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Volumn 11, Issue 1, 2013, Pages

Targeting the PDGF signaling pathway in tumor treatment

Author keywords

[No Author keywords available]

Indexed keywords

AXITINIB; CEDIRANIB; DASATINIB; IMATINIB; LINIFANIB; MOTESANIB; NILOTINIB; PAZOPANIB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PONATINIB; QUIZARTINIB; SORAFENIB; SUNITINIB; ANGIOGENESIS INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

EID: 84890467312     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-11-97     Document Type: Review
Times cited : (412)

References (283)
  • 1
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Mechanism of action and in vivo role of platelet-derived growth factor. Heldin C-H, Westermark B, Physiol Rev 1999 79 1283 1316 (Pubitemid 29473317)
    • (1999) Physiological Reviews , vol.79 , Issue.4 , pp. 1283-1316
    • Heldin, C.-H.1    Westermark, B.2
  • 2
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • DOI 10.1101/gad.1653708
    • Role of platelet-derived growth factors in physiology and medicine. Andrae J, Gallini R, Betsholtz C, Genes Dev 2008 22 1276 1312 (Pubitemid 351717519)
    • (2008) Genes and Development , vol.22 , Issue.10 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 3
    • 84896545696 scopus 로고    scopus 로고
    • Targeting the PDGF signaling pathway in the treatment of non-malignant diseases
    • in press
    • Targeting the PDGF signaling pathway in the treatment of non-malignant diseases. Heldin C-H, J Neuroimmune Pharmacol 2013 in press
    • (2013) J Neuroimmune Pharmacol
    • Heldin, C.-H.1
  • 4
    • 6344236867 scopus 로고    scopus 로고
    • Tissue plasminogen activator is a potent activator of PDGF-CC
    • DOI 10.1038/sj.emboj.7600397
    • Tissue plasminogen activator is a potent activator of PDGF-CC. Fredriksson L, Li H, Fieber C, Li X, Eriksson U, EMBO J 2004 23 3793 3802 (Pubitemid 39389710)
    • (2004) EMBO Journal , vol.23 , Issue.19 , pp. 3793-3802
    • Fredriksson, L.1    Li, H.2    Fieber, C.3    Li, X.4    Eriksson, U.5
  • 5
    • 2942676788 scopus 로고    scopus 로고
    • The PDGF family: Four gene products form five dimeric isoforms
    • DOI 10.1016/j.cytogfr.2004.03.007, PII S1359610104000176
    • The PDGF family: four gene products form five dimeric isoforms. Fredriksson L, Li H, Eriksson U, Cytokine Growth Factor Rev 2004 15 197 204 (Pubitemid 38781045)
    • (2004) Cytokine and Growth Factor Reviews , vol.15 , Issue.4 , pp. 197-204
    • Fredriksson, L.1    Li, H.2    Eriksson, U.3
  • 6
    • 21744439110 scopus 로고    scopus 로고
    • Platelet-Derived growth factor d is activated by urokinase plasminogen activator in prostate carcinoma cells
    • DOI 10.1128/MCB.25.14.6279-6288.2005
    • Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. Ustach CV, Kim HR, Mol Cell Biol 2005 25 6279 6288 (Pubitemid 40946575)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.14 , pp. 6279-6288
    • Ustach, C.V.1    Kim, H.-R.C.2
  • 8
    • 0030977132 scopus 로고    scopus 로고
    • Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization
    • DOI 10.1074/jbc.272.19.12676
    • Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization. Omura T, Heldin C-H, Östman A, J Biol Chem 1997 272 12676 12682 (Pubitemid 27203365)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.19 , pp. 12676-12682
    • Omura, T.1    Heldin, C.-H.2    Ostman, A.3
  • 9
    • 45549109855 scopus 로고    scopus 로고
    • Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization
    • DOI 10.1073/pnas.0802896105
    • Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization. Yang Y, Yuzawa S, Schlessinger J, Proc Natl Acad Sci USA 2008 105 7681 7686 (Pubitemid 351872698)
    • (2008) Proceedings of the National Academy of Sciences of the United States of America , vol.105 , Issue.22 , pp. 7681-7686
    • Yang, Y.1    Yuzawa, S.2    Schlessinger, J.3
  • 10
    • 0032479283 scopus 로고    scopus 로고
    • Full activation of the platelet-derived growth factor β-receptor kinase involves multiple events
    • DOI 10.1074/jbc.273.27.17050
    • Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events. Baxter RM, Secrist JP, Vaillancourt RR, Kazlauskas A, J Biol Chem 1998 273 17050 17055 (Pubitemid 28311738)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.27 , pp. 17050-17055
    • Baxter, R.M.1    Secrist, J.P.2    Vaillancourt, R.R.3    Kazlauskas, A.4
  • 11
    • 0037064087 scopus 로고    scopus 로고
    • Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor β receptor
    • DOI 10.1074/jbc.M204890200
    • Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor. Irusta PM, Luo Y, Bakht O, Lai CC, Smith SO, DiMaio D, J Biol Chem 2002 277 38627 38634 (Pubitemid 35154723)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.41 , pp. 38627-38634
    • Irusta, P.M.1    Luo, Y.2    Bakht, O.3    Lai, C.-C.4    Smith, S.O.5    DiMaio, D.6
  • 12
    • 2442437841 scopus 로고    scopus 로고
    • Autoinhibition of the platelet-derived Growth Factor β-receptor tyrosine kinase by its c-terminal tail
    • DOI 10.1074/jbc.M314070200
    • Autoinhibition of the platelet-derived growth factor β receptor tyrosine kinase by its C-terminal tail. Chiara F, Bishayee S, Heldin C-H, Demoulin J-B, J Biol Chem 2004 279 19732 19738 (Pubitemid 38623411)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.19 , pp. 19732-19738
    • Chiara, F.1    Bishayee, S.2    Heldin, C.-H.3    Demoulin, J.-B.4
  • 13
    • 0032547385 scopus 로고    scopus 로고
    • Signal transduction via platelet-derived growth factor receptors
    • Signal transduction via platelet-derived growth factor receptors. Heldin C-H, Östman A, Rönnstrand L, Biochim Biophys Acta 1998 1378 79 F113
    • (1998) Biochim Biophys Acta , vol.1378
    • Heldin, C.-H.1    Östman, A.2    Rönnstrand, L.3
  • 14
    • 0001288948 scopus 로고    scopus 로고
    • 2 production requires the activation of phosphatidylinositol 3-kinase
    • DOI 10.1074/jbc.275.14.10527
    • Platelet-derived growth factor-induced H§ssub§2§esub§ O§ssub§2§esub§ production requires the activation of phosphatidylinositol 3-kinase. Bae YS, Sung J-Y, Kim O-S, Kim YJ, Hur KC, Kazlauskas A, Rhee SG, J Biol Chem 2000 275 10527 10531 (Pubitemid 30202116)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.14 , pp. 10527-10531
    • Bae, Y.S.1    Sung, J.-Y.2    Kim, O.-S.3    Kim, Y.J.4    Hur, K.C.5    Kazlauskas, A.6    Rhee, S.G.7
  • 15
    • 0028973482 scopus 로고
    • Requirement for generation of H§ssub§2§esub§O§ ssub§2§esub§ for platelet-derived growth factor signal transduction
    • Requirement for generation of H§ssub§2§esub§O§ ssub§2§esub§ for platelet-derived growth factor signal transduction. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T, Science 1995 270 296 299
    • (1995) Science , vol.270 , pp. 296-299
    • Sundaresan, M.1    Yu, Z.X.2    Ferrans, V.J.3    Irani, K.4    Finkel, T.5
  • 16
    • 63249103444 scopus 로고    scopus 로고
    • Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation
    • Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation. Jurek A, Amagasaki K, Gembarska A, Heldin C-H, Lennartsson J, J Biol Chem 2009 284 4626 4634
    • (2009) J Biol Chem , vol.284 , pp. 4626-4634
    • Jurek, A.1    Amagasaki, K.2    Gembarska, A.3    Heldin, C.-H.4    Lennartsson, J.5
  • 17
    • 0026652899 scopus 로고
    • Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
    • Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F, Williams LT, Cell 1992 69 413 423
    • (1992) Cell , vol.69 , pp. 413-423
    • Fantl, W.J.1    Escobedo, J.A.2    Martin, G.A.3    Turck, C.W.4    Del Rosario, M.5    McCormick, F.6    Williams, L.T.7
  • 18
    • 77957777620 scopus 로고    scopus 로고
    • Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation
    • Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation. Jurek A, Heldin C-H, Lennartsson J, Cell Signal 2011 23 280 287
    • (2011) Cell Signal , vol.23 , pp. 280-287
    • Jurek, A.1    Heldin, C.-H.2    Lennartsson, J.3
  • 19
    • 0037428466 scopus 로고    scopus 로고
    • Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B
    • DOI 10.1074/jbc.M210194200
    • Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B. Haj FG, Markova B, Klaman LD, Bohmer FD, Neel BG, J Biol Chem 2003 278 739 744 (Pubitemid 36790744)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.2 , pp. 739-744
    • Haj, F.G.1    Markova, B.2    Klaman, L.D.3    Bohmer, F.D.4    Neel, B.G.5
  • 21
    • 0034717163 scopus 로고    scopus 로고
    • Site-selective dephosphorylation of the platelet-derived growth factor β-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
    • DOI 10.1074/jbc.275.21.16219
    • Site-selective dephosphorylation of the platelet-derived growth factor β-receptor by the receptor-like protein-tyrosine phosphatase DEP-1. Kovalenko M, Denner K, Sandström J, Persson C, Groß S, Jandt E, Vilella R, Böhmer F, Östman A, J Biol Chem 2000 275 16219 16226 (Pubitemid 30366934)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.21 , pp. 16219-16226
    • Kovalenko, M.1    Denner, K.2    Sandstrom, J.3    Persson, C.4    Gross, S.5    Jandt, E.6    Vilella, R.7    Bohmer, F.8    Ostman, A.9
  • 22
    • 33846811117 scopus 로고    scopus 로고
    • Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation
    • DOI 10.1096/fj.06-6219com
    • Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation. Kappert K, Paulsson J, Sparwel J, Leppänen O, Hellberg C, Östman A, Micke P, FASEB J 2007 21 523 534 (Pubitemid 46213499)
    • (2007) FASEB Journal , vol.21 , Issue.2 , pp. 523-534
    • Kappert, K.1    Paulsson, J.2    Sparwel, J.3    Leppanen, O.4    Hellberg, C.5    Ostman, A.6    Micke, P.7
  • 23
    • 0028837693 scopus 로고
    • Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association
    • Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association. Peng Z-Y, Cartwright CA, Oncogene 1995 11 1955 1962
    • (1995) Oncogene , vol.11 , pp. 1955-1962
    • Peng, Z.-Y.1    Cartwright, C.A.2
  • 24
    • 38349004658 scopus 로고    scopus 로고
    • The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway
    • The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway. Dance M, Montagner A, Salles JP, Yart A, Raynal P, Cell Signal 2008 20 453 459
    • (2008) Cell Signal , vol.20 , pp. 453-459
    • Dance, M.1    Montagner, A.2    Salles, J.P.3    Yart, A.4    Raynal, P.5
  • 25
    • 0034805908 scopus 로고    scopus 로고
