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Volumn 37, Issue 8, 2011, Pages 611-617

Multitargeted receptor tyrosine kinase inhibition: An antiangiogenic strategy in non-small cell lung cancer

Author keywords

Angiogenesis; FGFR; NSCLC; PDGFR; TKIs; VEGFR

Indexed keywords

AXITINIB; BEVACIZUMAB; BRIVANIB; CARBOPLATIN; CEDIRANIB; CISPLATIN; DOCETAXEL; ERLOTINIB; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; GEMCITABINE; INTEDANIB; LINIFANIB; MOTESANIB; PACLITAXEL; PAZOPANIB; PEMETREXED; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 80054063355     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2011.04.003     Document Type: Review
Times cited : (26)

References (85)
  • 2
    • 84857037076 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology™. Non-Small Cell Lung Cancer. V.2.2010. Available from: [accessed 8.4.2010].
    • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology™. Non-Small Cell Lung Cancer. V.2.2010. Available from: [accessed 8.4.2010]. http://www.nccn.org/professionals/physician_gls/PDF/nscl.pdf.
  • 3
    • 42049099094 scopus 로고    scopus 로고
    • Systemic chemotherapy for advanced non-small cell lung cancer: recent advances and future directions
    • Ramalingam S., Belani C. Systemic chemotherapy for advanced non-small cell lung cancer: recent advances and future directions. Oncologist 2008, 13(Suppl. 1):5-13.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 1 , pp. 5-13
    • Ramalingam, S.1    Belani, C.2
  • 4
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A., Gray R., Perry M.C., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355(24):2542-2550.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 5
    • 42049089207 scopus 로고    scopus 로고
    • Clinical evidence for second- and third-line treatment options in advanced non-small cell lung cancer
    • de Marinis F., Grossi F. Clinical evidence for second- and third-line treatment options in advanced non-small cell lung cancer. Oncologist 2008, 13(Suppl. 1):14-20.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 1 , pp. 14-20
    • de Marinis, F.1    Grossi, F.2
  • 6
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407(6801):249-257.
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 7
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J., Klagsbrun M. Angiogenic factors. Science 1987, 235(4787):442-447.
    • (1987) Science , vol.235 , Issue.4787 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 8
    • 0026639806 scopus 로고
    • Angiogenesis
    • Folkman J., Shing Y. Angiogenesis. J Biol Chem 1992, 267(16):10931-10934.
    • (1992) J Biol Chem , vol.267 , Issue.16 , pp. 10931-10934
    • Folkman, J.1    Shing, Y.2
  • 9
    • 0033179470 scopus 로고    scopus 로고
    • Molecular angiogenesis
    • Klagsbrun M., Moses M.A. Molecular angiogenesis. Chem Biol 1999, 6(8):R217-R224.
    • (1999) Chem Biol , vol.6 , Issue.8
    • Klagsbrun, M.1    Moses, M.A.2
  • 10
    • 0030498734 scopus 로고    scopus 로고
    • Angiogenesis and metastasis
    • Ellis L.M., Fidler I.J. Angiogenesis and metastasis. Eur J Cancer 1996, 32A(14):2451-2460.
    • (1996) Eur J Cancer , vol.32 A , Issue.14 , pp. 2451-2460
    • Ellis, L.M.1    Fidler, I.J.2
  • 11
    • 0035211504 scopus 로고    scopus 로고
    • Angiogenesis-dependent diseases
    • Folkman J. Angiogenesis-dependent diseases. Semin Oncol 2001, 28(6):536-542.
    • (2001) Semin Oncol , vol.28 , Issue.6 , pp. 536-542
    • Folkman, J.1
  • 12
    • 33344474964 scopus 로고    scopus 로고
    • Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    • Shibuya M., Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 2006, 312(5):549-560.
    • (2006) Exp Cell Res , vol.312 , Issue.5 , pp. 549-560
    • Shibuya, M.1    Claesson-Welsh, L.2
  • 13
    • 84857052343 scopus 로고    scopus 로고
    • Avastin® (bevacizumab) [package insert]. South San Francisco, CA: Genentech, Inc.
