Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: Applications of a chromatographic biosensor

Analytical Biochemistry

Volumn 319, Issue 1, 2003, Pages 1-12

  Chan, Nora W C ^a   Lewis, Darren F ^a   Rosner, Philip J ^b   Kelly, Michele A ^b   Schriemer, David C ^c  

^a MDS Proteomics Inc   (Canada)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Affinity chromatography; Binding assay; Biosensors; High throughput screening; Mass spectrometry

Indexed keywords

AFFINITY CHROMATOGRAPHY; ALCOHOLS; BIOASSAY; BIOSENSORS; DISEASES; DISSOCIATION; DRUG PRODUCTS; MASS SPECTROMETRY; MIXTURES;

BINDING ASSAYS; CHOLERA TOXIN B SUBUNIT; CHROMATOGRAPHY/MASS SPECTROMETRY; DISSOCIATION CONSTANT; FRONTAL AFFINITY CHROMATOGRAPHIES; HIGH THROUGHPUT SCREENING; SORBITOL DEHYDROGENASE; THREE ORDERS OF MAGNITUDE;

LIGANDS;

BETA GALACTOSIDASE; CHOLERA TOXIN B SUBUNIT; ESTROGEN RECEPTOR BETA; IDITOL DEHYDROGENASE; LIGAND; PLANT LECTIN; THROMBIN;

AFFINITY CHROMATOGRAPHY; ARTICLE; BINDING AFFINITY; BIOSENSOR; DISSOCIATION CONSTANT; ENZYME ASSAY; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR INTERACTION; PRIORITY JOURNAL; RELIABILITY; SCREENING TEST;

GRIFFONIA SIMPLICIFOLIA;

EID: 0038353368     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(03)00193-3     Document Type: Article

References (22)

1. Hill D.C. Trends in development of high-throughput screening technologies for rapid discovery of novel drugs. Curr. Opin. Drug Discov. Devel. 1:1998;92-97.
2. Finney N.S. Fluorescence assays for screening combinatorial libraries of drug candidates. Curr. Opin. Drug Discov. Devel. 1:1998;98-105.
3. Silverman L., Campbell R., Broach J.R. New assay technologies for high throughput screening. Curr. Opin. Chem. Biol. 2:1998;397-403.
4. Hage D.S. Chromatographic approaches to immunoassays. J. Clin. Ligand Assay. 20:1997;293-301.
5. Blom K.F., Larsen B.S., McEwen C.N. Determining affinity-selected ligands and estimating binding affinities by online size exclusion chromatography liquid chromatography-mass spectrometry. J. Comb. Chem. 1:1999;82-90.
6. Hage D.S., Tweed S.A. Recent advances in chromatographic and electrophoretic methods for the study of drug-protein interactions. J. Chromatogr. B. 699:1997;499-525.
7. Kelly M.A., Liang H., Sytwu I.-I., Vlattas I., Lyons N.L., Bowen B.R., Wennogle L.P. Characterization of SH2-ligand interactions via library affinity selection with mass spectrometric detection. Biochemistry. 35:1996;11747-11755.
8. Huyer G., Kelly J., Moffat J., Zamboni R., Jia Z., Gresser M.J., Ramachandran C. Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases. Anal. Biochem. 258:1998;19-30.
9. Woodbury C.P. Jr., Venton D.L. Methods of screening combinatorial libraries using immobilized or restrained receptors. J. Chromatogr. B. 725:1999;113-137.
10. Andersson H.S., Ohlson S. Bailon P., Ehrlich G.K., Fung W.-J., Berthold W. Affinity Chromatography: Methods and Protocols. vol. 147:2000;7-23 Humana Press, Totowa, NJ.
11. Lagercrantz C., Larsson T., Karlsson H. Binding of some fatty acids and drugs to immobilized bovine serum albumin studied by column affinity chromatography. Anal. Biochem. 99:1979;352-364.
12. Winzor D.J., Sawyer W.H. Quantitative Characterization of Ligand Binding. 1995;Wiley-Liss, New York.
13. Schriemer D.C., Bundle D.R., Li L., Hindsgaul O. Micro-scale frontal affinity chromatography with mass spectrometric detection: a new method for the screening of compound libraries. Angew. Chem. Int. Eng. Ed. 37:1998;3383-3387.
14. Schriemer D.C., Hindsgaul O. Deconvolution approaches in screening compound mixtures. Comb. Chem. High Throughput Screen. 1:1998;155-170.
15. Chan N.W.C., Lewis D.F., Hewko S., Hindsgaul O., Schriemer D.C. Frontal affinity chromatography for the screening of mixtures. Comb. Chem. High Throughput Screen. 5:2002;395-406.
16. Guiochon G., Shirazi S.G., Katti A.M. Fundamentals of Preparative and Nonlinear Chromatography. 1994;Academic Press, Toronto.
17. Kasai K.-I., Oda Y., Nishikata M., Ishii S.-I. Frontal affinity chromatography: theory for its application to studies on specific interactions of biomolecules. J. Chromatogr. 376:1986;33-47.
18. Zhang Y., Xiao Y., Kellar K.J., Wainer I.W. Immobilized nicotinic receptor stationary phase for on-line liquid chromatographic determination of drug-receptor affinities. Anal. Biochem. 264:1998;22-25.
19. Kuiper G.G.J.M., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., Gustafsson J. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β Endocrinology. 138:1997;863-870.
20. Zhang R.G., Westbrook M.L., Westbrook E.M., Scott D.L., Otwinowski Z., Maulik P.R., Reed R.A., Shipley G.G. The 2.4. Å crystal structure of cholera toxin B subunit pentamer: choleragenoid J. Mol. Biol. 251:1995;550-562.
21. Meyer B., Weimar T., Peters T. Screening mixtures for biological activity by NMR. Eur. J. Biochem. 246:1997;705-709.
22. Eliseev A.V. Emerging approaches to target-assisted screening of combinatorial mixtures. Curr. Opin. Drug Discov. Devel. 1:1998;106-115.