Localization of platelet-derived growth factor β receptor expression in the periepithelial stroma of human breast carcinoma

Clinical Cancer Research

Volumn 2, Issue 4, 1996, Pages 773-782

  Bhardwaj, Bhavna ^a,c   Klassen, Jennifer ^a   Cossette, Nadine ^a   Sterns, Ernest ^b   Tuck, Alan ^a   Deeley, Roger ^a   Sengupta, Sandip ^b   Elliott, Bruce ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b KINGSTON GENERAL HOSPITAL   (Canada)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GROWTH FACTOR RECEPTOR; THROMBOCYTE GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MYOEPITHELIUM; PRIORITY JOURNAL; STROMA; VASCULAR ENDOTHELIUM;

ACTINS; BASEMENT MEMBRANE; BREAST NEOPLASMS; ENDOTHELIUM, VASCULAR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IN SITU HYBRIDIZATION; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; STROMAL CELLS;

EID: 0029978211     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Ulich, T. R., Yi, E. S., Cardiff, R., Yin, S., Bikhazi, N., Biltz, R., Morris, C. F., and Pierce, G. F. Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor. Am. J. Pathol., 144: 862-868, 1994.
2. Coleman-Kmacik, S., and Rosen, J. M. Differential temporal and spatial gene expression of fibroblast growth factor family members durina mouse mammary gland development. Mol. Endocrinol., 8: 218-229, 1994.
3. Rahimi, N., Saulnier, R., Nakamura, T., Park, M., and Elliott, B. Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes. DNA Cell Biol., 13: 1189-1197, 1994.
4. Wright, J. H., McDonnell, S., Portella, G., Bowden, G. T., Balmain, A., and Matrisian, L. M. A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression. Mol. Carcinog., 10: 207-215, 1994.
5. Osteen, K. G., Rodgers, W H., Gaire, M., Hargrove, J. T., Gorstein, F., and Matrisian, L. M. Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium. Proc. Natl. Acad. Sci. USA, 91: 10129-10133, 1994.
6. Talts, J. F., Aufderheide, E., Sorokin, L., Ocklind, G., Mattsson, R., and Ekblom, P. Induction of mouse tenascin expression by a human sarcomatoid Wilms' tumor cell line growing in nude mice Int J. Cancer. 54: 868-874, 1993.
7. Clezardin. P , Frappart, L., Clerget, M., Pechoux, C., and Delmas, P. D. Expression of throrabospondin (TSPI) and its receptors (CD36 and CD51) in normal, hyperplastic, and neoplasric human breast. Cancer Res., 53: 1421-1430, 1993.
8. Rosen, E. M., Joseph, A., Jin, L., Rockwell, S., Elias, J. A., Knesel, J., Wines, J., McLellan, J., Kluger, M. J., Goldberg, I. D., and Zitnik, R. Regulation of scatter factor production via a soluble inducing factor. J. Cell Biol , 127: 225-234, 1994
9. Ariad, S., Seymour, L., and Bezwoda, W. R. Platelet-derived growth factor (PDGF) in plasma of breast cancer patients: correlation with stage and rate of progression. Breast Cancer Res. Treat., 20: 11-17, 1991.
10. Coombes, R. C , Barrett-Lee, P, and Luqmani, Y. Growth factor expression in breast tissue. J. Steroid Biochem. Mol. Biol., 37: 833-836, 1990.
11. Coltrera, M. D., Wang, J., Porter, P. L., and Gown, A. M. Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor β subunit in human breast tissue and breast carcinoma. Cancer Res., 55: 2703-2708, 1995.
12. Rozengurt, E., Sinnett-Smith, J., and Taylor-Papadimitriou, J. Production of PDGF-like growth factor by breast cancer cell lines. Int. J. Cancer, 36: 247-252, 1985.
13. Bronzert, D. A., Pantazis, P., Antoniades, H. N., Kasid, A., Davidson, N., Dickson, R. B., and Lippman, M. E. Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines. Proc. Natl. Acad. Sci. USA, 84: 5763-5767, 1987.