    • Avastin® (bevacizumab) [package insert]. South San Francisco, CA: Genentech, Inc.; 2009.
    • (2009)
  • 14
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson D.H., Fehrenbacher L., Novotny W.F., et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004, 22(11):2184-2191.
    • (2004) J Clin Oncol , vol.22 , Issue.11 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 15
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
    • Reck M., von P.J., Zatloukal P., et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 2010, 21(9):1804-1809.
    • (2010) Ann Oncol , vol.21 , Issue.9 , pp. 1804-1809
    • Reck, M.1    von, P.J.2    Zatloukal, P.3
  • 16
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R., Thurnher A., Katsen A.D., et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 2004, 18(2):338-340.
    • (2004) FASEB J , vol.18 , Issue.2 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 17
    • 34547100525 scopus 로고    scopus 로고
    • Dual targeting of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma
    • Lu C., Kamat A.A., Lin Y.G., et al. Dual targeting of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma. Clin Cancer Res 2007, 13(14):4209-4217.
    • (2007) Clin Cancer Res , vol.13 , Issue.14 , pp. 4209-4217
    • Lu, C.1    Kamat, A.A.2    Lin, Y.G.3
  • 18
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor T.T., Sorensen A.G., di T.E., et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007, 11(1):83-95.
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di, T.E.3
  • 19
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O., Hicklin D.J., Bergers G., Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005, 8(4):299-309.
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 20
    • 33748175142 scopus 로고    scopus 로고
    • Biology of platelet-derived growth factor and its involvement in disease
    • Alvarez R.H., Kantarjian H.M., Cortes J.E. Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 2006, 81(9):1241-1257.
    • (2006) Mayo Clin Proc , vol.81 , Issue.9 , pp. 1241-1257
    • Alvarez, R.H.1    Kantarjian, H.M.2    Cortes, J.E.3
  • 21
    • 0035003785 scopus 로고    scopus 로고
    • PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor
    • Bergsten E., Uutela M., Li X., et al. PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor. Nat Cell Biol 2001, 3(5):512-516.
    • (2001) Nat Cell Biol , vol.3 , Issue.5 , pp. 512-516
    • Bergsten, E.1    Uutela, M.2    Li, X.3
  • 22
    • 0028557063 scopus 로고
    • Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo
    • Oikawa T., Onozawa C., Sakaguchi M., Morita I., Murota S. Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo. Biol Pharm Bull 1994, 17(12):1686-1688.
    • (1994) Biol Pharm Bull , vol.17 , Issue.12 , pp. 1686-1688
    • Oikawa, T.1    Onozawa, C.2    Sakaguchi, M.3    Morita, I.4    Murota, S.5
  • 23
    • 0027082937 scopus 로고
    • Platelet-derived growth factor is angiogenic in vivo
    • Risau W., Drexler H., Mironov V., et al. Platelet-derived growth factor is angiogenic in vivo. Growth Factors 1992, 7(4):261-266.
    • (1992) Growth Factors , vol.7 , Issue.4 , pp. 261-266
    • Risau, W.1    Drexler, H.2    Mironov, V.3
  • 24
    • 39649096965 scopus 로고    scopus 로고
    • The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI
    • Robinson S.P., Ludwig C., Paulsson J., Ostman A. The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI. Int J Cancer 2008, 122(7):1548-1556.
    • (2008) Int J Cancer , vol.122 , Issue.7 , pp. 1548-1556
    • Robinson, S.P.1    Ludwig, C.2    Paulsson, J.3    Ostman, A.4
  • 25
    • 18544366585 scopus 로고    scopus 로고
    • Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    • Enge M., Bjarnegard M., Gerhardt H., et al. Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J 2002, 21(16):4307-4316.
    • (2002) EMBO J , vol.21 , Issue.16 , pp. 4307-4316
    • Enge, M.1    Bjarnegard, M.2    Gerhardt, H.3
  • 26
    • 0035972251 scopus 로고    scopus 로고
    • Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    • Hellstrom M., Gerhardt H., Kalen M., et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 2001, 153(3):543-553.