    • Receptor heterodimerization: Essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
    • DOI 10.1128/MCB.21.19.6387-6394.2001
    • Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation. Saito Y, Haendeler J, Hojo Y, Yamamoto K, Berk BC, Mol Cell Biol 2001 21 6387 6394 (Pubitemid 32927407)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.19 , pp. 6387-6394
    • Saito, Y.1    Haendeler, J.2    Hojo, Y.3    Yamamoto, K.4    Berk, B.C.5
  • 26
    • 0029670904 scopus 로고    scopus 로고
    • Stimulation of β§ssub§1§esub§ integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF β-receptors
    • Stimulation of β§ssub§1§esub§ integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF β-receptors. Sundberg C, Rubin K, J Cell Biol 1996 132 741 752
    • (1996) J Cell Biol , vol.132 , pp. 741-752
    • Sundberg, C.1    Rubin, K.2
  • 27
    • 18544378303 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF
    • DOI 10.1074/jbc.M200427200
    • Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF. Loukinova E, Ranganathan S, Kuznetsov S, Gorlatova N, Migliorini MM, Loukinov D, Ulery PG, Mikhailenko I, Lawrence DA, Strickland DK, J Biol Chem 2002 277 15499 15506 (Pubitemid 34967816)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.18 , pp. 15499-15506
    • Loukinova, E.1    Ranganathan, S.2    Kuznetsov, S.3    Gorlatova, N.4    Migliorini, M.M.5    Loukinov, D.6    Ulery, P.G.7    Mikhailenko, I.8    Lawrence, D.A.9    Strickland, D.K.10
  • 28
    • 0037013188 scopus 로고    scopus 로고
    • Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low density lipoprotein receptor-related protein in caveolae
    • DOI 10.1074/jbc.M200428200
    • Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low density lipoprotein receptor-related protein in caveolae. Boucher P, Liu P, Gotthardt M, Hiesberger T, Anderson RG, Herz J, J Biol Chem 2002 277 15507 15513 (Pubitemid 34967817)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.18 , pp. 15507-15513
    • Boucher, P.1    Liu, P.2    Gotthardt, M.3    Hiesberger, T.4    Anderson, R.G.W.5    Herz, J.6
  • 29
    • 23044469458 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor-β (PDGFR-β) activation promotes its association with the low density lipoprotein receptor-related protein (LRP): Evidence for co-receptor function
    • DOI 10.1074/jbc.M505410200
    • Platelet-derived growth factor receptor-β (PDGFR-β) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function. Newton CS, Loukinova E, Mikhailenko I, Ranganathan S, Gao Y, Haudenschild C, Strickland DK, J Biol Chem 2005 280 27872 27878 (Pubitemid 41076904)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.30 , pp. 27872-27878
    • Newton, C.S.1    Loukinova, E.2    Mikhailenko, I.3    Ranganathan, S.4    Gao, Y.5    Haudenschild, C.6    Strickland, D.K.7
  • 30
    • 33748751207 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44
    • DOI 10.1074/jbc.M605607200
    • Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44. Li L, Heldin C-H, Heldin P, J Biol Chem 2006 281 26512 26519 (Pubitemid 44401860)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.36 , pp. 26512-26519
    • Li, L.1    Heldin, C.-H.2    Heldin, P.3
  • 31
    • 0033523010 scopus 로고    scopus 로고
    • Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation - A critical role for Cbl tyrosine kinase-binding domain
    • Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation-a critical role for Cbl tyrosine kinase-binding domain. Miyake S, Mullane-Robinson KP, Lill NL, Douillard P, Band H, J Biol Chem 1999 274 16619 16628
    • (1999) J Biol Chem , vol.274 , pp. 16619-16628
    • Miyake, S.1    Mullane-Robinson, K.P.2    Lill, N.L.3    Douillard, P.4    Band, H.5
  • 32
    • 1542289711 scopus 로고    scopus 로고
    • Platelet-derived Growth Factor Receptor-mediated Signal Transduction from Endosomes
    • DOI 10.1074/jbc.M311494200
    • Platelet-derived growth factor receptor-mediated signal transduction from endosomes. Wang Y, Pennock SD, Chen X, Kazlauskas A, Wang Z, J Biol Chem 2004 279 8038 8046 (Pubitemid 38294692)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.9 , pp. 8038-8046
    • Wang, Y.1    Pennock, S.D.2    Chen, X.3    Kazlauskas, A.4    Wang, Z.5
  • 33
    • 67449116833 scopus 로고    scopus 로고
    • Activation of protein kinase C is necessary for sorting the PDGF β-receptor to Rab4a-dependent recycling
    • Activation of protein kinase C is necessary for sorting the PDGF β-receptor to Rab4a-dependent recycling. Hellberg C, Schmees C, Karlsson S, Åhgren A, Heldin C-H, Mol Biol Cell 2009 20 2856 2863
    • (2009) Mol Biol Cell , vol.20 , pp. 2856-2863
    • Hellberg, C.1    Schmees, C.2    Karlsson, S.3    Åhgren, A.4    Heldin, C.-H.5
  • 35
    • 0030808324 scopus 로고    scopus 로고
    • The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites
    • The PDGF receptor is required for neural crest cell development and for normal patterning of the somites. Soriano P, Development 1997 124 2691 2700 (Pubitemid 27354815)
    • (1997) Development , vol.124 , Issue.14 , pp. 2691-2700
    • Soriano, P.1
  • 37
    • 0033832891 scopus 로고    scopus 로고
    • Abnormal gastrointestinal development in PDGF-A and PDGFR- deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
    • Abnormal gastrointestinal development in PDGF-A and PDGFR- deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Karlsson L, Lindahl P, Heath JK, Betsholtz C, Development 2000 127 3457 3466
    • (2000) Development , vol.127 , pp. 3457-3466
    • Karlsson, L.1    Lindahl, P.2    Heath, J.K.3    Betsholtz, C.4
  • 38
    • 0028059309 scopus 로고
    • Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice
    • Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice. Soriano P, Genes Dev 1994 8 1888 1896
    • (1994) Genes Dev , vol.8 , pp. 1888-1896
    • Soriano, P.1
  • 40
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • DOI 10.1126/science.277.5323.242
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Lindahl P, Johansson BR, Levéen P, Betsholtz C, Science 1997 277 242 245 (Pubitemid 27446080)
    • (1997) Science , vol.277 , Issue.5323 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 41
    • 0030730837 scopus 로고    scopus 로고
    • Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development
    • Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Lindahl P, Karlsson L, Hellström M, Gebre-Medhin S, Willetts K, Heath JK, Betsholtz C, Development 1997 124 3943 3953 (Pubitemid 27483322)
    • (1997) Development , vol.124 , Issue.20 , pp. 3943-3953
    • Lindahl, P.1    Karlsson, L.2    Hellstrom, M.3    Gebre-Medhin, S.4    Willetts, K.5    Heath, J.K.6    Betsholtz, C.7
  • 42
  • 43
    • 0026595966 scopus 로고
    • Platelet-derived growth factor BB for the treatment of chronic pressure ulcers
    • Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Robson MC, Phillips LG, Thomason A, Robson LE, Pierce GF, Lancet 1992 339 23 25
    • (1992) Lancet , vol.339 , pp. 23-25
    • Robson, M.C.1    Phillips, L.G.2    Thomason, A.3    Robson, L.E.4    Pierce, G.F.5
  • 44
    • 0029824569 scopus 로고    scopus 로고
    • A novel physiological function for platelet-derived growth factor-BB in rat dermis
    • A novel physiological function for platelet-derived growth factor-BB in rat dermis. Rodt SÅ Åhlén K, Berg A, Rubin K, Reed RK, J Physiol 1996 495 193 200 (Pubitemid 26288464)
    • (1996) Journal of Physiology , vol.495 , Issue.1 , pp. 193-200
    • Rodt, S.A.1    Ahlen, K.2    Berg, A.3    Rubin, K.4    Reed, R.K.5
  • 45
    • 0029806701 scopus 로고    scopus 로고
    • Inhibitory DNA ligands to platelet-derived growth factor B-chain
    • DOI 10.1021/bi961544+
    • Inhibitory DNA ligands to platelet-derived growth factor B-chain. Green LS, Jellinek D, Jenison R, Östman A, Heldin C-H, Janjic N, Biochem 1996 35 14413 14424 (Pubitemid 26384438)
    • (1996) Biochemistry , vol.35 , Issue.45 , pp. 14413-14424
    • Green, L.S.1    Jellinek, D.2    Jenison, R.3    Ostman, A.4    Heldin, C.-H.5    Janjic, N.6
  • 49
    • 66449132035 scopus 로고    scopus 로고
    • Development of a fully human anti-PDGFRβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody
    • Development of a fully human anti-PDGFRβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody. Shen J, Vil MD, Prewett M, Damoci C, Zhang H, Li H, Jimenez X, Deevi DS, Iacolina M, Kayas A, et al. Neoplasia 2009 11 594 604
    • (2009) Neoplasia , vol.11 , pp. 594-604
    • Shen, J.1    Vil, M.D.2    Prewett, M.3    Damoci, C.4    Zhang, H.5    Li, H.6    Jimenez, X.7    Deevi, D.S.8    Iacolina, M.9    Kayas, A.10
  • 50
    • 80054063355 scopus 로고    scopus 로고
    • Multitargeted receptor tyrosine kinase inhibition: An antiangiogenic strategy in non-small cell lung cancer
    • Multitargeted receptor tyrosine kinase inhibition: an antiangiogenic strategy in non-small cell lung cancer. Socinski MA, Cancer Treat Rev 2011 37 611 617
    • (2011) Cancer Treat Rev , vol.37 , pp. 611-617
    • Socinski, M.A.1
  • 51
    • 72249087752 scopus 로고    scopus 로고
    • Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4- yl-ethoxy) imidazo [2,1-b] [1,3] benzothiazol-2-yl] phenyl} urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor
    • Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4- yl-ethoxy) imidazo [2,1-b] [1,3] benzothiazol-2-yl] phenyl} urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor. Chao Q, Sprankle KG, Grotzfeld RM, Lai AG, Carter TA, Velasco AM, Gunawardane RN, Cramer MD, Gardner MF, James J, et al. J Med Chem 2009 52 7808 7816
    • (2009) J Med Chem , vol.52 , pp. 7808-7816
    • Chao, Q.1    Sprankle, K.G.2    Grotzfeld, R.M.3    Lai, A.G.4    Carter, T.A.5    Velasco, A.M.6    Gunawardane, R.N.7    Cramer, M.D.8    Gardner, M.F.9    James, J.10
  • 52
    • 84874598006 scopus 로고    scopus 로고
    • Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms
    • Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. Kampa-Schittenhelm KM, Heinrich MC, Akmut F, Dohner H, Dohner K, Schittenhelm MM, Mol Cancer 2013 12 19
    • (2013) Mol Cancer , vol.12 , pp. 19
    • Kampa-Schittenhelm, K.M.1    Heinrich, M.C.2    Akmut, F.3    Dohner, H.4    Dohner, K.5    Schittenhelm, M.M.6
  • 53
    • 77953790762 scopus 로고    scopus 로고
    • Discovery of 3-[2-(imidazo [1,2-b] \pyridazin-3-yl) ethynyl]-4-methyl-N- {4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl) phenyl} benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant
    • Discovery of 3-[2-(imidazo [1,2-b] \pyridazin-3-yl) ethynyl]-4-methyl-N- {4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl) phenyl} benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant. Huang WS, Metcalf CA, Sundaramoorthi R, Wang Y, Zou D, Thomas RM, Zhu X, Cai L, Wen D, Liu S, et al. J Med Chem 2010 53 4701 4719
    • (2010) J Med Chem , vol.53 , pp. 4701-4719
    • Huang, W.S.1    Metcalf, C.A.2    Sundaramoorthi, R.3    Wang, Y.4    Zou, D.5    Thomas, R.M.6    Zhu, X.7    Cai, L.8    Wen, D.9    Liu, S.10
  • 55
    • 0141486251 scopus 로고    scopus 로고
    • PDGF receptors as cancer drug targets
    • DOI 10.1016/S1535-6108(03)00089-8, PII S1535610803000898
    • PDGF receptors as cancer drug targets. Pietras K, Sjöblom T, Rubin K, Heldin C-H, Östman A, Cancer Cell 2003 3 439 443 (Pubitemid 38340290)
    • (2003) Cancer Cell , vol.3 , Issue.5 , pp. 439-443
    • Pietras, K.1    Sjoblom, T.2    Rubin, K.3    Heldin, C.-H.4    Ostman, A.5
  • 56
    • 0031661840 scopus 로고    scopus 로고
    • Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant- cell fibroblastomas
    • Various regions within the -helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. O'Brien KP, Seroussi E, Dal Cin P, Sciot R, Mandahl N, Fletcher JA, Turc-Carel C, Dumanski JP, Gene Chrom Cancer 1998 23 187 193 (Pubitemid 28402346)
    • (1998) Genes Chromosomes and Cancer , vol.23 , Issue.2 , pp. 187-193
    • O'Brien, K.P.1    Seroussi, E.2    Dal Cin, P.3    Sciot, R.4    Mandahl, N.5    Fletcher, J.A.6    Turc-Carel, C.7    Dumanski, J.P.8
  • 58
    • 0033178762 scopus 로고    scopus 로고
    • The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB
    • The dermatofibrosarcoma protuberans-associated collagen type I1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Shimizu A, O'Brien KP, Sjöblom T, Pietras K, Buchdunger E, Collins VP, Heldin C-H, Dumanski JP, Östman A, Cancer Res 1999 59 3719 3723 (Pubitemid 29381878)
    • (1999) Cancer Research , vol.59 , Issue.15 , pp. 3719-3723
    • Shimizu, A.1    O'Brien, K.P.2    Sjoblom, T.3    Pietras, K.4    Buchdunger, E.5    Collins, V.P.6    Heldin, C.-H.7    Dumanski, J.P.8    Ostman, A.9
  • 60
    • 77957738175 scopus 로고    scopus 로고
    • New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases
    • New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases. Toffalini F, Demoulin JB, Blood 2010 116 2429 2437
    • (2010) Blood , vol.116 , pp. 2429-2437
    • Toffalini, F.1    Demoulin, J.B.2
  • 61
    • 0026793260 scopus 로고
    • Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
    • Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson SA, Ali IU, Cancer Res 1992 52 4550 4553
    • (1992) Cancer Res , vol.52 , pp. 4550-4553
    • Fleming, T.P.1    Saxena, A.2    Clark, W.C.3    Robertson, J.T.4    Oldfield, E.H.5    Aaronson, S.A.6    Ali, I.U.7
  • 62
    • 0026600613 scopus 로고
    • Amplification of -platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin
    • Amplification of -platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin. Kumabe T, Sohma Y, Kayama T, Yoshimoto T, Yamamoto T, Oncogene 1992 7 627 633
    • (1992) Oncogene , vol.7 , pp. 627-633
    • Kumabe, T.1    Sohma, Y.2    Kayama, T.3    Yoshimoto, T.4    Yamamoto, T.5
  • 65
    • 0141788552 scopus 로고    scopus 로고
    • Detection of amplified oncogenes by genome DNA microarrays in human primary esophageal squamous cell carcinoma: Comparison with conventional comparative genomic hybridization analysis
    • DOI 10.1016/S0165-4608(03)00106-7
    • Detection of amplified oncogenes by genome DNA microarrays in human primary esophageal squamous cell carcinoma: comparison with conventional comparative genomic hybridization analysis. Arai H, Ueno T, Tangoku A, Yoshino S, Abe T, Kawauchi S, Oga A, Furuya T, Oka M, Sasaki K, Cancer Genet Cytogenet 2003 146 16 21 (Pubitemid 37117429)
    • (2003) Cancer Genetics and Cytogenetics , vol.146 , Issue.1 , pp. 16-21
    • Arai, H.1    Ueno, T.2    Tangoku, A.3    Yoshino, S.4    Abe, T.5    Kawauchi, S.6    Oga, A.7    Furuya, T.8    Oka, M.9    Sasaki, K.10
  • 66
    • 0036211011 scopus 로고    scopus 로고
    • Combined comparative genomic hybridization and genomic microarray for detection of gene amplifications in pulmonary artery intimal sarcomas and adrenocortical tumors
    • DOI 10.1002/gcc.10035
    • Combined comparative genomic hybridization and genomic microarray for detection of gene amplifications in pulmonary artery intimal sarcomas and adrenocortical tumors. Zhao J, Roth J, Bode-Lesniewska B, Pfaltz M, Heitz PU, Komminoth P, Genes Chromosomes Cancer 2002 34 48 57 (Pubitemid 34260596)
    • (2002) Genes Chromosomes and Cancer , vol.34 , Issue.1 , pp. 48-57
    • Zhao, J.1    Roth, J.2    Bode-Lesniewska, B.3    Pfaltz, M.4    Heitz, P.U.5    Komminoth, P.6
  • 68
    • 0037421971 scopus 로고    scopus 로고
    • A human brain tumor-derived PDGFR-α deletion mutant is transforming
    • DOI 10.1038/sj.onc.1206160
    • A human brain tumor-derived PDGFR- deletion mutant is transforming. Clarke ID, Dirks PB, Oncogene 2003 22 722 733 (Pubitemid 36269285)
    • (2003) Oncogene , vol.22 , Issue.5 , pp. 722-733
    • Clarke, I.D.1    Dirks, P.B.2
  • 69
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Epithelial-mesenchymal transitions in development and disease. Thiery JP, Acloque H, Huang RY, Nieto MA, Cell 2009 139 871 890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 71
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - An obstacle in cancer therapy
    • DOI 10.1038/nrc1456
    • High interstitial fluid pressure-an obstacle in cancer therapy. Heldin C-H, Rubin K, Pietras K, Östman A, Nat Rev Cancer 2004 4 806 813 (Pubitemid 39331152)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 72
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • Oncogene addiction. Weinstein IB, Joe A, Cancer Res 2008 68 3077 3080
    • (2008) Cancer Res , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 73
    • 0001288041 scopus 로고
    • The biology of primate retrovirus
    • New York: Raven Press Klein G
    • The biology of primate retrovirus. Deinhardt F, Viral oncology New York: Raven Press, Klein G, 1980 359 398
    • (1980) Viral Oncology , pp. 359-398
    • Deinhardt, F.1
  • 74
    • 0020640259 scopus 로고
    • Platelet-derived growth factor is structurally related to the putative transforming protein p28(sis) of simian sarcoma virus
    • Platelet-derived growth factor is structurally related to the putative transforming protein p28§ssup§sis§esup§ of simian sarcoma virus. Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson Å Westermark B, Heldin C-H, Huang JS, Deuel TF, Nature (London) 1983 304 35 39 (Pubitemid 13063102)
    • (1983) Nature , vol.304 , Issue.5921 , pp. 35-39
    • Waterfield, M.D.1    Scrace, G.T.2    Whittle, N.3
  • 75
    • 0020533055 scopus 로고
    • Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor
    • Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Doolittle RF, Hunkapiller MW, Hood LE, Devare SD, Robbins KC, Aaronson SA, Antoniades HN, Science 1983 221 275 277 (Pubitemid 13062620)
    • (1983) Science , vol.221 , Issue.4607 , pp. 275-277
    • Doolittle, R.F.1    Hunkapiller, M.W.2    Hood, L.E.3
  • 76
    • 0023747564 scopus 로고
    • Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor- and their receptors in human malignant glioma cell lines
    • Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor- and their receptors in human malignant glioma cell lines. Nistér M, Libermann TA, Betsholtz C, Pettersson M, Claesson-Welsh L, Heldin C-H, Schlessinger J, Westermark B, Cancer Res 1988 48 3910 3918
    • (1988) Cancer Res , vol.48 , pp. 3910-3918
    • Nistér, M.1    Libermann, T.A.2    Betsholtz, C.3    Pettersson, M.4    Claesson-Welsh, L.5    Heldin, C.-H.6    Schlessinger, J.7    Westermark, B.8
  • 77
    • 0036645057 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    • Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA, Giese NA, Cancer Res 2002 62 3729 3735 (Pubitemid 34728854)
    • (2002) Cancer Research , vol.62 , Issue.13 , pp. 3729-3735
    • Lokker, N.A.1    Sullivan, C.M.2    Hollenbach, S.J.3    Israel, M.A.4    Giese, N.A.5
  • 78
    • 0026772431 scopus 로고
    • Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
    • Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Hermanson M, Funa K, Hartman M, Claesson-Welsh L, Heldin C-H, Westermark B, Nistér M, Cancer Res 1992 52 3213 3219
    • (1992) Cancer Res , vol.52 , pp. 3213-3219
    • Hermanson, M.1    Funa, K.2    Hartman, M.3    Claesson-Welsh, L.4    Heldin, C.-H.5    Westermark, B.6    Nistér, M.7
  • 79
    • 0031951740 scopus 로고    scopus 로고
    • Platelet-derived growth factor and its receptor expression in human oligodendrogliomas
    • DOI 10.1097/00006123-199802000-00080
    • Platelet-derived growth factor and its receptor expression in human oligodendrogliomas. Di Rocco F, Carroll RS, Zhang JP, Black PM, Neurosurgery 1998 42 341 346 (Pubitemid 28076794)
    • (1998) Neurosurgery , vol.42 , Issue.2 , pp. 341-346
    • Di Rocco, F.1    Carroll, R.S.2    Zhang, J.3    Black, P.McL.4
  • 82
    • 0028911678 scopus 로고
    • Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop
    • Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Guha A, Dashner K, Black PM, Wagner JA, Stiles CD, Int J Cancer 1995 60 168 173
    • (1995) Int J Cancer , vol.60 , pp. 168-173
    • Guha, A.1    Dashner, K.2    Black, P.M.3    Wagner, J.A.4    Stiles, C.D.5
  • 83
    • 0025282206 scopus 로고
    • Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance
    • Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. Maxwell M, Naber SP, Wolfe HJ, Galanopoulos T, Hedley-Whyte ET, Black PM, Antoniades HN, J Clin Invest 1990 86 131 140 (Pubitemid 20226985)
    • (1990) Journal of Clinical Investigation , vol.86 , Issue.1 , pp. 131-140
    • Maxwell, M.1    Naber, S.P.2    Wolfe, H.J.3    Galanopoulos, T.4    Hedley-Whyte, E.T.5    Black, P.M.6    Antoniades, H.N.7
  • 84
    • 0026439870 scopus 로고
    • Platelet-derived growth factor receptor-β is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas
    • Platelet-derived growth factor receptor-β is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas. Plate KH, Breier G, Farrell CL, Risau W, Lab Invest 1992 67 529 534
    • (1992) Lab Invest , vol.67 , pp. 529-534
