-
1
-
-
0027197245
-
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
-
Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-4.
-
(1993)
Nature
, vol.362
, pp. 841-844
-
-
Kim, K.J.1
Li, B.2
Winer, J.3
Armanini, M.4
Gillett, N.5
Phillips, H.S.6
Ferrara, N.7
-
2
-
-
0032893263
-
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
-
Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, Ullrich A, Hirth KP, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999;59:99-106.
-
(1999)
Cancer Res
, vol.59
, pp. 99-106
-
-
Fong, T.A.1
Shawver, L.K.2
Sun, L.3
Tang, C.4
App, H.5
Powell, T.J.6
Kim, Y.H.7
Schreck, R.8
Wang, X.9
Risau, W.10
Ullrich, A.11
Hirth, K.P.12
-
3
-
-
0034282515
-
Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model
-
Drevs J, Hofmann I, Hugenschmidt H, Wittig C, Madjar H, Muller M, Wood J, Martiny-Baron G, Unger C, Marme D. Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model. Cancer Res 2000;60:4819-24.
-
(2000)
Cancer Res
, vol.60
, pp. 4819-4824
-
-
Drevs, J.1
Hofmann, I.2
Hugenschmidt, H.3
Wittig, C.4
Madjar, H.5
Muller, M.6
Wood, J.7
Martiny-Baron, G.8
Unger, C.9
Marme, D.10
-
4
-
-
0033617532
-
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
-
Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 1999;284:808-12.
-
(1999)
Science
, vol.284
, pp. 808-812
-
-
Bergers, G.1
Javaherian, K.2
Lo, K.M.3
Folkman, J.4
Hanahan, D.5
-
5
-
-
0032698140
-
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
-
Prewett M, Huber J, Li Y, Santiago A, O'Connor W, King K, Overholser J. Hooper A, Pytowski B, Witte L, Bohlen P, Hicklin DJ. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res 1999;59:5209-18.
-
(1999)
Cancer Res
, vol.59
, pp. 5209-5218
-
-
Prewett, M.1
Huber, J.2
Li, Y.3
Santiago, A.4
O'Connor, W.5
King, K.6
Overholser, J.7
Hooper, A.8
Pytowski, B.9
Witte, L.10
Bohlen, P.11
Hicklin, D.J.12
-
6
-
-
2542628099
-
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
-
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004;64:3731-6.
-
(2004)
Cancer Res
, vol.64
, pp. 3731-3736
-
-
Tong, R.T.1
Boucher, Y.2
Kozin, S.V.3
Winkler, F.4
Hicklin, D.J.5
Jain, R.K.6
-
7
-
-
0038235987
-
Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
-
Wildiers H, Guetens G, De Boeck G, Verbeken E, Landuyt B, Landuyt W, de Bruijn EA, van Oosterom AT. Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer 2003;88:1979-86.
-
(2003)
Br J Cancer
, vol.88
, pp. 1979-1986
-
-
Wildiers, H.1
Guetens, G.2
De Boeck, G.3
Verbeken, E.4
Landuyt, B.5
Landuyt, W.6
de Bruijn, E.A.7
van Oosterom, A.T.8
-
8
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
-
9
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307:58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
10
-
-
0141486251
-
PDGF receptors as cancer drug targets
-
Pietras K, Sjoblom T, Rubin K, Heldin CH, Ostman A. PDGF receptors as cancer drug targets. Cancer Cell 2003;3:439-43.
-
(2003)
Cancer Cell
, vol.3
, pp. 439-443
-
-
Pietras, K.1
Sjoblom, T.2
Rubin, K.3
Heldin, C.H.4
Ostman, A.5
-
11
-
-
0030756325
-
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
-
Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997;277:242-5.
-
(1997)
Science
, vol.277
, pp. 242-245
-
-
Lindahl, P.1
Johansson, B.R.2
Leveen, P.3
Betsholtz, C.4
-
12
-
-
0028059309
-
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
-
Soriano P. Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev 1994;8:1888-96.
-
(1994)
Genes Dev
, vol.8
, pp. 1888-1896
-
-
Soriano, P.1
-
14
-
-
0242405617
-
Endothelial-pericyte interactions in angiogenesis
-
Gerhardt H, Betsholtz C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res 2003;314:15-23.
-
(2003)
Cell Tissue Res
, vol.314
, pp. 15-23
-
-
Gerhardt, H.1
Betsholtz, C.2
-
15
-
-
27644557532
-
The role of pericytes in blood-vessel formation and maintenance
-
Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro-oncol 2005;7:452-64.
-
(2005)
Neuro-oncol
, vol.7
, pp. 452-464
-
-
Bergers, G.1
Song, S.2
-
16
-
-
0036124520
-
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
-
Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 2002;160:985-1000.