    • (2001) J Cell Biol , vol.153 , Issue.3 , pp. 543-553
    • Hellstrom, M.1    Gerhardt, H.2    Kalen, M.3
  • 27
    • 0032768156 scopus 로고    scopus 로고
    • Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    • Hellstrom M., Kalen M., Lindahl P., Abramsson A., Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 1999, 126(14):3047-3055.
    • (1999) Development , vol.126 , Issue.14 , pp. 3047-3055
    • Hellstrom, M.1    Kalen, M.2    Lindahl, P.3    Abramsson, A.4    Betsholtz, C.5
  • 28
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • Lindahl P., Johansson B.R., Leveen P., Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997, 277(5323):242-245.
    • (1997) Science , vol.277 , Issue.5323 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 29
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    • Abramsson A., Lindblom P., Betsholtz C. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 2003, 112(8):1142-1151.
    • (2003) J Clin Invest , vol.112 , Issue.8 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 30
    • 0346727319 scopus 로고    scopus 로고
    • What brings pericytes to tumor vessels?
    • Jain R.K., Booth M.F. What brings pericytes to tumor vessels?. J Clin Invest 2003, 112(8):1134-1136.
    • (2003) J Clin Invest , vol.112 , Issue.8 , pp. 1134-1136
    • Jain, R.K.1    Booth, M.F.2
  • 31
    • 3543002277 scopus 로고    scopus 로고
    • VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis
    • Dong J., Grunstein J., Tejada M., et al. VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J 2004, 23(14):2800-2810.
    • (2004) EMBO J , vol.23 , Issue.14 , pp. 2800-2810
    • Dong, J.1    Grunstein, J.2    Tejada, M.3
  • 32
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003, 111(9):1287-1295.
    • (2003) J Clin Invest , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 33
    • 33749441325 scopus 로고    scopus 로고
    • Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    • Mancuso M.R., Davis R., Norberg S.M., et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 2006, 116(10):2610-2621.
    • (2006) J Clin Invest , vol.116 , Issue.10 , pp. 2610-2621
    • Mancuso, M.R.1    Davis, R.2    Norberg, S.M.3
  • 34
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin L.E., Hemo I., Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 1998, 125(9):1591-1598.
    • (1998) Development , vol.125 , Issue.9 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 35
    • 0035347301 scopus 로고    scopus 로고
    • Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival
    • Reinmuth N., Liu W., Jung Y.D., et al. Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival. FASEB J 2001, 15(7):1239-1241.
    • (2001) FASEB J , vol.15 , Issue.7 , pp. 1239-1241
    • Reinmuth, N.1    Liu, W.2    Jung, Y.D.3
  • 36
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin L.E., Golijanin D., Itin A., Pode D., Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999, 103(2):159-165.
    • (1999) J Clin Invest , vol.103 , Issue.2 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 37
    • 1642321880 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy
    • Wilkinson-Berka J.L., Babic S., De G.T., et al. Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy. Am J Pathol 2004, 164(4):1263-1273.
    • (2004) Am J Pathol , vol.164 , Issue.4 , pp. 1263-1273
    • Wilkinson-Berka, J.L.1    Babic, S.2    De, G.T.3
  • 38
    • 69249216604 scopus 로고    scopus 로고
    • The role of fibroblast growth factors in tumor growth
    • Korc M., Friesel R.E. The role of fibroblast growth factors in tumor growth. Curr Cancer Drug Targets 2009, 9(5):639-651.
    • (2009) Curr Cancer Drug Targets , vol.9 , Issue.5 , pp. 639-651
    • Korc, M.1    Friesel, R.E.2
  • 40
    • 41949092558 scopus 로고    scopus 로고
    • Fibroblast growth factor regulation of neovascularization
    • Murakami M., Simons M. Fibroblast growth factor regulation of neovascularization. Curr Opin Hematol 2008, 15(3):215-220.
    • (2008) Curr Opin Hematol , vol.15 , Issue.3 , pp. 215-220
    • Murakami, M.1    Simons, M.2
  • 41
    • 34948905351 scopus 로고    scopus 로고
    • Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
    • Nissen L.J., Cao R., Hedlund E.M., et al. Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest 2007, 117(10):2766-2777.
