Capillary bioreactors based on human purine nucleoside phosphorylase: A new approach for ligands identification and characterization

Journal of Chromatography A

Volumn 1232, Issue , 2012, Pages 110-115

  de Moraes, Marcela Cristina ^a   Ducati, Rodrigo Gay ^b   Donato, Augusto José ^b   Basso, Luiz Augusto ^b   Santos, Diógenes Santiago ^b   Cardoso, Carmen Lucia ^c   Cass, Quezia Bezerra ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Enzyme immobilization; Immucillin analogues; Ligands screening; Purine nucleoside phosphorylase

Indexed keywords

ENZYMATIC REACTION; FREE ENZYME; FUSED-SILICA CAPILLARIES; IMMOBILIZED ENZYME; IMMOBILIZED ENZYME REACTORS; IMMUCILLIN ANALOGUES; INOSINE; MECHANISTIC STUDIES; MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY; PHOSPHOROLYSIS; PURINE NUCLEOSIDE PHOSPHORYLASE; SCREENING METHODS; SPECTROPHOTOMETRIC ASSAYS; VALIDATED METHODS;

ASSAYS; BIOMOLECULES; DIAGNOSIS; ENZYME IMMOBILIZATION; LEAD COMPOUNDS; LIQUID CHROMATOGRAPHY; PHOSPHORYLATION;

LIGANDS;

IMMUCILLIN DERIVATIVE; LIGAND; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; SILICA GEL; UNCLASSIFIED DRUG;

ANALYTICAL EQUIPMENT; ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); ENZYME ASSAY; ENZYME BINDING; ENZYME MECHANISM; EQUIPMENT DESIGN; IMMOBILIZED ENZYME REACTOR; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MICHAELIS CONSTANT; MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; VALIDATION PROCESS;

BIOREACTORS; CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; ENZYMES, IMMOBILIZED; EQUIPMENT DESIGN; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; HYPOXANTHINE; INOSINE; KINETICS; LIGANDS; LINEAR MODELS; MODELS, CHEMICAL; PURINE-NUCLEOSIDE PHOSPHORYLASE; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS;

EID: 84858071823     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.10.056     Document Type: Article

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