-
(2002)
Am J Pathol
, vol.160
, pp. 985-1000
-
-
Morikawa, S.1
Baluk, P.2
Kaidoh, T.3
Haskell, A.4
Jain, R.K.5
McDonald, D.M.6
-
17
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, Steinberg SM, Chen HX, Rosenberg SA. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427-34.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
Hwu, P.4
Schwartzentruber, D.J.5
Topalian, S.L.6
Steinberg, S.M.7
Chen, H.X.8
Rosenberg, S.A.9
-
18
-
-
0242468884
-
A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer
-
Cobleigh MA, Langmuir VK, Sledge GW, Miller KD, Haney L, Novotny WF, Reimann JD, Vassel A. A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin Oncol 2003;30(5, Suppl 16):117-24.
-
(2003)
Semin Oncol
, vol.30
, Issue.5 and SUPPL. 16
, pp. 117-124
-
-
Cobleigh, M.A.1
Langmuir, V.K.2
Sledge, G.W.3
Miller, K.D.4
Haney, L.5
Novotny, W.F.6
Reimann, J.D.7
Vassel, A.8
-
19
-
-
2542520723
-
Two steps forward in the treatment of colorectal cancer
-
Mayer RJ. Two steps forward in the treatment of colorectal cancer. N Engl J Med 2004;350:2406-8.
-
(2004)
N Engl J Med
, vol.350
, pp. 2406-2408
-
-
Mayer, R.J.1
-
20
-
-
0032952010
-
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
-
Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103:159-65.
-
(1999)
J Clin Invest
, vol.103
, pp. 159-165
-
-
Benjamin, L.E.1
Golijanin, D.2
Itin, A.3
Pode, D.4
Keshet, E.5
-
21
-
-
0036223819
-
Stable expression of angiopoietin-1 and other markers by cultured pericytes: Phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo
-
Sundberg C, Kowanetz M, Brown LF, Detmar M, Dvorak HF. Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo. Lab Invest 2002;82:387-401.
-
(2002)
Lab Invest
, vol.82
, pp. 387-401
-
-
Sundberg, C.1
Kowanetz, M.2
Brown, L.F.3
Detmar, M.4
Dvorak, H.F.5
-
22
-
-
0033927061
-
N-cadherin mediates pericytic- endothelial interaction during brain angiogenesis in the chicken
-
Gerhardt H, Wolburg H, Redies C. N-cadherin mediates pericytic- endothelial interaction during brain angiogenesis in the chicken. Dev Dyn 2000;218:472-9.
-
(2000)
Dev Dyn
, vol.218
, pp. 472-479
-
-
Gerhardt, H.1
Wolburg, H.2
Redies, C.3
-
23
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003;111:1287-95.
-
(2003)
J Clin Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
24
-
-
1442290142
-
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
-
Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, Menger MD, Ullrich A, Vajkoczy P. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 2004;18:338-40.
-
(2004)
FASEB J
, vol.18
, pp. 338-340
-
-
Erber, R.1
Thurnher, A.2
Katsen, A.D.3
Groth, G.4
Kerger, H.5
Hammes, H.P.6
Menger, M.D.7
Ullrich, A.8
Vajkoczy, P.9
-
25
-
-
0842304140
-
Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis
-
Huang J, Soffer SZ, Kim ES, McCrudden KW, New T, Manley CA, Middlesworth W, O'Toole K, Yamashiro DJ, Kandel JJ. Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis. Mol Cancer Res 2004;2:36-42.
-
(2004)
Mol Cancer Res
, vol.2
, pp. 36-42
-
-
Huang, J.1
Soffer, S.Z.2
Kim, E.S.3
McCrudden, K.W.4
New, T.5
Manley, C.A.6
Middlesworth, W.7
O'Toole, K.8
Yamashiro, D.J.9
Kandel, J.J.10
-
26
-
-
16544382996
-
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
-
Furuhashi M, Sjoblom T, Abramsson A, Ellingsen J, Micke P, Li H, Bergsten-Folestad E, Eriksson U, Heuchel R, Betsholtz C, Heldin CH, Ostman A. Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate. Cancer Res 2004;64:2725-33.
-
(2004)
Cancer Res
, vol.64
, pp. 2725-2733
-
-
Furuhashi, M.1
Sjoblom, T.2
Abramsson, A.3
Ellingsen, J.4
Micke, P.5
Li, H.6
Bergsten-Folestad, E.7
Eriksson, U.8
Heuchel, R.9
Betsholtz, C.10
Heldin, C.H.11
Ostman, A.12
-
27
-
-
0035297541
-
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
-
Pietras K, Ostman A, Sjoquist M, Buchdunger E, Reed RK, Heldin CH, Rubin K. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res 2001;61:2929-34.