    • (2007) J Clin Invest , vol.117 , Issue.10 , pp. 2766-2777
    • Nissen, L.J.1    Cao, R.2    Hedlund, E.M.3
  • 42
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge S.R., Kendrew J., Hennequin L.F., et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005, 65(10):4389-4400.
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 43
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M., LeJeune S., Scott P.A., et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997, 57(5):963-969.
    • (1997) Cancer Res , vol.57 , Issue.5 , pp. 963-969
    • Relf, M.1    LeJeune, S.2    Scott, P.A.3
  • 44
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008, 8(8):592-603.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 45
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis L.M., Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008, 8(8):579-591.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 46
    • 42549173671 scopus 로고    scopus 로고
    • The potential of anti-vascular endothelial growth factor therapy in metastatic breast cancer: clinical experience with anti-angiogenic agents, focusing on bevacizumab
    • Marty M., Pivot X. The potential of anti-vascular endothelial growth factor therapy in metastatic breast cancer: clinical experience with anti-angiogenic agents, focusing on bevacizumab. Eur J Cancer 2008, 44(7):912-920.
    • (2008) Eur J Cancer , vol.44 , Issue.7 , pp. 912-920
    • Marty, M.1    Pivot, X.2
  • 47
    • 33745325007 scopus 로고    scopus 로고
    • Mechanisms of drug inhibition of signalling molecules
    • Sebolt-Leopold J.S., English J.M. Mechanisms of drug inhibition of signalling molecules. Nature 2006, 441(7092):457-462.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 457-462
    • Sebolt-Leopold, J.S.1    English, J.M.2
  • 48
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64(19):7099-7109.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 49
    • 34147161209 scopus 로고    scopus 로고
    • Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)
    • Murphy D.A., Makonnen S., Lassoued W., Feldman M.D., Carter C., Lee W.M. Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006, 169(5):1875-1885.
    • (2006) Am J Pathol , vol.169 , Issue.5 , pp. 1875-1885
    • Murphy, D.A.1    Makonnen, S.2    Lassoued, W.3    Feldman, M.D.4    Carter, C.5    Lee, W.M.6
  • 50
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • Blumenschein G.R., Gatzemeier U., Fossella F., et al. Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. J Clin Oncol 2009, 27(26):4274-4280.
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4274-4280
    • Blumenschein, G.R.1    Gatzemeier, U.2    Fossella, F.3
  • 51
    • 65349161533 scopus 로고    scopus 로고
    • A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501
    • (15S)
    • Schiller J.H., Lee J.W., Hanna N.H., Traynor A.M., Carbone D.P. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501. J Clin Oncol 2008, 26. (15S).
    • (2008) J Clin Oncol , vol.26
    • Schiller, J.H.1    Lee, J.W.2    Hanna, N.H.3    Traynor, A.M.4    Carbone, D.P.5
  • 52
    • 33748901860 scopus 로고    scopus 로고
    • Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: a phase I subset analysis
    • Abstract 7194
    • Schiller J.H., Flaherty K.T., Redlinger M., et al. Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: a phase I subset analysis. J Clin Oncol 2006, 24(18S). Abstract 7194.
    • (2006) J Clin Oncol , vol.24 , Issue.18 S
    • Schiller, J.H.1    Flaherty, K.T.2    Redlinger, M.3
  • 53
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
    • Scagliotti G., Novello S., von P.J., et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 2010, 28(11):1835-1842.
    • (2010) J Clin Oncol , vol.28 , Issue.11 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    von, P.J.3
  • 54
    • 84857059063 scopus 로고    scopus 로고
    • Bayer Healthcare Pharmaceuticals Inc., Onyx Pharmaceuticals Inc. Phase 3 trial of Nexavar in first-line advanced non-small cell lung cancer does not meet primary endpoint of overall survival. Press release. June 14, 2010. Available from: [accessed 27.7.2010].
