New trends in LC protein ligand screening

Journal of Pharmaceutical and Biomedical Analysis

Volumn 87, Issue , 2014, Pages 155-166

  de Moraes, Marcela C ^a   Vanzolini, Kenia L ^b   Cardoso, Carmen L ^c   Cass, Quezia B ^b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bioaffinity based strategies; Frontal chromatography; Nonlinear chromatography; Protein ligand screening; Zonal chromatography

Indexed keywords

ACETYLCHOLINESTERASE; BENZODIAZEPINE; BETA GALACTOSIDASE; BREAST CANCER RESISTANCE PROTEIN; CAMPTOTHECIN; CHLORPROMAZINE; CHOLINESTERASE; CYTISINE; EPIBATIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE B; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 ALPHA; IMIPRAMINE; IMMOBILIZED ENZYME; IMMOBILIZED PROTEIN; INDOLE; LECTIN; LIGAND; MAGNETIC NANOPARTICLE; N ACETYLGLUCOSAMINYLTRANSFERASE; NEUTROPHIL COLLAGENASE; NICOTINE; NICOTINIC RECEPTOR; PROTEIN; PURINE NUCLEOSIDE PHOSPHORYLASE; TAMOXIFEN; TRYPTOPHAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL;

AFFINITY CHROMATOGRAPHY; ASTROCYTOMA CELL; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CELL MEMBRANE; CELL NUCLEUS MEMBRANE; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; DIOSCOREA NIPPONICA; DISSOCIATION CONSTANT; ELUTION; ENZYME ACTIVITY; ENZYME STABILITY; EQUILIBRIUM CONSTANT; FRONTAL CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; IMMOBILIZED ENZYME REACTOR; IONIC STRENGTH; LIGAND BINDING; LIGAND PROTEIN BINDING; LIQUID CHROMATOGRAPHY; LIVER CELL CARCINOMA; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONLINEAR CHROMATOGRAPHY; PH; PLANT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN IMMOBILIZATION; PUERARIAE LOBATA; RADIX SOPHORAE FLAVESCENTIS; REVIEW; SCHISTOSOMA MANSONI; TANDEM MASS SPECTROMETRY; THERMODYNAMICS; ZONAL CHROMATOGRAPHY;

BIOAFFINITY-BASED STRATEGIES; FRONTAL CHROMATOGRAPHY; NONLINEAR CHROMATOGRAPHY; PROTEIN LIGAND SCREENING; ZONAL CHROMATOGRAPHY;

CHROMATOGRAPHY, AFFINITY; HUMANS; IMMOBILIZED PROTEINS; LIGANDS; MAGNETICS; NANOPARTICLES; PROTEIN BINDING; PROTEINS;

EID: 84889581004     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.07.021     Document Type: Review

References (148)

1. Chaiken I.M. Analytical Affinity Chromatography 1987, CRC Press, Boca Raton, FL.
2. Hage D.S. Affinity chromatography. Handbook of HPLC 1998, Marcel Dekker, New York. E. Katz, R. Eksteen, N. Miller (Eds.).
3. Hage D.S., Tweed S.A. Recent advances in chromatographic and electrophoretic methods for the study of drug-protein interactions. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1997, 699:499-525.
4. Nie Y.-I., Wang W.-h. Immobilized enzyme reactor in on-line LC and its application in drug screening. Chromatographia 2009, 69:S5-S12.
5. Dunn B.M., Chaiken I.M. Quantitative affinity chromatography: determination of binding constants by elution with competitive inhibitors. Proceedings of the National Academy of Sciences of the United States of America 1974, 71:2382-2385.
6. Hage D.S., Chen J. Quantitative affinity chromatography: practical aspects. Handbook of Affinity Chromatography 2006, 596-628. Taylor & Francis Group, Boca Raton. D. Hage (Ed.).
7. Hage D.S., Anguizola J.A., Bi C., Li R., Matsuda R., Papastavros E., Pfaunmiller E., Vargas J., Zheng X. Pharmaceutical and biomedical applications of affinity chromatography: recent trends and developments. Journal of Pharmaceutical and Biomedical Analysis 2012, 69:93-105.
8. Schiel J.E., Joseph K.S., Hage D.S. Biointeraction affinity chromatography: general principles and recent developments. Advances in Chromatography 2010, vol. 48:145-193. Crc Press-Taylor & Francis Group, Boca Raton.
9. Hage D.S., Sengupta A. Characterization of the binding of digitoxin and acetyldigitoxin to human serum-albumin by high-performance affinity chromatography. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1999, 91-100.
