High-throughput screening for enzyme inhibitors using frontal affinity chromatography with liquid chromatography and mass spectrometry

Analytical Chemistry

Volumn 77, Issue 19, 2005, Pages 6125-6133

  Ng, Ella S M ^a   Yang, Feng ^b   Kameyama, Akihiko ^b   Palcic, Monica M ^b,c   Hindsgaul, Ole ^c   Schriemer, David C ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c CARLSBERG LABORATORY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DATA SETS; FRONTAL AFFINITY CHROMATOGRAPHY (FAC); LIGANDS; TRISACCHARIDES;

AFFINITY CHROMATOGRAPHY; DATA REDUCTION; MASS SPECTROMETRY; MOLECULAR STRUCTURE;

ENZYME INHIBITION;

ALPHA 1,3(6) MANNOSYLGLYCOPROTEIN BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; ENZYME; ENZYME INHIBITOR; TRISACCHARIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; FRACTIONATION; FRONTAL AFFINITY CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SYNTHESIS;

CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, LIQUID; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; LIGANDS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; N-ACETYLGLUCOSAMINYLTRANSFERASES; REPRODUCIBILITY OF RESULTS;

EID: 26444610191     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac051131r     Document Type: Article

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