On-line chromatographic screening of matrix metalloproteinase inhibitors using immobilized MMP-9 enzyme reactor

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 21, 2010, Pages 1777-1783

  Ma, Xiang ^a   Chan, Eric Chun Yong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

High throughput screening; Immobilized enzyme reactor; Matrix metalloproteinase; MMP 9

Indexed keywords

ALTERNATIVE METHODS; CANCER INVASION; CANCER METASTASIS; CONJUGATED ENZYMES; DOXYCYCLINE; DRUG CANDIDATES; ENZYME REACTORS; FREE ENZYME; FREE SOLUTIONS; HIGH COSTS; HIGH THROUGHPUT SCREENING; HYDROXAMIC ACIDS; IMMOBILIZED ENZYME REACTORS; ISOBUTYL; ISOLATION AND PURIFICATION; MATRIX METALLOPROTEINASE-9; MATRIX METALLOPROTEINASES; MINOCYCLINE; MMP INHIBITOR; RECOMBINANT ENZYMES; SCREENING TOOL; STABLE CATALYSTS; THERAPEUTIC INTERVENTION; THIOPEPTIDE;

CATALYSTS; ORGANIC ACIDS; PATHOLOGY; THROUGHPUT;

ENZYMES;

CHROMOGENIC SUBSTRATE; DOXYCYCLINE; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; MINOCYCLINE; PEPTIDE DERIVATIVE; ENZYME INHIBITOR; IMMOBILIZED ENZYME; RECOMBINANT PROTEIN;

ARTICLE; CATALYST; CONJUGATION; COST EFFECTIVENESS ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IMMOBILIZED ENZYME REACTOR; KINETICS; ONLINE SYSTEM; PRIORITY JOURNAL; SCREENING; ULTRAVIOLET RADIATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; PROCEDURES; STATISTICAL MODEL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; ENZYMES, IMMOBILIZED; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LINEAR MODELS; MATRIX METALLOPROTEINASE 9; RECOMBINANT PROTEINS; MATRIX METALLOPROTEINASE INHIBITORS;

EID: 77953478714     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.04.040     Document Type: Article

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