10. Jozwiak K., Haginaka J., Moaddel R., Wainer I.W. Displacement and nonlinear chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor liquid chromatographic stationary phase. Analytical Chemistry 2002, 74:4618-4624.
11. Yoo M.J., Smith Q.R., Hage D.S. Studies of imipramine binding to human serum albumin by high-performance affinity chromatography. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2009, 877:1149-1154.
12. Yoo M.J., Hage D.S. High-throughput analysis of drug dissociation from serum proteins using affinity silica monoliths. Journal of Separation Science 2011, 34:2255-2263.
13. Basiaga S.B.G., Hage D.S. Chromatographic studies of changes in binding of sulfonylurea drugs to human serum albumin due to glycation and fatty acids. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2010, 878:3193-3197.
14. Duong-Thi M.-D., Meiby E., Bergstrom M., Fex T., Isaksson R., Ohlson S. Weak affinity chromatography as a new approach for fragment screening in drug discovery. Analytical Biochemistry 2011, 414:138-146.
15. Cheshev P., Morelli L., Marchesi M., Podlipnik C., Bergstrom M., Bernardi A. Synthesis and affinity evaluation of a small library of bidentate cholera toxin ligands: towards nonhydrolyzable ganglioside mimics. Chemistry - A European Journal 2010, 16:1951-1967.
16. Bergstrom M., Liu S., Kiick K.L., Ohlson S. Cholera toxin inhibitors studied with high-performance liquid affinity chromatography: a robust method to evaluate receptor-ligand interactions. Chemical Biology & Drug Design 2009, 73:132-141.
17. Landry Y., Gies J.P. Drugs and their molecular targets: an updated overview. Fundamental & Clinical Pharmacology 2008, 22:1-18.
18. Yang Q., Lundahl P. Immobilized proteoliposome affinity-chromatography for quantitative-analysis of specific interactions between solutes and membrane-proteins - interaction of cytochalasin-b and d-glucose with the glucose-transporter glut1. Biochemistry 1995, 34:7289-7294.
19. Fruh V., Ijzerman A.P., Siegal G. How to catch a membrane protein in action: a review of functional membrane protein immobilization strategies and their applications. Chemical Reviews 2011, 111:640-656.
20. Moaddel R., Wainer I.W. The preparation and development of cellular membrane affinity chromatography columns. Nature Protocols 2009, 4:197-205.
21. Sanghvi M., Moaddel R., Wainer I.W. The development and characterization of protein-based stationary phases for studying drug-protein and protein-protein interactions. Journal of Chromatography A 2011, 1218:8791-8798.
22. Moaddel R., Wainer I.W. Development of immobilized membrane-based affinity columns for use in the online characterization of membrane bound proteins and for targeted affinity isolations. Analytica Chimica Acta 2006, 564:97-105.
23. Moaddel R., Lu L.L., Baynham M., Wainer I.W. Immobilized receptor- and transporter-based liquid chromatographic phases for on-line pharmacological and biochemical studies: a mini-review. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2002, 768:41-53.
24. Zhang Y.X., Leonessa F., Clarke R., Wainer I.W. Development of an immobilized P-glycoprotein stationary phase for on-line liquid chromatographic determination of drug-binding affinities. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2000, 739:33-37.
25. Liu J., Yang J., Wang S., Sun J., Shi J., Rao G., Li A., Gou J. Combining human periodontal ligament cell membrane chromatography with online HPLC/MS for screening osteoplastic active compounds from Coptidis Rhizoma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2012, 904:115-120.
26. Wang S., Sun M., Zhang Y., Du H., He L. A new A431/cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening epidermal growth factor receptor antagonists from Radix sophorae flavescentis. Journal of Chromatography A 2010, 1217:5246-5252.
27. Wang S., Sun M., Zhang Y., Zhang J., He L. EGFR/cell membrane chromatography-online-high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Radix Angelicae Pubescentis. Science China Chemistry 2010, 53:2357-2362.
28. Sudlow G., Birkett D.J., Wade D.N. Further characterization of specific drug binding-sites on human-serum albumin. Molecular Pharmacology 1976, 12:1052-1061.
29. Yoo M.J., Hage D.S. Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates. Journal of Chromatography A 2011, 1218:2072-2078.
30. Pfaunmiller E.L., Hartmann M., Dupper C.M., Soman S., Hage D.S. Optimization of human serum albumin monoliths for chiral separations and high-performance affinity chromatography. Journal of Chromatography A 2012, 1269:198-207.
31. Hage D.S., Austin J. High-performance affinity chromatography and immobilized serum albumin as probes for drug- and hormone-protein binding. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2000, 739:39-54.
