Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies

Journal of Chromatography A

Volumn 1206, Issue 1, 2008, Pages 2-10

  Nicoli, R ^a   Bartolini, M ^b   Rudaz, S ^a   Andrisano, V ^b   Veuthey, J L ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

CYP2D6; CYP3A4; Immobilized enzyme reactors; LC MS MS; Monolithic minidisks; On line drug metabolism

Indexed keywords

ANIMAL CELL CULTURE; BIOCHEMISTRY; COMPUTER NETWORKS; CURVE FITTING; ELECTROSPRAY IONIZATION; METABOLISM; OPTIMIZATION;

CYP2D6; CYP3A4; IMMOBILIZED ENZYME REACTORS; LC-MS/MS; MONOLITHIC MINIDISKS; ON-LINE DRUG METABOLISM;

ENZYMES;

CYTOCHROME P450; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; RECOMBINANT ENZYME;

ARTICLE; BIOREACTOR; BIOTINYLATION; COMPETITIVE INHIBITION; DRUG METABOLISM; ENZYME IMMOBILIZATION; IMMOBILIZED ENZYME REACTOR; MASS SPECTROMETRY; PRIORITY JOURNAL;

AVIDIN; BIOREACTORS; BIOTINYLATION; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ENZYME STABILITY; ENZYMES, IMMOBILIZED; HUMANS; KINETICS; MICROSOMES, LIVER; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 51249111291     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.05.080     Document Type: Article

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