Rat proinflammatory cytokine and cytokine related mRNA quantitation by real-time polymerase chain reaction using SYBR Green. BMC Immunol 5:3-12, 2004
-
(2004)
BMC Immunol
, vol.5
, pp. 3-12
-
-
Peinnequin, A.1
Mouret, C.2
Birot, O.3
Alonso, A.4
Mathieu, J.5
Clarencon, D.6
Agay, D.7
Chancerelle, Y.8
Multon, E.9
-
17
-
-
0036293648
-
FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis
-
Boden G, Cheung P, Stein TP, Kresge K, Mozzoli M: FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am J Physiol 283:E12-E19, 2002
-
(2002)
Am J Physiol
, vol.283
-
-
Boden, G.1
Cheung, P.2
Stein, T.P.3
Kresge, K.4
Mozzoli, M.5
-
18
-
-
0028342686
-
Mechanisms of fatty acid-induced inhibition of glucose uptake
-
Boden G, Chen X, Ruiz J, White JV, Rossetti L: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
-
(1994)
J Clin Invest
, vol.93
, pp. 2438-2446
-
-
Boden, G.1
Chen, X.2
Ruiz, J.3
White, J.V.4
Rossetti, L.5
-
19
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI: Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
Zhang, D.4
Zong, H.5
Wang, Y.6
Bergeron, R.7
Kim, J.K.8
Cushman, S.W.9
Cooney, G.J.10
Atcheson, B.11
White, M.F.12
Kraegen, E.W.13
Shulman, G.I.14
-
20
-
-
0032946302
-
Malonyl-CoA, fuel sensing, and insulin resistance
-
Ruderman NB, Saha AK, Vavvas D, Witters LA: Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 276:E1-E18, 1999
-
(1999)
Am J Physiol
, vol.276
-
-
Ruderman, N.B.1
Saha, A.K.2
Vavvas, D.3
Witters, L.A.4
-
21
-
-
0023951837
-
Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA
-
Bronfman M, Morales MN, Orellana A: Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA. Biochem Biophys Res Commun 152:987-992, 1988
-
(1988)
Biochem Biophys Res Commun
, vol.152
, pp. 987-992
-
-
Bronfman, M.1
Morales, M.N.2
Orellana, A.3
-
22
-
-
0029060391
-
Protein kinase C and lipid signaling for sustained cellular responses
-
Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9:484-496, 1995
-
(1995)
FASEB J
, vol.9
, pp. 484-496
-
-
Nishizuka, Y.1
-
23
-
-
0025317854
-
1,2-Diacylglycerol and ceramide levels in rat skeletal muscle and liver in vivo: Studies with insulin, exercise, muscle denervation, and vasopressin
-
Turinsky J, Bayly BP, O'Sullivan DM: 1,2-Diacylglycerol and ceramide levels in rat skeletal muscle and liver in vivo: studies with insulin, exercise, muscle denervation, and vasopressin. J Biol Chem 265:7933-7938, 1990
-
(1990)
J Biol Chem
, vol.265
, pp. 7933-7938
-
-
Turinsky, J.1
Bayly, B.P.2
O'Sullivan, D.M.3
-
24
-
-
0033662759
-
Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization
-
Bell KS, Schmitz-Peiffer C, Lim-Fraser M, Biden TJ, Cooney GJ, Kraegen EW: Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization. Am J Physiol Endocrinol Metab 279:E1196-E1201, 2001
-
(2001)
Am J Physiol Endocrinol Metab
, vol.279
-
-
Bell, K.S.1
Schmitz-Peiffer, C.2
Lim-Fraser, M.3
Biden, T.J.4
Cooney, G.J.5
Kraegen, E.W.6
-
25
-
-
0026334132
-
Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle: Altered protein kinase C activity and possible link to insulin resistance
-
Heydrick SJ, Ruderman NB, Kurowski TG, Adams HB, Chen KS: Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle: altered protein kinase C activity and possible link to insulin resistance. Diabetes 40:1707-1711, 1991
-
(1991)
Diabetes
, vol.40
, pp. 1707-1711
-
-
Heydrick, S.J.1
Ruderman, N.B.2
Kurowski, T.G.3
Adams, H.B.4
Chen, K.S.5
-
26
-
-
0033765672
-
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
-
Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H: High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49:1939-1945, 2000
-
(2000)
Diabetes
, vol.49
, pp. 1939-1945
-
-
Inoguchi, T.1
Li, P.2
Umeda, F.3
Yu, H.Y.4
Kakimoto, M.5
Imamura, M.6
Aoki, T.7
Etoh, T.8
Hashimoto, T.9
Naruse, M.10
Sano, H.11
Utsumi, H.12
Nawata, H.13
-
27
-
-
0033625869
-
Protein kinase C theta: A new essential superstar on the T-cell stage
-