32. Chattopadhyay A., Tian T., Kortum L., Hage D.S. Development of tryptophan-modified human serum albumin columns for site-specific studies of drug-protein interactions by high-performance affinity chromatography. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1998, 715:183-190.
33. Yao C.H., Qi L., Qiao J.A., Zhang H.Z., Wang F.Y., Chen Y., Yang G.L. High-performance affinity monolith chromatography for chiral separation and determination of enzyme kinetic constants. Talanta 2010, 82:1332-1337.
34. Kim H.S., Wainer I.W. Rapid analysis of the interactions between drugs and human serum albumin (HSA) using high-performance affinity chromatography (HPAC). Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2008, 870:22-26.
35. Loun B., Hage D.S. Chiral separation mechanisms in protein-based hplc columns .1. Thermodynamic studies of (r)-warfarin and (s)-warfarin binding to immobilized human serum-albumin. Analytical Chemistry 1994, 66:3814-3822.
36. Loun B., Hage D.S. Chiral separation mechanisms in protein-based HPLC columns. 2. Kinetic studies of (R)- and (S)-warfarin binding to immobilised human serum albumin. Analytical Chemistry 1996, 68:1218-1225.
37. Wang C., Wang S., Fan G., Zou H. Screening of antinociceptive components in Corydalis yanhusuo WT Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2010, 396:1731-1740.
38. Wang Y., Kong L., Hu L., Lei X., Yang L., Chou G., Zou H., Wang C., Bligh S.W.A., Wang Z. Biological fingerprinting analysis of the traditional chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2007, 860:185-194.
39. Yoo M.J., Schiel J.E., Hage D.S. Evaluation of affinity microcolumns containing human serum albumin for rapid analysis of drug-protein binding. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2010, 878:1707-1713.
40. Yoo M.J., Hage D.S. Evaluation of silica monoliths in affinity microcolumns for high-throughput analysis of drug-protein interactions. Journal of Separation Science 2009, 32:2776-2785.
41. Kauvar L.M., Villar H.O., Sportsman J.R., Higgins D.L., Schmidt D.E. Protein affinity map of chemical space. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1998, 715:93-102.
42. Kauvar L.M. Affinity fingerprinting: a novel approach to quantitative chemical classification proves useful in drug discovery. Nature Biotechnology 1995, 13:965-966.
43. Cheng Y., Ho E., Subramanyam B., Tseng J.L. Measurements of drug-protein binding by using immobilized human serum albumin liquid chromatography-mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2004, 809:67-73.
44. Wang S., Wang C., Zhao X., Mao S., Wu Y., Fan G. Comprehensive two-dimensional high performance liquid chromatography system with immobilized liposome chromatography column and monolithic column for separation of the traditional Chinese medicine Schisandra chinensis. Analytica Chimica Acta 2012, 713:121-129.
45. Muhonen J., Holopainen J.M., Wiedmer S.K. Interactions between local anesthetics and lipid dispersions studied with liposome electrokinetic capillary chromatography. Journal of Chromatography A 2009, 1216:3392-3397.
46. Sun M., Guo Y., Dai B., Wang C., He L. High-expression EGFR/cell membrane chromatography-online-high-performance liquid chromatography/mass spectrometry: rapid screening of EGFR antagonists from Semen Strychni. Rapid Communications in Mass Spectrometry 2012, 26:2027-2032.
47. Chen X.F., Cao Y., Lv D.Y., Zhu Z.Y., Zhang J.P., Chai Y.F. Comprehensive two-dimensional HepG2/cell membrane chromatography/monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines. Journal of Chromatography A 2012, 1242:67-74.
48. He L.C., Wang S.C., Geng X.D. Coating and fusing cell membranes onto a silica surface and their chromatographic characteristics. Chromatographia 2001, 54:71-76.
49. Sun M., Ren J., Du H., Zhang Y., Zhang J., Wang S., He L. A combined A431 cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening compounds from total alkaloid of Radix Caulophylli acting on the human EGFR. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2010, 878:2712-2718.
50. Baynham M.T., Patel S., Moaddel R., Wainer I.W. Multidimensional on-line screening for ligands to the alpha 3 beta 4 neuronal nicotinic acetylcholine receptor using an immobilized nicotinic receptor liquid chromatographic stationary phase. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2002, 772:155-161.
51. Cardoso C.L., Lima V.V., Zottis A., Oliva G., Andricopulo A.D., Wainer I.W., Moaddel R., Cass Q.B. Development and characterization of an immobilized enzyme reactor (IMER) based on human glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies. Journal of Chromatography A 2005, 1120:1715-1722.