    • Plate, K.H.1    Breier, G.2    Farrell, C.L.3    Risau, W.4
  • 86
    • 0026935176 scopus 로고
    • Overexpression and amplification of alpha-PDGF receptor gene lacking exons coding for a portion of the extracellular region in a malignant glioma
    • Overexpression and amplification of alpha-PDGF receptor gene lacking exons coding for a portion of the extracellular region in a malignant glioma. Kumabe T, Sohma Y, Kayama T, Yoshimoto T, Yamamoto T, Tohoku J Exp Med 1992 168 265 269
    • (1992) Tohoku J Exp Med , vol.168 , pp. 265-269
    • Kumabe, T.1    Sohma, Y.2    Kayama, T.3    Yoshimoto, T.4    Yamamoto, T.5
  • 87
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, et al. Cancer Cell 2010 17 98 110
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6    Miller, C.R.7    Ding, L.8    Golub, T.9    Mesirov, J.P.10
  • 90
    • 0032401819 scopus 로고    scopus 로고
    • Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
    • Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Uhrbom L, Hesselager G, Nistér M, Westermark B, Cancer Res 1998 58 5275 5279 (Pubitemid 28551098)
    • (1998) Cancer Research , vol.58 , Issue.23 , pp. 5275-5279
    • Uhrbom, L.1    Hesselager, G.2    Nister, M.3    Westermark, B.4
  • 91
    • 0033986415 scopus 로고    scopus 로고
    • Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells
    • DOI 10.1002/(SICI)1097-0215(20000201) 85:3<398::AID-IJC17>3.0.CO;2- L
    • Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells. Uhrbom L, Hesselager G, Östman A, Nistér M, Westermark B, Int J Cancer 2000 85 398 406 (Pubitemid 30030415)
    • (2000) International Journal of Cancer , vol.85 , Issue.3 , pp. 398-406
    • Uhrbom, L.1    Hesselager, G.2    Ostman, A.3    Nister, M.4    Westermark, B.5
  • 92
    • 0042591478 scopus 로고    scopus 로고
    • Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or INK4a-Arf deletion in a mouse glioma model
    • Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. Hesselager G, Uhrbom L, Westermark B, Nister M, Cancer Res 2003 63 4305 4309 (Pubitemid 36950994)
    • (2003) Cancer Research , vol.63 , Issue.15 , pp. 4305-4309
    • Hesselager, G.1    Uhrbom, L.2    Westermark, B.3    Nister, M.4
  • 93
    • 77950083598 scopus 로고    scopus 로고
    • Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas
    • Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas. See WL, Miller JP, Squatrito M, Holland E, Resh MD, Koff A, Oncogene 2010 29 1720 1731
    • (2010) Oncogene , vol.29 , pp. 1720-1731
    • See, W.L.1    Miller, J.P.2    Squatrito, M.3    Holland, E.4    Resh, M.D.5    Koff, A.6
  • 94
    • 34648834721 scopus 로고    scopus 로고
    • Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma
    • DOI 10.1038/sj.onc.1210455, PII 1210455
    • Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma. Tchougounova E, Kastemar M, Brasater D, Holland EC, Westermark B, Uhrbom L, Oncogene 2007 26 6289 6296 (Pubitemid 47462106)
    • (2007) Oncogene , vol.26 , Issue.43 , pp. 6289-6296
    • Tchougounova, E.1    Kastemar, M.2    Brasater, D.3    Holland, E.C.4    Westermark, B.5    Uhrbom, L.6
  • 98
    • 0035425048 scopus 로고    scopus 로고
    • PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas from and oligoastrocytomas neural progenitors and astrocytes in vivo
    • DOI 10.1101/gad.903001
    • PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, Holland EC, Genes Dev 2001 15 1913 1925 (Pubitemid 32738621)
    • (2001) Genes and Development , vol.15 , Issue.15 , pp. 1913-1925
    • Dai, C.1    Celestino, J.C.2    Okada, Y.3    Louis, D.N.4    Fuller, G.N.5    Holland, E.C.6
  • 99
    • 33745778950 scopus 로고    scopus 로고
    • Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses
    • DOI 10.1523/JNEUROSCI.0514-06.2006
    • Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. Assanah M, Lochhead R, Ogden A, Bruce J, Goldman J, Canoll P, J Neurosci 2006 26 6781 6790 (Pubitemid 44315239)
    • (2006) Journal of Neuroscience , vol.26 , Issue.25 , pp. 6781-6790
    • Assanah, M.1    Lochhead, R.2    Ogden, A.3    Bruce, J.4    Goldman, J.5    Canoll, P.6
  • 100
  • 102
    • 79958098183 scopus 로고    scopus 로고
    • PDGF-B can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation
    • PDGF-B can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation. Jiang Y, Boije M, Westermark B, Uhrbom L, Neoplasia 2011 13 492 503
    • (2011) Neoplasia , vol.13 , pp. 492-503
    • Jiang, Y.1    Boije, M.2    Westermark, B.3    Uhrbom, L.4
  • 105
    • 53749096014 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with recurrent gliomas of various histologies: A European organisation for research and treatment of cancer brain tumor group study
    • Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European organisation for research and treatment of cancer brain tumor group study. Raymond E, Brandes AA, Dittrich C, Fumoleau P, Coudert B, Clement PM, Frenay M, Rampling R, Stupp R, Kros JM, et al. J Clin Oncol 2008 26 4659 4665
    • (2008) J Clin Oncol , vol.26 , pp. 4659-4665
    • Raymond, E.1    Brandes, A.A.2    Dittrich, C.3    Fumoleau, P.4    Coudert, B.5    Clement, P.M.6    Frenay, M.7    Rampling, R.8    Stupp, R.9    Kros, J.M.10
  • 107
    • 26444621412 scopus 로고    scopus 로고
    • Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: A patient series
    • DOI 10.1093/annonc/mdi317
    • Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series. Dresemann G, Ann Oncol 2005 16 1702 1708 (Pubitemid 41510147)
    • (2005) Annals of Oncology , vol.16 , Issue.10 , pp. 1702-1708
    • Dresemann, G.1
  • 108
    • 75049085049 scopus 로고    scopus 로고
    • Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
    • Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. Dresemann G, Weller M, Rosenthal MA, Wedding U, Wagner W, Engel E, Heinrich B, Mayer-Steinacker R, Karup-Hansen A, Fluge O, et al. J Neurooncol 2010 96 393 402
    • (2010) J Neurooncol , vol.96 , pp. 393-402
    • Dresemann, G.1    Weller, M.2    Rosenthal, M.A.3    Wedding, U.4    Wagner, W.5    Engel, E.6    Heinrich, B.7    Mayer-Steinacker, R.8    Karup-Hansen, A.9    Fluge, O.10
  • 109
    • 84879301451 scopus 로고    scopus 로고
    • Role of platelet derived growth factor receptor (PDGFR) over-expression and angiogenesis in ependymoma
    • Role of platelet derived growth factor receptor (PDGFR) over-expression and angiogenesis in ependymoma. Moreno L, Popov S, Jury A, Al Sarraj S, Jones C, Zacharoulis S, J Neurooncol 2013 111 169 176
    • (2013) J Neurooncol , vol.111 , pp. 169-176
    • Moreno, L.1    Popov, S.2    Jury, A.3    Al Sarraj, S.4    Jones, C.5    Zacharoulis, S.6
  • 114
    • 84866046901 scopus 로고    scopus 로고
    • Imatinib mesylate treatment of recurrent meningiomas in preselected patients: A retrospective analysis
    • Imatinib mesylate treatment of recurrent meningiomas in preselected patients: a retrospective analysis. Horak P, Wohrer A, Hassler M, Hainfellner J, Preusser M, Marosi C, J Neurooncol 2012 109 323 330
    • (2012) J Neurooncol , vol.109 , pp. 323-330
    • Horak, P.1    Wohrer, A.2    Hassler, M.3    Hainfellner, J.4    Preusser, M.5    Marosi, C.6
  • 115
    • 67449136112 scopus 로고    scopus 로고
    • Human schwannomas express activated platelet-derived growth factor receptors and c-kit and are growth inhibited by Gleevec (Imatinib Mesylate)
    • Human schwannomas express activated platelet-derived growth factor receptors and c-kit and are growth inhibited by Gleevec (Imatinib Mesylate). Mukherjee J, Kamnasaran D, Balasubramaniam A, Radovanovic I, Zadeh G, Kiehl TR, Guha A, Cancer Res 2009 69 5099 5107
    • (2009) Cancer Res , vol.69 , pp. 5099-5107
    • Mukherjee, J.1    Kamnasaran, D.2    Balasubramaniam, A.3    Radovanovic, I.4    Zadeh, G.5    Kiehl, T.R.6    Guha, A.7
  • 116
    • 84862679500 scopus 로고    scopus 로고
    • Investigation of the in vitro therapeutic efficacy of nilotinib in immortalized human NF2-null vestibular schwannoma cells
    • Investigation of the in vitro therapeutic efficacy of nilotinib in immortalized human NF2-null vestibular schwannoma cells. Sabha N, Au K, Agnihotri S, Singh S, Mangat R, Guha A, Zadeh G, PLoS One 2012 7 39412
    • (2012) PLoS One , vol.7 , pp. 539412
    • Sabha, N.1    Au, K.2    Agnihotri, S.3    Singh, S.4    Mangat, R.5    Guha, A.6    Zadeh, G.7
  • 117
    • 80052726645 scopus 로고    scopus 로고
    • Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2
    • Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2. Ammoun S, Schmid MC, Triner J, Manley P, Hanemann CO, Neuro Oncol 2011 13 759 766
    • (2011) Neuro Oncol , vol.13 , pp. 759-766
    • Ammoun, S.1    Schmid, M.C.2    Triner, J.3    Manley, P.4    Hanemann, C.O.5
  • 118
    • 84862117864 scopus 로고    scopus 로고
    • Dermatofibrosarcoma protruberans treatment with platelet-derived growth factor receptor inhibitor: A review of clinical trial results
    • Dermatofibrosarcoma protruberans treatment with platelet-derived growth factor receptor inhibitor: a review of clinical trial results. Malhotra B, Schuetze SM, Curr Opin Oncol 2012 24 419 424
    • (2012) Curr Opin Oncol , vol.24 , pp. 419-424
    • Malhotra, B.1    Schuetze, S.M.2
  • 119
    • 38149075090 scopus 로고    scopus 로고
    • Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization assays
    • Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization assays. Patel KU, Szabo SS, Hernandez VS, Prieto VG, Abruzzo LV, Lazar AJ, Lopez-Terrada D, Hum Pathol 2008 39 184 193
    • (2008) Hum Pathol , vol.39 , pp. 184-193
    • Patel, K.U.1    Szabo, S.S.2    Hernandez, V.S.3    Prieto, V.G.4    Abruzzo, L.V.5    Lazar, A.J.6    Lopez-Terrada, D.7
  • 121
    • 0035421175 scopus 로고    scopus 로고
    • Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis
    • Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Sjöblom T, Shimizu A, O'Brien KP, Pietras K, Dal Cin P, Buchdunger E, Dumanski JP, Östman A, Heldin C-H, Cancer Res 2001 61 5778 5783 (Pubitemid 32769094)
    • (2001) Cancer Research , vol.61 , Issue.15 , pp. 5778-5783
    • Sjoblom, T.1    Shimizu, A.2    O'Brien, K.P.3    Pietras, K.4    Dal Cin, P.5    Buchdunger, E.6    Dumanski, J.P.7    Ostman, A.8    Heldin, C.-H.9
  • 122
    • 0036727124 scopus 로고    scopus 로고
    • Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
    • DOI 10.1200/JCO.2002.01.027
    • Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. Rubin BP, Schuetze SM, Eary JF, Norwood TH, Mirza S, Conrad EU, Bruckner JD, J Clin Oncol 2002 20 3586 3591 (Pubitemid 34983217)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.17 , pp. 3586-3591
    • Rubin, B.P.1    Schuetze, S.M.2    Eary, J.F.3    Norwood, T.H.4    Mirza, S.5    Conrad, E.U.6    Bruckner, J.D.7
  • 123
    • 18144401652 scopus 로고    scopus 로고
    • Imatinib mesylate: An attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans
    • DOI 10.1002/pbc.20249
    • Imatinib mesylate: an attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans. Price VE, Fletcher JA, Zielenska M, Cole W, Viero S, Manson DE, Stuart M, Pappo AS, Pediatr Blood Cancer 2005 44 511 515 (Pubitemid 40614501)
    • (2005) Pediatric Blood and Cancer , vol.44 , Issue.5 , pp. 511-515
    • Price, V.E.1    Fletcher, J.A.2    Zielenska, M.3    Cole, W.4    Viero, S.5    Manson, D.E.6    Stuart, M.7    Pappo, A.S.8
  • 124
    • 0037143794 scopus 로고    scopus 로고
    • Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans
    • DOI 10.1002/ijc.10535
    • Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR, Int J Cancer 2002 100 623 626 (Pubitemid 34832970)
    • (2002) International Journal of Cancer , vol.100 , Issue.6 , pp. 623-626
    • Maki, R.G.1    Awan, R.A.2    Dixon, R.H.3    Jhanwar, S.4    Antonescu, C.R.5
  • 125
    • 15944412898 scopus 로고    scopus 로고
    • Sustained complete remission of metastatic dermatofibrosarcoma protuberans with imatinib mesylate
    • DOI 10.1097/00001813-200504000-00014
    • Sustained complete remission of metastatic dermatofibrosarcoma protuberans with imatinib mesylate. Labropoulos SV, Fletcher JA, Oliveira AM, Papadopoulos S, Razis ED, Anti-cancer drugs 2005 16 461 466 (Pubitemid 40434613)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.4 , pp. 461-466
    • Labropoulos, S.V.1    Fletcher, J.A.2    Oliveira, A.M.3    Papadopoulos, S.4    Razis, E.D.5
  • 126
    • 4043068508 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the growth of metastatic lung lesions in a patient with dermatofibrosarcoma protuberans [3]
    • DOI 10.1111/j.1365-2133.2004.06024.x
    • Imatinib mesylate inhibits the growth of metastatic lung lesions in a patient with dermatofibrosarcoma protuberans. Mizutani K, Tamada Y, Hara K, Tsuzuki T, Saeki H, Tamaki K, Matsumoto Y, Br J Dermatol 2004 151 235 237 (Pubitemid 39061309)
    • (2004) British Journal of Dermatology , vol.151 , Issue.1 , pp. 235-237
    • Mizutani, K.1    Tamada, Y.2    Hara, K.3    Tsuzuki, T.4    Saeki, H.5    Tamaki, K.6    Matsumoto, Y.7
  • 128
    • 52049089936 scopus 로고    scopus 로고
    • Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases
    • Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases. Heinrich MC, Joensuu H, Demetri GD, Corless CL, Apperley J, Fletcher JA, Soulieres D, Dirnhofer S, Harlow A, Town A, et al. Clin Cancer Res 2008 14 2717 2725
    • (2008) Clin Cancer Res , vol.14 , pp. 2717-2725
    • Heinrich, M.C.1    Joensuu, H.2    Demetri, G.D.3    Corless, C.L.4    Apperley, J.5    Fletcher, J.A.6    Soulieres, D.7    Dirnhofer, S.8    Harlow, A.9    Town, A.10
  • 139
    • 0021678482 scopus 로고
    • Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation
    • Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation. Betsholtz C, Westermark B, Ek B, Heldin C-H, Cell 1984 39 447 457 (Pubitemid 15198584)
    • (1984) Cell , vol.39 , Issue.3 , pp. 447-457
    • Betsholtz, C.1    Westermark, B.2    Ek, B.3    Heldin, C.-H.4
  • 141
    • 0028012103 scopus 로고
    • Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: An immunohistochemical and in situ hybridization study
    • Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: an immunohistochemical and in situ hybridization study. Wang J, Coltrera MD, Gown AM, Cancer Res 1994 54 560 564
    • (1994) Cancer Res , vol.54 , pp. 560-564
    • Wang, J.1    Coltrera, M.D.2    Gown, A.M.3
  • 142
    • 43049095679 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma
    • DOI 10.1002/cncr.23437
    • Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. Kubo T, Piperdi S, Rosenblum J, Antonescu CR, Chen W, Kim HS, Huvos AG, Sowers R, Meyers PA, Healey JH, Gorlick R, Cancer 2008 112 2119 2129 (Pubitemid 351628620)
    • (2008) Cancer , vol.112 , Issue.10 , pp. 2119-2129
    • Kubo, T.1    Piperdi, S.2    Rosenblum, J.3    Antonescu, C.R.4    Chen, W.5    Kim, H.-S.6    Huvos, A.G.7    Sowers, R.8    Meyers, P.A.9    Healey, J.H.10    Gorlick, R.11
  • 143
    • 84865722534 scopus 로고    scopus 로고
    • PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: Implications for combination targeted therapy of synovial sarcoma
    • PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma. Ho AL, Vasudeva SD, Lae M, Saito T, Barbashina V, Antonescu CR, Ladanyi M, Schwartz GK, Cancer Res 2012 72 4515 4525
    • (2012) Cancer Res , vol.72 , pp. 4515-4525
    • Ho, A.L.1    Vasudeva, S.D.2    Lae, M.3    Saito, T.4    Barbashina, V.5    Antonescu, C.R.6    Ladanyi, M.7    Schwartz, G.K.8
  • 144
    • 0037198637 scopus 로고    scopus 로고
    • Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines
    • DOI 10.1038/sj/onc/1205486
    • Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. Zwerner JP, May WA, Oncogene 2002 21 3847 3854 (Pubitemid 34620852)
    • (2002) Oncogene , vol.21 , Issue.24 , pp. 3847-3854
    • Zwerner, J.P.1    May, W.A.2
  • 147
    • 32044469857 scopus 로고    scopus 로고
    • Rhabdomyosarcomas utilize developmental, myogenic growth factors for disease advantage: A report from the children's oncology group
    • DOI 10.1002/pbc.20466
    • Rhabdomyosarcomas utilize developmental, myogenic growth factors for disease advantage: a report from the children's oncology group. Blandford MC, Barr FG, Lynch JC, Randall RL, Qualman SJ, Keller C, Pediatr Blood Cancer 2006 46 329 338 (Pubitemid 43201849)
    • (2006) Pediatric Blood and Cancer , vol.46 , Issue.3 , pp. 329-338
    • Blandford, M.C.1    Barr, F.G.2    Lynch, J.C.3    Randall, R.L.4    Qualman, S.J.5    Keller, C.6
  • 148
    • 36049018288 scopus 로고    scopus 로고
    • Expression of receptor tyrosine kinases and apoptotic molecules in rhabdomyosarcoma: Correlation with overall survival in 105 patients
    • DOI 10.1002/cncr.23038
    • Expression of receptor tyrosine kinases and apoptotic molecules in rhabdomyosarcoma: correlation with overall survival in 105 patients. Armistead PM, Salganick J, Roh JS, Steinert DM, Patel S, Munsell M, El-Naggar AK, Benjamin RS, Zhang W, Trent JC, Cancer 2007 110 2293 2303 (Pubitemid 350100752)
    • (2007) Cancer , vol.110 , Issue.10 , pp. 2293-2303
    • Armistead, P.M.1    Salganick, J.2    Roh, J.S.3    Steinert, D.M.4    Patel, S.5    Munsell, M.6    El-Naggar, A.K.7    Benjamin, R.S.8    Zhang, W.9    Trent, J.C.10
  • 152
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • DOI 10.1016/0092-8674(94)90322-0
    • Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t (5;12) chromosomal translocation. Golub TR, Barker GF, Lovett M, Gilliland DG, Cell 1994 77 307 316 (Pubitemid 24138627)
    • (1994) Cell , vol.77 , Issue.2 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gary Gilliland, D.4
  • 153
    • 0035889128 scopus 로고    scopus 로고
    • Rabaptin-5 is a novel fusion partner to platelet-derived growth factor β receptor in chronic myelomonocytic leukemia
    • Rabaptin-5 is a novel fusion partner to platelet-derived growth factor β receptor in chronic myelomonocytic leukemia. Magnusson MK, Meade KE, Brown KE, Arthur DC, Krueger LA, Barrett AJ, Dunbar CE, Blood 2001 98 2518 2525
    • (2001) Blood , vol.98 , pp. 2518-2525
    • Magnusson, M.K.1    Meade, K.E.2    Brown, K.E.3    Arthur, D.C.4    Krueger, L.A.5    Barrett, A.J.6    Dunbar, C.E.7
  • 154
    • 0033529599 scopus 로고    scopus 로고
    • Transforming properties of the Huntingtin interacting protein 1/platelet-derived growth factor beta receptor fusion protein
    • Transforming properties of the Huntingtin interacting protein 1/platelet-derived growth factor beta receptor fusion protein. Ross TS, Gilliland DG, J Biol Chem 1999 274 22328 22336
    • (1999) J Biol Chem , vol.274 , pp. 22328-22336
    • Ross, T.S.1    Gilliland, D.G.2
  • 155
    • 0035877975 scopus 로고    scopus 로고
    • H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t (5;10) (q33; Q22)
    • H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t (5;10) (q33; q22). Schwaller J, Anastasiadou E, Cain D, Kutok J, Wojiski S, Williams IR, LaStarza R, Crescenzi B, Sternberg DW, Andreasson P, et al. Blood 2001 97 3910 3918
    • (2001) Blood , vol.97 , pp. 3910-3918
    • Schwaller, J.1    Anastasiadou, E.2    Cain, D.3    Kutok, J.4    Wojiski, S.5    Williams, I.R.6    Lastarza, R.7    Crescenzi, B.8    Sternberg, D.W.9    Andreasson, P.10
  • 160
    • 79953091929 scopus 로고    scopus 로고
    • Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease
    • Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease. Elling C, Erben P, Walz C, Frickenhaus M, Schemionek M, Stehling M, Serve H, Cross NC, Hochhaus A, Hofmann WK, et al. Blood 2011 117 2935 2943
    • (2011) Blood , vol.117 , pp. 2935-2943
    • Elling, C.1    Erben, P.2    Walz, C.3    Frickenhaus, M.4    Schemionek, M.5    Stehling, M.6    Serve, H.7    Cross, N.C.8    Hochhaus, A.9    Hofmann, W.K.10
  • 161
    • 77951216988 scopus 로고    scopus 로고
    • Critical role of the platelet-derived growth factor receptor (PDGFR) β transmembrane domain in the TEL-PDGFRβ cytosolic oncoprotein
    • Critical role of the platelet-derived growth factor receptor (PDGFR) β transmembrane domain in the TEL-PDGFRβ cytosolic oncoprotein. Toffalini F, Hellberg C, Demoulin J-B, J Biol Chem 2010 285 12268 12278
    • (2010) J Biol Chem , vol.285 , pp. 12268-12278
    • Toffalini, F.1    Hellberg, C.2    Demoulin, J.-B.3
  • 165
    • 0038792233 scopus 로고    scopus 로고
    • Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness
    • Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Klion AD, Noel P, Akin C, Law MA, Gilliland DG, Cools J, Metcalfe DD, Nutman TB, Blood 2003 101 4660 4666 (Pubitemid 36857718)
    • (2003) Blood , vol.101 , Issue.12 , pp. 4660-4666
    • Klion, A.D.1    Noel, P.2    Akin, C.3    Law, M.A.4    Gilliland, D.G.5    Cools, J.6    Metcalfe, D.D.7    Nutman, T.B.8
  • 167
    • 34248569784 scopus 로고    scopus 로고
    • Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation
    • DOI 10.1158/0008-5472.CAN-06-4183
    • Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation. Buitenhuis M, Verhagen LP, Cools J, Coffer PJ, Cancer Res 2007 67 3759 3766 (Pubitemid 46762162)
    • (2007) Cancer Research , vol.67 , Issue.8 , pp. 3759-3766
    • Buitenhuis, M.1    Verhagen, L.P.2    Cools, J.3    Coffer, P.J.4
  • 168
    • 84862694326 scopus 로고    scopus 로고
    • ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: The role of nuclear factor-κB
    • ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of nuclear factor-κB. Montano-Almendras CP, Essaghir A, Schoemans H, Varis I, Noel LA, Velghe AI, Latinne D, Knoops L, Demoulin JB, Haematologica 2012 97 1064 1072
    • (2012) Haematologica , vol.97 , pp. 1064-1072
    • Montano-Almendras, C.P.1    Essaghir, A.2    Schoemans, H.3    Varis, I.4    Noel, L.A.5    Velghe, A.I.6    Latinne, D.7    Knoops, L.8    Demoulin, J.B.9
  • 170
    • 0037018763 scopus 로고    scopus 로고
    • Treatment of hypereosinophilic syndrome with imatinib mesilate
    • DOI 10.1016/S0140-6736(02)08505-7
    • Treatment of hypereosinophilic syndrome with imatinib mesilate. Gleich GJ, Leiferman KM, Pardanani A, Tefferi A, Butterfield JH, Lancet 2002 359 1577 1578 (Pubitemid 34621126)
    • (2002) Lancet , vol.359 , Issue.9317 , pp. 1577-1578
    • Gleich, G.J.1    Leiferman, K.M.2    Pardanani, A.3    Tefferi, A.4    Butterfield, J.H.5
  • 172
    • 0036063077 scopus 로고    scopus 로고
    • Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate
    • DOI 10.1016/S0145-2126(02)00046-2, PII S0145212602000462
    • Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate. Ault P, Cortes J, Koller C, Kaled ES, Kantarjian H, Leuk Res 2002 26 881 884 (Pubitemid 34790218)
    • (2002) Leukemia Research , vol.26 , Issue.9 , pp. 881-884
    • Ault, P.1    Cortes, J.2    Koller, C.3    Kaled, E.S.4    Kantarjian, H.5
  • 177
    • 79952004905 scopus 로고    scopus 로고
    • The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro
    • The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro. von Bubnoff N, Gorantla SP, Engh RA, Oliveira TM, Thone S, Aberg E, Peschel C, Duyster J, Oncogene 2011 30 933 943
    • (2011) Oncogene , vol.30 , pp. 933-943
    • Von Bubnoff, N.1    Gorantla, S.P.2    Engh, R.A.3    Oliveira, T.M.4    Thone, S.5    Aberg, E.6    Peschel, C.7    Duyster, J.8
  • 178
    • 0025721123 scopus 로고
    • Platelet-derived growth factor is a potent biologic response modifier of T cells
    • Platelet-derived growth factor is a potent biologic response modifier of T cells. Daynes RA, Dowell T, Araneo BA, J Exp Med 1991 174 1323 1333
    • (1991) J Exp Med , vol.174 , pp. 1323-1333
    • Daynes, R.A.1    Dowell, T.2    Araneo, B.A.3
  • 179
    • 0025810898 scopus 로고
    • Inhibition of human natural killer cell activity by platelet-derived growth factor (PDGF): III membrane binding studies and differential biological effect of recombinant PDGF isoforms
    • Inhibition of human natural killer cell activity by platelet-derived growth factor (PDGF): III membrane binding studies and differential biological effect of recombinant PDGF isoforms. Gersuk GM, Westermark B, Mohabeer AJ, Challita PM, Pattamakom S, Pattengale PK, Scand J Immunol 1991 33 521 532
    • (1991) Scand J Immunol , vol.33 , pp. 521-532
    • Gersuk, G.M.1    Westermark, B.2    Mohabeer, A.J.3    Challita, P.M.4    Pattamakom, S.5    Pattengale, P.K.6
  • 186
    • 77957902732 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
    • Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. Kong D, Banerjee S, Ahmad A, Li Y, Wang Z, Sethi S, Sarkar FH, PLoS One 2010 5 12445
    • (2010) PLoS One , vol.5 , pp. 512445
    • Kong, D.1    Banerjee, S.2    Ahmad, A.3    Li, Y.4    Wang, Z.5    Sethi, S.6    Sarkar, F.H.7
  • 187
    • 84865304366 scopus 로고    scopus 로고
    • Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer
    • Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer. Najy AJ, Won JJ, Movilla LS, Kim HR, Mol Cancer Res 2012 10 1087 1097
    • (2012) Mol Cancer Res , vol.10 , pp. 1087-1097
    • Najy, A.J.1    Won, J.J.2    Movilla, L.S.3    Kim, H.R.4
  • 189
    • 33846692221 scopus 로고    scopus 로고
    • Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the α-platelet-derived growth factor receptor
    • DOI 10.1158/0008-5472.CAN-06-2593
    • Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor. Dolloff NG, Russell MR, Loizos N, Fatatis A, Cancer Res 2007 67 555 562 (Pubitemid 46192192)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 555-562
    • Dolloff, N.G.1    Russell, M.R.2    Loizos, N.3    Fatatis, A.4
  • 190
    • 59649103684 scopus 로고    scopus 로고
    • The receptor for platelet-derived growth factor as a target for antibody-mediated inhibition of skeletal metastases from prostate cancer cells
    • The receptor for platelet-derived growth factor as a target for antibody-mediated inhibition of skeletal metastases from prostate cancer cells. Russell MR, Jamieson WL, Dolloff NG, Fatatis A, Oncogene 2009 28 412 421
    • (2009) Oncogene , vol.28 , pp. 412-421
    • Russell, M.R.1    Jamieson, W.L.2    Dolloff, N.G.3    Fatatis, A.4
  • 191
    • 79957912758 scopus 로고    scopus 로고
    • Inhibition of prostate cancer using RNA interference-directed knockdown of platelet-derived growth factor receptor
    • e1509-1515
    • Inhibition of prostate cancer using RNA interference-directed knockdown of platelet-derived growth factor receptor. Park YH, Seo SY, Ha M, Ku JH, Kim HH, Kwak C, Urology 2011 77 1509 e1509-1515
    • (2011) Urology , vol.77 , pp. 1509
    • Park, Y.H.1    Seo, S.Y.2    Ha, M.3    Ku, J.H.4    Kim, H.H.5    Kwak, C.6
  • 192
    • 77952850723 scopus 로고    scopus 로고
    • The receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms
    • The receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms. Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A, Cancer Res 2010 70 4195 4203
    • (2010) Cancer Res , vol.70 , pp. 4195-4203
    • Russell, M.R.1    Liu, Q.2    Lei, H.3    Kazlauskas, A.4    Fatatis, A.5
  • 194
    • 3042523539 scopus 로고    scopus 로고
    • Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice
    • DOI 10.1158/0008-5472.CAN-03-3763
    • Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice. Kim SJ, Uehara H, Yazici S, Langley RR, He J, Tsan R, Fan D, Killion JJ, Fidler IJ, Cancer Res 2004 64 4201 4208 (Pubitemid 38802424)
    • (2004) Cancer Research , vol.64 , Issue.12 , pp. 4201-4208
    • Kim, S.J.1    Uehara, H.2    Yazici, S.3    Langley, R.R.4    He, J.5    Tsan, R.6    Fan, D.7    Killion, J.J.8    Fidler, I.J.9
  • 195
    • 4344717475 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel: A modular phase I trial in androgen-independent prostate cancer
    • DOI 10.1200/JCO.2004.10.116
    • Platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel: a modular phase I trial in androgen-independent prostate cancer. Mathew P, Thall PF, Jones D, Perez C, Bucana C, Troncoso P, Kim SJ, Fidler IJ, Logothetis C, J Clin Oncol 2004 22 3323 3329 (Pubitemid 41103689)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.16 , pp. 3323-3329
    • Mathew, P.1    Thall, P.F.2    Jones, D.3    Perez, C.4    Bucana, C.5    Troncoso, P.6    Kim, S.-J.7    Fidler, I.J.8    Logothetis, C.9
  • 197
    • 55249099055 scopus 로고    scopus 로고
    • Dynamic change in phosphorylated platelet-derived growth factor receptor in peripheral blood leukocytes following docetaxel therapy predicts progression-free and overall survival in prostate cancer
    • Dynamic change in phosphorylated platelet-derived growth factor receptor in peripheral blood leukocytes following docetaxel therapy predicts progression-free and overall survival in prostate cancer. Mathew P, Thall PF, Wen S, Bucana C, Jones D, Horne E, Oh WK, Morris MJ, Lee YC, Logothetis CJ, et al. Br J Cancer 2008 99 1426 1432
    • (2008) Br J Cancer , vol.99 , pp. 1426-1432
    • Mathew, P.1    Thall, P.F.2    Wen, S.3    Bucana, C.4    Jones, D.5    Horne, E.6    Oh, W.K.7    Morris, M.J.8    Lee, Y.C.9    Logothetis, C.J.10
  • 200
    • 34249028607 scopus 로고    scopus 로고
    • PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression
    • DOI 10.1038/sj.onc.1210121, PII 1210121
    • PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression. Fischer AN, Fuchs E, Mikula M, Huber H, Beug H, Mikulits W, Oncogene 2007 26 3395 3405 (Pubitemid 46788880)
    • (2007) Oncogene , vol.26 , Issue.23 , pp. 3395-3405
    • Fischer, A.N.M.1    Fuchs, E.2    Mikula, M.3    Huber, H.4    Beug, H.5    Mikulits, W.6
  • 202
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, et al. Lancet Oncol 2009 10 25 34
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3    Tsao, C.J.4    Qin, S.5    Kim, J.S.6    Luo, R.7    Feng, J.8    Ye, S.9    Yang, T.S.10
  • 207
    • 0030725954 scopus 로고    scopus 로고
    • Expression in lung carcinomas of platelet-derived growth factor and its receptors
    • Expression in lung carcinomas of platelet-derived growth factor and its receptors. Kawai T, Hiroi S, Torikata C, Lab Invest 1997 77 431 436 (Pubitemid 27508614)
    • (1997) Laboratory Investigation , vol.77 , Issue.5 , pp. 431-436
    • Kawai, T.1    Hiroi, S.2    Torikata, C.3
  • 208
    • 0027535962 scopus 로고
    • Expression of functionally intact PDGF-α receptors in highly metastatic 3LL Lewis lung carcinoma cells
    • DOI 10.1002/ijc.2910530224
    • Expression of functionally intact PDGF receptors in highly metastatic 3LL Lewis lung carcinoma cells. Fitzer-Attas C, Feldman M, Eisenbach L, Int J Cancer 1993 53 315 322 (Pubitemid 23042885)
    • (1993) International Journal of Cancer , vol.53 , Issue.2 , pp. 315-322
    • Fitzer-Attas, C.1    Feldman, M.2    Eisenbach, L.3
  • 209
    • 0026594044 scopus 로고
    • Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products
    • Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Antoniades HN, Galanopoulos T, Neville-Golden J, O'Hara CJ, Proc Natl Acad Sci USA 1992 89 3942 3946
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3942-3946
    • Antoniades, H.N.1    Galanopoulos, T.2    Neville-Golden, J.3    O'Hara, C.J.4
  • 210
    • 80155161298 scopus 로고    scopus 로고
    • Immunohistochemical overexpression of platelet-derived growth factor receptor-beta (PDGFR-β) is associated with PDGFRB gene copy number gain in sarcomatoid non-small-cell lung cancer