    • Bayer Healthcare Pharmaceuticals Inc., Onyx Pharmaceuticals Inc. Phase 3 trial of Nexavar in first-line advanced non-small cell lung cancer does not meet primary endpoint of overall survival. Press release. June 14, 2010. Available from: [accessed 27.7.2010]. http://www.onyx-pharm.com/view.cfm/685/Phase-3-Trial-of-Nexavar-in-First-Line-Advanced-Non-Small-Cell-Lung-Cancer-Does-Not-Meet-Primary-Endpoint-of-Overall-Survival.
  • 55
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams T.J., Lee L.B., Murray L.J., Pryer N.K., Cherrington J.M. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2003, 2(5):471-478.
    • (2003) Mol Cancer Ther , vol.2 , Issue.5 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 56
    • 84857052335 scopus 로고    scopus 로고
    • SUTENT® (sunitinib malate) capsules, oral [package insert]. New York, NY: Pfizer Inc.
    • SUTENT® (sunitinib malate) capsules, oral [package insert]. New York, NY: Pfizer Inc.; 2010.
    • (2010)
  • 57
    • 39149120621 scopus 로고    scopus 로고
    • Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
    • Socinski M.A., Novello S., Brahmer J.R., et al. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. J Clin Oncol 2008, 26(4):650-656.
    • (2008) J Clin Oncol , vol.26 , Issue.4 , pp. 650-656
    • Socinski, M.A.1    Novello, S.2    Brahmer, J.R.3
  • 58
    • 70350655546 scopus 로고    scopus 로고
    • Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer
    • Novello S., Scagliotti G.V., Rosell R., et al. Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer. Br J Cancer 2009, 101(9):1543-1548.
    • (2009) Br J Cancer , vol.101 , Issue.9 , pp. 1543-1548
    • Novello, S.1    Scagliotti, G.V.2    Rosell, R.3
  • 59
    • 79959297851 scopus 로고    scopus 로고
    • Randomized phase II study of sunitinib plus erlotinib versus placebo plus erlotinib for the treatment of metastatic Non-small Cell Lung Cancer
    • Groen H.J.M., Socinski M.A., Grossi F., et al. Randomized phase II study of sunitinib plus erlotinib versus placebo plus erlotinib for the treatment of metastatic Non-small Cell Lung Cancer. Ann Oncol 2010, 21(Suppl. 8):viii139.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Groen, H.J.M.1    Socinski, M.A.2    Grossi, F.3
  • 60
    • 42949105645 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group
    • Laurie S.A., Gauthier I., Arnold A., et al. Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. J Clin Oncol 2008, 26(11):1871-1878.
    • (2008) J Clin Oncol , vol.26 , Issue.11 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 61
    • 73949092851 scopus 로고    scopus 로고
    • Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC Clinical Trials Group BR24 study
    • Goss G.D., Arnold A., Shepherd F.A., et al. Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC Clinical Trials Group BR24 study. J Clin Oncol 2010, 28(1):49-55.
    • (2010) J Clin Oncol , vol.28 , Issue.1 , pp. 49-55
    • Goss, G.D.1    Arnold, A.2    Shepherd, F.A.3
  • 62
    • 77957092171 scopus 로고    scopus 로고
    • Cediranib, a VEGF receptor 1, 2, and 3 inhibitor, and pemetrexed in patients (pts) with recurrent non-small cell lung cancer (NSCLC)
    • Abstract e19007
    • Gadgeel S.M., Wozniak A., Edelman M.J., et al. Cediranib, a VEGF receptor 1, 2, and 3 inhibitor, and pemetrexed in patients (pts) with recurrent non-small cell lung cancer (NSCLC). J Clin Oncol 2009, 27(15S). Abstract e19007.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Gadgeel, S.M.1    Wozniak, A.2    Edelman, M.J.3
  • 63
    • 58149337448 scopus 로고    scopus 로고
    • Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
    • Hu-Lowe D.D., Zou H.Y., Grazzini M.L., et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res 2008, 14(22):7272-7283.