52. Cardoso C.L., de Moraes M.C., Guido R.V.C., Oliva G., Andricopulo A.D., Wainer I.W., Cass Q.B. The development of an immobilized enzyme reactor containing glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi: the effect of species' specific differences on the immobilization. Analyst 2008, 133:93-99.
53. Bartolini M., Cavrini V., Andrisano V. Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies. Journal of Chromatography A 2004, 1031:27-34.
54. Bartolini M., Greig N.H., Yu Q.-s., Andrisano V. Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease. Journal of Chromatography A 2009, 1216:2730-2738.
55. Cardoso C.L., de Moraes M.C. Immobilized enzymes in the identification of new ligands. Analytical Chemistry for Pharmaceutical and Medical Sciences 2009, 91-110. Transworld Research Networks, Kerala, India. N.P. Lopes, T. Guaratini (Eds.).
56. de Moraes M.C., Cardoso C.L., Cass Q.B. Immobilized purine nucleoside phosphorylase from Schistosoma mansoni for specific inhibition studies. Analytical and Bioanalytical Chemistry 2013, 405:4871-4878.
57. Girelli A.M., Mattei E. Application of immobilized enzyme reactor in on-line high performance liquid chromatography: a review. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2005, 819:3-16.
58. Cheng Y.-C., Prusoff W. Relationship between the inhibition constant and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochemical Pharmacology 1973, 22:3099-3108.
59. Bisswanger H. Enzyme Kinetics: Principles and Methods 2008, Wiley-VCH, Weinheim. 2nd ed.
60. Dixon M., Webb E.C. Enzymes 1979, Academic Press, New York. 3rd ed.
61. Copeland R.A. Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists 2005, Wiley, New York.
62. Raczkowski D., Matosiuk D., Jozwiak K. Affinity chromatography as a tool for quantification of interactions between drug molecules and their protein targets. Affinity Chromatography 2012, 281-290. InTech. S. Magdeldin (Ed.).
63. 50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2001, 753:375-383.
64. da Silva J.I., de Moraes M.C., Vieira L.C.C., Corrêa A.G., Cass Q.B., Cardoso C.L. Acetylcholinesterase capillary enzyme reactor for screening and characterization of selective inhibitors. Journal of Pharmaceutical and Biomedical Analysis 2013, 73:44-52.
65. He P., Davies J., Greenway G., Haswell S.J. Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection. Analytica Chimica Acta 2010, 659:9-14.
66. Vilela A.F.L., Vieira L.C.C., Corrêa A.G., Cass Q.B., Cardoso C.L. Screening of selective cholinesterase inhibitors by immobilized enzyme capillary reactors: development and application. Journal of Pharmacy and Pharmacology 2013, 73:44-52.
67. Luckarift H.R., Johnson G.R., Spain J.C. Silica-immobilized enzyme reactors; application to cholinesterase-inhibition studies. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2006, 843:310-316.
68. Vanzolini K.L., Vieira L.C.C., Corrêa A.G., Cardoso C.L., Cass Q.B. Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening. Journal of Medicinal Chemistry 2013, 56:2038-2044.
69. de Moraes M.C., Ducati R.G., Donato A.J., Basso L.A., Santos D.S., Cardoso C.L., Cass Q.B. Capillary bioreactors based on human purine nucleoside phosphorylase: a new approach for ligands identification and characterization. Journal of Chromatography A 2012, 1232:110-115.
70. Mancini F., Andrisano V. Development of a liquid chromatographic system with fluorescent detection for [beta]-secretase immobilized enzyme reactor on-line enzymatic studies. Journal of Pharmaceutical and Biomedical Analysis 2010, 52:355-361.
71. De Simone A., Mancini F., Cosconati S., Marinelli L., La Pietra V., Novellino E., Andrisano V. Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library. Journal of Pharmaceutical and Biomedical Analysis 2013, 73:131-134.
72. Ma X., Chan E.C.Y. On-line chromatographic screening of matrix metalloproteinase inhibitors using immobilized MMP-9 enzyme reactor. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2010, 878:1777-1783.
73. Mazzini F., Nuti E., Petri A., Rossello A. Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2011, 879:756-762.
74. Andre C., Herlem G., Gharbi T., Guillaume Y.C. A new arginase enzymatic reactor: development and application for the research of plant-derived inhibitors. Journal of Pharmaceutical and Biomedical Analysis 2011, 55:48-53.
75. Cloix J.F., Wainer I.W. Development of an immobilized brain glutamine synthetase liquid chromatographic stationary phase for on-line biochemical studies. Journal of Chromatography A 2001, 913:133-140.