14. Peres, R., Betsholtz, C., Westermark, B., and Heldin, C. H. Frequent expression of growth factors for raesenchymal cells in human mammary carcinoma cell lines. Cancer Res., 47: 3425-3429, 1987.
15. Heldin, C. H., and Westermark, B. Platelet-derived growth factor: mechanism of action and possible in vivo function. Cell Regul., 1: 555-566, 1990.
16. Grotendorst, G. R., Chang, T., Seppa, H. E , Kleinman, H. K., and Martin, G. R. Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells. J. Cell Physiol., 113: 261-266, 1982.
17. Pierce, G. F., Mustoe, T. A., Lingelbach, J., Masakowski, V. R., Griffin, G. L., Senior, R M., and Deuel, T. F Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J. Cell. Biol., 109: 429-440, 1989.
18. Hammacher, A., Hellman, U., Johnsson, A., Ostrnan, A., Gunnarsson, K., Westermark, B., Wasteson, A., and Heldin, C. H. A major part of platelet-denved growth factor purified from human platelets is a heterodimer of one A and one B chain. J. Biol. Chem., 263: 16493-16498, 1988.
19. Westermark, B. The molecular and cellular biology of plateletderived growth factor. Acta Endocrinol., 123: 131-142, 1990.
20. Heldin, C-H., and Roonstrand, L. The platelet-derived growth factor receptor. In: V. K. Moudgil (ed.). Receptor Phosphorylation. Boca Raton, FL: CRC Press, Inc., 1989
21. Doolitte, R. F., Hunkapitler, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., and Antomades, H. N. Simian sarcoma virus one gene, v-sts, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (Washington DC). 221: 275-277, 1983.
22. Waterfteld, M. D., Scrace, G. T., Whittle, N., Stroobam, P., Johnsson, A., Wasteson, A., Westermark, B., Heldin, C. H., Huang, J. S., and Deuel, T. F. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature (Lond.), 304. 35-39, 1983.
23. Beckmann, M. P , Betsholtz, C., Heldin, C. H., Westermark, B., Di Marco, E. Di Fiore, P. P., Robbins, K. C., and Aaronson, S. A. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science (Washington DC), 241: 1346-1349, 1988.
24. Tingstrom, A., Remerdahl, C., Lindahl, P., Heldin, C. H., and Rubin, K. Expression of platelet-derived growth factor-beta receptors on human fibroblasts. Regulation by recombinant platelet-derived growth factor-BB, IL-I. and tumor necrosis factor-alpha. J. Immunol., 148: 546-554, 1992.
25. Smits, A., Hermansson, M., Nister, M., Karnushina, I., Heldin, C. H , Westermark, B., and Funa, K. Rat brain capillary endothelial cells express functional PDGF B-type receptors. Growth Factors, 2: 1-8, 1989.
26. Heldin, P., Pertoft, H., Nordlinder, H., Heldin, C. H., and Laurent. T. C. Differential expression of platelet-derived growth factor alphaand beta-receptors on fat-stonng cells and endothelial cells of rat liver. Exp Cell Res., 193: 364-369, 1991
27. Ginsburg, E., and Vonderhaar, B. K. Stimulation of growth of human breast cancer cells (T47D) by platelet derived growth factor. Cancer Lett. 58: 137-144, 1991
28. Antoniades, H. N., Galanopoulos, T., Neville-Golden, J., and O'Hara, C. J. Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proc. Natl. Acad. Sci. USA, 89: 3942-3946, 1992.
29. Heldin, N. E., Gustavsson, B., Claesson-Welsh, L., Hammacher, A., Mark, J., Heldin, C. H., and Westermark, B. Aberrant expression of receptors for platelet-derived growth factor in an anaplastic thyroid carcinoma cell line. Proc. Natl. Acad. Sci. USA, 85: 9302-9306. 1988.
