Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease

Journal of Chromatography A

Volumn 1216, Issue 13, 2009, Pages 2730-2738

  Bartolini, Manuela ^a   Greig, Nigel H ^b   Yu, Qian sheng ^b   Andrisano, Vincenza ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Covalent immobilization; Cymserine; Human butyrylcholinesterase; Kinetic constants; Monolithic disks; On line studies; Phenserine; Pseudo irreversible inhibitors

Indexed keywords

COVALENT IMMOBILIZATION; CYMSERINE; HUMAN BUTYRYLCHOLINESTERASE; KINETIC CONSTANTS; MONOLITHIC DISKS; ON-LINE STUDIES; PHENSERINE; PSEUDO-IRREVERSIBLE INHIBITORS;

ASSAYS; DISKS (MACHINE COMPONENTS); DISKS (STRUCTURAL COMPONENTS);

ENZYMES;

BISNORCYMSERINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CYMSERINE DERIVATIVE; IMMOBILIZED ENZYME; ISOBUTYLBISNORCYMSERINE; PHENSERINE; PHYSOSTIGMINE; RECOMBINANT ENZYME; TOLSERINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CARBAMOYLATION; CHEMICAL REACTION; COVALENT BOND; DECARBAMOYLATION; DRUG POTENCY; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMOBILIZED ENZYME REACTOR; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET IRRADIATION; VALIDATION PROCESS;

ALZHEIMER DISEASE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; ENZYMES, IMMOBILIZED; HUMANS; RECOMBINANT PROTEINS;

EID: 61449149521     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.09.100     Document Type: Article

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