Altman A, Isakov N, Baier G: Protein kinase C theta: a new essential superstar on the T-cell stage. Immunol Today 21:567-573, 2000
-
(2000)
Immunol Today
, vol.21
, pp. 567-573
-
-
Altman, A.1
Isakov, N.2
Baier, G.3
-
28
-
-
9144241794
-
Protein kinase C βII Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion
-
Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Rawlings DJ, Kawakami T: Protein kinase C βII Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem 279:47720-47725, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 47720-47725
-
-
Kawakami, Y.1
Nishimoto, H.2
Kitaura, J.3
Maeda-Yamamoto, M.4
Kato, R.M.5
Littman, D.R.6
Rawlings, D.J.7
Kawakami, T.8
-
29
-
-
0030669094
-
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612
-
De Fea K, Roth RA: Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. Biochemistry 36:12939-12947, 1997
-
(1997)
Biochemistry
, vol.36
, pp. 12939-12947
-
-
De Fea, K.1
Roth, R.A.2
-
30
-
-
0035793592
-
Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
-
Ravichandran V, Esposito DL, Chen J, Quon MJ: Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin. J Biol Chem 276:3543-3549, 2001
-
(2001)
J Biol Chem
, vol.276
, pp. 3543-3549
-
-
Ravichandran, V.1
Esposito, D.L.2
Chen, J.3
Quon, M.J.4
-
31
-
-
8544233570
-
1010
-
1010. J Biol Chem 279:45304-45307, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 45304-45307
-
-
Li, Y.1
Nishimoto, H.2
Kitaura, J.3
Maeda-Yamamoto, M.4
Kato, R.M.5
Littman, D.R.6
Rawlings, D.J.7
Kawakami, T.8
-
32
-
-
1542284652
-
Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cδ
-
Greene MW, Morrice N, Garofalo RS, Roth RA: Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cδ. Biochem J 378:105-116, 2004
-
(2004)
Biochem J
, vol.378
, pp. 105-116
-
-
Greene, M.W.1
Morrice, N.2
Garofalo, R.S.3
Roth, R.A.4
-
33
-
-
0346374720
-
Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
-
Saha AK, Avilucea PR, Assifi MM, Kraegen EW, Ruderman NB: Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun 314:580-585, 2004
-
(2004)
Biochem Biophys Res Commun
, vol.314
, pp. 580-585
-
-
Saha, A.K.1
Avilucea, P.R.2
Assifi, M.M.3
Kraegen, E.W.4
Ruderman, N.B.5
-
34
-
-
0346505340
-
The IKK NFκB system: A treasure trove for drug development
-
Karin M, Yamamoto Y, Wang QM: The IKK NFκB system: a treasure trove for drug development. Nat Rev 3:17-26, 2004
-
(2004)
Nat Rev
, vol.3
, pp. 17-26
-
-
Karin, M.1
Yamamoto, Y.2
Wang, Q.M.3
-
35
-
-
0030615201
-
Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
-
Barnes PJ, Karin M: Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071, 1997
-
(1997)
N Engl J Med
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
36
-
-
4043077961
-
Molecular mediators of hepatic steatosis and liver injury
-
Browning JD, Horton JD: Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114:147-152, 2004
-
(2004)
J Clin Invest
, vol.114
, pp. 147-152
-
-
Browning, J.D.1
Horton, J.D.2
-
37
-
-
0023277545
-
Single-step method of RNA isolation by acid guadinium thiocyanate-phenol-chloroform extraction
-
Chomcznki P, Saacchi N: Single-step method of RNA isolation by acid guadinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
-
(1987)
Anal Biochem
, vol.162
, pp. 156-159
-
-
Chomcznki, P.1
Saacchi, N.2
-
38
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shelson SE: Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat Med 11:183-190, 2005
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shelson, S.E.7
-
39
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE: Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293:1673-1677, 2001
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
40
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li Z-W, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M: IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191-198, 2005
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.-W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
|