Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 22, 2008, Pages 7681-7686

  Yang, Yan ^a   Yuzawa, Satoru ^a   Schlessinger, Joseph ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell proliferation; Cell signaling; Phosphorylation; Surface receptors; Tyrosine kinases

Indexed keywords

AMINO ACID; ARGININE; GLUTAMINE; MUTANT PROTEIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE; CROSS LINKING REAGENT; GLUTAMIC ACID;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STIMULATION; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; EMBRYO; ENZYME ACTIVATION; MEMBRANE BINDING; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL MEMBRANE; CHEMISTRY; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; CELL LINE; CELL MEMBRANE; CONSERVED SEQUENCE; CROSS-LINKING REAGENTS; DIMERIZATION; ENZYME ACTIVATION; GLUTAMIC ACID; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA;

EID: 45549109855     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802896105     Document Type: Article

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