    • Immunohistochemical overexpression of platelet-derived growth factor receptor-beta (PDGFR-β) is associated with PDGFRB gene copy number gain in sarcomatoid non-small-cell lung cancer. Tsao AS, Wei W, Kuhn E, Spencer L, Solis LM, Suraokar M, Lee JJ, Hong WK, Wistuba II, Clin Lung Cancer 2011 12 369 374
    • (2011) Clin Lung Cancer , vol.12 , pp. 369-374
    • Tsao, A.S.1    Wei, W.2    Kuhn, E.3    Spencer, L.4    Solis, L.M.5    Suraokar, M.6    Lee, J.J.7    Hong, W.K.8    Wistuba, I.I.9
  • 211
    • 58149106094 scopus 로고    scopus 로고
    • Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
    • Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells. Donnem T, Al-Saad S, Al-Shibli K, Andersen S, Busund LT, Bremnes RM, J Thorac Oncol 2008 3 963 970
    • (2008) J Thorac Oncol , vol.3 , pp. 963-970
    • Donnem, T.1    Al-Saad, S.2    Al-Shibli, K.3    Andersen, S.4    Busund, L.T.5    Bremnes, R.M.6
  • 212
    • 84877794872 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor receptor by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancer
    • Inhibition of platelet-derived growth factor receptor by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancer. Laing N, McDermott B, Wen S, Yang D, Lawson D, Collins M, Reimer C, Hall PA, Andersen H, Snaith M, et al. Mol Pharmacol 2013 83 1247 1256
    • (2013) Mol Pharmacol , vol.83 , pp. 1247-1256
    • Laing, N.1    McDermott, B.2    Wen, S.3    Yang, D.4    Lawson, D.5    Collins, M.6    Reimer, C.7    Hall, P.A.8    Andersen, H.9    Snaith, M.10
  • 215
    • 79960295130 scopus 로고    scopus 로고
    • Sunitinib in pretreated advanced non-small-cell lung carcinoma: A primary result from Asian population
    • Sunitinib in pretreated advanced non-small-cell lung carcinoma: a primary result from Asian population. Ping G, Hui-Min W, Wei-Min W, Bao-Hui H, Med Oncol 2011 28 578 583
    • (2011) Med Oncol , vol.28 , pp. 578-583
    • Ping, G.1    Hui-Min, W.2    Wei-Min, W.3    Bao-Hui, H.4
  • 216
    • 0029978211 scopus 로고    scopus 로고
    • Localization of platelet-derived growth factor β receptor expression in the periepithelial stroma of human breast carcinoma
    • Localization of platelet-derived growth factor β receptor expression in the periepithelial stroma of human breast carcinoma. Bhardwaj B, Klassen J, Cossette N, Sterns E, Tuck A, Deeley R, Sengupta S, Elliott B, Clin Cancer Res 1996 2 773 782 (Pubitemid 26135343)
    • (1996) Clinical Cancer Research , vol.2 , Issue.4 , pp. 773-782
    • Bhardwaj, B.1    Klassen, J.2    Cossette, N.3    Sterns, E.4    Tuck, A.5    Deeley, R.6    Sengupta, S.7    Elliott, B.8
  • 217
    • 0029039982 scopus 로고
    • Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor β subunit in human breast tissue and breast carcinoma
    • Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor β subunit in human breast tissue and breast carcinoma. Coltrera MD, Wang J, Porter PL, Gown AM, Cancer Res 1995 55 2703 2708
    • (1995) Cancer Res , vol.55 , pp. 2703-2708
    • Coltrera, M.D.1    Wang, J.2    Porter, P.L.3    Gown, A.M.4
  • 218
    • 0027997909 scopus 로고
    • Positive immunostaining for platelet derived growth factor (PDGF) is an adverse prognostic factor in patients with advanced breast cancer
    • DOI 10.1007/BF00665774
    • Positive immunostaining for platelet derived growth factor (PDGF) is an adverse prognostic factor in patients with advanced breast cancer. Seymour L, Bezwoda WR, Breast Cancer Res Treat 1994 32 229 233 (Pubitemid 24313348)
    • (1994) Breast Cancer Research and Treatment , vol.32 , Issue.2 , pp. 229-233
    • Seymour, L.1    Bezwoda, W.R.2
  • 219
    • 33644873490 scopus 로고    scopus 로고
    • Overexpression of platelet-derived growth factor receptor in breast cancer is associated with tumour progression
    • Overexpression of platelet-derived growth factor receptor in breast cancer is associated with tumour progression. Carvalho I, Milanezi F, Martins A, Reis RM, Schmitt F, Breast Cancer Res 2005 7 788 R795
    • (2005) Breast Cancer Res , vol.7
    • Carvalho, I.1    Milanezi, F.2    Martins, A.3    Reis, R.M.4    Schmitt, F.5
  • 220
    • 80655139160 scopus 로고    scopus 로고
    • Mammary tumors that become independent of the type i insulin-like growth factor receptor express elevated levels of platelet-derived growth factor receptors
    • Mammary tumors that become independent of the type I insulin-like growth factor receptor express elevated levels of platelet-derived growth factor receptors. Campbell CI, Moorehead RA, BMC cancer 2011 11 480
    • (2011) BMC Cancer , vol.11 , pp. 480
    • Campbell, C.I.1    Moorehead, R.A.2
  • 222
    • 84863209310 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in breast cancer lines is mediated through PDGF-D released by tissue-resident stem cells
    • Epithelial-mesenchymal transition in breast cancer lines is mediated through PDGF-D released by tissue-resident stem cells. Devarajan E, Song YH, Krishnappa S, Alt E, Int J Cancer 2012 131 1023 1031
    • (2012) Int J Cancer , vol.131 , pp. 1023-1031
    • Devarajan, E.1    Song, Y.H.2    Krishnappa, S.3    Alt, E.4
  • 223
    • 84861112214 scopus 로고    scopus 로고
    • Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer
    • Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer. Weigel MT, Ghazoui Z, Dunbier A, Pancholi S, Dowsett M, Martin LA, Breast Cancer Res 2012 14 78
    • (2012) Breast Cancer Res , vol.14 , pp. 1878
    • Weigel, M.T.1    Ghazoui, Z.2    Dunbier, A.3    Pancholi, S.4    Dowsett, M.5    Martin, L.A.6
  • 224
    • 0027723524 scopus 로고
    • Stromal expression of platelet-derived growth factor β-receptor and platelet-derived growth factor B-chain in colorectal cancer
    • Stromal expression of platelet-derived growth factor β-receptor and platelet-derived growth factor B-chain in colorectal cancer. Lindmark G, Sundberg C, Glimelius B, Påhlman L, Rubin K, Gerdin B, Lab Invest 1993 69 682 689 (Pubitemid 24026849)
    • (1993) Laboratory Investigation , vol.69 , Issue.6 , pp. 682-689
    • Lindmark, G.1    Sundberg, C.2    Glimelius, B.3    Pahlman, L.4    Rubin, K.5    Gerdin, B.6
  • 225
    • 0027744498 scopus 로고
    • Microvascular pericytes express platelet-derived growth factor-β receptors in human healing wounds and colorectal adenocarcinoma
    • Microvascular pericytes express platelet-derived growth factor-β receptors in human healing wounds and colorectal adenocarcinoma. Sundberg C, Ljungström M, Lindmark G, Gerdin B, Rubin K, Am J Pathol 1993 143 1377 1388 (Pubitemid 24057108)
    • (1993) American Journal of Pathology , vol.143 , Issue.5 , pp. 1377-1388
    • Sundberg, C.1    Ljungstrom, M.2    Lindmark, G.3    Gerdin, B.4    Rubin, K.5
  • 228
    • 33750622812 scopus 로고    scopus 로고
    • Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential
    • DOI 10.1002/ijc.22229
    • Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential. Kitadai Y, Sasaki T, Kuwai T, Nakamura T, Bucana CD, Hamilton SR, Fidler IJ, Int J Cancer 2006 119 2567 2574 (Pubitemid 44691309)
    • (2006) International Journal of Cancer , vol.119 , Issue.11 , pp. 2567-2574
    • Kitadai, Y.1    Sasaki, T.2    Kuwai, T.3    Nakamura, T.4    Bucana, C.D.5    Hamilton, S.R.6    Fidler, I.J.7
  • 231
    • 77950427275 scopus 로고    scopus 로고
    • Expression and prognostic value of platelet-derived growth factor-AA and its receptor in nephroblastoma
    • Expression and prognostic value of platelet-derived growth factor-AA and its receptor in nephroblastoma. Ghanem M, Nijman R, Safan M, van der Kwast T, Vansteenbrugge G, BJU Int 2010 106 1389 1393
    • (2010) BJU Int , vol.106 , pp. 1389-1393
    • Ghanem, M.1    Nijman, R.2    Safan, M.3    Van Der Kwast, T.4    Vansteenbrugge, G.5
  • 232
    • 0027488086 scopus 로고
    • Tissue platelet derived-growth factor (PDGF) predicts for shortened survival and treatment failure in advanced breast cancer
    • DOI 10.1007/BF00665802
    • Tissue platelet derived-growth factor (PDGF) predicts for shortened survival and treatment failure in advanced breast cancer. Seymour L, Dajee D, Bezwoda WR, Breast Cancer Res Treat 1993 26 247 252 (Pubitemid 23304240)
    • (1993) Breast Cancer Research and Treatment , vol.26 , Issue.3 , pp. 247-252
    • Seymour, L.1    Dajee, D.2    Bezwoda, W.R.3
  • 233
    • 0027365546 scopus 로고
    • Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms
    • Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms. Henriksen R, Funa K, Wilander E, Bäckström T, Ridderheim M, Öberg K, Cancer Res 1993 53 4550 4554 (Pubitemid 23304378)
    • (1993) Cancer Research , vol.53 , Issue.18 , pp. 4550-4554
    • Henriksen, R.1    Funa, K.2    Wilander, E.3    Backstrom, T.4    Ridderheim, M.5    Oberg, K.6
  • 234
    • 0028919501 scopus 로고
    • Usefulness of platelet-derived growth factor as a prognostic factor in pulmonary adenocarcinoma
    • Usefulness of platelet-derived growth factor as a prognostic factor in pulmonary adenocarcinoma. Takanami I, Imamura T, Yamamoto Y, Kodaira S, J Surg Oncol 1995 58 40 43
    • (1995) J Surg Oncol , vol.58 , pp. 40-43
    • Takanami, I.1    Imamura, T.2    Yamamoto, Y.3    Kodaira, S.4
  • 235
    • 0027258968 scopus 로고
    • Human neuroblastoma cells express α and β platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling
    • Human neuroblastoma cells express and β platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling. Matsui T, Sano K, Tsukamoto T, Ito M, Takaishi T, Nakata H, Nakamura H, Chihara K, J Clin Invest 1993 92 1153 1160 (Pubitemid 23273886)
    • (1993) Journal of Clinical Investigation , vol.92 , Issue.3 , pp. 1153-1160
    • Matsui, T.1    Sano, K.2    Tsukamoto, T.3    Ito, M.4    Takaishi, T.5    Nakata, H.6    Nakamura, H.7    Chihara, K.8
  • 237
    • 37549041711 scopus 로고    scopus 로고
    • A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A children's oncology group study
    • A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a children's oncology group study. Bond M, Bernstein ML, Pappo A, Schultz KR, Krailo M, Blaney SM, Adamson PC, Pediatr Blood Cancer 2008 50 254 258
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 254-258
    • Bond, M.1    Bernstein, M.L.2    Pappo, A.3    Schultz, K.R.4    Krailo, M.5    Blaney, S.M.6    Adamson, P.C.7
  • 242
    • 82355182817 scopus 로고    scopus 로고
    • Significantly high expression of platelet-derived growth factor (PDGF) in benign nodules of the thyroid: Relevance in the development of goitre recurrence?