76. Nicoli R., Bartolini M., Rudaz S., Andrisano V., Veuthey J.L. Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies. Journal of Chromatography A 2008, 1206:2-10.
77. Wade J.L., Bergold A.F., Carr P.W. Theorical description of nonlinear chromatography, with applications to physicochemical measurements in affinity chromatography and implications for preparative-scale separations. Analytical Chemistry 1987, 59:1286-1295.
78. Gotmar G., Albareda N.R., Frornstedt T. Investigation of the heterogeneous Adsorption behavior of selected enantiomers on immobilized alpha1-acid glycoprotein. Analytical Chemistry 2002, 74:2950-2959.
79. Asnin L., Kaczmarski K., Guiochon G. Features of the adsorption of naproxen enantiomers on weak chiral anion-exchangers in nonlinear chromatography. Journal of Chromatography A 2008, 1192:62-73.
80. Szabelski P. A simple model of enantioselective adsorption on chiral stationary phases. Applied Surface Science 2004, 227:94-103.
81. Moaddel R., Jozwiak K., Yamaguchi R., Wainer I.W. Direct chromatographic determination of dissociation rate constants of ligand-receptor complexes: assessment of the interaction of noncompetitive inhibitors with an immobilized nicotinic acetylcholine receptor-based liquid chromatography stationary phase. Analytical Chemistry 2005, 77:5421-5426.
82. Marszall M.P., Moaddel R., Jozwiak K., Bernier M., Wainer I.W. Initial synthesis and characterization of an immobilized heat shock protein 90 column for online determination of binding affinities. Analytical Biochemistry 2008, 373:313-321.
83. Moaddel R., Jozwiak K., Wainer I.W. Conformational mobility of immobilized neuronal nicotinic receptors: demonstrated by bioaffinity chromatography. Biophysical Journal 2004, 86:511a.
84. Jozwiak K., Hernandez S.C., Kellar K.J., Wainer I.W. Enantioselective interactions of dextromethorphan and levomethorphan with the alpha3beta4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data. Journal of Chromatography B 2003, 797:373-379.
85. Jozwiak K., Moaddel R., Ravichandran S., Plazinska A., Kozak J., Patel S., Yamaguchi R., Wainer I.W. Exploring enantiospecific ligand-protein interations using cellular membrane affinity chromatography: chiral recognition as a dynamic process. Journal of Chromatography B 2008, 875:200-207.
86. Sanghvi M., Moaddel R., Frazier C., Wainer I.W. Synthesis and characterization of liquid chromatographic columns containing the immobilized ligand binding domain of the estrogen related receptor alpha and estrogen related receptor gamma. Journal of Pharmaceutical and Biomedical Analysis 2010, 53:777-780.
87. Vanzolini K.L., Vieira L.C.C., Devkota K., Jiang Z., Zhang X., Beutler J., Corrêa A.G., Cardoso C.L., Cass Q.B., Moaddel R. Acetylcholinesterase Immobilized Capillary Reactors Coupled to Protein Coated Magnetic Beads: A New Tool for Plant Extract Ligand Screening 2013, (unpublised results).
88. Peter S. Frontal Chromatography, in: Encyclopedia of Chromatography 2009, CRC Press. 3rd ed. (Print Version).
89. Deng G.J., Sanyal G. Applications of mass spectrometry in early stages of target based drug discovery. Journal of Pharmaceutical and Biomedical Analysis 2006, 40:528-538.
90. Kasai K., Ishii S. Quantitative-analysis of affinity chromatography of trypsin - new technique for investigation of protein-ligand interaction. The Journal of Biochemistry 1975, 77:261-264.
91. Kasai K., Oda Y., Nishikata M., Ishii S. Frontal affinity-chromatography: theory for its application to studies on specific interactions of biomolecules. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1986, 376:33-47.
92. Chan N.W.C., Lewis D.F., Rosner P.J., Kelly M.A., Schriemer D.C. Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug. discovery: applications of a chromatographic biosensor. Analytical Biochemistry 2003, 319:1-12.
93. Calleri E., Temporini C., Massolini G. Frontal affinity chromatography in characterizing immobilized receptors. Journal of Pharmaceutical and Biomedical Analysis 2011, 54:911-925.
94. Tejeda-Mansir A., Montesinos R.M., Guzman R. Mathematical analysis of frontal affinity chromatography in particle and membrane configurations. Journal of Biochemical and Biophysical Methods 2001, 49:1-28.