-
(2001)
Cancer Res
, vol.61
, pp. 2929-2934
-
-
Pietras, K.1
Ostman, A.2
Sjoquist, M.3
Buchdunger, E.4
Reed, R.K.5
Heldin, C.H.6
Rubin, K.7
-
28
-
-
0023792617
-
UKCCCR guidelines for the welfare of animals in experimental neoplasia
-
Workman P, Balmain A, Hickman JA, McNally NJ, Rohas AM, Mitchison NA, Pierrepoint CG, Raymond R, Rowlatt C, Stephens TC, et al. UKCCCR guidelines for the welfare of animals in experimental neoplasia. Lab Anim 1988;22:195-201.
-
(1988)
Lab Anim
, vol.22
, pp. 195-201
-
-
Workman, P.1
Balmain, A.2
Hickman, J.A.3
McNally, N.J.4
Rohas, A.M.5
Mitchison, N.A.6
Pierrepoint, C.G.7
Raymond, R.8
Rowlatt, C.9
Stephens, T.C.10
-
29
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood JM, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, Hofmann F, Mestan J, Mett H, O'Reilly T, Persohn E, Rosel J, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000;60:2178-89.
-
(2000)
Cancer Res
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
Cozens, R.4
Ferrari, S.5
Frei, J.6
Hofmann, F.7
Mestan, J.8
Mett, H.9
O'Reilly, T.10
Persohn, E.11
Rosel, J.12
-
30
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
-
Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Druker BJ, Lydon NB. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996;56:100-4.
-
(1996)
Cancer Res
, vol.56
, pp. 100-104
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
Meyer, T.4
Muller, M.5
Druker, B.J.6
Lydon, N.B.7
-
31
-
-
0023722311
-
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains
-
Beckmann MP, Betsholtz C, Heldin CH, Westermark B, Di Marco E, Di Fiore PP, Robbins KC, Aaronson SA. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science 1988;241:1346-9.
-
(1988)
Science
, vol.241
, pp. 1346-1349
-
-
Beckmann, M.P.1
Betsholtz, C.2
Heldin, C.H.3
Westermark, B.4
Di Marco, E.5
Di Fiore, P.P.6
Robbins, K.C.7
Aaronson, S.A.8
-
32
-
-
0035421175
-
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis
-
Sjoblom T, Shimizu A, O'Brien KP, Pietras K, Dal Cin P, Buchdunger E, Dumanski JP, Ostman A, Heldin CH. Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Cancer Res 2001;61:5778-83.
-
(2001)
Cancer Res
, vol.61
, pp. 5778-5783
-
-
Sjoblom, T.1
Shimizu, A.2
O'Brien, K.P.3
Pietras, K.4
Dal Cin, P.5
Buchdunger, E.6
Dumanski, J.P.7
Ostman, A.8
Heldin, C.H.9
-
33
-
-
27644582050
-
Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma
-
Ozawa MG, Yao VJ, Chanthery YH, Troncoso P, Uemura A, Varner AS, Kasman IM, Pasqualini R, Arap W, McDonald DM. Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma. Cancer 2005;104:2104-15.
-
(2005)
Cancer
, vol.104
, pp. 2104-2115
-
-
Ozawa, M.G.1
Yao, V.J.2
Chanthery, Y.H.3
Troncoso, P.4
Uemura, A.5
Varner, A.S.6
Kasman, I.M.7
Pasqualini, R.8
Arap, W.9
McDonald, D.M.10
-
34
-
-
0036140857
-
Analysis of mural cell recruitment to tumor vessels
-
Abramsson A, Berlin O, Papayan H, Paulin D, Shani M, Betsholtz C. Analysis of mural cell recruitment to tumor vessels. Circulation 2002;105:112-7.
-
(2002)
Circulation
, vol.105
, pp. 112-117
-
-
Abramsson, A.1
Berlin, O.2
Papayan, H.3
Paulin, D.4
Shani, M.5
Betsholtz, C.6
-
35
-
-
26944437515
-
PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
-
Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 2005;7:870-9.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 870-879
-
-
Song, S.1
Ewald, A.J.2
Stallcup, W.3
Werb, Z.4
Bergers, G.5
-
36
-
-
14644446018
-
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
-
Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005;23:939-52.
-
(2005)
J Clin Oncol
, vol.23
, pp. 939-952
-
-
Pietras, K.1
Hanahan, D.2
-
37
-
-
3242885697
-
Characterization of smooth muscle cell and pericyte differentiation in the rat retina in vivo
-
Hughes S, Chan-Ling T. Characterization of smooth muscle cell and pericyte differentiation in the rat retina in vivo. Invest Ophthalmol Vis Sci 2004;45:2795-806.
-
(2004)
Invest Ophthalmol Vis Sci
, vol.45
, pp. 2795-2806
-
-
Hughes, S.1
Chan-Ling, T.2
|