30. Lazard, D., Sastre, X., Fnd, M. G., Glukhova, M. A.. Thiery, J. P., and Koteliansky, V. E. Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc, Natl. Acad. Sci. USA, 90: 999-1003, 1993.
31. Schlingemann. R. O., Dingjan, G. M., Emeis, J. J., Blok, J., Warnaar, S. O., and Ruiter, D. J. Monoclonal antibody PAL-E specific for endothelium. Lab. Invest., 52: 71-76, 1985.
32. Sundberg, C., Ljungstrom, M., Lindmark, G., Gerdin, B., and Rubin, K. Microvascular pericytes express platelet-derived growth factor-beta receptors in human healing wounds and colorectal adenocarcinoma. Am. J. Pathol., 143: 1377-1388, 1993.
33. Rönnstrand, L., Teracio, L., Claesson-Welsh, L., Heldin, C-H., and Rubin. K. Characterization of two monoclonal antibodies against the external domain of the receptor for platelet-derived growth factor. J. Biol. Chem., 263: 10429-10435, 1988.
34. Gusterson, B. A., Monaghan, P., Mahendran, R., Ellis, J., and O'Hare, M. J. Identification of myoepithelial cells in human and rat breasts by anti-common acute lymphoblastic leukemia antigen antibody A12. J. Natl. Cancer Inst., 77: 343-349, 1986.
35. Yang, X. M., and Park, M. Expression of the met/hepatocyte growth factor/scatter factor receptor and its ligand during differentiation of murine P19 embryonal carcinoma cells. Dev. Biol., 157: 308-320, 1993.
36. Claesson-Welsh, L., Eriksson, A., Moren, A., Severinsson, L., Ek, B., Osrman, A., Betsholtz, C., and Heldin, C. H. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol. Cell. Biol., 8: 3476-3486, 1988.
37. Rennov-Jessen, L., Petersen, O. W., Koteliansky, V. E., and Bissell, M. J. The origin of the myofibroblasts in breast cancer recapitulation of tumor environment in culture unravels diversity and implicates con-verted fibroblasts and recruited smooth muscle cells. J. Clin. Invest., 95: 859-873, 1995.
38. Seppa, H., Grotendorst, G., Seppa, S., Schiffmann, E., and Martin, G. R. Platelet-derived growth factor is chemotactic for fibroblasts. J. Cell Biol., 92: 584-588, 1982.
39. Sato, Y., Hamanaka, R., Ono, J., Kuwano, M., Rifkin, D. B., and Takaki, R. The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF. Biochem. Biophys. Res. Commun., 174: 1260-1266, 1991.
40. Cullen, K. J., Smith, H S., Hill, S., Rosen, N., and Lippman, M. E. Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions. Cancer Res., 57: 4978-4985, 1991.
41. Yee, D., Rosen, N., Favoni, R. E., and Cullen, K. J. The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer. Cancer Treat. Res., 53: 93-106, 1991.
42. Westermark, B., and Heldin, C. H. Platelet-derived growth factor in autocnne transformation. Cancer Res., 51: 5087-5092, 1991.
43. Forsberg, K., Valyi-Nagy, I., Heldin, C. H., Herlyn, M., and Westermark. B. Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc. Natl. Acad. Sci. USA, 90: 393-397, 1993.
44. Majack, R. A., Cook, S. C., and Bornstein, P. Pfatelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondm synthesis and deposition in the matrix by smooth muscle cells. J. Cell Biol., 101: 1059-1070, 1985.
45. Good, D. J., Polverini, P. J., Rastinejad, F., Le Beau, M. M., Lemons, R. S., Frazier, W. A., and Bouck, N. P. A tumor suppressordependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. USA, 87: 6624-6628, 1990.
46. Ponten, F., Ren, Z., Nister, M., Westermark, B., and Ponten, J. Epithelial-stromal interactions in basal cell cancer: the PDGF system. J. Invest. Dermatol., 102: 304-309, 1994
47. Tuck, A. B., Park, M., Sterns, E., Boas, A., and Elliott, B. Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma. Am. J. Pathol., 148: 225-232, 1996.