95. Luo H., Chen L., Li Z., Ding Z., Xu X. Frontal immunoaffinity chromatography with mass spectrometric detection: a method for finding active compounds from traditional chinese herbs. Analytical Chemistry 2003, 75:3994-3998.
96. Zhu L.-L., Xu X.-J. The novel application of polyclonal antibodies in recognizing anti-EGFR inhibitors directly from herb. Acta Physico-Chimica Sinica 2003, 19:385-388.
97. Besanger T.R., Hodgson R.J., Guillon D., Brennan J.D. Monolithic membrane-receptor columns: optimization of column performance for frontal affinity chromatography/mass spectrometry applications. Analytica Chimica Acta 2006, 561:107-118.
98. Slon-Usakiewicz J.J., Ng W., Foster J.E., Dai J.R., Deretey E., Toledo-Sherman L., Redden P.R., Pasternak A., Reid N. Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA. Journal of Medicinal Chemistry 2004, 47:5094-5100.
99. Calleri E., Fracchiolla G., Montanari R., Pochetti G., Lavecchia A., Loiodice F., Laghezza A., Piemontese L., Massolini G., Temporini C. Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor:Ligand affinity screening and stereoselective ligand-macromolecule interaction. Journal of Chromatography A 2012, 1232:84-92.
100. Temporini C., Ceruti S., Calleri E., Ferrario S., Moaddel R., Abbracchio M.P., Massolini G. Development of an immobilized GPR17 receptor stationary phase for binding determination using frontal affinity chromatography coupled to mass spectrometry. Analytical Biochemistry 2009, 384:123-129.
101. Ng E.S.M., Yang F., Kameyama A., Palcic M.M., Hindsgaul O., Schriemer D.C. High-throughput screening for enzyme inhibitors using frontal affinity chromatography with liquid chromatography and mass spectrometry. Analytical Chemistry 2005, 77:6125-6133.
102. Chan N.W.C., Lewis D.F., Hewko S., Hindsgaul O., Schriemer D.C. Frontal affinity chromatography for the screening of mixtures. Combinatorial Chemistry & High Throughput Screening 2002, 5:395-406.
103. Zhang B., Palcic M.M., Schriemer D.C., Alvarez-Manilla G., Pierce M., Hindsgaul O. Frontal affinity chromatography coupled to mass spectrometry for screening mixtures of enzyme inhibitors. Analytical Biochemistry 2001, 299:173-182.
104. Matsumura K., Higashida K., Hata Y., Kominami J., Nakamura-Tsuruta S., Hirabayashi J. Comparative analysis of oligosaccharide specificities of fucose-specific lectins from Aspergillus oryzae and Aleuria aurantia using frontal affinity chromatography. Analytical Biochemistry 2009, 386:217-221.
105. Fort S., Kim H.-S., Hindsgaul O. Screening for galectin-3 inhibitors from synthetic lacto-n-biose libraries using microscale affinity chromatography coupled to mass spectrometry. The Journal of Organic Chemistry 2006, 71:7146-7154.
106. Hirabayashi J., Arata Y., Kasai K.-i. Reinforcement of frontal affinity chromatography for effective analysis of lectin-oligosaccharide interactions. Journal of Chromatography A 2000, 890:261-271.
107. Habicht K.L., Frazier C., Singh N., Shimmo R., Wainer I.W., Moaddel R. The synthesis and characterization of a nuclear membrane affinity chromatography column for the study of human breast cancer resistant protein (BCRP) using nuclear membranes obtained from the LN-229 cells. Journal of Pharmaceutical and Biomedical Analysis 2013, 72:159-162.
108. Zhang B., Palcic M.M., Mo H., Goldstein I.J., Hindsgaul O. Rapid determination of the binding affinity and specificity of the mushroom Polyporus squamosus lectin using frontal affinity chromatography coupled to electrospray mass spectrometry. Glycobiology 2001, 11:141-147.
109. Yuan X., Hu D., Zhu W., Xu X., Lu C. Application of frontal affinity chromatography combined on-line with mass spectrometry to screening PAI-1 inhibitors from traditional Chinese medicine. Analytical Methods 2012, 4:3744-3747.
110. Temporini C., Massolini G., Marucci G., Lambertucci C., Buccioni M., Volpini R., Calleri E. Development of new chromatographic tools based on A2A adenosine receptor subtype for ligand characterization and screening by FAC-MS. Analytical and Bioanalytical Chemistry 2013, 405:837-845.
111. Moaddel R., Jozwiak K., Whittington K., Wainer I.W. Conformational mobility of immobilized α3β2, α3β4, α4β2, and α4β4 nicotinic acetylcholine receptors. Analytical Chemistry 2005, 77:895-901.
