Magnetic "fishing" assay to screen small-molecule mixtures for modulators of protein - Protein interactions

Analytical Chemistry

Volumn 82, Issue 23, 2010, Pages 9850-9857

  McFadden, Meghan J ^a   Junop, Murray S ^a   Brennan, John D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPOUNDS; BIOACTIVE COMPOUNDS; BIOLOGICAL PATHWAYS; DOSE-DEPENDENT; DRUG DISCOVERY; FUNCTIONALIZED; INHIBITION CONSTANTS; INTACT PROTEINS; MAGNETIC BEAD ASSAY; MAGNETIC BEADS; MELITTIN; NATURALLY OCCURRING; PHENOLIC COMPOUNDS; PHOSPHODIESTERASE ACTIVITY; POLYHISTIDINE; PROTEIN-PROTEIN INTERACTIONS; RESPONSE CURVES; SMALL MOLECULES; TRIFLUOPERAZINE; TWO STAGE;

CAMS; DRUG INTERACTIONS; FISHERIES; MASS SPECTROMETRY; MIXTURES; PHENOLS;

CALMODULIN;

BENZETHONIUM CHLORIDE; CALMODULIN; DRUG DERIVATIVE; HIS HIS HIS HIS HIS HIS; HIS-HIS-HIS-HIS-HIS-HIS; HISTIDINE; MELITTIN; METHYLBENZETHONIUM; NICKEL; OLIGOPEPTIDE; PEMPIDINE; TRIFLUOPERAZINE;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; ELECTROSPRAY MASS SPECTROMETRY; KINETICS; MAGNETISM; METABOLISM; METHODOLOGY; PROTEIN ANALYSIS; PROTEIN BINDING;

BENZETHONIUM; CALMODULIN; HISTIDINE; KINETICS; MAGNETICS; MELITTEN; NICKEL; OLIGOPEPTIDES; PEMPIDINE; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRIFLUOPERAZINE;

EID: 78649716882     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac102164d     Document Type: Article

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