    • (2008) Clin Cancer Res , vol.14 , Issue.22 , pp. 7272-7283
    • Hu-Lowe, D.D.1    Zou, H.Y.2    Grazzini, M.L.3
  • 64
    • 36349033172 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): a phase II trial
    • Abstract 7507
    • Schiller J.H., Larson T., Ou S.I., et al. Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): a phase II trial. J Clin Oncol 2007, 25(18S). Abstract 7507.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S
    • Schiller, J.H.1    Larson, T.2    Ou, S.I.3
  • 65
    • 78049378399 scopus 로고    scopus 로고
    • Axtinib (AG-013736; AG) combined with chemotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) and other solid tumors
    • Abstract 3559
    • Martin L.P., Kozloff M.F., Krzakowski M., et al. Axtinib (AG-013736; AG) combined with chemotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) and other solid tumors. J Clin Oncol 2009, 27(15S). Abstract 3559.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Martin, L.P.1    Kozloff, M.F.2    Krzakowski, M.3
  • 66
    • 33646586669 scopus 로고    scopus 로고
    • Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
    • Albert D.H., Tapang P., Magoc T.J., et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther 2006, 5(4):995-1006.
    • (2006) Mol Cancer Ther , vol.5 , Issue.4 , pp. 995-1006
    • Albert, D.H.1    Tapang, P.2    Magoc, T.J.3
  • 67
    • 69249150154 scopus 로고    scopus 로고
    • ABT-869 in non-small cell lung cancer (NSCLC): interim results
    • Abstract 8074.
    • Tan E, Salgia R, Besse B, et al. ABT-869 in non-small cell lung cancer (NSCLC): interim results. J Clin Oncol 2009;27(15S). Abstract 8074.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Tan, E.1    Salgia, R.2    Besse, B.3
  • 68
    • 33749000911 scopus 로고    scopus 로고
    • AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • Polverino A., Coxon A., Starnes C., et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006, 66(17):8715-8721.
    • (2006) Cancer Res , vol.66 , Issue.17 , pp. 8715-8721
    • Polverino, A.1    Coxon, A.2    Starnes, C.3
  • 69
    • 78049392715 scopus 로고    scopus 로고
    • Randomized, open-label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC)
    • Blumenschein GR, Kabbinavar FF, Menon H, et al. Randomized, open-label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC). J Clin Oncol 2010;28(15s):7528.
    • (2010) J Clin Oncol , vol.28 , Issue.15 S , pp. 7528
    • Blumenschein, G.R.1    Kabbinavar, F.F.2    Menon, H.3
  • 70
    • 33645670595 scopus 로고    scopus 로고
    • Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor
    • Bhide R.S., Cai Z.W., Zhang Y.Z., et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem 2006, 49(7):2143-2146.
    • (2006) J Med Chem , vol.49 , Issue.7 , pp. 2143-2146
    • Bhide, R.S.1    Cai, Z.W.2    Zhang, Y.Z.3
  • 71
    • 0033883776 scopus 로고    scopus 로고
    • SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
    • Laird A.D., Vajkoczy P., Shawver L.K., et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res 2000, 60(15):4152-4160.
    • (2000) Cancer Res , vol.60 , Issue.15 , pp. 4152-4160
    • Laird, A.D.1    Vajkoczy, P.2    Shawver, L.K.3
  • 72
    • 29144484059 scopus 로고    scopus 로고
    • Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions
    • Laschke M.W., Elitzsch A., Vollmar B., Vajkoczy P., Menger M.D. Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions. Hum Reprod 2006, 21(1):262-268.
    • (2006) Hum Reprod , vol.21 , Issue.1 , pp. 262-268
    • Laschke, M.W.1    Elitzsch, A.2    Vollmar, B.3    Vajkoczy, P.4    Menger, M.D.5
  • 73
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F., Roth G.J., Krssak M., et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008, 68(12):4774-4782.
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 74
    • 79957452054 scopus 로고    scopus 로고
    • A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
    • [Epub ahead of print]
    • Reck M., Kaiser R., Eschbach C., et al. A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Ann Oncol 2011, [Epub ahead of print].
    • (2011) Ann Oncol
    • Reck, M.1    Kaiser, R.2    Eschbach, C.3
  • 75
    • 34547683305 scopus 로고    scopus 로고
    • Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: clinical toxicity, therapeutic target, or novel biomarker?
    • van Heeckeren W.J., Ortiz J., Cooney M.M., Remick S.C. Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: clinical toxicity, therapeutic target, or novel biomarker?. J Clin Oncol 2007, 25(21):2993-2995.