112. Bhatia P.A., Moaddel R., Wainer I.W. The synthesis and characterization of cellular membrane affinity chromatography columns for the study of human multidrug resistant proteins MRP1, MRP2 and human breast cancer resistant protein BCRP using membranes obtained from Spodoptera frugiperda (Sf9) insect cells. Talanta 2010, 81:1477-1481.
113. Singh N., Ravichandran S., Norton D.D., Fugmann S.D., Moaddel R. Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography. Analytical Biochemistry 2013, 436:78-83.
114. Kimura T., Perry J., Anzai N., Pritchard J.B., Moaddel R. Development and characterization of immobilized human organic anion transporter-based liquid chromatographic stationary phase: hOAT1 and hOAT2. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2007, 859:267-271.
115. Slon-Usakiewicz J.J., Ng W., Dai J.-R., Pasternak A., Redden P.R. Frontal affinity chromatography with MS detection (FAC-MS) in drug discovery. Drug Discovery Today 2005, 10:409-416.
116. Renaud J.-P., Delsuc M.-A. Biophysical techniques for ligand screening and drug design. Current Opinion in Pharmacology 2009, 9:622-628.
117. Sharma J., Besanger T.R., Brennan J.D. Assaying small-molecule-receptor interactions by continuous flow competitive displacement chromatography/mass spectrometry. Analytical Chemistry 2008, 80:3213-3220.
118. Calleri E., Temporini C., Caccialanza G., Massolini G. Target-based drug discovery: the emerging success of frontal affinity chromatography coupled to mass spectrometry. ChemMedChem 2009, 4:905-916.
119. Schluter H., Jankowski J., Michael K. Displacement chromatography. Journal of Chromatography Library 1999, 505-524. Elsevier.
120. Moaddel R., Rosenberg A., Spelman K., Frazier J., Frazier C., Nocerino S., Brizzi A., Mugnaini C., Wainer I.W. Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening. Analytical Biochemistry 2011, 412:85-91.
121. Marsilje T.H., Milkiewicz K.L., Hangauer D.G. The design, synthesis and activity of non-ATP competitive inhibitors of pp60c-src tyrosine kinase. Part 1: Hydroxynaphthalene derivatives. Bioorganic & Medicinal Chemistry Letters 2000, 10:477-481.
122. Forsberg E.M., Green J.R.A., Brennan J.D. Continuous flow immobilized enzyme reactor-tandem mass spectrometry for screening of AChE inhibitors in complex mixtures. Analytical Chemistry 2011, 83:5230-5236.
123. Hodgson R.J., Besanger T.R., Brook M.A., Brennan J.D. Inhibitor screening using immobilized enzyme reactor chromatography/mass spectrometry. Analytical Chemistry 2005, 77:7512-7519.
124. Salwiński A., Delépée R., Maunit B. Continuous-flow step gradient mass spectrometry based method for the determination of kinetic parameters of immobilized mushroom tyrosinase in equilibrating conditions: comparison with free enzyme. Rapid Communications in Mass Spectrometry 2011, 25:3549-3554.
125. Marszall M.P. Application of magnetic nanoparticles in pharmaceutical sciences. Pharmaceutical Research 2011, 28:480-483.
126. Pamme N. On-chip bioanalysis with magnetic particles. Current Opinion in Chemical Biology 2012, 16:436-443.
127. Moaddel R., Marszall M.P., Bighi F., Yang Q., Duan X., Wainer I.W. Automated ligand fishing using human serum albumin-coated magnetic beads. Analytical Chemistry 2007, 79:5414-5417.
128. Marszall M.P., Bucinski A., Kruszewski S., Ziomkowska B. A new approach to determine camptothecin and its analogues affinity to human serum albumin. Journal of Pharmaceutical Sciences 2011, 100:1142-1146.
129. Marszall M.P., Bucinski A. A protein-coated magnetic beads as a tool for the rapid drug-protein binding study. Journal of Pharmaceutical and Biomedical Analysis 2010, 52:420-424.
130. Adalberto P.R., dos Santos F.J., Golfeto C.C., Iemma M.R.C., de Souza D.H.F., Cass Q.B. Immobilization of pectinase from Leucoagaricus gongylophorus on magnetic particles. Analyst 2012, 137:4855-4859.
131. Marszall M.P., Moaddel R., Kole S., Gandhari M., Bernier M., Wainer I.W. Ligand and protein fishing with heat shock protein 90 coated magnetic beads. Analytical Chemistry 2008, 80:7571-7575.