    • Significantly high expression of platelet-derived growth factor (PDGF) in benign nodules of the thyroid: relevance in the development of goitre recurrence? Malkomes P, Oppermann E, Bechstein WO, Holzer K, Langenbecks Arch Surg 2011 396 1165 1172
    • (2011) Langenbecks Arch Surg , vol.396 , pp. 1165-1172
    • Malkomes, P.1    Oppermann, E.2    Bechstein, W.O.3    Holzer, K.4
  • 243
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • DOI 10.1056/NEJMra0706596
    • Tumor angiogenesis. Kerbel RS, N Engl J Med 2008 358 2039 2049 (Pubitemid 351656458)
    • (2008) New England Journal of Medicine , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 244
    • 34547637867 scopus 로고    scopus 로고
    • Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
    • DOI 10.1158/0008-5472.CAN-07-0293
    • Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Sennino B, Falcon BL, McCauley D, Le T, McCauley T, Kurz JC, Haskell A, Epstein DM, McDonald DM, Cancer Res 2007 67 7358 7367 (Pubitemid 47206566)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7358-7367
    • Sennino, B.1    Falcon, B.L.2    McCauley, D.3    Le, T.4    McCauley, T.5    Kurz, J.C.6    Haskell, A.7    Epstein, D.M.8    McDonald, D.M.9
  • 246
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, Menger MD, Ullrich A, Vajkoczy P, Faseb J 2004 18 338 340
    • (2004) Faseb J , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6    Menger, M.D.7    Ullrich, A.8    Vajkoczy, P.9
  • 247
  • 248
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • DOI 10.1172/JCI200317929
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D, J Clin Invest 2003 111 1287 1295 (Pubitemid 36554699)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 249
    • 81055124256 scopus 로고    scopus 로고
    • Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer
    • Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer. Taeger J, Moser C, Hellerbrand C, Mycielska ME, Glockzin G, Schlitt HJ, Geissler EK, Stoeltzing O, Lang SA, Mol Cancer Ther 2011 10 2157 2167
    • (2011) Mol Cancer Ther , vol.10 , pp. 2157-2167
    • Taeger, J.1    Moser, C.2    Hellerbrand, C.3    Mycielska, M.E.4    Glockzin, G.5    Schlitt, H.J.6    Geissler, E.K.7    Stoeltzing, O.8    Lang, S.A.9
  • 250
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, Kaminker J, Ferrara N, Cancer Cell 2009 15 21 34
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6    Kaminker, J.7    Ferrara, N.8
  • 252
    • 84871599135 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis
    • Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis. Ho IA, Toh HC, Ng WH, Teo YL, Guo CM, Hui KM, Lam PY, Stem Cells 2013 31 146 155
    • (2013) Stem Cells , vol.31 , pp. 146-155
    • Ho, I.A.1    Toh, H.C.2    Ng, W.H.3    Teo, Y.L.4    Guo, C.M.5    Hui, K.M.6    Lam, P.Y.7
  • 254
    • 77958178317 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: Implications for an angiogenic switch
    • Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic
    • (2010) Blood , vol.116 , pp. 2984-2993
    • Ding, W.1    Knox, T.R.2    Tschumper, R.C.3    Wu, W.4    Schwager, S.M.5    Boysen, J.C.6    Jelinek, D.F.7    Kay, N.E.8
  • 256
    • 77955950139 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma
    • Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma. Kodama M, Kitadai Y, Sumida T, Ohnishi M, Ohara E, Tanaka M, Shinagawa K, Tanaka S, Yasui W, Chayama K, Cancer Sci 2010 101 1984 1989
    • (2010) Cancer Sci , vol.101 , pp. 1984-1989
    • Kodama, M.1    Kitadai, Y.2    Sumida, T.3    Ohnishi, M.4    Ohara, E.5    Tanaka, M.6    Shinagawa, K.7    Tanaka, S.8    Yasui, W.9    Chayama, K.10
  • 258
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: Interactions with the tumor stroma
    • Hallmarks of cancer: interactions with the tumor stroma. Pietras K, Östman A, Exp Cell Res 2010 316 1324 1331
    • (2010) Exp Cell Res , vol.316 , pp. 1324-1331
    • Pietras, K.1    Östman, A.2
  • 259
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment. Hanahan D, Coussens LM, Cancer Cell 2012 21 309 322
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 262
    • 84877695000 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB accelerates prostate cancer growth by promoting the proliferation of mesenchymal stem cells
    • Platelet-derived growth factor-BB accelerates prostate cancer growth by promoting the proliferation of mesenchymal stem cells. Cheng J, Ye H, Liu Z, Xu C, Zhang Z, Liu Y, Sun Y, J Cell Biochem 2013 114 1510 1518
    • (2013) J Cell Biochem , vol.114 , pp. 1510-1518
    • Cheng, J.1    Ye, H.2    Liu, Z.3    Xu, C.4    Zhang, Z.5    Liu, Y.6    Sun, Y.7
  • 263
    • 0034618408 scopus 로고    scopus 로고
    • Human breast carcinoma desmoplasia is PDGF initiated
    • Human breast carcinoma desmoplasia is PDGF initiated. Shao Z-M, Nguyen M, Barsky SH, Oncogene 2000 19 4337 4345
    • (2000) Oncogene , vol.19 , pp. 4337-4345
    • Shao, Z.-M.1    Nguyen, M.2    Barsky, S.H.3
  • 264
    • 33646736321 scopus 로고    scopus 로고
    • Tumor-driven paracrine platelet-derived growth factor receptor signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma
    • Tumor-driven paracrine platelet-derived growth factor receptor signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma. Tejada ML, Yu L, Dong J, Jung K, Meng G, Peale FV, Frantz GD, Hall L, Liang X, Gerber HP, Ferrara N, Clin Cancer Res 2006 12 2676 2688
    • (2006) Clin Cancer Res , vol.12 , pp. 2676-2688
    • Tejada, M.L.1    Yu, L.2    Dong, J.3    Jung, K.4    Meng, G.5    Peale, F.V.6    Frantz, G.D.7    Hall, L.8    Liang, X.9    Gerber, H.P.10    Ferrara, N.11
  • 266
    • 58249095931 scopus 로고    scopus 로고
    • Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts
    • Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Anderberg C, Li H, Fredriksson L, Andrae J, Betsholtz C, Li X, Eriksson U, Pietras K, Cancer Res 2009 69 369 378
    • (2009) Cancer Res , vol.69 , pp. 369-378
    • Anderberg, C.1    Li, H.2    Fredriksson, L.3    Andrae, J.4    Betsholtz, C.5    Li, X.6    Eriksson, U.7    Pietras, K.8
  • 267
    • 84862319355 scopus 로고    scopus 로고
    • Paracrine signalling in colorectal liver metastases involving tumor cell-derived PDGF-C and hepatic stellate cell-derived PAK-2
    • Paracrine signalling in colorectal liver metastases involving tumor cell-derived PDGF-C and hepatic stellate cell-derived PAK-2. Bandapalli OR, Macher-Goeppinger S, Schirmacher P, Brand K, Clin Exp Metastasis 2012 29 409 417
    • (2012) Clin Exp Metastasis , vol.29 , pp. 409-417
    • Bandapalli, O.R.1    Macher-Goeppinger, S.2    Schirmacher, P.3    Brand, K.4
  • 268
    • 0037434985 scopus 로고    scopus 로고
    • PDGF-D is a potent transforming and angiogenic growth factor
    • DOI 10.1038/sj.onc.1206223
    • PDGF-D is a potent transforming and angiogenic growth factor. Li H, Fredriksson L, Li X, Eriksson U, Oncogene 2003 22 1501 1510 (Pubitemid 36390599)
    • (2003) Oncogene , vol.22 , Issue.10 , pp. 1501-1510
    • Li, H.1    Fredriksson, L.2    Li, X.3    Eriksson, U.4
  • 270
    • 77956281456 scopus 로고    scopus 로고
    • Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival
    • Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival. Hägglöf C, Hammarsten P, Josefsson A, Stattin P, Paulsson J, Bergh A, Östman A, PLoS One 2010 5 10747
    • (2010) PLoS One , vol.5 , pp. 510747
    • Hägglöf, C.1    Hammarsten, P.2    Josefsson, A.3    Stattin, P.4    Paulsson, J.5    Bergh, A.6    Östman, A.7
  • 272
    • 34547643983 scopus 로고    scopus 로고
    • Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
    • DOI 10.2353/ajpath.2006.060653
    • Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma. Kitadai Y, Sasaki T, Kuwai T, Nakamura T, Bucana CD, Fidler IJ, Am J Pathol 2006 169 2054 2065 (Pubitemid 351181965)
    • (2006) American Journal of Pathology , vol.169 , Issue.6 , pp. 2054-2065
    • Kitadai, Y.1    Sasaki, T.2    Kuwai, T.3    Nakamura, T.4    Bucana, C.D.5    Fidler, I.J.6
  • 273
    • 84867979311 scopus 로고    scopus 로고
    • PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker
    • PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker. Yuzawa S, Kano MR, Einama T, Nishihara H, Med Oncol 2012 29 2824 2830
    • (2012) Med Oncol , vol.29 , pp. 2824-2830
    • Yuzawa, S.1    Kano, M.R.2    Einama, T.3    Nishihara, H.4
  • 274
    • 0035297541 scopus 로고    scopus 로고
    • Ihibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
    • Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Pietras K, Östman A, Sjöquist M, Buchdunger E, Reed RK, Heldin C-H, Rubin K, Cancer Res 2001 61 2929 2934 (Pubitemid 32691937)
    • (2001) Cancer Research , vol.61 , Issue.7 , pp. 2929-2934
    • Pietras, K.1    Ostman, A.2    Sjoquist, M.3    Buchdunger, E.4    Reed, R.K.5    Heldin, C.-H.6    Rubin, K.7
  • 276
    • 79959384972 scopus 로고    scopus 로고
    • Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B
    • Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B. Falcon BL, Pietras K, Chou J, Chen D, Sennino B, Hanahan D, McDonald DM, Am J Pathol 2011 178 2920 2930
    • (2011) Am J Pathol , vol.178 , pp. 2920-2930
    • Falcon, B.L.1    Pietras, K.2    Chou, J.3    Chen, D.4    Sennino, B.5    Hanahan, D.6    McDonald, D.M.7
  • 277
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • DOI 10.1158/0008-5472.CAN-04-0074
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK, Cancer Res 2004 64 3731 3736 (Pubitemid 38697278)
    • (2004) Cancer Research , vol.64 , Issue.11 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 281
    • 77956543006 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells
    • Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells. Kinoshita K, Nakagawa K, Hamada J, Hida Y, Tada M, Kondo S, Moriuchi T, Int J Oncol 2010 37 869 877
    • (2010) Int J Oncol , vol.37 , pp. 869-877
    • Kinoshita, K.1    Nakagawa, K.2    Hamada, J.3    Hida, Y.4    Tada, M.5    Kondo, S.6    Moriuchi, T.7
  • 283
    • 84871365780 scopus 로고    scopus 로고
    • Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
    • Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer. Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Onoyama M, Ohnishi M, Ohara E, Higashi Y, Tanaka S, Yasui W, Chayama K, Int J Cancer 2013 132 813 823
    • (2013) Int J Cancer , vol.132 , pp. 813-823
    • Shinagawa, K.1    Kitadai, Y.2    Tanaka, M.3    Sumida, T.4    Onoyama, M.5    Ohnishi, M.6    Ohara, E.7    Higashi, Y.8    Tanaka, S.9    Yasui, W.10    Chayama, K.11


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