    • (2007) J Clin Oncol , vol.25 , Issue.21 , pp. 2993-2995
    • van Heeckeren, W.J.1    Ortiz, J.2    Cooney, M.M.3    Remick, S.C.4
  • 76
    • 52949128348 scopus 로고    scopus 로고
    • Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib
    • Lacouture M.E., Wu S., Robert C., et al. Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib. Oncologist 2008, 13(9):1001-1011.
    • (2008) Oncologist , vol.13 , Issue.9 , pp. 1001-1011
    • Lacouture, M.E.1    Wu, S.2    Robert, C.3
  • 77
    • 77952325749 scopus 로고    scopus 로고
    • Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients
    • Ellis P.M., Kaiser R., Zhao Y., Stopfer P., Gyorffy S., Hanna N. Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients. Clin Cancer Res 2010, 16(10):2881-2889.
    • (2010) Clin Cancer Res , vol.16 , Issue.10 , pp. 2881-2889
    • Ellis, P.M.1    Kaiser, R.2    Zhao, Y.3    Stopfer, P.4    Gyorffy, S.5    Hanna, N.6
  • 78
    • 34447322566 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
    • Kumar R., Knick V.B., Rudolph S.K., et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007, 6(7):2012-2021.
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 2012-2021
    • Kumar, R.1    Knick, V.B.2    Rudolph, S.K.3
  • 79
    • 68349097499 scopus 로고    scopus 로고
    • Phase II study of pazopanib (GW786034) given preoperatively in stage II non-small cell lung cancer (NSCLC): a proof-of-concept study
    • Altorki N., Heymach J., Guarino M., et al. Phase II study of pazopanib (GW786034) given preoperatively in stage II non-small cell lung cancer (NSCLC): a proof-of-concept study. Ann Oncol 2008, 19(Suppl. 8):viii89-viii124.
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 8
    • Altorki, N.1    Heymach, J.2    Guarino, M.3
  • 80
    • 33749544080 scopus 로고    scopus 로고
    • An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases
    • Kim D.W., Jo Y.S., Jung H.S., et al. An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. J Clin Endocrinol Metab 2006, 91(10):4070-4076.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.10 , pp. 4070-4076
    • Kim, D.W.1    Jo, Y.S.2    Jung, H.S.3
  • 81
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., Laird A.D., Xin X., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003, 9(1):327-337.
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 82
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell A.M., Abrams T.J., Yuen H.A., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003, 101(9):3597-3605.
    • (2003) Blood , vol.101 , Issue.9 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 83
    • 65349185527 scopus 로고    scopus 로고
    • A phase II study of multikinase inhibitor sorafenib in patients with relapsed non-small cell lung cancer (NSCLC)
    • Abstract 19084
    • Gutierrez M., Kummar S., Allen D., et al. A phase II study of multikinase inhibitor sorafenib in patients with relapsed non-small cell lung cancer (NSCLC). J Clin Oncol 2008, 26(15S). Abstract 19084.
    • (2008) J Clin Oncol , vol.26 , Issue.15 S
    • Gutierrez, M.1    Kummar, S.2    Allen, D.3
  • 84
    • 35548976756 scopus 로고    scopus 로고
    • A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: a North Central Cancer Treatment Group study
    • Abstract 7547
    • Adjei A.A., Molina J.R., Hillman S.L., et al. A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: a North Central Cancer Treatment Group study. J Clin Oncol 2007, 25(18S). Abstract 7547.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S
    • Adjei, A.A.1    Molina, J.R.2    Hillman, S.L.3
  • 85
    • 65349099972 scopus 로고    scopus 로고
    • A phase I dose escalation study of sunitinib in combination with gemcitabine+cisplatin for advanced non-small cell lung cancer (NSCLC)
    • Abstract 18057
    • Reck M., Frickhofen N., Gatzemeier U., et al. A phase I dose escalation study of sunitinib in combination with gemcitabine+cisplatin for advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007, 25(18S). Abstract 18057.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S
    • Reck, M.1    Frickhofen, N.2    Gatzemeier, U.3


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