132. Hu F.L., Zhang H.Y., Lin H.Q., Deng C.H., Zhang X.M. Enzyme inhibitor screening by electrospray mass spectrometry with immobilized enzyme on magnetic silica microspheres. Journal of the American Society for Mass Spectrometry 2008, 19:865-873.
133. Corchero J.L., Mendoza R., Ferrer-Miralles N., Montras A., Martinez L.M., Villaverde A. Enzymatic characterization of highly stable human alpha-galactosidase A displayed on magnetic particles. Biochemical Engineering Journal 2012, 67:20-27.
134. Marszall M.P., Bucinski A., Gorynski K., Proszowska A., Kaliszan R. Magnetic beads method for determination of binding of drugs to melanin. Journal of Chromatography A 2011, 1218:229-236.
135. Marszall M.P., Siodmiak T. Immobilization of Candida rugosa lipase onto magnetic beads for kinetic resolution of (R,S)-ibuprofen. Catalysis Communications 2012, 24:80-84.
136. du Puch C.B.M., Barbier E., Kraut A., Coute Y., Fuchs J., Buhot A., Livache T., Seve M., Favier A., Douki T., Gasparutto D., Sauvaigo S., Breton J. TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugs. Archives of Biochemistry and Biophysics 2011, 507:296-303.
137. Ershov P., Mezentsev Y., Gnedenko O., Mukha D., Yantsevich A., Britikov V., Kaluzhskiy L., Yablokov E., Molnar A., Ivanov A., Lisitsa A., Gilep A., Usanov S., Archakov A. Protein interactomics based on direct molecular fishing on paramagnetic particles: Experimental simulation and SPR validation. Proteomics 2012, 12:3295-3298.
138. Fu H.Y., Yuan J., Zhou X.M., Sun Y.B., Huang Y.J., Hou L.P., Song C.Y., Yang B.A., Zhen P., Gao R., Mao P.Y., Lin L.Z., Xu S.F., Xiao H.Z., Wei K.H. Determination of hepatocellular carcinoma serum polypeptide based on antibody pre-concentration coupled with mass spectrometry. Chinese Journal of Analytical Chemistry 2012, 40:1803-1806.
139. Qing L.S., Xue Y., Zheng Y., Xiong J., Liao X., Ding L.S., Li B.G., Liu Y.M. Ligand fishing from Dioscorea nipponica extract using human serum albumin functionalized magnetic nanoparticles. Journal of Chromatography A 2010, 1217:4663-4668.
140. 4 magnetic nanoparticles coupled with HPLC-MS/MS. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2012, 887:55-60.
141. Qing L.S., Xue Y., Deng W.L., Liao X., Xu X.M., Li B.G., Liu Y.M. Ligand fishing with functionalized magnetic nanoparticles coupled with mass spectrometry for herbal medicine analysis. Analytical and Bioanalytical Chemistry 2011, 399:1223-1231.
142. Qing L.S., Shan X.Q., Xu X.M., Xue Y., Deng W.L., Li B.G., Wang X.L., Liao X. Rapid probe and isolation of bioactive compounds from Dioscorea panthaica using human serum albumin functionalized magnetic nano-particles (HSA-MNPs)-based ligand fishing coupled with electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2010, 24:3335-3339.
143. Xu N.S., Yang H.M., Cui M., Wan C.H., Liu S.Y. High-performance liquid chromatography-electrospray ionization-mass spectrometry ligand fishing assay: a method for screening triplex DNA binders from natural plant extracts. Analytical Chemistry 2012, 84:2562-2568.
144. Qing L.S., Tang N., Xue Y., Liang J., Liu Y.M., Liao X. Identification of enzyme inhibitors using therapeutic target protein-magnetic nanoparticle conjugates. Analytical Methods 2012, 4:1612-1615.
145. Tao Y., Zhang Y.F., Cheng Y.Y., Wang Y. Rapid screening and identification of alpha-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/MS and NMR. Biomedical Chromatography 2013, 27:148-155.
146. Jonker N., Kretschmer A., Kool J., Fernandez A., Kloos D., Krabbe J.G., Lingeman H., Irth H. Online magnetic bead dynamic protein-affinity selection coupled to LC-MS for the screening of pharmacologically active compounds. Analytical Chemistry 2009, 81:4263-4270.
147. McFadden M.J., Junop M.S., Brennan J.D. Magnetic "fishing" assay to screen small-molecule mixtures for modulators of protein-protein interactions. Analytical Chemistry 2010, 82:9850-9857.
148. Pochet L., Heus F., Jonker N., Lingeman H., Smit A.B., Niessen W.M.A., Kool J. Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2011, 879:1781-1788.