Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis

Cancer Research

Volumn 61, Issue 15, 2001, Pages 5778-5783

  Sjöblom, Tobias ^a   Shimizu, Akira ^a   O'Brien, Kevin P ^a   Östman, Arne ^a   Heldin, Carl Henrik ^a   Pietras, Kristian ^b   Dumanski, Jan P ^b   Dal Cin, Paola ^c   Buchdunger, Elisabeth ^d  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d Novartis Institutes of BioMedical Research   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; HYBRID PROTEIN; IMATINIB; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN SUBUNIT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; BETA CHAIN; CANCER INHIBITION; CANCER TRANSPLANTATION; CHROMOSOME REARRANGEMENT; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOFIBROSARCOMA PROTUBERANS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN PROCESSING; RECEPTOR BLOCKING; SKIN FIBROBLAST; SKIN TUMOR;

ADULT; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CHILD, PRESCHOOL; DERMATOFIBROSARCOMA; FEMALE; FIBROSARCOMA; GIANT CELL TUMORS; GROWTH INHIBITORS; HUMANS; INFANT; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICE, SCID; NEOVASCULARIZATION, PATHOLOGIC; ONCOGENE PROTEINS, FUSION; PIPERAZINES; PYRIMIDINES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SKIN NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035421175     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
2. Various regions within the α-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas
3. The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGFBB
4. Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor B-chain gene in dermatofibrosarcoma protuberans
5. Growth-inhibitory effect of STI571 on cells transformed by the COL1A1/PDGFB rearrangement
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