Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor

Cellular Physiology and Biochemistry

Volumn 29, Issue 5-6, 2012, Pages 667-674

  Honda, Miki ^a   Kanno, Takeshi ^a   Fujita, Yumiko ^a   Gotoh, Akinobu ^a   Nakano, Takashi ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Malignant mesothelioma cell; PDGF D; PDGF receptor; Proliferation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ANTINEOPLASTIC AGENT; BX 912; FR 180204; FR180204; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR D; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; CANCER CELL; CANCER INHIBITION; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MESOTHELIOMA; PRIORITY JOURNAL;

EID: 84861404077     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000176386     Document Type: Article

References (16)

1. Nakano T: Malignant mesotheliomadiagnosis and treatment strategies. Gan To Kagaku Ryoho 2006;33:1215-1220.
2. Halper J: Growth factors as active participants in carcinogenesis: a perspective. Vet Pathol 2010;47:77-97.
3. Garlepp MJ, Leong CC: Biological and immunological aspects of malignant mesothelioma. Eur Respir J 1995;8:643-650.
4. Upham JW, Garlepp MJ, Musk AW, Robinson BW: Malignant mesothelioma: new insights into tumour biology and immunology as a basis for new treatment approaches. Thorax 1995;50:887-893.
5. Filiberti R, Marroni P, Neri M, Ardizzoni A, Betta PG, Cafferata MA, Canessa PA, Puntoni R, Ivaldi GP, Paganuzzi M: Serum PDGF-AB in pleural mesothelioma. Tumour Biol 2005;26:221-226. (Pubitemid 41243222)
6. Versnel MA, Hagemeijer A, Bouts MJ, van der Kwast TH, Hoogsteden HC: Expression of c-sis (PDGF B-chain) and PDGF A-chain genes in ten human malignant mesothelioma cell lines derived from primary and metastatic tumors. Oncogene 1988;2:601-605.
7. Gerwin BI, Lechner JF, Reddel RR, Roberts AB, Robbins KC, Gabrielson EW, Harris CC: Comparison of production of transforming growth factor-β and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. Cancer Res 1987;47:6180-6184. (Pubitemid 18011059)
8. Van der Meeren A, Seddon MB, Betsholtz CA, Lechner JF, Gerwin BI: Tumorigenic conversion of human mesothelial cells as a consequence of platelet-derived growth factor-A chain overexpression. Am J Respir Cell Mol Biol 1993;8:214-221.
9. Alvarez RH, Kantarjian HM, Cortes JE: Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 2006;81:1241-1257. (Pubitemid 44316290)
10. Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U: PDGF-D is a specific, protease-activated ligand for the PDGFβ-receptor. Nat Cell Biol 2001;3:512-516. (Pubitemid 32422089)
11. Fredriksson L, Ehnman M, Fieber C, Eriksson U: Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator. J Biol Chem 2005;280:26856-26862. (Pubitemid 41040719)
12. Ehnman M, Li H, Fredriksson L, Pietras K, Eriksson U: The uPA/uPAR system regulates the bioavailability of PDGFDD: implications for tumour growth. Oncogene 2009;28:534-544.
13. Fredriksson L, Li H, Fieber C, Li X, Eriksson U: Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J 2004;23:3793-3802. (Pubitemid 39389710)
14. Ustach CV, Kim HR: Platelet-derived growth factor β is activated by urokinase plasminogen activator in prostate carcinoma cells. Mol Cell Biol 2005;25:6279-6288. (Pubitemid 40946575)
15. Yaguchi T, Muramoto M, Nakano T, Nishizaki T: Urinary trypsin inhibitor suppresses migration of malignant mesothelioma. Cancer Lett 2010;288:214-218.
16. Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T: Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition. Cell Physiol Biochem 2010;26:125-134.